Ralph Hurd

Summary

Affiliation: GE Healthcare
Country: USA

Publications

  1. ncbi request reprint Measurement of brain glutamate using TE-averaged PRESS at 3T
    Ralph Hurd
    GE Medical Systems, Menlo Park, California, USA
    Magn Reson Med 51:435-40. 2004
  2. pmc Dynamic metabolic imaging of hyperpolarized [2-(13) C]pyruvate using spiral chemical shift imaging with alternating spectral band excitation
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, California, USA Department of Radiology, Stanford University, Lucas MRI Center, Stanford, California, USA
    Magn Reson Med 71:2051-8. 2014
  3. pmc Effects of isoflurane anesthesia on hyperpolarized (13)C metabolic measurements in rat brain
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, California, USA Department of Radiology, Stanford University, Lucas MRI Center, Stanford, California, USA
    Magn Reson Med 70:1117-24. 2013
  4. pmc In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA Stanford University, Department of Radiology, Lucas MRI Center, Stanford, CA, USA
    NMR Biomed 26:1680-7. 2013
  5. pmc T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate
    Yi Fen Yen
    Global Applied Science Laboratory, GE Healthcare, CA, USA
    NMR Biomed 23:414-23. 2010
  6. pmc In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA
    NMR Biomed 26:607-12. 2013
  7. ncbi request reprint Detection of myoglobin desaturation in Mirounga angustirostris during apnea
    Paul J Ponganis
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla 92093 0204, California, USA
    Am J Physiol Regul Integr Comp Physiol 282:R267-72. 2002
  8. ncbi request reprint TE-averaged two-dimensional proton spectroscopic imaging of glutamate at 3 T
    Radhika Srinivasan
    Center for Molecular and Functional Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 1739, USA
    Neuroimage 30:1171-8. 2006
  9. ncbi request reprint Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T
    Radhika Srinivasan
    Center for Molecular and Functional Imaging, Department of Radiology, University of California San Francisco, 185 Berry Street, 350, San Francisco, CA 94107 1739, USA
    Brain 128:1016-25. 2005
  10. ncbi request reprint A comparative study of myo-inositol quantification using LCmodel at 1.5 T and 3.0 T with 3 D 1H proton spectroscopic imaging of the human brain
    Radhika Srinivasan
    Magnetic Resonance Science Center, University of California, AC109, Box 1290, San Francisco, CA 94143, USA
    Magn Reson Imaging 22:523-8. 2004

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Measurement of brain glutamate using TE-averaged PRESS at 3T
    Ralph Hurd
    GE Medical Systems, Menlo Park, California, USA
    Magn Reson Med 51:435-40. 2004
    ..A repeatibility error of <5%, and a coefficient of variation (CV) of <10% were observed for brain Glu levels in a study of six normal volunteers...
  2. pmc Dynamic metabolic imaging of hyperpolarized [2-(13) C]pyruvate using spiral chemical shift imaging with alternating spectral band excitation
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, California, USA Department of Radiology, Stanford University, Lucas MRI Center, Stanford, California, USA
    Magn Reson Med 71:2051-8. 2014
    ..However, chemical shift imaging (CSI) with [2-(13) C]pyruvate is challenging owing to the large spectral dispersion of the resonances, which also leads to severe chemical shift displacement artifacts for slice-selective acquisitions...
  3. pmc Effects of isoflurane anesthesia on hyperpolarized (13)C metabolic measurements in rat brain
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, California, USA Department of Radiology, Stanford University, Lucas MRI Center, Stanford, California, USA
    Magn Reson Med 70:1117-24. 2013
    ..This work investigates the effect of isoflurane anesthesia dose on hyperpolarized (13)C MR metabolic measurements in rat brain for [1-(13)C]pyruvate and 2-keto[1-(13)C]isocaproate...
  4. pmc In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA Stanford University, Department of Radiology, Lucas MRI Center, Stanford, CA, USA
    NMR Biomed 26:1680-7. 2013
    ..Using a high dose of pyruvate may provide an improved ability to observe changes in glutamate...
  5. pmc T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate
    Yi Fen Yen
    Global Applied Science Laboratory, GE Healthcare, CA, USA
    NMR Biomed 23:414-23. 2010
    ..The study results show that the signal level and relaxivity of [1-(13)C]alanine may be promising biomarkers for HCC tumors. Its diagnostic values in HCC staging and treatment monitoring are yet to be explored...
  6. pmc In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate
    Sonal Josan
    SRI International, Neuroscience Program, Menlo Park, CA, USA
    NMR Biomed 26:607-12. 2013
    ..Results from a rat liver ethanol model (nā€‰=ā€‰9) show that changes in (13) C-lactate labeling following the bolus injection of hyperpolarized pyruvate are highly correlated with changes in ALDH2 activity (R(2) =ā€‰0.76)...
  7. ncbi request reprint Detection of myoglobin desaturation in Mirounga angustirostris during apnea
    Paul J Ponganis
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla 92093 0204, California, USA
    Am J Physiol Regul Integr Comp Physiol 282:R267-72. 2002
    ..The study establishes a firm methodological basis for using NMR to investigate the metabolic responses during sleep apnea of the elephant seal and to secure insights into oxygen regulation in diving mammals...
  8. ncbi request reprint TE-averaged two-dimensional proton spectroscopic imaging of glutamate at 3 T
    Radhika Srinivasan
    Center for Molecular and Functional Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 1739, USA
    Neuroimage 30:1171-8. 2006
    ....
  9. ncbi request reprint Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T
    Radhika Srinivasan
    Center for Molecular and Functional Imaging, Department of Radiology, University of California San Francisco, 185 Berry Street, 350, San Francisco, CA 94107 1739, USA
    Brain 128:1016-25. 2005
    ..001) myo-inositol levels in acute lesions compared with control white matter. These in vivo results support the hypothesis that altered glutamate metabolism is present in brains of multiple sclerosis patients...
  10. ncbi request reprint A comparative study of myo-inositol quantification using LCmodel at 1.5 T and 3.0 T with 3 D 1H proton spectroscopic imaging of the human brain
    Radhika Srinivasan
    Magnetic Resonance Science Center, University of California, AC109, Box 1290, San Francisco, CA 94143, USA
    Magn Reson Imaging 22:523-8. 2004
    ..Using data from normal controls and the LCmodel quantification procedure, we found that the quantification precision, reproducibility and detection sensitivity of myo-inositol is significantly better at 3 T relative to 1.5 T...
  11. pmc Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI
    Simon Hu
    Department of Radiology, University of California, Box 2512, 1700 4th Street, QB3 Building, Suite 102, San Francisco, CA 94158 2512, USA
    J Magn Reson 192:258-64. 2008
    ..Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility...