Yichin Liu

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi request reprint Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
    Yichin Liu
    Center for Neurologic Diseases, Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Chem Biol 10:837-46. 2003
  2. doi request reprint High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay
    Yichin Liu
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Anal Biochem 378:53-9. 2008
  3. doi request reprint A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
    Jasvinder K Atwal
    Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Sci Transl Med 3:84ra43. 2011
  4. doi request reprint Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates
    Yichin Liu
    Biochemical Pharmacology and Early Leads, Genentech, Inc, South San Francisco, CA 90480, USA
    J Biomol Screen 17:225-36. 2012
  5. doi request reprint Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
    David Meininger
    Protein Sciences, Amgen Inc, Seattle, WA 98119, USA
    Biochim Biophys Acta 1814:1947-54. 2011
  6. doi request reprint Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2)
    Brian Lovitt
    Biochemical Pharmacology and Early Leads, Genentech, Inc, One DNA Way, South San Francisco, California 90480, USA
    Biochemistry 49:3092-100. 2010
  7. ncbi request reprint Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay
    Ada Chen
    Therapeutic Discovery, Amgen, Inc, 1120 Veterans Blvd, South San Francisco, CA 94080 USA
    Comb Chem High Throughput Screen 16:644-51. 2013
  8. doi request reprint Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling
    Huifen Chen
    Discovery Chemistry Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, United States
    J Med Chem 55:5536-45. 2012
  9. ncbi request reprint Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based phosphate assay and a fluorescence polarization-based ADP Assay for high-throughput screening
    Yichin Liu
    Amgen Inc, Thousand Oaks, CA 91320 1799, USA
    Assay Drug Dev Technol 5:225-35. 2007

Collaborators

  • Christopher E Heise
  • Xiaoyang Xia
  • Xingrong Liu
  • Thuy Tran
  • Zachary K Sweeney
  • Ping Wu
  • Kun Peng
  • Ada Chen
  • Leeanne Zalameda
  • Huifen Chen
  • John D McCarter
  • Haitao Zhu
  • Jasvinder K Atwal
  • David Meininger
  • Brian Lovitt
  • Shouhua Xiao
  • Heather Eastwood
  • Cheng Su
  • Laina Mercer
  • Amanda Lembke
  • Stephen W Young
  • Xiaoning Zhao
  • Thim Oung
  • Son Dang
  • Daniel J Burdick
  • Daniel Shore
  • John Moffat
  • Shumei Wang
  • Jason Drummond
  • Janet Gunzner-Toste
  • Anthony A Estrada
  • Bryan K Chan
  • Guiling Zhao
  • Marc Tessier-Lavigne
  • Yan Wu
  • Kimberly Scearce-Levie
  • Luis Borges
  • Lara P Stepan
  • Kwame Hoyte
  • Robert A Lazarus
  • William J Meilandt
  • Cecilia Chiu
  • Weiru Wang
  • Deborah L Mortensen
  • Ryan J Watts
  • Yingnan Zhang
  • Claire L Sutherland
  • Wilman Luk
  • Yongmei Chen
  • Lionel Rouge
  • Yanmei Lu
  • Zejuan Sheng
  • Erica C VanderPorten
  • Jake Drummond

Detail Information

Publications9

  1. ncbi request reprint Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
    Yichin Liu
    Center for Neurologic Diseases, Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Chem Biol 10:837-46. 2003
    ..The molecular mechanism of this response remains to be determined...
  2. doi request reprint High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay
    Yichin Liu
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Anal Biochem 378:53-9. 2008
    ..Kinetic parameters of peptide and NAD(+) cosubstrates and IC(50) values of standard reference inhibitors determined in either assay were similar. With robust Z' values (0.7), both assays are amenable to high-throughput screening...
  3. doi request reprint A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
    Jasvinder K Atwal
    Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Sci Transl Med 3:84ra43. 2011
    ..Nevertheless, therapeutic success with anti-BACE1 will depend on improving antibody uptake into the brain...
  4. doi request reprint Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates
    Yichin Liu
    Biochemical Pharmacology and Early Leads, Genentech, Inc, South San Francisco, CA 90480, USA
    J Biomol Screen 17:225-36. 2012
    ..These case studies support a model where a diversity set of compounds should be tested first for hit rates as a function of order of addition, carrier protein, and relevant mechanistic studies prior to launch of the HTS campaign...
  5. doi request reprint Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
    David Meininger
    Protein Sciences, Amgen Inc, Seattle, WA 98119, USA
    Biochim Biophys Acta 1814:1947-54. 2011
    ..Docking of Amg-1 and related analogs to the known structure of IDO1 and to homology-modeled IDO2 suggests possible rationales for the different inhibition profiles of IDO1 and IDO2...
  6. doi request reprint Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2)
    Brian Lovitt
    Biochemical Pharmacology and Early Leads, Genentech, Inc, One DNA Way, South San Francisco, California 90480, USA
    Biochemistry 49:3092-100. 2010
    ....
  7. ncbi request reprint Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay
    Ada Chen
    Therapeutic Discovery, Amgen, Inc, 1120 Veterans Blvd, South San Francisco, CA 94080 USA
    Comb Chem High Throughput Screen 16:644-51. 2013
    ....
  8. doi request reprint Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling
    Huifen Chen
    Discovery Chemistry Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, United States
    J Med Chem 55:5536-45. 2012
    ....
  9. ncbi request reprint Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based phosphate assay and a fluorescence polarization-based ADP Assay for high-throughput screening
    Yichin Liu
    Amgen Inc, Thousand Oaks, CA 91320 1799, USA
    Assay Drug Dev Technol 5:225-35. 2007
    ..Acetyl-coenzyme A carboxylase inhibitors were identified by these high-throughput screening methods and were confirmed in a radiometric high performance liquid chromatography assay of malonyl-coenzyme A production...