Affiliation: Geisinger Medical Center
- Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: A multicentric phase II studyVincenzo Valentini
Department of Radiation Therapy, Universita Cattolica del Sacro Cuore, Rome, Italy
Int J Radiat Oncol Biol Phys 64:1129-39. 2006....
- Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012Mohammed Mohiuddin
Geisinger Cancer Institute, Wilkes Barre, PA 18711, USA
J Clin Oncol 24:650-5. 2006..To evaluate the rate of pathologic complete response and toxicity of neoadjuvant chemoradiation for advanced T3/T4 distal rectal cancers in a randomized phase II study..
- Future directions in neoadjuvant therapy of rectal cancer: maximizing pathological complete response ratesMohammed Mohiuddin
Geisinger Cancer Institute, 1000 E Mountain Blvd, Wilkes Barre, PA 18711, USA
Cancer Treat Rev 35:547-52. 2009..New paradigms in neoadjuvant therapy are therefore needed to further improve results of treatment. This review presents strategies for neoadjuvant therapy, with the potential to improve pCR rates and also survival of patients...
- Management of rectal cancer: short- vs. long-course preoperative radiationMohammed Mohiuddin
Geisinger Cancer Institute, Wilkes Barre, PA, USA
Int J Radiat Oncol Biol Phys 72:636-43. 2008....
- Genetic markers predictive of response to induction chemoradiotherapy for locally advanced rectal cancersMahesh Kudrimoti
Department of Radiation Medicine, University of Kentucky Medical Center, Lexington, 40536 0293, USA
J Ky Med Assoc 105:18-22. 2007..Pre-operative induction chemoradiotherapy has been used to downstage advanced rectal cancers. The variation in response rates is believed to be not only dependent on tumor size but also on the biological properties of individual tumors...
- Long-term results of reirradiation for patients with recurrent rectal carcinomaMohammed Mohiuddin
Department of Radiation Medicine, University of Kentucky Medical Center, Lexington 40536 0293, USA
Cancer 95:1144-50. 2002..The current study was conducted to assess the long-term results of reirradiation in patients with recurrent rectal carcinoma...
- Lack of P-glycoprotein expression by low-dose fractionated radiation results from loss of nuclear factor-kappaB and NF-Y activation in oral carcinoma cellsMohammed Momin Shareef
Weis Center for Research, Geisinger Clinic, Danville, PA, USA
Mol Cancer Res 6:89-98. 2008..Together, these results provide evidence for the lack of induction of P-glycoprotein expression by LDFRT, which has important implications in combinatorial cancer therapy, including the use of LDFRT as an adjuvant for chemotherapy...
- ACR Appropriateness Criteria on resectable rectal cancer: expert panel on radiation oncology--rectal/anal cancerW Warren Suh
Department of Radiation Oncology, Dana Farber Cancer Institute Brigham and Women s Hospital, Boston, MA 02459, USA
Int J Radiat Oncol Biol Phys 70:1427-30. 2008..A summary of the major randomized clinical trials spanning the past several decades is provided...
- Low-dose radiotherapy as a chemopotentiator of gemcitabine in tumors of the pancreas or small bowel: a phase I study exploring a new treatment paradigmWilliam F Regine
Department of Radiation Oncology, University of Maryland, Baltimore, MD, USA
Int J Radiat Oncol Biol Phys 68:172-7. 2007..To determine the maximum tolerated dose of upper abdominal low-dose fractionated radiotherapy (<1.0 Gy per fraction) given in combination with, and as a chemopotentiator for, gemcitabine...
- Spatially fractionated GRID radiation treatment of advanced neck disease associated with head and neck cancerJeniffer L Huhn
University of Kentucky, 800 Rose St N15, Lexington, KY 40536, USA
Technol Cancer Res Treat 5:607-12. 2006..It may improve pathologic complete response rates in those patients who undergo planned neck dissection, possibly leading to improved survival. In patients with inoperable bulky disease, addition of GRID enhances local-regional control...
