Nobuhiko Kayagaki

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. doi request reprint Noncanonical inflammasome activation by intracellular LPS independent of TLR4
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    Science 341:1246-9. 2013
  2. doi request reprint Non-canonical inflammasome activation targets caspase-11
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
    Nature 479:117-21. 2011
  3. ncbi request reprint Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL)
    Nobuhiko Kayagaki
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Cell Immunol 219:82-91. 2002
  4. doi request reprint Phosphorylation of NLRC4 is critical for inflammasome activation
    Yan Qu
    Department of Physiological Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 490:539-42. 2012
  5. doi request reprint Phosphorylation-dependent activity of the deubiquitinase DUBA
    Oscar W Huang
    Department of Early Discovery Biochemistry, Genentech, South San Francisco, California, USA
    Nat Struct Mol Biol 19:171-5. 2012
  6. ncbi request reprint Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors
    Chinatsu Kasuga
    Department of Neurosurgery, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Sci 95:840-4. 2004
  7. pmc Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    J Exp Med 195:161-9. 2002
  8. ncbi request reprint BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2
    Nobuhiko Kayagaki
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    Immunity 17:515-24. 2002
  9. ncbi request reprint Multiple pathways of TWEAK-induced cell death
    Masafumi Nakayama
    Department of Immunology, Allergy Research Center, Division of Pathology, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 168:734-43. 2002
  10. ncbi request reprint DUBA: a deubiquitinase that regulates type I interferon production
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    Science 318:1628-32. 2007

Collaborators

Detail Information

Publications17

  1. doi request reprint Noncanonical inflammasome activation by intracellular LPS independent of TLR4
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    Science 341:1246-9. 2013
    ..coli LPS. These data unveil a TLR4-independent mechanism for innate immune recognition of LPS. ..
  2. doi request reprint Non-canonical inflammasome activation targets caspase-11
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
    Nature 479:117-21. 2011
    ..These data highlight a unique pro-inflammatory role for caspase-11 in the innate immune response to clinically significant bacterial infections...
  3. ncbi request reprint Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL)
    Nobuhiko Kayagaki
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Cell Immunol 219:82-91. 2002
    ..These results suggest a new role for TRAIL in the suppression of Ab production...
  4. doi request reprint Phosphorylation of NLRC4 is critical for inflammasome activation
    Yan Qu
    Department of Physiological Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 490:539-42. 2012
    ..typhimurium infection, so phosphorylation of NLRC4 S533 probably drives conformational changes necessary for NLRC4 inflammasome activity and host innate immunity...
  5. doi request reprint Phosphorylation-dependent activity of the deubiquitinase DUBA
    Oscar W Huang
    Department of Early Discovery Biochemistry, Genentech, South San Francisco, California, USA
    Nat Struct Mol Biol 19:171-5. 2012
    ..Phosphoactivation of DUBA represents an unprecedented mode of protease regulation and a clear link between two major cellular signal transduction systems: phosphorylation and ubiquitin modification...
  6. ncbi request reprint Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors
    Chinatsu Kasuga
    Department of Neurosurgery, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Sci 95:840-4. 2004
    ....
  7. pmc Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University, School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    J Exp Med 195:161-9. 2002
    ..Moreover, development of spontaneous tumors in p53(+/-) mice was also promoted by neutralization of TRAIL. These results indicated a substantial role of TRAIL as an effector molecule that eliminates developing tumors...
  8. ncbi request reprint BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2
    Nobuhiko Kayagaki
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    Immunity 17:515-24. 2002
    ..When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF...
  9. ncbi request reprint Multiple pathways of TWEAK-induced cell death
    Masafumi Nakayama
    Department of Immunology, Allergy Research Center, Division of Pathology, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 168:734-43. 2002
    ..These results indicated that TWEAK could induce multiple pathways of cell death, including both caspase-dependent apoptosis and cathepsin B-dependent necrosis, in a cell type-specific manner via TWEAK receptor(s) distinct from DR3...
  10. ncbi request reprint DUBA: a deubiquitinase that regulates type I interferon production
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    Science 318:1628-32. 2007
    ..A discrete ubiquitin interaction motif within DUBA was required for efficient deubiquitination of TRAF3 and optimal suppression of IFN-I. Our data identify DUBA as a negative regulator of innate immune responses...
  11. ncbi request reprint IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
    Eugene Varfolomeev
    Department of Protein Engineering, Genentech, Inc, South San Francisco, CA 94080, USA
    Cell 131:669-81. 2007
    ..Through their ubiquitin E3 ligase activities c-IAP1 and c-IAP2 promote proteasomal degradation of NIK, the central ser/thr kinase in the noncanonical NF-kappaB pathway...
  12. pmc Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation
    Honglin Zhou
    Molecular Oncology Department, Genentech, Inc, San Francisco, CA 94080, USA
    J Exp Med 202:1327-32. 2005
    ..Moreover, an in vitro assay was established to demonstrate directly the deubiquitinating activity of purified YopJ...
  13. ncbi request reprint Molecular cloning, functional characterization, and enzyme-linked immunosorbent assay of cynomolgus monkey Fas ligand
    Yasuyuki Kirii
    Research and Development Laboratories, Nippon Organon K K, 1 5 90 Tomobuchi cho, Miyakojima, Osaka 534 0016, Japan
    J Immunol Methods 278:201-9. 2003
    ..Plasma from normal monkey did not contain detectable levels of sFasL, whereas plasma from monkeys acutely infected with simian immunodeficiency virus (SIV) displayed increased levels of sFasL...
  14. ncbi request reprint TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice
    Erika Cretney
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, Victoria, Australia
    Immunol Cell Biol 83:511-9. 2005
    ..These data are the first to illustrate the potential therapeutic value of recombinant TRAIL/Apo2L in suppressing T-cell-mediated autoimmune diseases...
  15. ncbi request reprint Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice
    Lisa M Sedger
    Department of Molecular Immunology, Immunex Corporation, Seattle, USA
    Eur J Immunol 32:2246-54. 2002
    ..Thus, TRAIL/Apo2L is important in controlling tumors in vivo, but is not an essential regulator of osteoprotegerin-mediated biology, under normal physiological conditions...
  16. ncbi request reprint Role of Fas/FasL pathway in the activation of infiltrating cells in murine acute myocarditis caused by Coxsackievirus B3
    Yoshinori Seko
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Am Coll Cardiol 39:1399-403. 2002
    ..This study was designed to investigate the roles of Fas/FasL pathway in myocardial damage in murine acute myocarditis caused by Coxsackie virus B3 (CVB3)...
  17. ncbi request reprint TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells
    Kanako Uno
    Department of Pediatrics, School of Medicine, University of Yamanashi, Nakakoma, Japan
    Blood 101:3658-67. 2003
    ..These results suggested the potential utility of recombinant TRAIL as a novel therapeutic agent and the possible contribution of endogenously expressed TRAIL to immunotherapy against Ph1-positive leukemias...