Zengjun Xu

Summary

Affiliation: Gene Logic Inc
Country: USA

Publications

  1. pmc A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics tools
    Zengjun Xu
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S8. 2005
  2. pmc Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S12. 2005
  3. pmc Microarray scanner calibration curves: characteristics and implications
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S11. 2005
  4. ncbi request reprint Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells
    Jianyong Wang
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Neurochem Int 52:1037-43. 2008
  5. ncbi request reprint Gene expression profiling of MPP+-treated MN9D cells: a mechanism of toxicity study
    Jianyong Wang
    Neurochemistry Laboratory, Division of Neurotoxicology, HFT 132, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Neurotoxicology 28:979-87. 2007

Detail Information

Publications5

  1. pmc A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics tools
    Zengjun Xu
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S8. 2005
    ..MPP+ depletes dopamine content and elicits cell death in PC12 cells. However, the mechanism of MPP+-induced neurotoxicity is still unclear...
  2. pmc Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S12. 2005
    ..Nucleic Acids Res., 31, 5676-5684, 2003), portrays a disturbingly negative picture of the cross-platform comparability, and, hence, the reliability of microarray technology...
  3. pmc Microarray scanner calibration curves: characteristics and implications
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S11. 2005
    ..Microarray-based measurement of mRNA abundance assumes a linear relationship between the fluorescence intensity and the dye concentration. In reality, however, the calibration curve can be nonlinear...
  4. ncbi request reprint Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells
    Jianyong Wang
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Neurochem Int 52:1037-43. 2008
    ....
  5. ncbi request reprint Gene expression profiling of MPP+-treated MN9D cells: a mechanism of toxicity study
    Jianyong Wang
    Neurochemistry Laboratory, Division of Neurotoxicology, HFT 132, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Neurotoxicology 28:979-87. 2007
    ..These data also indicate that MPP+-induced toxicity shares common molecular mechanisms with the pathogenesis of PD and further pathway analyses will be conducted to explore these mechanisms...