A W Koch

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi request reprint Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics
    Alexander W Koch
    Fishberg Research Center for Neurobiology, Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 USA
    Structure 12:793-805. 2004
  2. ncbi request reprint Structure-based models of cadherin-mediated cell adhesion: the evolution continues
    A W Koch
    Montreal Neurological Institute, McGill University, 3801 University Street, H3A 2B4, Montreal, Quebec, Canada
    Cell Mol Life Sci 61:1884-95. 2004
  3. ncbi request reprint A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3
    Karishma L Manzur
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, One Gustave L Levy Place, New York, New York 10029, USA
    Nat Struct Biol 10:187-96. 2003
  4. ncbi request reprint 1H, 13C and 15N resonance assignments for the N-cadherin prodomain
    Alexander W Koch
    J Biomol NMR 28:87-8. 2004
  5. ncbi request reprint Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library
    Wei Ching Liang
    Antibody Engineering, Genentech Inc, South San Francisco, CA 94080, USA
    J Mol Biol 366:815-29. 2007
  6. pmc Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
    Brent A Appleton
    Department of Protein Engineering, Genentech, Inc, South San Francisco, CA 94080, USA
    EMBO J 26:4902-12. 2007

Collaborators

  • Weisong Shan
  • Amjad Farooq
  • Ming Ming Zhou
  • Charles Eigenbrot
  • Wei Ching Liang
  • Marc Tessier-Lavigne
  • Yan Wu
  • JianPing Yin
  • Ryan J Watts
  • Scott Stawicki
  • Anil Bagri
  • Brent A Appleton
  • Karishma L Manzur
  • Christian Wiesmann
  • William Desmarais
  • Napoleone Ferrara
  • Mark S Dennis
  • Ping Wu
  • Janice Maloney
  • Xiumin Wu
  • J Michael Elliott
  • Kyle Mortara
  • Qi Pan
  • Krista K Bowman
  • J Fernando Bazan
  • Yvan Chanthery
  • Yongmei Chen
  • Olga Plotnikova
  • - Sachchidanand
  • Lei Zeng

Detail Information

Publications6

  1. ncbi request reprint Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics
    Alexander W Koch
    Fishberg Research Center for Neurobiology, Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 USA
    Structure 12:793-805. 2004
    ....
  2. ncbi request reprint Structure-based models of cadherin-mediated cell adhesion: the evolution continues
    A W Koch
    Montreal Neurological Institute, McGill University, 3801 University Street, H3A 2B4, Montreal, Quebec, Canada
    Cell Mol Life Sci 61:1884-95. 2004
    ..This review gives an overview of the structural studies of cadherins over the past decade while focusing on recent developments that reconcile some of the earlier findings...
  3. ncbi request reprint A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3
    Karishma L Manzur
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, One Gustave L Levy Place, New York, New York 10029, USA
    Nat Struct Biol 10:187-96. 2003
    ..Cofactor S-adenosyl-L-methionine (SAM) binds at the opening of the beta-barrel, and amino acids C-terminal to Lys27 in H3 and in the flexible C-terminal tail of the enzyme confer the specificity of this viral histone methyltransferase...
  4. ncbi request reprint 1H, 13C and 15N resonance assignments for the N-cadherin prodomain
    Alexander W Koch
    J Biomol NMR 28:87-8. 2004
  5. ncbi request reprint Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library
    Wei Ching Liang
    Antibody Engineering, Genentech Inc, South San Francisco, CA 94080, USA
    J Mol Biol 366:815-29. 2007
    ..YW107.4.87 inhibits tumor growth in animal xenograft models. These antibodies have provided valuable tools to study the roles of NRP1 in vascular and tumor biology...
  6. pmc Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
    Brent A Appleton
    Department of Protein Engineering, Genentech, Inc, South San Francisco, CA 94080, USA
    EMBO J 26:4902-12. 2007
    ..Based upon our structural and functional data, we propose possible models for ligand binding to neuropilins...