Peter K Jackson

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. pmc Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene
    Christopher J Westlake
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 104:1236-41. 2007
  2. pmc TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
    Saikat Mukhopadhyay
    Department of Cell Regulation, Genentech, Inc, South San Francisco, California 94080, USA
    Genes Dev 24:2180-93. 2010
  3. doi request reprint Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
    Ingrid E Wertz
    Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA
    Nature 471:110-4. 2011
  4. doi request reprint TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias
    Peter K Jackson
    Genentech Inc, 1 DNA Way, South San Francisco, CA 94070, USA Electronic address
    Cell 151:697-9. 2012
  5. pmc The tubby family proteins
    Saikat Mukhopadhyay
    Department of Cell Regulation, Genentech Inc, South San Francisco, CA 94080, USA
    Genome Biol 12:225. 2011
  6. doi request reprint Navigating the deubiquitinating proteome with a CompPASS
    Peter K Jackson
    Department of Cell Regulation, Genentech Inc, South San Francisco, CA 94080, USA
    Cell 138:222-4. 2009
  7. doi request reprint The hunt for cyclin
    Peter K Jackson
    Genentech, Inc, Department of Cell Regulation, South San Francisco, CA 94080, USA
    Cell 134:199-202. 2008
  8. doi request reprint Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry
    Xiaodong Huang
    Department of Physiological Chemistry, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Mol Cell 42:511-23. 2011
  9. doi request reprint The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
    Saikat Mukhopadhyay
    Department of Research Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Cell 152:210-23. 2013
  10. doi request reprint High-throughput generation of tagged stable cell lines for proteomic analysis
    Jorge Z Torres
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Proteomics 9:2888-91. 2009

Collaborators

Detail Information

Publications52

  1. pmc Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene
    Christopher J Westlake
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 104:1236-41. 2007
    ..These data demonstrate that Evi5 is a Rab11 binding protein and that Evi5 may cooperate with Rab11 to coordinate vesicular trafficking, cytokinesis, and cell cycle control independent of GTPase-activating protein function...
  2. pmc TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
    Saikat Mukhopadhyay
    Department of Cell Regulation, Genentech, Inc, South San Francisco, California 94080, USA
    Genes Dev 24:2180-93. 2010
    ..TULP3 and IFT-A proteins both negatively regulate Hedgehog signaling in the mouse embryo, and the TULP3-IFT-A interaction suggests how these proteins cooperate during neural tube patterning...
  3. doi request reprint Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
    Ingrid E Wertz
    Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA
    Nature 471:110-4. 2011
    ..Our findings suggest that profiling the FBW7 and MCL1 status of tumours, in terms of protein levels, messenger RNA levels and genetic status, could be useful to predict the response of patients to antitubulin chemotherapeutics...
  4. doi request reprint TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias
    Peter K Jackson
    Genentech Inc, 1 DNA Way, South San Francisco, CA 94070, USA Electronic address
    Cell 151:697-9. 2012
    ..Ciliary targeting mutations in human TTBK2 are linked to spinocerebellar ataxia, suggesting cilia protect from neurodegeneration...
  5. pmc The tubby family proteins
    Saikat Mukhopadhyay
    Department of Cell Regulation, Genentech Inc, South San Francisco, CA 94080, USA
    Genome Biol 12:225. 2011
    ..Molecular studies on this functionally diverse protein family are beginning to provide us with remarkable insights into the tubby-mouse syndrome and other related diseases...
  6. doi request reprint Navigating the deubiquitinating proteome with a CompPASS
    Peter K Jackson
    Department of Cell Regulation, Genentech Inc, South San Francisco, CA 94080, USA
    Cell 138:222-4. 2009
    ..In this issue, Sowa et al. (2009) present a comprehensive proteomic analysis of DUB interacting proteins in humans and a new quantitative scoring system for hits (CompPASS), providing a resource that links DUBs to biological pathways...
  7. doi request reprint The hunt for cyclin
    Peter K Jackson
    Genentech, Inc, Department of Cell Regulation, South San Francisco, CA 94080, USA
    Cell 134:199-202. 2008
    ..It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983)...
