Ping L Zhang

Summary

Affiliation: Geisinger Medical Center
Country: USA

Publications

  1. ncbi Pamidronate resistance and associated low ras levels in breast cancer cells: a role for combinatorial therapy
    Ping L Zhang
    Department of Laboratory Medicine, Geisinger Clinic, Danville, Pennsylvania 17822, USA
    Ann Clin Lab Sci 34:263-70. 2004
  2. ncbi Morphoproteomic expression of H-ras (p21ras) correlates with serum monoclonal immunoglobulin reduction in multiple myeloma patients following pamidronate treatment
    Ping L Zhang
    Division of Laboratory Medicine, Department of Adult Hematology and Oncology, Geisinger Medical Center, 100 North Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 37:34-8. 2007
  3. ncbi C4d positivity is often associated with acute cellular rejection in renal transplant biopsies following Campath-1H (Alemtuzumab) induction
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 37:121-6. 2007
  4. ncbi Monocyte-mediated acute renal rejection after combined treatment with preoperative Campath-1H (alemtuzumab) and postoperative immunosuppression
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Ann Clin Lab Sci 34:209-13. 2004
  5. ncbi Chronic active thrombotic microangiopathy in native and transplanted kidneys
    Ping L Zhang
    Laboratory Medicine, Geisinger Medical Center, 100 North Academy, Danville, PA 17822, USA
    Ann Clin Lab Sci 36:319-25. 2006
  6. ncbi Case report: IgM type of membranous glomerulopathy in a diabetic patient
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 35:184-8. 2005
  7. ncbi CD52 antigen may be a therapeutic target for eosinophilic rhinosinusitis
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Ann Clin Lab Sci 37:148-51. 2007
  8. ncbi Preinduced molecular chaperones in the endoplasmic reticulum protect cardiomyocytes from lethal injury
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, 100 North Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 34:449-57. 2004
  9. ncbi Acute cellular rejection predominated by monocytes is a severe form of rejection in human renal recipients with or without Campath-1H (alemtuzumab) induction therapy
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA, USA
    Am J Transplant 5:604-7. 2005
  10. ncbi Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB
    Mingyue Lun
    Weis Center for Research, Geisinger Medical Center, 100 North Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 35:251-8. 2005

