Research Topics
| Robert D LangerSummaryAffiliation: Geisinger Medical Center Country: USA Publications
| Collaborators
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Detail Information
Publications
Effects of E2 and E2/norgestimate hormone therapy on elevated baseline lipidsRobert D Langer
Center for Health Research and Rural Advocacy, Geisinger Health System, 100 North Academy Avenue, MC 30 03, Danville, PA 17822, USA
J Reprod Med 51:610-6. 2006..To evaluate lipid effects of estradiol/ norgestimate hormone therapy in postmenopausal women with elevated lipid levels...- Effects of tibolone and continuous combined conjugated equine estrogen/medroxyprogesterone acetate on the endometrium and vaginal bleeding: results of the OPAL studyRobert D Langer
Gesinger Health System, Danville, PA 17822 3003, USA
Am J Obstet Gynecol 195:1320-7. 2006..5 mg), continuous combined conjugated equine estrogen/medroxyprogesterone acetate [0.625/2.5 mg], and placebo on the endometrium and vaginal bleeding; these results are the subject of this report... 
Efficacy, safety, and tolerability of low-dose hormone therapy in managing menopausal symptomsRobert D Langer
Outcomes Research Institute, Geisinger Center for Health Research, Danville, PA, USA
J Am Board Fam Med 22:563-73. 2009..This review evaluates current evidence on the efficacy, safety, and tolerability of these preparations and their role in menopausal management...- A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women's Health Initiative Memory StudyKaren C Johnson
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennesse 38163, USA
J Am Geriatr Soc 56:1449-58. 2008..To examine the relationship between baseline hypertension, blood pressure, and the development of cognitive decline in participants in the Women's Health Initiative Memory Study (WHIMS)... - Estrogen plus progestin and breast cancer detection by means of mammography and breast biopsyRowan T Chlebowski
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Arch Intern Med 168:370-7; quiz 345. 2008..The effect of combined hormone therapy on breast cancer detection is not established... - Combined analysis of Women's Health Initiative observational and clinical trial data on postmenopausal hormone treatment and cardiovascular diseaseRoss L Prentice
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 163:589-99. 2006..An application to postmenopausal hormone treatment effects on coronary heart disease among younger women is also provided... - Calcium plus vitamin D supplementation and the risk of colorectal cancerJean Wactawski-Wende
Department of Social and Preventive Medicine, University at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA
N Engl J Med 354:684-96. 2006..However, randomized-trial evidence that calcium with vitamin D supplementation is beneficial in the primary prevention of colorectal cancer is lacking... - Calcium plus vitamin D supplementation and the risk of fracturesRebecca D Jackson
Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
N Engl J Med 354:669-83. 2006..The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal... - Conjugated equine estrogens and coronary heart disease: the Women's Health InitiativeJudith Hsia
Department of Medicine, George Washington University, Washington, DC, USA
Arch Intern Med 166:357-65. 2006..These trials did not address the role of unopposed estrogen for coronary protection... - Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trialGarnet L Anderson
Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
JAMA 291:1701-12. 2004..Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain... - Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized TrialRowan T Chlebowski
Harbor UCLA Research and Education Institute, Torrance 90502, USA
JAMA 289:3243-53. 2003..Outstanding issues not previously addressed include characteristics of breast cancers observed among women using hormones and whether diagnosis may be influenced by hormone effects on mammography... - Bleeding patterns of the hormone replacement therapies in the postmenopausal estrogen and progestin interventions trialEtta A Lindenfeld
Department of Psychiatry, University of California, San Diego, California 92037, USA
Obstet Gynecol 100:853-63. 2002..To explore whether significant differences exist between bleeding patterns with common regimens of hormone replacement therapy using two different progestogens... - Estrogen plus progestin and the risk of peripheral arterial disease: the Women's Health InitiativeJudith Hsia
Department of Medicine, George Washington University, Washington, DC, USA
Circulation 109:620-6. 2004..This analysis evaluates clinical peripheral arterial disease among generally healthy women in the Women's Health Initiative randomized trial of estrogen plus progestin... 
Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health InitiativeIan H De Boer
Division of Nephrology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
Diabetes Care 31:701-7. 2008..We examined the effect of calcium plus vitamin D supplementation on the incidence of drug-treated diabetes in postmenopausal women...- Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal womenAnne McTiernan
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Breast Cancer Res Treat 108:217-31. 2008..These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period... - Conjugated equine estrogens and breast cancer risk in the Women's Health Initiative clinical trial and observational studyRoss L Prentice
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 167:1407-15. 2008.... - Tissue plasminogen activator antigen and D-dimer as markers for atherothrombotic risk among healthy postmenopausal womenAruna D Pradhan
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, Mass 02215, USA
Circulation 110:292-300. 2004..Few studies have evaluated this relationship in women. In addition, although menopausal hormone therapy (HT) may alter markers of fibrinolytic function, the relevance of this effect for coronary risk assessment has not been studied... - Oophorectomy, hormone therapy, and subclinical coronary artery disease in women with hysterectomy: the Women's Health Initiative coronary artery calcium studyMatthew A Allison
University of California San Diego, La Jolla, CA, USA
Menopause 15:639-47. 2008..In this study, we aimed to determine the associations between coronary artery calcium (CAC) and hysterectomy, oophorectomy, and hormone therapy use with a focus on the duration of menopause for which there was no hormone therapy use... - Effects of estrogen with and without progestin and obesity on symptomatic gastroesophageal refluxZongli Zheng
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Gastroenterology 135:72-81. 2008..An association between female hormones and symptomatic gastroesophageal reflux disease (GERD) and may be modified by obesity is suggested but not proven. Factors affecting GERD progression, however, are largely unknown... - Hormone replacement and the prevention of cardiovascular diseaseRobert D Langer
University of California at San Diego, School of Medicine, La Jolla, California 92037, USA
Am J Cardiol 89:36E-46E; discussion 46E. 2002..This information should be considered when deciding whether to use HRT in an individual woman, and if so, which formulation to use... - Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trialLesley F Tinker
Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
Arch Intern Med 168:1500-11. 2008..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women... - Hip bone density predicts breast cancer risk independently of Gail score: results from the Women's Health InitiativeZhao Chen
Division of Epidemiology and Biostatistics, University of Arizona College of Public Health, Tucson, Arizona 85724 5211, USA
Cancer 113:907-15. 2008..The objective of the current study was to investigate whether hip BMD predicts postmenopausal breast cancer risk independently of the Gail score... - Calcium, vitamin D supplementation, and physical function in the Women's Health InitiativeRobert L Brunner
University of Nevada School of Medicine, PMB 251, MS 145, Reno, NV 89557, USA
J Am Diet Assoc 108:1472-9. 2008..Now we examine whether the treatment affected self-reported physical functioning and objective measures of physical functioning... - Association between different measures of blood pressure and coronary artery calcium in postmenopausal womenMatthew A Allison
University of California San Diego, La Jolla, California, USA
Hypertension 52:833-40. 2008..03 to 2.90; P=0.04). In postmenopausal women, higher levels of pulse pressure and systolic blood pressure were strong determinants of CAC, whereas diastolic blood pressure was inversely related... - Self-reported sleep latency in postmenopausal womenDoo Heum Park
Department of Psychiatry, Konkuk University School of Medicine, Seoul, Korea
J Korean Med Sci 22:1007-14. 2007..Therapeutic approaches suggested for trouble falling asleep might include increased daylight exposure, improvements in general health, and modification of anti-hypertensive pharmacotherapy... - Estrogen therapy and coronary-artery calcificationJoAnn E Manson
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
N Engl J Med 356:2591-602. 2007..We examined the relationship between estrogen therapy and coronary-artery calcium in the context of a randomized clinical trial... - Cardiovascular disease, its risk factors and treatment, and age-related macular degeneration: Women's Health Initiative Sight Exam ancillary studyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53726, USA
