L Hayflick

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi request reprint Living forever and dying in the attempt
    Leonard Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, P O Box 89, The Sea Ranch, CA 95497, USA
    Exp Gerontol 38:1231-41. 2003
  2. ncbi request reprint A brief history of the mortality and immortality of cultured cells
    L Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, Sea Ranch, USA
    Keio J Med 47:174-82. 1998
  3. ncbi request reprint "Anti-aging" is an oxymoron
    Leonard Hayflick
    Professor of Anatomy, Department of Anatomy, University of California, San Francisco, School of Medicine, P O Box 89, The Sea Ranch, CA 95497, USA
    J Gerontol A Biol Sci Med Sci 59:B573-8. 2004
  4. ncbi request reprint A novel technique for transforming the theft of mortal human cells into praiseworthy federal policy
    L Hayflick
    Department of Anatomy, University of California, San Francisco, USA
    Exp Gerontol 33:191-207. 1998
  5. ncbi request reprint The not-so-close relationship between biological aging and age-associated pathologies in humans
    Leonard Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, P O Box 89, The Sea Ranch, CA 95497, USA
    J Gerontol A Biol Sci Med Sci 59:B547-50; discussion 551-3. 2004
  6. ncbi request reprint Biological aging is no longer an unsolved problem
    Leonard Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, P O Box 89, The Sea Ranch, CA 95497, USA
    Ann N Y Acad Sci 1100:1-13. 2007
  7. ncbi request reprint The future of ageing
    L Hayflick
    Department of Anatomy, School of Medicine, University of California at San Francisco, 95497, USA
    Nature 408:267-9. 2000
  8. ncbi request reprint How and why we age
    L Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, Sea Ranch 95497, USA
    Exp Gerontol 33:639-53. 1998
  9. ncbi request reprint Mortality and immortality at the cellular level. A review
    L Hayflick
    University of California, San Francisco, The Sea Ranch 95497, USA
    Biochemistry (Mosc) 62:1180-90. 1997
  10. pmc The illusion of cell immortality
    L Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, P O Box 89, The Sea Ranch, CA 95497, USA
    Br J Cancer 83:841-6. 2000

Detail Information

Publications18

  1. ncbi request reprint Living forever and dying in the attempt
    Leonard Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, P O Box 89, The Sea Ranch, CA 95497, USA
    Exp Gerontol 38:1231-41. 2003
    ..Thus, key events in our understanding of aging, longevity determination and cancer have been revealed...
  2. ncbi request reprint A brief history of the mortality and immortality of cultured cells
    L Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, Sea Ranch, USA
    Keio J Med 47:174-82. 1998
    ..Physiological reserve does not renew at the same rate that it incurs losses because molecular disorder increases. These age changes increase vulnerability to predation, accidents or disease...
  3. ncbi request reprint "Anti-aging" is an oxymoron
    Leonard Hayflick
    Professor of Anatomy, Department of Anatomy, University of California, San Francisco, School of Medicine, P O Box 89, The Sea Ranch, CA 95497, USA
    J Gerontol A Biol Sci Med Sci 59:B573-8. 2004
    ..If age changes are the greatest risk factor for age-associated diseases (an almost universal belief), then why is the study of aging virtually neglected?..
  4. ncbi request reprint A novel technique for transforming the theft of mortal human cells into praiseworthy federal policy
    L Hayflick
    Department of Anatomy, University of California, San Francisco, USA
    Exp Gerontol 33:191-207. 1998
    ..Universities have also pursued similar alliances to the extent that today the distinction between a research university and a commercial organization is only in the eyes of the Internal Revenue Service...
  5. ncbi request reprint The not-so-close relationship between biological aging and age-associated pathologies in humans
    Leonard Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, P O Box 89, The Sea Ranch, CA 95497, USA
    J Gerontol A Biol Sci Med Sci 59:B547-50; discussion 551-3. 2004
  6. ncbi request reprint Biological aging is no longer an unsolved problem
    Leonard Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, P O Box 89, The Sea Ranch, CA 95497, USA
    Ann N Y Acad Sci 1100:1-13. 2007
    ..by attempting to answer this fundamental question-"What changes occur in biomolecules that lead to the manifestations of aging at higher orders of complexity and then increase vulnerability to all age-associated pathology?"..
  7. ncbi request reprint The future of ageing
    L Hayflick
    Department of Anatomy, School of Medicine, University of California at San Francisco, 95497, USA
    Nature 408:267-9. 2000
    ....
  8. ncbi request reprint How and why we age
    L Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, Sea Ranch 95497, USA
    Exp Gerontol 33:639-53. 1998
    ..Immortal cancer cells express the enzyme telomerase that prevents shortening. Recently, it was discovered that when the catalytic subunit of the telomerase gene is inserted into normal cells they become immortal...
  9. ncbi request reprint Mortality and immortality at the cellular level. A review
    L Hayflick
    University of California, San Francisco, The Sea Ranch 95497, USA
    Biochemistry (Mosc) 62:1180-90. 1997
    ..The hundreds of biological changes that herald the loss of replicative capacity in normal cells are more likely age changes...
  10. pmc The illusion of cell immortality
    L Hayflick
    Department of Anatomy, University of California, San Francisco, School of Medicine, P O Box 89, The Sea Ranch, CA 95497, USA
    Br J Cancer 83:841-6. 2000
    ..It is suggested that telomere attrition may be better understood as a direct measure of longevity determination and to only have an indirect association with age changes...
  11. ncbi request reprint The hype and the reality--part I
    S Jay Olshansky
    School of Public Health, University of Illinois at Chicago, 1603 W Taylor St, Rm 885, Chicago, IL 60612, USA
    J Gerontol A Biol Sci Med Sci 59:B513-4. 2004
  12. ncbi request reprint No truth to the fountain of youth
    S Jay Olshansky
    School of Public Health, University of Illinois at Chicago, Chicago, IL 60612, USA
    Sci Aging Knowledge Environ 2002:vp5. 2002
  13. ncbi request reprint Position statement on human aging
    S Jay Olshansky
    School of Public Health, University of Illinois at Chicago, 60612, USA
    J Gerontol A Biol Sci Med Sci 57:B292-7. 2002
    ....
  14. pmc Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both
    Leonard Hayflick
    PLoS Genet 3:e220. 2007
  15. ncbi request reprint DNA replication and traintracks
    Leonard Hayflick
    Science 296:1611-2. 2002
  16. ncbi request reprint A potential decline in life expectancy in the United States in the 21st century
    S Jay Olshansky
    University of Illinois at Chicago, Chicago 60612, USA
    N Engl J Med 352:1138-45. 2005
    ..From our analysis of the effect of obesity on longevity, we conclude that the steady rise in life expectancy during the past two centuries may soon come to an end...
  17. ncbi request reprint Misdirection on the road to Shangri-La
    S Jay Olshansky
    Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60612, USA
    Sci Aging Knowledge Environ 2005:pe15. 2005
    ..S. pattern of longevity will follow that of other longer lived nations and on the extrapolation of historical trends in life expectancy into the future...
  18. ncbi request reprint No truth to the fountain of youth
    S Jay Olshansky
    University of Illinois at Chicago, USA
    Sci Am 286:92-5. 2002