Robert D Langer

Summary

Affiliation: Geisinger Medical Center
Country: USA

Publications

  1. ncbi request reprint Effects of E2 and E2/norgestimate hormone therapy on elevated baseline lipids
    Robert D Langer
    Center for Health Research and Rural Advocacy, Geisinger Health System, 100 North Academy Avenue, MC 30 03, Danville, PA 17822, USA
    J Reprod Med 51:610-6. 2006
  2. ncbi request reprint Effects of tibolone and continuous combined conjugated equine estrogen/medroxyprogesterone acetate on the endometrium and vaginal bleeding: results of the OPAL study
    Robert D Langer
    Gesinger Health System, Danville, PA 17822 3003, USA
    Am J Obstet Gynecol 195:1320-7. 2006
  3. doi request reprint Efficacy, safety, and tolerability of low-dose hormone therapy in managing menopausal symptoms
    Robert D Langer
    Outcomes Research Institute, Geisinger Center for Health Research, Danville, PA, USA
    J Am Board Fam Med 22:563-73. 2009
  4. doi request reprint A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women's Health Initiative Memory Study
    Karen C Johnson
    Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennesse 38163, USA
    J Am Geriatr Soc 56:1449-58. 2008
  5. doi request reprint Estrogen plus progestin and breast cancer detection by means of mammography and breast biopsy
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Arch Intern Med 168:370-7; quiz 345. 2008
  6. ncbi request reprint Combined analysis of Women's Health Initiative observational and clinical trial data on postmenopausal hormone treatment and cardiovascular disease
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 163:589-99. 2006
  7. ncbi request reprint Calcium plus vitamin D supplementation and the risk of colorectal cancer
    Jean Wactawski-Wende
    Department of Social and Preventive Medicine, University at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA
    N Engl J Med 354:684-96. 2006
  8. ncbi request reprint Calcium plus vitamin D supplementation and the risk of fractures
    Rebecca D Jackson
    Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
    N Engl J Med 354:669-83. 2006
  9. ncbi request reprint Conjugated equine estrogens and coronary heart disease: the Women's Health Initiative
    Judith Hsia
    Department of Medicine, George Washington University, Washington, DC, USA
    Arch Intern Med 166:357-65. 2006
  10. ncbi request reprint Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    Garnet L Anderson
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 291:1701-12. 2004