Am J Ophthalmol 143:473-83. 2007..To examine the association of cardiovascular disease (CVD), CVD risk factors, and CVD treatment with age-related macular degeneration (AMD)... - Naps and circadian rhythms in postmenopausal womenIn-Young Yoon
Department of Psychiatry, 0667, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0667, USA
J Gerontol A Biol Sci Med Sci 59:844-8. 2004..Relationships between evening napping and earlier wake-up time may be a common manifestation of advanced circadian rhythms or may be a homeostatic effect... - Association between reported alcohol intake and cognition: results from the Women's Health Initiative Memory StudyMark A Espeland
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Epidemiol 161:228-38. 2005..Moderate levels of alcohol intake may be associated with better cognition and reduced risk of significant cognitive decline; however, confounding associations with unmeasured factors cannot be ruled out... - Postmenopausal hormone therapy: critical reappraisal and a unified hypothesisLawrence S Phillips
General Clinical Research Center, Emory University Hospital, Division of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Fertil Steril 83:558-66. 2005.... - Baseline associations between postmenopausal hormone therapy and inflammatory, haemostatic, and lipid biomarkers of coronary heart disease. The Women's Health Initiative Observational StudyRobert D Langer
Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0978, La Jolla, CA 92093 0978, USA
Thromb Haemost 93:1108-16. 2005..Some associations differed between women with and without incident CHD, especially for EP, where inflammatory and thrombotic markers were higher in cases. These associations remain speculative pending confirmation in randomized trials... - Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification TrialRoss L Prentice
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
JAMA 295:629-42. 2006..The hypothesis that a low-fat dietary pattern can reduce breast cancer risk has existed for decades but has never been tested in a controlled intervention trial... - Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification TrialShirley A A Beresford
Department of Epidemiology, University of Washington, Seattle, WA 98195 7236, USA
JAMA 295:643-54. 2006..Observational studies and polyp recurrence trials are not conclusive regarding the effects of a low-fat dietary pattern on risk of colorectal cancer, necessitating a primary prevention trial... - Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification TrialBarbara V Howard
MedStar Research Institute Howard University, Washington, DC, USA
JAMA 295:655-66. 2006..Multiple epidemiologic studies and some trials have linked diet with cardiovascular disease (CVD) prevention, but long-term intervention data are needed... - Ethnicity, sleep, mood, and illumination in postmenopausal womenDaniel F Kripke
Department of Psychiatry, University of California, San Diego, CA, USA
BMC Psychiatry 4:8. 2004..This study examined how ethnic differences in sleep and depression were related to environmental illumination and circadian rhythms... - Postmenopausal hormone therapy and migraine headacheAnastasia L Misakian
University of California-San Diego School of Medicine, San Diego, California, USA
J Womens Health (Larchmt) 12:1027-36. 2003..63). CONCLUSIONS: In this cross-sectional study, current HT use was associated with higher rates of migraine headache than nonuse. Clinical trials are needed to determine if HT increases the incidence of migraine in postmenopausal women... - Venous thrombosis and conjugated equine estrogen in women without a uterusJ David Curb
University of Hawaii and Pacific Health Research Institute, Honolulu, USA
Arch Intern Med 166:772-80. 2006..03), even after adjusting for VT risk factors. CONCLUSION: An early increased VT risk is associated with use of estrogen, especially within the first 2 years, but this risk increase is less than that for estrogen plus progestin... - Sex and time differences in the associations of non-high-density lipoprotein cholesterol versus other lipid and lipoprotein factors in the prediction of cardiovascular death (The Rancho Bernardo Study)Denise von Muhlen
Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 93093 0607, USA
Am J Cardiol 91:1311-5. 2003..Thus, non-HDL cholesterol is not superior to individual lipids, lipoproteins, or their ratios in the prediction of cardiovascular death in older adults... - Evening light exposure: implications for sleep and depressionGeralyn M Wallace-Guy
Department of Psychiatry and the Sam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla, California 92093, USA
J Am Geriatr Soc 50:738-9. 2002..CONCLUSIONS: Low evening lighting does not appear to be a crucial factor in sleep and mood disturbances of aging, but overall lighting may contribute to these disturbances...