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Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safetyS K Kelley
Department of Pharmacologic Sciences, Genentech, Inc, South San Francisco, California, USA
J Pharmacol Exp Ther 299:31-8. 2001..In conclusion, these studies have characterized the disposition of Apo2L/TRAIL in rodents and primates and provide information that will be used to predict the pharmacokinetics of Apo2L/TRAIL in humans...
