Yichin Liu

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi request reprint Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
    Yichin Liu
    Center for Neurologic Diseases, Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Chem Biol 10:837-46. 2003
  2. doi request reprint High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay
    Yichin Liu
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Anal Biochem 378:53-9. 2008
  3. doi request reprint A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
    Jasvinder K Atwal
    Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Sci Transl Med 3:84ra43. 2011
  4. ncbi request reprint Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates
    Yichin Liu
    Biochemical Pharmacology and Early Leads, Genentech, Inc, South San Francisco, CA 90480, USA
    J Biomol Screen 17:225-36. 2012
  5. ncbi request reprint Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase
    Benjamin P Fauber
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA Electronic address
    Bioorg Med Chem Lett 23:5533-9. 2013
  6. doi request reprint Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
    David Meininger
    Protein Sciences, Amgen Inc, Seattle, WA 98119, USA
    Biochim Biophys Acta 1814:1947-54. 2011
  7. doi request reprint Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase
    Peter S Dragovich
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Bioorg Med Chem Lett 23:3186-94. 2013
  8. ncbi request reprint Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase
    Angela Oh
    Genentech, Inc, Department of Structural Biology, 1 DNA Way, South San Francisco, California 94080 USA
    Chembiochem 15:1121-30. 2014
  9. doi request reprint Label-free high-throughput assays to screen and characterize novel lactate dehydrogenase inhibitors
    Erica Vanderporten
    Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA 94080, USA
    Anal Biochem 441:115-22. 2013
  10. ncbi request reprint Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay
    Ada Chen
    Therapeutic Discovery, Amgen, Inc, 1120 Veterans Blvd, South San Francisco, CA 94080 USA
    Comb Chem High Throughput Screen 16:644-51. 2013

Collaborators

  • Weiru Wang
  • Peter S Dragovich
  • Charles Z Ding
  • Robert A Lazarus
  • Jing Wang
  • Kimberly Scearce-Levie
  • Ping Wu
  • Anthony M Giannetti
  • Charles Eigenbrot
  • Christopher E Heise
  • Xingrong Liu
  • Thuy Tran
  • Kun Peng
  • Xiaoyang Xia
  • Zachary K Sweeney
  • Erica Vanderporten
  • Angela Oh
  • Benjamin P Fauber
  • Ada Chen
  • John D McCarter
  • Leeanne Zalameda
  • Huifen Chen
  • Jasvinder K Atwal
  • Haitao Zhu
  • David Meininger
  • Brian Lovitt
  • Xiaozhang Zheng
  • Mark Zak
  • Po Wai Yuen
  • Xukun Chen
  • Yen Ching Ho
  • Laina Mercer
  • Rebecca Turincio
  • David Peterson
  • Laura B Corson
  • Thim Oung
  • Son Dang
  • Mark Ultsch
  • Heather Eastwood
  • Sharada Labadie
  • Amanda Lembke
  • Steve Sideris
  • Stephen W Young
  • Shiva Malek
  • Keith Pitts
  • Shouhua Xiao
  • Qin Yue
  • Ivana Yen
  • Cheng Su
  • Binqing Wei
  • Jinhua Chen
  • William LaMarr
  • Lauren Frick
  • Thomas Hunsaker
  • Xiaoning Zhao
  • Peter Thana
  • John Moffat
  • Anthony A Estrada
  • Daniel J Burdick
  • Janet Gunzner-Toste
  • Bryan K Chan
  • Daniel Shore
  • Shumei Wang
  • Jason Drummond
  • Guiling Zhao
  • Marc Tessier-Lavigne
  • Yan Wu
  • Lara P Stepan
  • William J Meilandt
  • Ryan J Watts
  • Claire L Sutherland
  • Lionel Rouge
  • Cecilia Chiu
  • Deborah L Mortensen
  • Yingnan Zhang
  • Wilman Luk
  • Yanmei Lu
  • Luis Borges
  • Kwame Hoyte
  • Yongmei Chen
  • Zejuan Sheng
  • Erica C VanderPorten
  • Jake Drummond

