Marius Sudol

Summary

Affiliation: Geisinger Medical Center
Country: USA

Publications

  1. doi request reprint WW Domains in the Heart of Smad Regulation
    Marius Sudol
    Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17821, USA Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA Electronic address
    Structure 20:1619-20. 2012
  2. pmc Molecular insights into the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1
    Marius Sudol
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, PA 17821, USA
    FEBS Lett 586:2795-9. 2012
  3. pmc Structures of YAP protein domains reveal promising targets for development of new cancer drugs
    Marius Sudol
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, PA 17821, USA
    Semin Cell Dev Biol 23:827-33. 2012
  4. doi request reprint From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management
    M Sudol
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, PA 17822 2608, USA
    Oncogene 30:3003-10. 2011
  5. doi request reprint Modularity in the Hippo signaling pathway
    Marius Sudol
    Weis Center for Research, Laboratory of Signal Transduction, Geisinger Clinic, Danville, PA 17822, USA
    Trends Biochem Sci 35:627-33. 2010
  6. doi request reprint Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)
    Tsutomu Oka
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA
    J Biol Chem 283:27534-46. 2008
  7. pmc Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene
    Christian J Gaffney
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17821 2608, USA
    Gene 509:215-22. 2012
  8. pmc HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK
    Qiong Lin
    Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA
    Mol Cell Biol 30:1541-54. 2010
  9. ncbi request reprint WW or WoW: the WW domains in a union of bliss
    Marius Sudol
    Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania, USA
    IUBMB Life 57:773-8. 2005
  10. doi request reprint Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif
    Tsutomu Oka
    Geisinger Clinic, Weis Center for Research, Danville, PA 17822 2608, USA
    Genes Cells 14:607-15. 2009

Research Grants

  1. FUNCTION OF THE WW DOMAIN OF DYSTROPHIN
    Marius Sudol; Fiscal Year: 2002

Collaborators

Detail Information

Publications14

  1. doi request reprint WW Domains in the Heart of Smad Regulation
    Marius Sudol
    Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17821, USA Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA Electronic address
    Structure 20:1619-20. 2012
    ..The propensity of YAP WW to recognize a pSP motif is a surprising find with a number of far-reaching ramifications...
  2. pmc Molecular insights into the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1
    Marius Sudol
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, PA 17821, USA
    FEBS Lett 586:2795-9. 2012
    ....
  3. pmc Structures of YAP protein domains reveal promising targets for development of new cancer drugs
    Marius Sudol
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, PA 17821, USA
    Semin Cell Dev Biol 23:827-33. 2012
    ....
  4. doi request reprint From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management
    M Sudol
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, PA 17822 2608, USA
    Oncogene 30:3003-10. 2011
    ..This vignette reviews the history of PLAU and Src discovery, and illuminates the complexity of their relationship, but also points to their emerging impact on public health...
  5. doi request reprint Modularity in the Hippo signaling pathway
    Marius Sudol
    Weis Center for Research, Laboratory of Signal Transduction, Geisinger Clinic, Danville, PA 17822, USA
    Trends Biochem Sci 35:627-33. 2010
    ..We suggest that the prevalence of WW domain-mediated complexes in the Hippo pathway should facilitate its molecular analysis and aid prediction of new pathway components...
  6. doi request reprint Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)
    Tsutomu Oka
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA
    J Biol Chem 283:27534-46. 2008
    ....
  7. pmc Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene
    Christian J Gaffney
    Laboratory of Signal Transduction and Proteomic Profiling, Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17821 2608, USA
    Gene 509:215-22. 2012
    ..We also propose a normalized nomenclature for the mRNA splice variants of the YAP1 gene, which should aid in the characterization of signaling differences among the potential protein products of the YAP1 gene...
  8. pmc HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK
    Qiong Lin
    Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA
    Mol Cell Biol 30:1541-54. 2010
    ..Our findings suggest an essential role of Nedd4-1 in regulation of EGFR degradation through interaction with and ubiquitination of ACK...
  9. ncbi request reprint WW or WoW: the WW domains in a union of bliss
    Marius Sudol
    Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania, USA
    IUBMB Life 57:773-8. 2005
    ..We emphasize here the implications of tandem arrangement and cooperative function of the domains for signaling pathways...
  10. doi request reprint Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif
    Tsutomu Oka
    Geisinger Clinic, Weis Center for Research, Danville, PA 17822 2608, USA
    Genes Cells 14:607-15. 2009
    ..Since the Hippo pathway acts as a tumor suppressor pathway, the PDZ complex of YAP represents a potential target of cancer therapy...
  11. doi request reprint Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling
    Tsutomu Oka
    Weis Center for Research, 100 North Academy Avenue, Danville, PA 17822, USA
    Biochem J 432:461-72. 2010
    ..The present paper is the first report on a PDZ-based nuclear translocation mechanism. Moreover, since the Hippo pathway acts as a tumour suppressor pathway, the YAP2-ZO-2 complex could represent a target for cancer therapy...
  12. pmc Yes-associated protein (YAP) promotes cell survival by inhibiting proapoptotic dendrin signaling
    Kirk N Campbell
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 288:17057-62. 2013
    ..Our findings elucidate YAP binding to dendrin as a prosurvival mechanism. The antiapoptotic signaling properties of YAP in podocytes could hold significance in the quest for targeted therapeutics aimed at preventing podocyte loss...
  13. ncbi request reprint WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
    Akihiko Komuro
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:33334-41. 2003
    ..Our data indicate that YAP is a potential signaling partner of the full-length ErbB4 receptor at the membrane and of the COOH-terminal fragment of ErbB-4 that translocates to the nucleus to regulate transcription...
  14. pmc Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src
    Kathryn Masker
    Weis Center for Research, Danville, PA 17822 2608, USA
    Virology 364:10-20. 2007
    ..The set of strongly repressed genes contains TGF beta 3, TGF beta-induced gene, and deiodinase. The function of several robustly modulated genes sheds new light on the molecular mechanism of oncogenic transformation...

Research Grants3

  1. FUNCTION OF THE WW DOMAIN OF DYSTROPHIN
    Marius Sudol; Fiscal Year: 2002
    ..These studies will provide insight into molecular function of dystrophin and could point towards potential therapies for Duchenne and Becker muscular dystrophies. ..