Fan Lin

Summary

Affiliation: Geisinger Medical Center
Country: USA

Publications

  1. ncbi request reprint Expression of S-100 protein in renal cell neoplasms
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Hum Pathol 37:462-70. 2006
  2. doi request reprint Immunohistochemical reevaluation of carbonic anhydrase IX (CA IX) expression in tumors and normal tissues
    Adelina Luong-Player
    Dept of Laboratory Medicine, MC 01 31, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822
    Am J Clin Pathol 141:219-25. 2014
  3. ncbi request reprint Immunohistochemical detection of P504S in primary and metastatic renal cell carcinomas
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Appl Immunohistochem Mol Morphol 12:153-9. 2004
  4. ncbi request reprint Diagnostic utility of S100P and von Hippel-Lindau gene product (pVHL) in pancreatic adenocarcinoma-with implication of their roles in early tumorigenesis
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Am J Surg Pathol 32:78-91. 2008
  5. ncbi request reprint Human kidney injury molecule-1 (hKIM-1): a useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Avenue, Danville, PA 17822, USA
    Am J Surg Pathol 31:371-81. 2007
  6. ncbi request reprint Plasmablastic lymphoma of the cervical lymph nodes in a human immunodeficiency virus-negative patient: a case report and review of the literature
    Fan Lin
    Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Arch Pathol Lab Med 128:581-4. 2004
  7. ncbi request reprint Diagnostic utility of CD10 in differentiating hepatocellular carcinoma from metastatic carcinoma in fine-needle aspiration biopsy (FNAB) of the liver
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Diagn Cytopathol 30:92-7. 2004
  8. ncbi request reprint Detection of Her-2/neu oncogene in breast carcinoma by chromogenic in situ hybridization in cytologic specimens
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Diagn Cytopathol 33:376-80. 2005
  9. ncbi request reprint Cytologic criteria for well differentiated adenocarcinoma of the pancreas in fine-needle aspiration biopsy specimens
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Cancer 99:44-50. 2003
  10. ncbi request reprint Acute cellular rejection predominated by monocytes is a severe form of rejection in human renal recipients with or without Campath-1H (alemtuzumab) induction therapy
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA, USA
    Am J Transplant 5:604-7. 2005

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Expression of S-100 protein in renal cell neoplasms
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Hum Pathol 37:462-70. 2006
    ..These data indicate that caution should be taken in interpreting an unknown primary with S-100 positivity and cytokeratin negativity. In addition, it suggests that S-100 has a diagnostic value in differentiating oncocytoma from ChRCC...
  2. doi request reprint Immunohistochemical reevaluation of carbonic anhydrase IX (CA IX) expression in tumors and normal tissues
    Adelina Luong-Player
    Dept of Laboratory Medicine, MC 01 31, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822
    Am J Clin Pathol 141:219-25. 2014
    ..To immunohistochemically evaluate the carbonic anhydrase IX (CA IX) expression on 1,551 cases of tumors and normal tissues from various organs...
  3. ncbi request reprint Immunohistochemical detection of P504S in primary and metastatic renal cell carcinomas
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Appl Immunohistochem Mol Morphol 12:153-9. 2004
    ..These findings suggest that P504S is a useful marker in diagnosing primary and metastatic RCCs, although it has little value in differentiating chromophobe RCC from oncocytoma...
  4. ncbi request reprint Diagnostic utility of S100P and von Hippel-Lindau gene product (pVHL) in pancreatic adenocarcinoma-with implication of their roles in early tumorigenesis
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Am J Surg Pathol 32:78-91. 2008
    ....
  5. ncbi request reprint Human kidney injury molecule-1 (hKIM-1): a useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Avenue, Danville, PA 17822, USA
    Am J Surg Pathol 31:371-81. 2007
    ....
  6. ncbi request reprint Plasmablastic lymphoma of the cervical lymph nodes in a human immunodeficiency virus-negative patient: a case report and review of the literature
    Fan Lin
    Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Arch Pathol Lab Med 128:581-4. 2004
    ..The cytologic, histologic, immunohistochemical, and molecular features of plasmablastic lymphoma are reviewed. The potential diagnostic pitfalls and differential diagnoses, especially in a fine-needle aspiration specimen, are addressed...