- Long-term results of hyperfractionated radiation and high-dose intraarterial cisplatin for unresectable oropharyngeal carcinomaPaul M Spring
Division of Otolaryngology Head and Neck Surgery, University of Kentucky Chandler Medical Center, Lexington, Kentucky, USA
Cancer 104:1765-71. 2005....
- Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: implications for endothelial apoptosisSabapathi Sathishkumar
Deptartment of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA
Cancer Biol Ther 4:979-86. 2005..Apparently, these changes are in the LDL-associated ceramide and may contribute to better tumor reduction after SFGRT, due to the ability of LDL-derived ceramide to sensitize endothelial cells for apoptosis...
- A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancerNeil E Martin
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Clin Cancer Res 10:5447-54. 2004..CONCLUSIONS: The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed...
- Low-dose fractionated radiation as a chemopotentiator of neoadjuvant paclitaxel and carboplatin for locally advanced squamous cell carcinoma of the head and neck: results of a new treatment paradigmSusanne M Arnold
Department of Medicine, University of Kentucky Markey Cancer Center, Lexington 40536, USA
Int J Radiat Oncol Biol Phys 58:1411-7. 2004..On the basis of the demonstrated synergy between chemotherapy and low-dose fractionated RT, a novel neoadjuvant therapy was designed using low-dose fractionated RT as a chemopotentiator for locally advanced SCCHN...
- Low dose fractionated radiation potentiates the effects of taxotere in nude mice xenografts of squamous cell carcinoma of head and neckPaul M Spring
Division of Otolaryngology, Department of Surgery, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0084, USA
Cell Cycle 3:479-85. 2004..Furthermore, the G(2)/M cell cycle arrest by TXT appears to be an important component of the enhanced apoptotic effect of TXT + LDFRT combined treatment...
- Low-dose fractionated radiation potentiates the effects of Paclitaxel in wild-type and mutant p53 head and neck tumor cell linesSwatee Dey
Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
Clin Cancer Res 9:1557-65. 2003..These findings strongly suggest that LDFRT (at these doses, HRS phenomenon is observed) can be used in combination with Paclitaxel to overcome the antiapoptotic effects of BCL-2 and nuclear factor kappa B...
- The impact of TNF-alpha induction on therapeutic efficacy following high dose spatially fractionated (GRID) radiationSabapathi Sathishkumar
University of Kentucky, Department of Radiation Medicine, 800 Rose Street, Lexington, KY 40536-0293, USA
Technol Cancer Res Treat 1:141-7. 2002..Complete tumor response strongly correlated with the induction of TNF-alpha levels in the serum...
- A phase II study of concomitant hyperfractionated radiation therapy and double dose intra-arterial cisplatin for squamous cell carcinoma of the head and neckWilliam F Regine
University of Kentucky, Department of Radiation Medicine, 800 Rose Street, Lexington, KY 40536 0293, USA
Technol Cancer Res Treat 1:133-40. 2002..Future investigation of this novel treatment strategy utilizing modern angiographic catheter/microcatherter technology will involve a single dose of IA cisplatin with HFX-RT and dose intensification using neoadjuvant therapy...
- Concurrent infusional gemcitabine and radiation in the treatment of advanced unresectable GI malignancy: a phase I studyMohammed Mohiuddin
Department of Radiation Medicine, University of Kentucky, Lexington 40536-0293, USA
Cancer J 8:255-62. 2002..Further evaluation of gemcitabine at 100 mg/m2 is being undertaken in preparation for a confirmatory multi-institutional phase II study...
- Influence of p53 status on radiation and 5-flourouracil synergy in pancreatic cancer cellsMeraj Mohiuddin
Department of Radiation Medicine, University of Kentucky Medical Center, Lexington 40536-0293, USA
Anticancer Res 22:825-30. 2002..When XRT and 5-FU were combined, this led only to an additive effect in wild-type cell lines and a synergistic effect in mutant cell lines...