Detail Information

Publications26

  1. ncbi Pamidronate resistance and associated low ras levels in breast cancer cells: a role for combinatorial therapy
    Ping L Zhang
    Department of Laboratory Medicine, Geisinger Clinic, Danville, Pennsylvania 17822, USA
    Ann Clin Lab Sci 34:263-70. 2004
    ..Combinatorial therapies directed against other signaling pathways, not dependent upon ras, may be required to overcome such resistance...
  2. ncbi Morphoproteomic expression of H-ras (p21ras) correlates with serum monoclonal immunoglobulin reduction in multiple myeloma patients following pamidronate treatment
    Ping L Zhang
    Division of Laboratory Medicine, Department of Adult Hematology and Oncology, Geisinger Medical Center, 100 North Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 37:34-8. 2007
    ..H-ras expression in myeloma cells may prove to be valuable in predicting the therapeutic effects of pamidronate...
  3. ncbi C4d positivity is often associated with acute cellular rejection in renal transplant biopsies following Campath-1H (Alemtuzumab) induction
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 37:121-6. 2007
    ..Moreover, the high percentage of monocytes observed in ACR cases (due to monocytes being less sensitive to Campath-1H depletion) suggests that monocytes are involved in antibody-mediated rejection...
  4. ncbi Monocyte-mediated acute renal rejection after combined treatment with preoperative Campath-1H (alemtuzumab) and postoperative immunosuppression
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Ann Clin Lab Sci 34:209-13. 2004
    ..5 mg/dl. The histopathological features of acute rejection were absent in a second biopsy of the transplanted kidney. In summary, this case is an instance of monocyte-mediated acute rejection of a transplanted kidney...
  5. ncbi Chronic active thrombotic microangiopathy in native and transplanted kidneys
    Ping L Zhang
    Laboratory Medicine, Geisinger Medical Center, 100 North Academy, Danville, PA 17822, USA
    Ann Clin Lab Sci 36:319-25. 2006
    ..The patient received a living related-donor transplant, but thrombotic microangiopathy recurred in the donor kidney only 40 days after the renal transplantation...
  6. ncbi Case report: IgM type of membranous glomerulopathy in a diabetic patient
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 35:184-8. 2005
    ....
  7. ncbi CD52 antigen may be a therapeutic target for eosinophilic rhinosinusitis
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Ann Clin Lab Sci 37:148-51. 2007
    ..These findings indirectly support the hypothesis that CD52 may be a target for treating eosinophilic rhinosinusitis with Campath 1H...
  8. ncbi Preinduced molecular chaperones in the endoplasmic reticulum protect cardiomyocytes from lethal injury
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, 100 North Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 34:449-57. 2004
    ..These observations suggest that preinduced ER chaperones protect cardiomyocytes from lethal injury, at least in part, by preventing an increase in cytosolic Ca2+...
  9. ncbi Acute cellular rejection predominated by monocytes is a severe form of rejection in human renal recipients with or without Campath-1H (alemtuzumab) induction therapy
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA, USA
    Am J Transplant 5:604-7. 2005
    ..We conclude that monocyte-predominate ACR may represent a severe form of rejection, with or without Campath-1H treatment...
  10. ncbi Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB
    Mingyue Lun
    Weis Center for Research, Geisinger Medical Center, 100 North Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 35:251-8. 2005
    ..p-kappaB complex. The free p-NF-kappaB can then be translocated to the nucleus where it effects transcriptional activation of genes leading to the synthesis of proteins that are generally pro-growth and anti-apoptosis...
  11. doi Immunohistochemical detection of the von Hippel-Lindau gene product (pVHL) in human tissues and tumors: a useful marker for metastatic renal cell carcinoma and clear cell carcinoma of the ovary and uterus
    Fan Lin
    Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Am J Clin Pathol 129:592-605. 2008
    ..These data indicate that this anti-pVHL antibody is a useful marker in assisting diagnosis of metastatic RCC and may serve as a diagnostic marker for clear cell carcinomas of the ovary and uterus...
  12. ncbi Intracellular inhibitory effects of Velcade correlate with morphoproteomic expression of phosphorylated-nuclear factor-kappaB and p53 in breast cancer cell lines
    Mingyue Lun
    Weis Center for Research, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Ann Clin Lab Sci 35:15-24. 2005
    ..We propose that this proliferative inhibition is variably associated with blocking p-NF-kappaB function by upregulation of nuclear I-kappaB, stabilization of p53, and induction of p21WAF1...
  13. ncbi Transplantation and 6-month follow-up of renal transplantation from a donor with systemic lupus erythematosus and lupus nephritis
    Michael S Schwartzman
    Departments of Nephrology, Pathology and Transplant Surgery, Geisinger Medical Center, Danville, PA 17822, USA
    Am J Transplant 5:1772-6. 2005
    ..Use of expanded pool kidneys should be guided by functional, biopsy and demographic information, as no single factor alone predicts outcome...
  14. ncbi Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822 0131, USA
    Mod Pathol 18:924-32. 2005
    ....
  15. ncbi Heat shock protein expression is highly sensitive to ischemia-reperfusion injury in rat kidneys
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania, USA
    Ann Clin Lab Sci 38:57-64. 2008
    ....
  16. ncbi Morphoproteomics and bortezomib/dexamethasone-induced response in relapsed acute lymphoblastic leukemia
    Robert E Brown
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822 0131, USA
    Ann Clin Lab Sci 34:203-5. 2004
    ..This communication illustrates the successful application of such an approach in a patient with relapsed acute lymphoblastic leukemia...
  17. ncbi Morphoproteomic and pharmacoproteomic correlates in hormone-receptor-negative breast carcinoma cell lines
    Robert E Brown
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822 0131, USA
    Ann Clin Lab Sci 34:251-62. 2004
    ..Such morphoproteomic and pharmacoproteomic profiling of individual tumors may enable the pathologist and oncologist to design antitumor therapy that is customized for an individual patient...
  18. ncbi Human kidney injury molecule-1 (hKIM-1): a useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Avenue, Danville, PA 17822, USA
    Am J Surg Pathol 31:371-81. 2007
    ....
  19. ncbi Morphoproteomic and molecular concomitants of an overexpressed and activated mTOR pathway in renal cell carcinomas
    Fan Lin
    Department of Pathology, University of Texas Houston Medical School, 6431 Fannin Street, Room 2 286, Houston, TX 77030, USA
    Ann Clin Lab Sci 36:283-93. 2006
    ....
  20. ncbi Nephrotic range proteinuria: rare manifestation of scleroderma renal crisis
    Manish Nepal
    Department of Internal Medicine, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 38:163-7. 2008
    ..These findings suggest that fusion of foot processes and activation of mammalian target of rapamycin-dependent pathways in podocytes are most likely responsible for the severe proteinuria in this patient with scleroderma nephropathy...
  21. ncbi TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease
    Bei Liu
    Department of Immunology, Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    J Immunol 177:6880-8. 2006
    ..Our study has revealed that increased TLR4 signaling alone without exogenous insult can break immunological tolerance. It provides a strong experimental evidence for TLR4 dysregulation as an etiology of lupus-like renal disease...
  22. ncbi Morphoproteomic and pharmacoproteomic rationale for mTOR effectors as therapeutic targets in head and neck squamous cell carcinoma
    Robert E Brown
    Department of Pathology, University of Texas Houston Medical School, 6431 Fannin Street, Room 2 286, Houston, TX 77030, USA
    Ann Clin Lab Sci 36:273-82. 2006
    ..In conclusion, these morphoproteomic and pharmacoproteomic data collectively provide a rationale for selecting mTOR effectors as therapeutic targets in HNSCC...
  23. ncbi Kidney injury molecule-1 expression identifies proximal tubular injury in urate nephropathy
    Manish Nepal
    Department of Internal Medicine, William Beaumont Hospital, Royal Oak, MI 48073 6769, USA
    Ann Clin Lab Sci 38:210-4. 2008
    ..In their renal biopsies, we demonstrate upregulation of kidney injury molecule-1 (KIM-1), a specific injury marker, in proximal tubular cells. This finding implicates a role for proximal tubular injury in urate nephropathy...
  24. ncbi Insights into mechanisms responsible for mesangial alterations associated with fibrogenic glomerulopathic light chains
    Jiamin Teng
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport 71130, USA
    Nephron Physiol 94:p28-38. 2003
    ..Furthermore, the data also reveal that PDGF-beta and TGF-beta act independently and that PDGF-beta activation by itself cannot increase ECM proteins directly, but only by increasing the number of HMCs...
  25. ncbi P53 protein is a reliable marker in identification of renal tubular injury
    Bernadette K McLaren
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Appl Immunohistochem Mol Morphol 12:225-9. 2004
    ....
  26. ncbi Association between prostate cancer and serum testosterone levels
    Ping L Zhang
    Department of Laboratory Medicine, Geisinger Health System, Danville, Pennsylvania, USA
    Prostate 53:179-82. 2002
    ..The purpose of the current study was to determine whether the presence of prostate cancer altered serum testosterone levels...