  7. ncbi request reprint Diagnostic utility of CD10 in differentiating hepatocellular carcinoma from metastatic carcinoma in fine-needle aspiration biopsy (FNAB) of the liver
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Diagn Cytopathol 30:92-7. 2004
    ..In conclusion, CD10 appears to be a useful marker in discriminating between HCC and metastatic carcinoma when applied to FNAB of the liver. CD10 does not provide discrimination between WD HCC and benign hepatocytes...
  8. ncbi request reprint Detection of Her-2/neu oncogene in breast carcinoma by chromogenic in situ hybridization in cytologic specimens
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Diagn Cytopathol 33:376-80. 2005
    ..In a case of low-level amplification, a CISH chromosome 17 probe should be used, or FISH is recommended for confirmation...
  9. ncbi request reprint Cytologic criteria for well differentiated adenocarcinoma of the pancreas in fine-needle aspiration biopsy specimens
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Cancer 99:44-50. 2003
    ..Existing cytologic criteria do not specifically focus on WDA. In this study, the authors attempt to add to, redefine, and test cytologic criteria for WDA of the pancreas in FNAB specimens...
  10. ncbi request reprint Acute cellular rejection predominated by monocytes is a severe form of rejection in human renal recipients with or without Campath-1H (alemtuzumab) induction therapy
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA, USA
    Am J Transplant 5:604-7. 2005
    ..We conclude that monocyte-predominate ACR may represent a severe form of rejection, with or without Campath-1H treatment...
  11. doi request reprint Immunohistochemical detection of the von Hippel-Lindau gene product (pVHL) in human tissues and tumors: a useful marker for metastatic renal cell carcinoma and clear cell carcinoma of the ovary and uterus
    Fan Lin
    Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Am J Clin Pathol 129:592-605. 2008
    ..These data indicate that this anti-pVHL antibody is a useful marker in assisting diagnosis of metastatic RCC and may serve as a diagnostic marker for clear cell carcinomas of the ovary and uterus...
  12. ncbi request reprint Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens
    Hongbing Deng
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Am J Clin Pathol 129:81-8. 2008
    ..All cases in group 4 were negative for S100P. S100P is a sensitive and specific marker for the detection of PDA on FNAB specimens on cell-block and smear preparations...
  13. ncbi request reprint Expression of von Hippel-Lindau gene product (pVHL) and S100P in cystic neoplasms of the pancreas--with an implication for their roles in tumorigenesis
    Haiyan Liu
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Ann Clin Lab Sci 42:109-17. 2012
    ....
  14. ncbi request reprint Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIalpha, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial lesions
    Jianhui Shi
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Hum Pathol 38:1335-44. 2007
    ....
  15. doi request reprint Diagnostic utility of von Hippel-Lindau gene product, maspin, IMP3, and S100P in adenocarcinoma of the gallbladder
    Jianhui Shi
    Geisinger Medical Center, Danville, PA 17822, USA
    Hum Pathol 44:503-11. 2013
    ..This study demonstrates that the immunostaining profile of pVHL-/IMP3+/maspin+/S100P+ is useful in the distinction of adenocarcinoma of the gallbladder from normal/reactive conditions...
  16. ncbi request reprint Immunohistochemical evaluation of ERG expression in various benign and malignant tissues
    Haiyan Liu
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Ann Clin Lab Sci 43:3-9. 2013
    ..Partly presented at the United States and Canadian Academy of Pathology Annual Meeting in March 2011...
  17. ncbi request reprint Chronic active thrombotic microangiopathy in native and transplanted kidneys
    Ping L Zhang
    Laboratory Medicine, Geisinger Medical Center, 100 North Academy, Danville, PA 17822, USA
    Ann Clin Lab Sci 36:319-25. 2006
    ..The patient received a living related-donor transplant, but thrombotic microangiopathy recurred in the donor kidney only 40 days after the renal transplantation...
  18. ncbi request reprint Immunohistochemical evaluation of GATA-3 expression in ER-negative breast carcinomas
    Haiyan Liu
    Dept of Laboratory Medicine, MC 01 31, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822
    Am J Clin Pathol 141:648-55. 2014
    ..The purpose of this study is to investigate expression of GATA-3 in ER-negative breast carcinomas...
  19. doi request reprint Arginase-1, HepPar-1, and Glypican-3 are the most effective panel of markers in distinguishing hepatocellular carcinoma from metastatic tumor on fine-needle aspiration specimens
    Dana T Timek
    Geisinger Medical Center, Danville, PA 17822, USA
    Am J Clin Pathol 138:203-10. 2012
    ..These data demonstrate that Arg-1 is the most specific marker in differentiating a non-HCC from HCC. It is recommended to use 3 markers as a panel in distinguishing HCC from metastatic carcinoma...