  8. doi request reprint Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry
    Xiaodong Huang
    Department of Physiological Chemistry, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Mol Cell 42:511-23. 2011
    ..USP37 was inactive in mitosis because it was no longer phosphorylated by CDK2. Indeed, it switched from an antagonist to a substrate of APC(CDH1) and was modified with degradative K11-linked polyubiquitin...
  9. doi request reprint The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
    Saikat Mukhopadhyay
    Department of Research Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Cell 152:210-23. 2013
    ..Conversely, Shh signaling directs Gpr161 to be internalized from cilia, preventing its activity. Thus, Gpr161 defines a morphogenetic pathway coupling protein kinase A activation to Shh signaling during neural tube development...
  10. doi request reprint High-throughput generation of tagged stable cell lines for proteomic analysis
    Jorge Z Torres
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Proteomics 9:2888-91. 2009
    ..We have applied this method to the study of cell-cycle regulators and novel microtubule-associated proteins...
  11. ncbi request reprint A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
    Maxence V Nachury
    Genentech, Inc, South San Francisco, CA 94080, USA
    Cell 129:1201-13. 2007
    ..Conversely, preventing Rab8(GTP) production blocks ciliation in cells and yields characteristic BBS phenotypes in zebrafish. Our data reveal that BBS may be caused by defects in vesicular transport to the cilium...
  12. doi request reprint A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress
    David Peterson
    Research Oncology, Genentech, Inc, South San Francisco, California, USA
    Cancer Res 70:6325-35. 2010
    ..Because expression levels of TP53RK vary in cancers, TP53RK levels could provide a molecular marker to predict response to antimitotic agents. TP53RK inhibition may also sensitize cancers to taxanes...
  13. doi request reprint A BBSome subunit links ciliogenesis, microtubule stability, and acetylation
    Alexander V Loktev
    Genentech, Inc, South San Francisco, CA 94080, USA
    Dev Cell 15:854-65. 2008
    ..BBSome-bound BBIP10 may therefore function to couple acetylation of axonemal microtubules and ciliary membrane growth...
  14. pmc An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium
    Kevin J Wright
    Genentech Inc, South San Francisco, California 94080, USA
    Genes Dev 25:2347-60. 2011
    ..Our results uncover a selective, membrane targeting GTPase cycle that delivers myristoylated proteins to the ciliary membrane and suggest that other myristoylated proteins may be similarly targeted to specialized membrane domains...
  15. doi request reprint Biochemical analysis of the Anaphase Promoting Complex: activities of E2 enzymes and substrate competitive (pseudosubstrate) inhibitors
    Matthew K Summers
    Department of Cellular Regulation, Genentech Inc, South San Francisco, CA, USA
    Methods Mol Biol 545:313-30. 2009
    ..These assays are instrumental in examining the use of E2 enzymes by the APC and the intimate relationship this has with pseudosubstrate inhibition...
  16. pmc Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics
    Daniel J Anderson
    Department of Cell Regulation, Genentech, Inc, South San Francisco, California, United States of America
    PLoS ONE 6:e22607. 2011
    ..Since both single agent and combination studies of Raf and Mek inhibitors are currently in the clinic, our assays provide valuable insight into their effects on MAPK signaling in live cells...
  17. pmc Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence
    Emmy W Verschuren
    Department of Tumor Biology and Angiogenesis, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Mol Cell Biol 27:7955-65. 2007
    ..Our data suggest that maintenance of a protein stabilization/mRNA expression positive-feedback circuit fueled by Emi1 is required for accurate cell cycle progression, maintenance of DNA integrity, and prevention of cellular senescence...
  18. ncbi request reprint Emi2 at the crossroads: where CSF meets MPF
    David V Hansen
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cell Cycle 6:732-8. 2007
    ..Finally, we propose that inactivation of Emi2 by Cdc2 permits mitotic progression during early embryonic cleavage cycles...
  19. pmc The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC
    Matthew K Summers
    Department of Cellular Regulation, Genentech Inc, South San Francisco, CA 94080, USA
    Mol Cell 31:544-56. 2008
    ..Thus, UbcH10 combines a specific E2-E3 interface and regulation via its N-terminal extension to limit APC activity for substrate selection and checkpoint control...
  20. ncbi request reprint The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells
    Eli Berdougo
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cell Cycle 7:1184-90. 2008
    ..Our findings reveal substantial divergence in mitotic regulation between yeast and mammalian cells, as the latter possess efficient mechanisms for completing late M-phase events in the absence of a nucleolar Cdc14-related phosphatase...
