Yi Fen Yen

Summary

Affiliation: GE Healthcare
Country: USA

Publications

  1. pmc T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate
    Yi Fen Yen
    Global Applied Science Laboratory, GE Healthcare, CA, USA
    NMR Biomed 23:414-23. 2010
  2. pmc In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA
    NMR Biomed 26:607-12. 2013
  3. pmc Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSI
    Tao Xu
    Department of Electrical Engineering, Stanford University, Stanford, CA, USA
    NMR Biomed 24:997-1005. 2011
  4. pmc Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imaging
    Ralph E Hurd
    Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
    J Cereb Blood Flow Metab 30:1734-41. 2010
  5. pmc In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA Stanford University, Department of Radiology, Lucas MRI Center, Stanford, CA, USA
    NMR Biomed 26:1680-7. 2013
  6. pmc Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging
    Jae Mo Park
    Stanford University, Department of Radiology, The Lucas Center for Imaging, 1201 Welch Road, Stanford, CA, 94305, USA
    Neuro Oncol 15:433-41. 2013
  7. pmc Measuring mitochondrial metabolism in rat brain in vivo using MR Spectroscopy of hyperpolarized [2-¹³C]pyruvate
    Jae Mo Park
    Department of Electrical Engineering, Stanford University, Stanford, CA, USA Department of Radiology, Stanford University, Stanford, CA, USA
    NMR Biomed 26:1197-203. 2013
  8. doi request reprint Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization
    Ralph E Hurd
    GE Healthcare, Menlo Park, California, USA
    J Magn Reson Imaging 36:1314-28. 2012
  9. pmc Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism
    Dirk Mayer
    SRI International, Neuroscience Program, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    NMR Biomed 25:1119-24. 2012
  10. pmc Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1-(13) C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA 94025, USA
    NMR Biomed 25:993-9. 2012

Detail Information

Publications13

  1. pmc T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate
    Yi Fen Yen
    Global Applied Science Laboratory, GE Healthcare, CA, USA
    NMR Biomed 23:414-23. 2010
    ..The study results show that the signal level and relaxivity of [1-(13)C]alanine may be promising biomarkers for HCC tumors. Its diagnostic values in HCC staging and treatment monitoring are yet to be explored...
  2. pmc In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA
    NMR Biomed 26:607-12. 2013
    ..Results from a rat liver ethanol model (n = 9) show that changes in (13) C-lactate labeling following the bolus injection of hyperpolarized pyruvate are highly correlated with changes in ALDH2 activity (R(2) = 0.76)...
  3. pmc Quantification of in vivo metabolic kinetics of hyperpolarized pyruvate in rat kidneys using dynamic 13C MRSI
    Tao Xu
    Department of Electrical Engineering, Stanford University, Stanford, CA, USA
    NMR Biomed 24:997-1005. 2011
    ....
  4. pmc Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imaging
    Ralph E Hurd
    Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
    J Cereb Blood Flow Metab 30:1734-41. 2010
    ..A model for brain [1-(13)C]lactate, based on blood-brain transport kinetics, CBV, and the observed pyruvate dynamics is described...
  5. pmc In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA Stanford University, Department of Radiology, Lucas MRI Center, Stanford, CA, USA
    NMR Biomed 26:1680-7. 2013
    ..Using a high dose of pyruvate may provide an improved ability to observe changes in glutamate...
  6. pmc Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging
    Jae Mo Park
    Stanford University, Department of Radiology, The Lucas Center for Imaging, 1201 Welch Road, Stanford, CA, 94305, USA
    Neuro Oncol 15:433-41. 2013
    ..The aim of this study is to improve the detection of (13)C-labeled metabolites, in particular bicarbonate, in glioma and normal brain in vivo and to measure the metabolic response to dichloroacetate, which upregulates PDH activity...
  7. pmc Measuring mitochondrial metabolism in rat brain in vivo using MR Spectroscopy of hyperpolarized [2-¹³C]pyruvate
    Jae Mo Park
    Department of Electrical Engineering, Stanford University, Stanford, CA, USA Department of Radiology, Stanford University, Stanford, CA, USA
    NMR Biomed 26:1197-203. 2013
    ..This study demonstrates, for the first time, that hyperpolarized [2-(13) C]Pyr can be used for the in vivo investigation of mitochondrial function and tricarboxylic acid cycle metabolism in brain...
  8. doi request reprint Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization
    Ralph E Hurd
    GE Healthcare, Menlo Park, California, USA
    J Magn Reson Imaging 36:1314-28. 2012
    ..The principles behind these measurements, as well as the choice of agent, and progress toward the application of hyperpolarized (13)C metabolic imaging in oncology, cardiology, and neurology are reviewed...
  9. pmc Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism
    Dirk Mayer
    SRI International, Neuroscience Program, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    NMR Biomed 25:1119-24. 2012
    ..5-fold increase in bicarbonate-to-substrate ratio was found after administration of DCA, similar to the effect when using [1-(13) C]pyruvate as the substrate...
  10. pmc Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1-(13) C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA 94025, USA
    NMR Biomed 25:993-9. 2012
    ..A significant increase in the pyruvate to lactate conversion was observed in the liver as a result of the greater availability of NADH (nicotinamide adenine dinucleotide, reduced form) from ethanol metabolism...
  11. pmc Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate
    Ralph E Hurd
    Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
    Magn Reson Med 63:1137-43. 2010
    ..Hyperpolarized [1-(13)C]-ethyl pyruvate and [1-(13)C]-pyruvate metabolic imaging in normal brain is demonstrated and quantified in this feasibility and range-finding study...
  12. pmc Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner
    James Tropp
    GE Healthcare Technologies, Global Applied Sciences Lab, Fremont, CA, United States
    J Magn Reson 208:171-7. 2011
    ..The signal to noise ratio in was in some instances unexpectedly high in the parallel images; variability of the polarization among different trials, plus partial volume effects, are noted as a possible cause of this...
  13. ncbi request reprint Promising application of dynamic nuclear polarization for in vivo (13)C MR imaging
    Yi Fen Yen
    Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, USA
    Magn Reson Med Sci 10:211-7. 2011
    ....