  20. doi request reprint Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues: a useful immunomarker for breast and urothelial carcinomas
    Haiyan Liu
    Department of Laboratory Medicine, MC 01 31, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822, USA
    Am J Clin Pathol 138:57-64. 2012
    ..When working on a tumor of unknown origin, GATA3 should be routinely included in the initial screening panel if either a breast or urothelial primary tumor is suspected...
  21. doi request reprint Reevaluation and identification of the best immunohistochemical panel (pVHL, Maspin, S100P, IMP-3) for ductal adenocarcinoma of the pancreas
    Haiyan Liu
    Department of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822, USA
    Arch Pathol Lab Med 136:601-9. 2012
    ..Differentiation of ductal adenocarcinoma of the pancreas from nonneoplastic pancreatic tissues can be challenging, especially in small biopsy and fine-needle aspiration specimens...
  22. ncbi request reprint Immunohistochemical evaluation of inhibin-alpha in non-small-cell lung carcinomas--a pitfall in diagnosing metastatic pulmonary carcinomas
    Kai Zhang
    Geisinger Medical Laboratory, Geisinger Medical Center, Danville, PA 17822, USA
    Ann Clin Lab Sci 42:118-22. 2012
    ..Inhibin-alpha is commonly used in differentiating non-small-cell lung carcinoma from certain metastatic carcinomas, but a study on a large series of primary lung cancer cases has not yet been published...
  23. ncbi request reprint Case report: IgM type of membranous glomerulopathy in a diabetic patient
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822, USA
    Ann Clin Lab Sci 35:184-8. 2005
    ....
  24. doi request reprint Patient safety: a macrosystems perspective
    William B Dupree
    Department of Anatomic Pathology, Geisinger Medical Center, Danville, PA 17822, USA
    Clin Lab Med 28:189-205, v-vi. 2008
    ..They conclude with an analysis of the potential for enhanced patient safety through macrosystem consolidation, standardization, and communication in a best care algorithm based on outcome analysis...
  25. ncbi request reprint Cytodiagnosis of primary lymphoma of bone on fine-needle aspiration cytology specimens: review of 25 cases
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Diagn Cytopathol 28:205-11. 2003
    ..The nondiagnostic and suspicious categories can be further reduced or eliminated by improving FNA techniques or by recommendation of surgical core biopsies together with other techniques such as flow cytometry and molecular analysis...
  26. ncbi request reprint Monocyte-mediated acute renal rejection after combined treatment with preoperative Campath-1H (alemtuzumab) and postoperative immunosuppression
    Ping L Zhang
    Division of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Ann Clin Lab Sci 34:209-13. 2004
    ..5 mg/dl. The histopathological features of acute rejection were absent in a second biopsy of the transplanted kidney. In summary, this case is an instance of monocyte-mediated acute rejection of a transplanted kidney...
  27. doi request reprint Histiocytic sarcoma in the small intestine: a case report with flow cytometry study and review of the literature
    Xiaohong Zhang
    Department of Pathology, Geisinger Medical Center, 1000 E Mountain Blvd Wilkes Barre, PA 18711, USA
    Pathol Res Pract 204:763-70. 2008
    ..The diagnostic methods and the possible prognostic factors are discussed. We believe that the correct diagnosis of HS is important for clinical treatment and prognostic prediction, although it is very rare...
  28. ncbi request reprint Utility of SKP2 and MIB-1 in grading follicular lymphoma using quantitative imaging analysis
    Kai Zhang
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Hum Pathol 38:878-82. 2007
    ..Compared with traditional methods, quantitation of SKP2 expression using a quantitative image analysis system might be a useful and objective approach in grading follicular lymphoma...
  29. doi request reprint Use of IMP3, S100P, and pVHL immunopanel to aid in the interpretation of bile duct biopsies with atypical histology or suspicious for malignancy
    Michael T Schmidt
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Appl Immunohistochem Mol Morphol 20:478-87. 2012
    ..However, caution should be exercised when using this immunopanel in the interpretation of challenging bile duct biopsies, because S100P and pVHL stains may give rise to variable patterns that can be difficult to interpret...
  30. ncbi request reprint Endothelin receptor antagonist combined with a calcium channel blocker attenuates renal injury in spontaneous hypertensive rats with diabetes
    Jing Chen
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China
    Chin Med J (Engl) 115:972-8. 2002
    ....