  21. ncbi request reprint Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase
    Florence Margottin-Goguet
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Dev Cell 4:813-26. 2003
    ..We hypothesize that Emi1 destruction relieves a late prophase checkpoint for APC activation...
  22. pmc Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1
    David V Hansen
    Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Mol Biol Cell 15:5623-34. 2004
    ..These data support the hypothesis that Plk1 activates the APC by directing the SCF-dependent destruction of Emi1 in prophase...
  23. ncbi request reprint Emi1 class of proteins regulate entry into meiosis and the meiosis I to meiosis II transition in Xenopus oocytes
    Jeffrey J Tung
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Cycle 4:478-82. 2005
    ..Prior ablation of Cdc20, addition of methyl-ubiquitin, or addition of nondestructible Delta90 cyclin B rescues the MI-MII transition in Emi1-inhibited oocytes...
  24. pmc Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase
    Brett K Kaiser
    Departments of Pathology and Microbiology, and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Biol Cell 13:2289-300. 2002
    ..Thus, the hCdc14A phosphatase appears to play a role in the regulation of the centrosome cycle, mitosis, and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells...
  25. ncbi request reprint Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation
    Niels Mailand
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 4:317-22. 2002
    ..These results indicate that Cdc14A is a physiological regulator of the centrosome duplication cycle, which, when disrupted, can lead to genomic instability in mammalian cells...
  26. doi request reprint Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma
    Ines Gütgemann
    Department of Pathology, Stanford University, Stanford, CA, USA
    Mod Pathol 21:445-54. 2008
    ..These findings represent a potentially important insight into the molecular pathway underlying ovarian carcinogenesis and provide a possible cell cycle model for the development and progression of ovarian clear cell carcinoma...
  27. doi request reprint Stopping replication, at the beginning
    Peter K Jackson
    Nat Chem Biol 4:331-2. 2008
  28. ncbi request reprint A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling
    Hiroki Iwai
    Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cell 130:611-23. 2007
    ..These results strongly indicate that Shigella employ special tactics to influence epithelial renewal in order to promote bacterial colonization of intestinal epithelium...
  29. ncbi request reprint Ubiquitinating a phosphorylated Cdk inhibitor on the blades of the Cdc4 beta-propeller
    Peter K Jackson
    Programs in Chemical Biology and Cancer Biology and Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Cell 112:142-4. 2003
    ..This structure provides insights into the binding interaction and how a precise mechanism involving multiple regulatory phosphorylations may be mediated by a single binding site...
  30. pmc Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1)
    Jamie M Keck
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037
    J Cell Biol 178:371-85. 2007
    ..We further show that the accumulation of securin and cyclin B1 can account for the cyclin E-mediated mitotic phenotype...
  31. ncbi request reprint The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis
    Kenneth H Ban
    Program in Cancer Biology, Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Dev Cell 13:29-42. 2007
    ..The organization of the APC/C on the spindle also provides a framework for understanding microtubule-dependent organization of protein destruction...
  32. pmc Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors
    Norman L Lehman
    Department of Pathology, MC5324, Stanford University, Stanford, CA, USA
    Am J Pathol 170:1793-805. 2007
    ..This profile of misregulated mitotic APC/C substrates and regulators in malignant tumors suggests that analysis of this pathway may be diagnostically useful and represent a potentially important therapeutic target...
  33. ncbi request reprint Wagging the dogma; tissue-specific cell cycle control in the mouse embryo
    Michele Pagano
    Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell 118:535-8. 2004
    ....
  34. pmc Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division
    Brett K Kaiser
    Departments of Pathology and Microbiology and Immunology, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305 USA
    BMC Cell Biol 5:27. 2004
    ..Therefore, it is of great interest to examine the function Cdc14 homologs in other vertebrate species...
  35. ncbi request reprint Linking tumor suppression, DNA damage and the anaphase-promoting complex
    Peter K Jackson
    Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, CA 94305, USA
    Trends Cell Biol 14:331-4. 2004
    ..Furthermore, another recent study shows that protein kinase A, which is a key growth regulator, inhibits the APC during mitosis in yeast...
  36. ncbi request reprint Can Fizzy fly solo?