Detail Information

Publications14

  1. ncbi request reprint Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
    Yichin Liu
    Center for Neurologic Diseases, Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Chem Biol 10:837-46. 2003
    ..The molecular mechanism of this response remains to be determined...
  2. doi request reprint High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay
    Yichin Liu
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Anal Biochem 378:53-9. 2008
    ..Kinetic parameters of peptide and NAD(+) cosubstrates and IC(50) values of standard reference inhibitors determined in either assay were similar. With robust Z' values (0.7), both assays are amenable to high-throughput screening...
  3. doi request reprint A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
    Jasvinder K Atwal
    Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Sci Transl Med 3:84ra43. 2011
    ..Nevertheless, therapeutic success with anti-BACE1 will depend on improving antibody uptake into the brain...
  4. ncbi request reprint Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates
    Yichin Liu
    Biochemical Pharmacology and Early Leads, Genentech, Inc, South San Francisco, CA 90480, USA
    J Biomol Screen 17:225-36. 2012
    ..These case studies support a model where a diversity set of compounds should be tested first for hit rates as a function of order of addition, carrier protein, and relevant mechanistic studies prior to launch of the HTS campaign...
  5. ncbi request reprint Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase
    Benjamin P Fauber
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA Electronic address
    Bioorg Med Chem Lett 23:5533-9. 2013
    ..A crystal structure of an improved compound bound to human LDHA was also obtained and it explained many of the observed structure-activity relationships. ..
  6. doi request reprint Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
    David Meininger
    Protein Sciences, Amgen Inc, Seattle, WA 98119, USA
    Biochim Biophys Acta 1814:1947-54. 2011
    ..Docking of Amg-1 and related analogs to the known structure of IDO1 and to homology-modeled IDO2 suggests possible rationales for the different inhibition profiles of IDO1 and IDO2...
  7. doi request reprint Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase
    Peter S Dragovich
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Bioorg Med Chem Lett 23:3186-94. 2013
    ..48 μM). A crystal structure of an optimized compound bound to human LDHA was obtained and explained many of the observed structure-activity relationships...
  8. ncbi request reprint Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase
    Angela Oh
    Genentech, Inc, Department of Structural Biology, 1 DNA Way, South San Francisco, California 94080 USA
    Chembiochem 15:1121-30. 2014
    ..Our data support a model for cellularly active NAMPT inhibitors that undergo NAMPT-catalyzed phosphoribosylation to produce pRib adducts that retain efficient binding to the enzyme. ..
  9. doi request reprint Label-free high-throughput assays to screen and characterize novel lactate dehydrogenase inhibitors
    Erica Vanderporten
    Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA 94080, USA
    Anal Biochem 441:115-22. 2013
    ..7, these two high-throughput assays for LDH are both label free and complementary to each other in the HTS workflow by monitoring the activities of the compounds on each half of the LDH redox reaction...
  10. ncbi request reprint Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay
    Ada Chen
    Therapeutic Discovery, Amgen, Inc, 1120 Veterans Blvd, South San Francisco, CA 94080 USA
    Comb Chem High Throughput Screen 16:644-51. 2013
    ....
  11. ncbi request reprint Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2)
    Brian Lovitt
    Biochemical Pharmacology and Early Leads, Genentech, Inc, One DNA Way, South San Francisco, California 90480, USA
    Biochemistry 49:3092-100. 2010
    ....
  12. ncbi request reprint Allosteric inhibition of BACE1 by an exosite-binding antibody
    Weiru Wang
    Department of Structural Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, United States Electronic address
    Curr Opin Struct Biol 23:797-805. 2013
    ..This binding mode, along with the enzymatic inhibition pattern, suggests that anti-BACE1 functions through an allosteric inhibition mechanism. ..
  13. doi request reprint Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling
    Huifen Chen
    Discovery Chemistry Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, United States
    J Med Chem 55:5536-45. 2012
    ....
  14. ncbi request reprint Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based phosphate assay and a fluorescence polarization-based ADP Assay for high-throughput screening
    Yichin Liu
    Amgen Inc, Thousand Oaks, CA 91320 1799, USA
    Assay Drug Dev Technol 5:225-35. 2007
    ..Acetyl-coenzyme A carboxylase inhibitors were identified by these high-throughput screening methods and were confirmed in a radiometric high performance liquid chromatography assay of malonyl-coenzyme A production...