John Lee

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. pmc Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein
    John Lee
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Cell Biol 170:661-73. 2005
  2. ncbi Mitochondrial localization of CNP2 is regulated by phosphorylation of the N-terminal targeting signal by PKC: implications of a mitochondrial function for CNP2 in glial and non-glial cells
    John Lee
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Neurosci 31:446-62. 2006
  3. ncbi Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase superfamily
    Guennadi Kozlov
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 278:46021-8. 2003
  4. ncbi Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
    Corinna Lappe-Siefke
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    Nat Genet 33:366-74. 2003
  5. ncbi Assignment of the 1H, 13C and 15N resonances of the catalytic domain of the rat 2',3'-cyclic nucleotide 3'-phosphodiesterase
    Guennadi Kozlov
    J Biomol NMR 22:99-100. 2002
  6. ncbi Determination of tumour hypoxia with the PET tracer [18F]EF3: improvement of the tumour-to-background ratio in a mouse tumour model
    Nicolas Christian
    Center for Molecular Imaging and Experimental Radiotherapy, Universite Catholique de Louvain, Av Hippocrate, 10, Brussels, 1200, Brussels, Belgium
    Eur J Nucl Med Mol Imaging 34:1348-54. 2007
  7. pmc All three Ca2+-binding loops of photoproteins bind calcium ions: the crystal structures of calcium-loaded apo-aequorin and apo-obelin
    Lu Deng
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Protein Sci 14:663-75. 2005
  8. ncbi Preparation and X-ray crystallographic analysis of the Ca2+-discharged photoprotein obelin
    Lu Deng
    Department of Chemistry, University of Georgia, Athens, GA 30602, USA
    Acta Crystallogr D Biol Crystallogr 60:512-4. 2004
  9. ncbi Atomic resolution structure of obelin: soaking with calcium enhances electron density of the second oxygen atom substituted at the C2-position of coelenterazine
    Zhi Jie Liu
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Biochem Biophys Res Commun 311:433-9. 2003
  10. ncbi Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes
    Francesco Azzaroli
    Liver Center, Department of Internal Medicine and Immunology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8019, USA
    Hepatology 36:49-54. 2002

Collaborators

  • Kalle Gehring
  • Guennadi Kozlov
  • James Boyer
  • Klaus Armin Nave
  • Zhi Jie Liu
  • Lu Deng
  • Eugene S Vysotski
  • Bi Cheng Wang
  • John Rose
  • Galina A Stepanyuk
  • Nicolas Christian
  • Svetlana V Markova
  • Corinna Lappe-Siefke
  • Francesco Azzaroli
  • Svetlana S Markova
  • Ludmila A Frank
  • Pierre Mahy
  • Daniel Labar
  • Anne Bol
  • Marc De Bast
  • Vincent Gregoire
  • Michel Gravel
  • Ian R Griffiths
  • Eva Nicksch
  • Peter E Braun
  • Sandra Goebbels
  • Ian Nicholas Crispe
  • Carol J Soroka
  • Wajahat Mehal
  • Lin Wang
  • Nicholas Crispe

Detail Information

Publications11

  1. pmc Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein
    John Lee
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Cell Biol 170:661-73. 2005
    ..Accordingly, cultured OLs from CNP-deficient mice extend smaller outgrowths with less arborized processes. We propose that CNP is an important component of the cytoskeletal machinery that directs process outgrowth in OLs...
  2. ncbi Mitochondrial localization of CNP2 is regulated by phosphorylation of the N-terminal targeting signal by PKC: implications of a mitochondrial function for CNP2 in glial and non-glial cells
    John Lee
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Neurosci 31:446-62. 2006
    ..Our results point to a broader biological role for CNP2 in mitochondria that is likely to be different from its specific role in the cytoplasm, along with CNP1, during myelination...
  3. ncbi Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase superfamily
    Guennadi Kozlov
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 278:46021-8. 2003
    ..NMR titrations of the CNP catalytic domain with inhibitors and kinetic studies of site-directed mutants reveal a protein conformational change that occurs upon binding...
  4. ncbi Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
    Corinna Lappe-Siefke
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    Nat Genet 33:366-74. 2003
    ..Oligodendrocyte dysfunction, such as that in multiple sclerosis lesions, may suffice to cause secondary axonal loss...
  5. ncbi Assignment of the 1H, 13C and 15N resonances of the catalytic domain of the rat 2',3'-cyclic nucleotide 3'-phosphodiesterase
    Guennadi Kozlov
    J Biomol NMR 22:99-100. 2002
  6. ncbi Determination of tumour hypoxia with the PET tracer [18F]EF3: improvement of the tumour-to-background ratio in a mouse tumour model
    Nicolas Christian
    Center for Molecular Imaging and Experimental Radiotherapy, Universite Catholique de Louvain, Av Hippocrate, 10, Brussels, 1200, Brussels, Belgium
    Eur J Nucl Med Mol Imaging 34:1348-54. 2007
    ....
  7. pmc All three Ca2+-binding loops of photoproteins bind calcium ions: the crystal structures of calcium-loaded apo-aequorin and apo-obelin
    Lu Deng
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Protein Sci 14:663-75. 2005
    ..It is suggested that these photoproteins to sense Ca2+ concentration transients and to produce their bioluminescence response on the millisecond timescale. A mechanism of intrastructural transmission of the calcium signal is proposed...
  8. ncbi Preparation and X-ray crystallographic analysis of the Ca2+-discharged photoprotein obelin
    Lu Deng
    Department of Chemistry, University of Georgia, Athens, GA 30602, USA
    Acta Crystallogr D Biol Crystallogr 60:512-4. 2004
    ..Systematic absences indicate that the space group is either P4(3)2(1)2 or P4(1)2(1)2. The unit-cell parameters are a = b = 53.4, c = 144.0 A. The crystals diffract to 1.9 A resolution...
  9. ncbi Atomic resolution structure of obelin: soaking with calcium enhances electron density of the second oxygen atom substituted at the C2-position of coelenterazine
    Zhi Jie Liu
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Biochem Biophys Res Commun 311:433-9. 2003
    ....
  10. ncbi Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes
    Francesco Azzaroli
    Liver Center, Department of Internal Medicine and Immunology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8019, USA
    Hepatology 36:49-54. 2002
    ..This protective effect is not associated with reductions in Fas trimerization, but may be related to a direct effect on the mitochondrial membrane...
  11. doi Crystal structure of coelenterazine-binding protein from Renilla muelleri at 1.7 A: why it is not a calcium-regulated photoprotein
    Galina A Stepanyuk
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Photochem Photobiol Sci 7:442-7. 2008
    ..The different amino acid environments and hydrogen bond interactions within the binding cavity, are proposed to account for the different properties of the two classes of proteins...