    Peter K Jackson
    Nat Cell Biol 5:864-5. 2003
  37. ncbi request reprint Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo
    Daniele Guardavaccaro
    Department of Pathology and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 4:799-812. 2003
    ..Thus, beta-Trcp1 regulates the timely order of meiotic and mitotic events...
  38. ncbi request reprint Control of the centriole and centrosome cycles by ubiquitination enzymes
    David V Hansen
    Programs in Chemical Biology and Cancer Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, CA 94305 5324, USA
    Oncogene 21:6209-21. 2002
  39. ncbi request reprint The SCF ubiquitin ligase: an extended look
    Peter K Jackson
    Stanford University School of Medicine, Department of Pathology, 300 Pasteur Drive, Palo Alto, CA 94305, USA
    Mol Cell 9:923-5. 2002
    ..A new crystal structure of the SCF(Skp2) ubiquitin ligase shows the molecular organization of this complex and raises important questions as to how substrate ubiquitination is accomplished...
  40. ncbi request reprint E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
    Jerry Y Hsu
    Department of Pathology and Program in Biophysics, Stanford University School of Medicine, CA 94305, USA
    Nat Cell Biol 4:358-66. 2002
    ..These data suggest that E2F can activate both transcription of cyclin A and the hEmi1-dependent stabilization of APC(Cdh1) targets, such as cyclin A, to promote S phase entry...
  41. pmc A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs
    Jeffrey J Tung
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:4318-23. 2005
    ..These results identify Emi2 as a candidate CSF maintenance protein...
  42. pmc Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase
    Jessica B Casaletto
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 169:61-71. 2005
    ..Furthermore, Xnf7 was required for spindle assembly checkpoint function in egg extracts. These data suggest that Xnf7 is an APC inhibitor able to link spindle status to the APC through direct association with APC core components...
  43. pmc CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit
    David V Hansen
    Program in Cancer Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:608-13. 2006
    ....
  44. pmc A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest
    Qiju Wu
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Biol 17:213-24. 2007
    ..However, the mechanism that controls this continuous degradation is not understood...
  45. pmc Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)
    Petros Marangos
    Department of Physiology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 176:65-75. 2007
    ..Finally, we show that Emi1-dependent effects on meiosis I require the presence of Cdh1. These observations reveal a novel mechanism for the control of entry into the first meiotic division: an Emi1-dependent inhibition of APC(Cdh1)...
  46. pmc Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis
    Suzanne Madgwick
    Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Newcastle NE2 4HH, England, UK
    J Cell Biol 174:791-801. 2006
    ....
  47. pmc Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
    Julie J Miller
    Program in Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 20:2410-20. 2006
    ..The combination of a degron/E3 recognition site and an anti-ligase function in Emi1 suggests a general model for how E3 substrates evolve to become pseudosubstrate inhibitors...
  48. ncbi request reprint Developmental neurobiology: a destructive switch for neurons
    Peter K Jackson
    Nature 442:365-6. 2006
  49. ncbi request reprint Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells
    Norman L Lehman
    Department of Pathology, Stanford University, Stanford, California 94305, USA
    Cell Cycle 5:1569-73. 2006
    ..This represents a potentially important mechanism by which pRb and p53 dysfunction may contribute to tumorigenesis through the generation of genomic instability...
  50. ncbi request reprint Climbing the Greatwall to mitosis
    Peter K Jackson
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Cell 22:156-7. 2006
    ..2006) shows that Greatwall is required for the positive feedback loop that removes inhibitory tyrosine phosphate from the central mitotic regulatory kinase Cdc2...
  51. ncbi request reprint The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1
    Adam G Eldridge
    Department of Cancer Biology, Stanford University School of Medicine, CA 94305, USA
    Cell 124:367-80. 2006
    ..We propose that the balance of Evi5 and Polo-like kinase activities determines the timely accumulation of Emi1 and cyclin, ensuring mitotic fidelity...
  52. ncbi request reprint Emi1 is required for cytostatic factor arrest in vertebrate eggs
    Julie D R Reimann
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nature 416:850-4. 2002
    ..Addition of Emi1 to these Emi1-depleted extracts blocks premature inactivation of the CSF-arrested state. Emi1 is required to arrest unfertilized eggs at metaphase of meiosis II and seems to be the long-sought mediator of CSF activity...