Research Topics
| H P GerberSummaryAffiliation: Genentech Inc Country: USA Publications
| Collaborators
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Detail Information
Publications
ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivoGieri Camenisch
Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 277:17281-90. 2002..Taken together, our data demonstrate that ANGPTL3 is the first member of the angiopoietin-like family of secreted factors binding to integrin alpha(v)beta(3) and suggest a possible role in the regulation of angiogenesis...- VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanismHans Peter Gerber
Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 417:954-8. 2002..Not only ligands selective for VEGF and VEGFR-2 but also VEGFR-1 agonists rescued survival and repopulation of VEGF-deficient HSCs, revealing a function for VEGFR-1 signalling during haematopoiesis... - Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studiesHans Peter Gerber
Departments of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Cancer Res 65:671-80. 2005..Finally, safety pharmacology studies with bevacizumab in cynomolgus monkeys showed that this agent is generally well tolerated with no unexpected adverse events... - The role of VEGF in normal and neoplastic hematopoiesisHans Peter Gerber
Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
J Mol Med (Berl) 81:20-31. 2003.... - Angiogenesis and bone growthH P Gerber
Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
Trends Cardiovasc Med 10:223-8. 2000..The fundamental importance of chondrocytes in the growth, development and repair of the skeleton has led to intense investigation of the mechanisms that regulate chondrocyte maturation and apoptosis... - VEGF is required for growth and survival in neonatal miceH P Gerber
Departments of Cardiovascular Research and Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
Development 126:1149-59. 1999..Thus, VEGF is essential for growth and survival in early postnatal life. However, in the fully developed animal, VEGF is likely to be involved primarily in active angiogenesis processes such as corpus luteum development... - The role of vascular endothelial growth factor in angiogenesisN Ferrara
Department of Molecular Oncology, Genentech, Inc, South San Francisco, Calif 94080, USA
Acta Haematol 106:148-56. 2001..Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that inhibition of VEGF activity may be beneficial for these conditions... - Vascular endothelial growth factor is essential for corpus luteum angiogenesisN Ferrara
Department of Cardiovascular Research, Genentech Inc, South San Francisco, California 94080, USA
Nat Med 4:336-40. 1998..Furthermore, they have implications for the control of fertility and the treatment of ovarian disorders characterized by hypervascularity and hyperplasia... - Angiogenesis-independent endothelial protection of liver: role of VEGFR-1Jennifer LeCouter
Departments of Molecular Oncology, Protein Engineering, and Pathology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Science 299:890-3. 2003..Thus, VEGFR-1 agonists may have therapeutic potential for preservation of organ function in certain liver disorders... - Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout miceS P Williams
Genentech, Inc, 1 DNA Way 72A, South San Francisco, CA 94080, USA
J Magn Reson Imaging 14:374-82. 2001..A prolonged high-dose dobutamine challenge was monitored by MRI. A maximal response was sustained for 90 minutes, suggesting that it did not depend on endogenous glycogen stores... - Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activationH P Gerber
Department of Cardiovascular Research, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 273:30336-43. 1998..Inhibition of apoptosis may represent a major aspect of the regulatory activity of VEGF on the vascular endothelium... - Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxiaH P Gerber
Department of Cardiovascular Research, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 272:23659-67. 1997..These findings indicate that, unlike the KDR/Flk-1 gene, the Flt-1 receptor gene is directly up-regulated by hypoxia via a hypoxia-inducible enhancer element located at positions -976 to -937 of the Flt-1 promoter... - Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cellsFarbod Shojaei
Genentech, Inc, 1 DNA Way, S San Francisco, California 94080, USA
Nat Biotechnol 25:911-20. 2007..These findings indicate that, in our models, refractoriness to anti-VEGF treatment is determined by the ability of tumors to prime and recruit CD11b+Gr1+ cells... 
Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodiesHans Peter Gerber
Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Proc Natl Acad Sci U S A 104:3478-83. 2007..However, higher-affinity antibodies were more likely to result in glomerulosclerosis during long-term treatment...- Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGFWei-Ching Liang
Department of Protein Engineering, Genentech Inc, South San Francisco, CA 94080, USA
J Biol Chem 281:951-61. 2006..Thus, the functional contribution of stromal VEGF varies greatly among tumors, and systemic blockade of both tumor and stroma-derived VEGF is sufficient for inhibiting the growth of tumor xenografts... - Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in miceAjay K Malik
Department of Pathology, Genentech, South San Francisco, CA 94080, USA
Blood 107:550-7. 2006..The absence of compensatory VEGFR-1 signaling by VEGF-B and PlGF may have important implications for the development of anticancer strategies targeting the VEGF ligand/receptor system... - Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumabFrank A Scappaticci
Genentech, Inc, BioOncology, 455 East Grand Ave, South San Francisco, CA 94080, USA
J Natl Cancer Inst 99:1232-9. 2007..Low-dose aspirin was permitted in these trials, and its safety was also analyzed... - VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesisJianying Dong
Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
EMBO J 23:2800-10. 2004..Thus, PDGFR alpha signaling is required for the recruitment of VEGF-producing stromal fibroblasts for tumor angiogenesis and growth. Our findings highlight a novel aspect of PDGFR alpha signaling in tumorigenesis... - Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancerNapoleone Ferrara
Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nat Rev Drug Discov 3:391-400. 2004 - The biology of VEGF and its receptorsNapoleone Ferrara
Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nat Med 9:669-76. 2003..VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration... - Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinomaMax L Tejada
Department of Molecular Oncology, Pathology, Genentech, Inc, South San Francisco, California 94080, USA
Clin Cancer Res 12:2676-88. 2006..We propose that therapies targeting this stromal cell type may be effective in treating certain types of solid tumors... 