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Effects of E2 and E2/norgestimate hormone therapy on elevated baseline lipids
    Robert D Langer
    Center for Health Research and Rural Advocacy, Geisinger Health System, 100 North Academy Avenue, MC 30 03, Danville, PA 17822, USA
    J Reprod Med 51:610-6. 2006
    ..To evaluate lipid effects of estradiol/ norgestimate hormone therapy in postmenopausal women with elevated lipid levels...
  2. ncbi request reprint Effects of tibolone and continuous combined conjugated equine estrogen/medroxyprogesterone acetate on the endometrium and vaginal bleeding: results of the OPAL study
    Robert D Langer
    Gesinger Health System, Danville, PA 17822 3003, USA
    Am J Obstet Gynecol 195:1320-7. 2006
    ..5 mg), continuous combined conjugated equine estrogen/medroxyprogesterone acetate [0.625/2.5 mg], and placebo on the endometrium and vaginal bleeding; these results are the subject of this report...
  3. doi request reprint Efficacy, safety, and tolerability of low-dose hormone therapy in managing menopausal symptoms
    Robert D Langer
    Outcomes Research Institute, Geisinger Center for Health Research, Danville, PA, USA
    J Am Board Fam Med 22:563-73. 2009
    ..This review evaluates current evidence on the efficacy, safety, and tolerability of these preparations and their role in menopausal management...
  4. doi request reprint A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women's Health Initiative Memory Study
    Karen C Johnson
    Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennesse 38163, USA
    J Am Geriatr Soc 56:1449-58. 2008
    ..To examine the relationship between baseline hypertension, blood pressure, and the development of cognitive decline in participants in the Women's Health Initiative Memory Study (WHIMS)...
  5. doi request reprint Estrogen plus progestin and breast cancer detection by means of mammography and breast biopsy
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Arch Intern Med 168:370-7; quiz 345. 2008
    ..The effect of combined hormone therapy on breast cancer detection is not established...
  6. ncbi request reprint Combined analysis of Women's Health Initiative observational and clinical trial data on postmenopausal hormone treatment and cardiovascular disease
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 163:589-99. 2006
    ..An application to postmenopausal hormone treatment effects on coronary heart disease among younger women is also provided...
  7. ncbi request reprint Calcium plus vitamin D supplementation and the risk of colorectal cancer
    Jean Wactawski-Wende
    Department of Social and Preventive Medicine, University at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA
    N Engl J Med 354:684-96. 2006
    ..However, randomized-trial evidence that calcium with vitamin D supplementation is beneficial in the primary prevention of colorectal cancer is lacking...
  8. ncbi request reprint Calcium plus vitamin D supplementation and the risk of fractures
    Rebecca D Jackson
    Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
    N Engl J Med 354:669-83. 2006
    ..The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal...
  9. ncbi request reprint Conjugated equine estrogens and coronary heart disease: the Women's Health Initiative
    Judith Hsia
    Department of Medicine, George Washington University, Washington, DC, USA
    Arch Intern Med 166:357-65. 2006
    ..These trials did not address the role of unopposed estrogen for coronary protection...
  10. ncbi request reprint Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    Garnet L Anderson
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 291:1701-12. 2004
    ..Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain...
  11. ncbi request reprint Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial
    Rowan T Chlebowski
    Harbor UCLA Research and Education Institute, Torrance 90502, USA
    JAMA 289:3243-53. 2003
    ..Outstanding issues not previously addressed include characteristics of breast cancers observed among women using hormones and whether diagnosis may be influenced by hormone effects on mammography...
  12. ncbi request reprint Bleeding patterns of the hormone replacement therapies in the postmenopausal estrogen and progestin interventions trial
    Etta A Lindenfeld
    Department of Psychiatry, University of California, San Diego, California 92037, USA
    Obstet Gynecol 100:853-63. 2002
    ..To explore whether significant differences exist between bleeding patterns with common regimens of hormone replacement therapy using two different progestogens...
  13. ncbi request reprint Estrogen plus progestin and the risk of peripheral arterial disease: the Women's Health Initiative
    Judith Hsia
    Department of Medicine, George Washington University, Washington, DC, USA
    Circulation 109:620-6. 2004
    ..This analysis evaluates clinical peripheral arterial disease among generally healthy women in the Women's Health Initiative randomized trial of estrogen plus progestin...
  14. pmc Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative
    Ian H De Boer
    Division of Nephrology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Diabetes Care 31:701-7. 2008
    ..We examined the effect of calcium plus vitamin D supplementation on the incidence of drug-treated diabetes in postmenopausal women...
  15. doi request reprint Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women
    Anne McTiernan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Breast Cancer Res Treat 108:217-31. 2008
    ..These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period...
  16. pmc Conjugated equine estrogens and breast cancer risk in the Women's Health Initiative clinical trial and observational study
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 167:1407-15. 2008
    ....
  17. ncbi request reprint Tissue plasminogen activator antigen and D-dimer as markers for atherothrombotic risk among healthy postmenopausal women
    Aruna D Pradhan
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, Mass 02215, USA
    Circulation 110:292-300. 2004
    ..Few studies have evaluated this relationship in women. In addition, although menopausal hormone therapy (HT) may alter markers of fibrinolytic function, the relevance of this effect for coronary risk assessment has not been studied...
  18. pmc Oophorectomy, hormone therapy, and subclinical coronary artery disease in women with hysterectomy: the Women's Health Initiative coronary artery calcium study
    Matthew A Allison
    University of California San Diego, La Jolla, CA, USA
    Menopause 15:639-47. 2008
    ..In this study, we aimed to determine the associations between coronary artery calcium (CAC) and hysterectomy, oophorectomy, and hormone therapy use with a focus on the duration of menopause for which there was no hormone therapy use...
  19. pmc Effects of estrogen with and without progestin and obesity on symptomatic gastroesophageal reflux
    Zongli Zheng
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 135:72-81. 2008
    ..An association between female hormones and symptomatic gastroesophageal reflux disease (GERD) and may be modified by obesity is suggested but not proven. Factors affecting GERD progression, however, are largely unknown...
  20. ncbi request reprint Hormone replacement and the prevention of cardiovascular disease
    Robert D Langer
    University of California at San Diego, School of Medicine, La Jolla, California 92037, USA
    Am J Cardiol 89:36E-46E; discussion 46E. 2002
