Leslie A Khawli
Affiliation: Genentech Inc
- Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer modelCinthia V Pastuskovas
Genentech Research and Early Development, South San Francisco, California, USA
Mol Cancer Ther 11:752-62. 2012..These findings may ultimately help inform dosing strategies to achieve improved clinical outcomes...
- Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in ratsLeslie A Khawli
Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech, Inc, South San Francisco, CA, USA
MAbs 2:613-24. 2010....
- Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flowC Andrew Boswell
Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc, South San Francisco, California, United States of America
PLoS ONE 6:e17874. 2011..In particular, the growing interest in preclinical evaluation of anti-angiogenic agents alone or in combination with other drugs requires a complete understanding of the associated physiological consequences...
- Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in miceDaniela Bumbaca
Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Research and Early Development, South San Francisco, CA, USA
Br J Pharmacol 166:368-77. 2012..The objective of this study was to assess MNRP1685A biodistribution in tumour-bearing mice to understand the relationships between dose, non-tumour tissue uptake and tumour uptake...