  31. ncbi request reprint Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma
    Maria S Tretiakova
    Department of Pathology, University of Chicago, Chicago, IL 60611, USA
    Am J Surg Pathol 28:69-76. 2004
    ....
  32. ncbi request reprint Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma
    Kim L Wang
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hum Pathol 38:239-46. 2007
    ..In contrast, adenomas associated with APKD exhibit distinct morphological and immunohistochemical features and, therefore, may have an entirely different pathogenesis...
  33. ncbi request reprint Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma
    Brian P Adley
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Clin Pathol 126:79-85. 2006
    ..Ksp-cad was present in chromophobe RCCs and oncocytomas at mRNA and protein levels, providing strong evidence that Ksp-cad immunohistochemical analysis cannot be used in differentiating these tumors...
  34. doi request reprint Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization
    Ximing J Yang
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA
    Am J Surg Pathol 32:177-87. 2008
    ....
  35. ncbi request reprint Expression of mucins, SIMA, villin, and CDX2 in small-intestinal adenocarcinoma
    Megan Q Zhang
    Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Pathol 128:808-16. 2007
    ..These observations further support the notion that SIA is immunophenotypically distinct from CRC despite their morphologic similarity...
  36. ncbi request reprint Overexpression of glutathione s-transferase alpha in clear cell renal cell carcinoma
    Shang Tian Chuang
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Clin Pathol 123:421-9. 2005
    ..62). Other renal tumor types did not exhibit significant GST-alpha immunoreactivity, confirming mRNA results. Through cDNA microarrays and immunohistochemical analysis, we demonstrated GST-alpha as a biomarker for clear cell RCCs...
  37. ncbi request reprint [The effects of endothelin blockade on renal expression of angiotensin II type 1 receptor in diabetic hypertensive rats]
    Yong Gu
    Department of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China
    Zhonghua Yi Xue Za Zhi 82:10-3. 2002
    ..To investigate the changes of angiotensin II type 1 (AT1) receptor in the kidney of spontaneously hypertensive rats (SHR) with diabetes and the influence of endothelin receptor antagonist bosentan...
  38. ncbi request reprint [Expression of energy metabolism-related genes in myocardial tissues of rats with diabetic cardiomyopathy]
    Gang Chen
    Department of Endocrinology, Fujian Provincial Hospital, Fuzhou 350001, China
    Di Yi Jun Yi Da Xue Xue Bao 22:1009-10. 2002
    ..To study the pathogenesis of diabetic cardiomyopathy using DNA microarray...
  39. ncbi request reprint Gene expression analysis of prostate cancers
    Jian Hua Luo
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pensylvania 15261, USA
    Mol Carcinog 33:25-35. 2002
    ..Cluster analysis using the 84-gene list showed that the highly aggressive prostate cancers contained gene-expression patterns that were distinct from organ-confined prostate cancers...
  40. ncbi request reprint Morphoproteomic and molecular concomitants of an overexpressed and activated mTOR pathway in renal cell carcinomas
    Fan Lin
    Department of Pathology, University of Texas Houston Medical School, 6431 Fannin Street, Room 2 286, Houston, TX 77030, USA
    Ann Clin Lab Sci 36:283-93. 2006
    ....
  41. ncbi request reprint Immunohistochemical detection of p16INK4a in liquid-based cytology specimens on cell block sections
    Haiyan Liu
    Department of Pathology, Lehigh Valley Hospital, Allentown, Pennsylvania, USA
    Cancer 111:74-82. 2007
    ..To further improve the diagnostic accuracy of the ASC-H Papanicolaou smear and to reduce unnecessary procedures, the authors evaluated the utility of immunodetection of p16 in liquid-based cytology specimens on cell blocks...
  42. ncbi request reprint TCM treatment of infectious atypical pneumonia--a report of 16 cases
    Xiaolin Tong
    Sino Japanese Friendship Hospital, Beijing 100029, China
    J Tradit Chin Med 24:266-9. 2004
    ..To probe into the mechanism on TCM treatment of infectious atypical pneumonia (severe acute respiratory syndrome, SARS) and evaluate its feasibility and effectiveness...
  43. ncbi request reprint Over expression of insulin-like growth factor binding protein 3 in clear cell renal cell carcinoma
    Shang Tian Chuang
    Department of Pathology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 179:445-9. 2008
    ..We further investigated IGFBP-3 expression in renal tumors using gene expression microarrays, immunohistochemistry and Western blotting...