    ..This information should be considered when deciding whether to use HRT in an individual woman, and if so, which formulation to use...
  21. doi request reprint Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial
    Lesley F Tinker
    Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
    Arch Intern Med 168:1500-11. 2008
    ..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women...
  22. pmc Hip bone density predicts breast cancer risk independently of Gail score: results from the Women's Health Initiative
    Zhao Chen
    Division of Epidemiology and Biostatistics, University of Arizona College of Public Health, Tucson, Arizona 85724 5211, USA
    Cancer 113:907-15. 2008
    ..The objective of the current study was to investigate whether hip BMD predicts postmenopausal breast cancer risk independently of the Gail score...
  23. doi request reprint Calcium, vitamin D supplementation, and physical function in the Women's Health Initiative
    Robert L Brunner
    University of Nevada School of Medicine, PMB 251, MS 145, Reno, NV 89557, USA
    J Am Diet Assoc 108:1472-9. 2008
    ..Now we examine whether the treatment affected self-reported physical functioning and objective measures of physical functioning...
  24. doi request reprint Association between different measures of blood pressure and coronary artery calcium in postmenopausal women
    Matthew A Allison
    University of California San Diego, La Jolla, California, USA
    Hypertension 52:833-40. 2008
    ..03 to 2.90; P=0.04). In postmenopausal women, higher levels of pulse pressure and systolic blood pressure were strong determinants of CAC, whereas diastolic blood pressure was inversely related...
  25. pmc Self-reported sleep latency in postmenopausal women
    Doo Heum Park
    Department of Psychiatry, Konkuk University School of Medicine, Seoul, Korea
    J Korean Med Sci 22:1007-14. 2007
    ..Therapeutic approaches suggested for trouble falling asleep might include increased daylight exposure, improvements in general health, and modification of anti-hypertensive pharmacotherapy...
  26. ncbi request reprint Estrogen therapy and coronary-artery calcification
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 356:2591-602. 2007
    ..We examined the relationship between estrogen therapy and coronary-artery calcium in the context of a randomized clinical trial...
  27. pmc Cardiovascular disease, its risk factors and treatment, and age-related macular degeneration: Women's Health Initiative Sight Exam ancillary study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53726, USA
    Am J Ophthalmol 143:473-83. 2007
    ..To examine the association of cardiovascular disease (CVD), CVD risk factors, and CVD treatment with age-related macular degeneration (AMD)...
  28. ncbi request reprint Naps and circadian rhythms in postmenopausal women
    In Young Yoon
    Department of Psychiatry, 0667, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0667, USA
    J Gerontol A Biol Sci Med Sci 59:844-8. 2004
    ..Napping patterns and relationships among naps, circadian rhythms, and nocturnal sleep were evaluated in postmenopausal women. Naps and nocturnal sleep were compared between depressed women and healthy volunteers...
  29. ncbi request reprint Association between reported alcohol intake and cognition: results from the Women's Health Initiative Memory Study
    Mark A Espeland
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Epidemiol 161:228-38. 2005
    ..Moderate levels of alcohol intake may be associated with better cognition and reduced risk of significant cognitive decline; however, confounding associations with unmeasured factors cannot be ruled out...
  30. ncbi request reprint Postmenopausal hormone therapy: critical reappraisal and a unified hypothesis
    Lawrence S Phillips
    General Clinical Research Center, Emory University Hospital, Division of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Fertil Steril 83:558-66. 2005
    ....
  31. ncbi request reprint Baseline associations between postmenopausal hormone therapy and inflammatory, haemostatic, and lipid biomarkers of coronary heart disease. The Women's Health Initiative Observational Study
    Robert D Langer
    Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0978, La Jolla, CA 92093 0978, USA
    Thromb Haemost 93:1108-16. 2005
    ..Some associations differed between women with and without incident CHD, especially for EP, where inflammatory and thrombotic markers were higher in cases. These associations remain speculative pending confirmation in randomized trials...
  32. ncbi request reprint Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
    JAMA 295:629-42. 2006
    ..The hypothesis that a low-fat dietary pattern can reduce breast cancer risk has existed for decades but has never been tested in a controlled intervention trial...
  33. ncbi request reprint Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial
    Shirley A A Beresford
    Department of Epidemiology, University of Washington, Seattle, WA 98195 7236, USA
    JAMA 295:643-54. 2006
    ..Observational studies and polyp recurrence trials are not conclusive regarding the effects of a low-fat dietary pattern on risk of colorectal cancer, necessitating a primary prevention trial...
  34. ncbi request reprint Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial
    Barbara V Howard
    MedStar Research Institute Howard University, Washington, DC, USA
    JAMA 295:655-66. 2006
    ..Multiple epidemiologic studies and some trials have linked diet with cardiovascular disease (CVD) prevention, but long-term intervention data are needed...
  35. pmc Ethnicity, sleep, mood, and illumination in postmenopausal women
    Daniel F Kripke
    Department of Psychiatry, University of California, San Diego, CA, USA
    BMC Psychiatry 4:8. 2004
    ..This study examined how ethnic differences in sleep and depression were related to environmental illumination and circadian rhythms...
  36. ncbi request reprint Postmenopausal hormone therapy and migraine headache
    Anastasia L Misakian
    University of California San Diego School of Medicine, San Diego, California, USA
    J Womens Health (Larchmt) 12:1027-36. 2003
    ..No population-based studies have examined the association between hormone therapy (HT) and migraine among postmenopausal women...
  37. ncbi request reprint Venous thrombosis and conjugated equine estrogen in women without a uterus
    J David Curb
    University of Hawaii and Pacific Health Research Institute, Honolulu, USA
    Arch Intern Med 166:772-80. 2006
    ..Clinical trial data on the effects of estrogen alone on VT are limited...
  38. ncbi request reprint Sex and time differences in the associations of non-high-density lipoprotein cholesterol versus other lipid and lipoprotein factors in the prediction of cardiovascular death (The Rancho Bernardo Study)
    Denise von Muhlen
    Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 93093 0607, USA
    Am J Cardiol 91:1311-5. 2003
    ..Thus, non-HDL cholesterol is not superior to individual lipids, lipoproteins, or their ratios in the prediction of cardiovascular death in older adults...
  39. ncbi request reprint Evening light exposure: implications for sleep and depression
    Geralyn M Wallace-Guy
    Department of Psychiatry and the Sam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla, California 92093, USA
    J Am Geriatr Soc 50:738-9. 2002
    ..To examine whether dim illumination in the evening is a factor in sleep disturbances of aging, depression, and circadian phase advance...