Anti-CD30 diabody-drug conjugates with potent antitumor activityKristine M Kim
Seattle Genetics, Inc, 21823 30th Drive Southeast, Bothell, WA 98021, USA
Mol Cancer Ther 7:2486-97. 2008..Diabody-drug conjugates can have potent antitumor activity at well-tolerated doses and warrant further optimization for cancer therapy...- Engineered anti-CD70 antibody-drug conjugate with increased therapeutic indexCharlotte F McDonagh
Seattle Genetics, Inc, 21823 30th Drive Southeast, Bothell, WA 98021, USA
Mol Cancer Ther 7:2913-23. 2008..The strategy used here for enhancing the therapeutic index of antibody-drug conjugates is independent of the antigen-binding variable domains and potentially applicable to other antibodies... - Angiogenesis: new opportunities and solutions for drug development. Predictive markers for antiangiogenic drugsHans-Peter Gerber
Department of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
Expert Opin Investig Drugs 12:2001-4. 2003 - Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cellsBoris A Hesser
Department of Molecular Oncology, Genentech, South San Francisco, CA 94080, USA
Blood 104:149-58. 2004.... - VEGF inhibition and renal thrombotic microangiopathyVera Eremina
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
N Engl J Med 358:1129-36. 2008..These observations provide evidence that glomerular injury in patients who are treated with bevacizumab is probably due to direct targeting of VEGF by antiangiogenic therapy... - VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesisMasahiro Inoue
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, San Francisco, CA 94143, USA
Cancer Cell 1:193-202. 2002..Thus, VEGF-A is crucial for angiogenesis in a prototypical model of carcinogenesis, whose loss is not readily compensated... - Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesisHiroaki Yamamoto
Department of Medicine and Lung Biology Center, University of California, San Francisco, CA 94143, USA
Dev Biol 308:44-53. 2007.... - Corneal avascularity is due to soluble VEGF receptor-1Balamurali K Ambati
Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
Nature 443:993-7. 2006.... - Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factorSabine Raab
Max Plank Institut für physiologische und klinische Forschung, Bad Nauheim, Germany
Thromb Haemost 91:595-605. 2004..VEGF acts as a key regulator of brain angiogenesis and provides instructive cues for the correct spatial organization of the vasculature... - Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedbackYoh suke Mukouyama
Division of Biology 216 76, California Institute of Technology, 1201 E California Boulevard, Pasadena, CA 91125, USA
Development 132:941-52. 2005..Different mechanisms therefore probably underlie these endothelial patterning and differentiation processes... - Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesisNan Tang
Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, San Diego, California 92093, USA
Cancer Cell 6:485-95. 2004..We thus show that a HIF-1alpha-driven, VEGF-mediated autocrine loop in EC is an essential component of solid tumor angiogenesis... - Capillary regression in vascular endothelial growth factor-deficient skeletal muscleKechun Tang
Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
Physiol Genomics 18:63-9. 2004..These data implicate VEGF as an essential survival factor for muscle capillarity and also demonstrate insufficient VEGF-dependent signaling leads to apoptosis in mouse skeletal muscle... - Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseasesVera Eremina
The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
J Clin Invest 111:707-16. 2003..Our data demonstrate that tight regulation of VEGF-A signaling is critical for establishment and maintenance of the glomerular filtration barrier and strongly supports a pivotal role for VEGF-A in renal disease... - The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferationGanka Nikolova
Max-Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Dev Cell 10:397-405. 2006..The proposed mechanism explains why beta cells must interact with endothelial cells, and it may apply to other cellular processes in which endothelial signals are required... - Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30Ezogelin Oflazoglu
Department of Translational Biology, Seattle Genetics, WA 98021, USA
Blood 110:4370-2. 2007..These findings may have implications for patient stratification or combination treatment strategies in clinical trials conducted with SGN-30 in HD and ALCL...