Li Li

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. pmc Discovering cancer genes by integrating network and functional properties
    Li Li
    Department of Bioinformatics, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    BMC Med Genomics 2:61. 2009
  2. ncbi Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas
    Mark L McCleland
    Department of Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
    Clin Cancer Res 19:773-84. 2013
  3. ncbi Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes
    Genee Y Lee
    Authors Affiliations Departments of Discovery Oncology, Molecular Biology, Bioinformatics, Pathology, and Molecular Oncology, Genentech Inc, South San Francisco, California
    Cancer Res 74:3114-26. 2014
  4. pmc A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis
    Nicholas Dompe
    Department of Molecular Biology, Genentech, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 108:E943-51. 2011
  5. pmc Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines
    Steffan Vartanian
    Department of Discovery Oncology, Genentech Inc, South San Francisco, California 94080, USA
    J Biol Chem 288:2403-13. 2013
  6. ncbi PPM1H is a p27 phosphatase implicated in trastuzumab resistance
    Si Tuen Lee-Hoeflich
    Genentech Research and Early Development, South San Francisco, California 94080, USA
    Cancer Discov 1:326-37. 2011
  7. doi Diverse somatic mutation patterns and pathway alterations in human cancers
    Zhengyan Kan
    Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 466:869-73. 2010
  8. doi Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers
    Eva Lin
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080, USA
    Mol Cancer Res 7:1466-76. 2009
  9. doi Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy
    Yuting Sun
    Department of Discovery Oncology, Genentech Inc, South San Francisco, California, USA
    Cancer Res 72:527-36. 2012
  10. doi Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
    Ai Luen Wu
    Molecular Biology, Genentech Inc, South San Francisco, CA 94080, USA
    Sci Transl Med 3:113ra126. 2011

Collaborators

Detail Information

Publications15

  1. pmc Discovering cancer genes by integrating network and functional properties
    Li Li
    Department of Bioinformatics, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    BMC Med Genomics 2:61. 2009
    ..It is important to integrate multiple genomic data sources, including PPI networks, protein domains and Gene Ontology (GO) annotations, to facilitate the identification of cancer genes...
  2. ncbi Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas
    Mark L McCleland
    Department of Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
    Clin Cancer Res 19:773-84. 2013
    ..This study is aimed to identify genes within the KRAS genomic amplicon that are both coupregulated and essential for cell proliferation when KRAS is amplified in lung cancer...
  3. ncbi Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes
    Genee Y Lee
    Authors Affiliations Departments of Discovery Oncology, Molecular Biology, Bioinformatics, Pathology, and Molecular Oncology, Genentech Inc, South San Francisco, California
    Cancer Res 74:3114-26. 2014
    ..Elevated expression of SHMT2 and PSMB4 was found to be associated with poor prognosis in human cancer, supporting the development of molecular therapies targeting these genes or components of their pathways...
  4. pmc A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis
    Nicholas Dompe
    Department of Molecular Biology, Genentech, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 108:E943-51. 2011
    ..Our findings highlight a mechanism by which cancer cells may evade apoptosis, and therefore provide insight in the search for new targets and functional biomarkers for this pathway...
  5. pmc Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines
    Steffan Vartanian
    Department of Discovery Oncology, Genentech Inc, South San Francisco, California 94080, USA
    J Biol Chem 288:2403-13. 2013
    ..We conclude that there are conserved components of mutant K-Ras signaling and phenotypes but that many depend on cell context and environmental cues...
  6. ncbi PPM1H is a p27 phosphatase implicated in trastuzumab resistance
    Si Tuen Lee-Hoeflich
    Genentech Research and Early Development, South San Francisco, California 94080, USA
    Cancer Discov 1:326-37. 2011
    ..Furthermore, low PPM1H expression may identify a subset of HER2-positive tumors that are harder to treat...
  7. doi Diverse somatic mutation patterns and pathway alterations in human cancers
    Zhengyan Kan
    Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 466:869-73. 2010
    ..Our study provides an overview of the mutational spectra across major human cancers and identifies several potential therapeutic targets...
  8. doi Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers
    Eva Lin
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080, USA
    Mol Cancer Res 7:1466-76. 2009
    ..Collectively, these findings show the recurrence of EML4-ALK fusion in multiple solid tumors and further substantiate its role in tumorigenesis...
  9. doi Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy
    Yuting Sun
    Department of Discovery Oncology, Genentech Inc, South San Francisco, California, USA
    Cancer Res 72:527-36. 2012
    ..This finding could have significant implications for second-line treatment strategies in this clinical setting...
  10. doi Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
    Ai Luen Wu
    Molecular Biology, Genentech Inc, South San Francisco, CA 94080, USA
    Sci Transl Med 3:113ra126. 2011
    ....
  11. doi High-resolution genomic and expression analyses of copy number alterations in breast tumors
    Peter M Haverty
    Department of Bioinformatics, Genentech, Inc, South San Francisco, CA 94080, USA
    Genes Chromosomes Cancer 47:530-42. 2008
    ..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...
  12. doi An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer
    Mark L McCleland
    Departments of Pathology, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Res 72:5812-23. 2012
    ..These findings suggest that targeting LDHB or other components of lactate metabolism would be of clinical benefit in triple-negative breast cancer...
  13. doi A mouse knockout library for secreted and transmembrane proteins
    Tracy Tang
    Department of Molecular Biology, Genentech, Inc, South San Francisco, California, USA
    Nat Biotechnol 28:749-55. 2010
    ..To our knowledge, a comprehensive phenotypic assessment of a large number of mouse mutants generated by a gene-specific approach has not been described previously...
  14. pmc Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse
    Deanna G Wilson
    Department of Molecular Biology, Genentech, South San Francisco, CA 94080, USA
    J Cell Biol 193:935-51. 2011
    ..Thus, Mia3's role in protein secretion is much broader than previously realized, and it may, in fact, be required for the efficient secretion of all collagen molecules in higher organisms...
  15. ncbi PADGE: analysis of heterogeneous patterns of differential gene expression
    Li Li
    Department of Bioinformatics, Genentech Incorporated, South San Francisco, CA 94080, USA
    Physiol Genomics 32:154-9. 2007
    ..Availability: http://www.cgl.ucsf.edu/Research/genentech/padge/...