Ralph E Hurd

Summary

Affiliation: GE Healthcare
Country: USA

Publications

  1. pmc Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate
    Ralph E Hurd
    Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
    Magn Reson Med 63:1137-43. 2010
  2. doi request reprint Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization
    Ralph E Hurd
    GE Healthcare, Menlo Park, California, USA
    J Magn Reson Imaging 36:1314-28. 2012
  3. pmc Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imaging
    Ralph E Hurd
    Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
    J Cereb Blood Flow Metab 30:1734-41. 2010
  4. ncbi request reprint Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience
    Albert P Chen
    Department of Radiology, University of California San Francisco, San Francisco, California, USA
    Magn Reson Med 58:1099-106. 2007
  5. pmc Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvate
    Jae Mo Park
    Department of Electrical Engineering, Stanford University, Stanford, California, USA
    Magn Reson Med 68:1886-93. 2012
  6. pmc Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism
    Dirk Mayer
    SRI International, Neuroscience Program, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    NMR Biomed 25:1119-24. 2012
  7. ncbi request reprint Sequence design for magnetic resonance spectroscopic imaging of prostate cancer at 3 T
    Charles H Cunningham
    Department of Electrical Engineering, Stanford University, California, USA
    Magn Reson Med 53:1033-9. 2005
  8. ncbi request reprint Design of flyback echo-planar readout gradients for magnetic resonance spectroscopic imaging
    Charles H Cunningham
    Department of Electrical Engineering, Stanford University, Stanford, California, USA
    Magn Reson Med 54:1286-9. 2005
  9. pmc Dynamic and high-resolution metabolic imaging of hyperpolarized [1-13C]-pyruvate in the rat brain using a high-performance gradient insert
    Dirk Mayer
    SRI International, Neuroscience Program, Menlo Park, California 94025, USA
    Magn Reson Med 65:1228-33. 2011
  10. doi request reprint Exchange-linked dissolution agents in dissolution-DNP (13)C metabolic imaging
    Ralph E Hurd
    GE Healthcare, California, USA
    Magn Reson Med 70:936-42. 2013

Detail Information

Publications15

  1. pmc Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate
    Ralph E Hurd
    Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
    Magn Reson Med 63:1137-43. 2010
    ..Hyperpolarized [1-(13)C]-ethyl pyruvate and [1-(13)C]-pyruvate metabolic imaging in normal brain is demonstrated and quantified in this feasibility and range-finding study...
  2. doi request reprint Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization
    Ralph E Hurd
    GE Healthcare, Menlo Park, California, USA
    J Magn Reson Imaging 36:1314-28. 2012
    ..The principles behind these measurements, as well as the choice of agent, and progress toward the application of hyperpolarized (13)C metabolic imaging in oncology, cardiology, and neurology are reviewed...
  3. pmc Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imaging
    Ralph E Hurd
    Global Applied Science Laboratory, GE Healthcare, Menlo Park, California 94025, USA
    J Cereb Blood Flow Metab 30:1734-41. 2010
    ..A model for brain [1-(13)C]lactate, based on blood-brain transport kinetics, CBV, and the observed pyruvate dynamics is described...
  4. ncbi request reprint Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience
    Albert P Chen
    Department of Radiology, University of California San Francisco, San Francisco, California, USA
    Magn Reson Med 58:1099-106. 2007
    ..135 cm(3) nominal spatial resolution. Elevated (13)C lactate (lac) was observed in both primary and metastatic tumors, demonstrating the feasibility of studying cellular bioenergetics in vivo with DNP hyperpolarized (13)C MRSI...
  5. pmc Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvate
    Jae Mo Park
    Department of Electrical Engineering, Stanford University, Stanford, California, USA
    Magn Reson Med 68:1886-93. 2012
    ..12 ± 0.02 for glioma, normal brain, and vasculature, respectively. The data suggest that the apparent conversion rate better differentiate glioma from normal brain (P = 0.001, n = 6) than the lactate-to-pyruvate ratio (P = 0.02)...
  6. pmc Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism
    Dirk Mayer
    SRI International, Neuroscience Program, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    NMR Biomed 25:1119-24. 2012
    ..5-fold increase in bicarbonate-to-substrate ratio was found after administration of DCA, similar to the effect when using [1-(13) C]pyruvate as the substrate...
  7. ncbi request reprint Sequence design for magnetic resonance spectroscopic imaging of prostate cancer at 3 T
    Charles H Cunningham
    Department of Electrical Engineering, Stanford University, California, USA
    Magn Reson Med 53:1033-9. 2005
    ..Studies in a human subject verified that this behavior is reproduced in vivo and demonstrated that the water and lipid suppression of the new pulse sequence are sufficient for application in prostate cancer patients...
  8. ncbi request reprint Design of flyback echo-planar readout gradients for magnetic resonance spectroscopic imaging
    Charles H Cunningham
    Department of Electrical Engineering, Stanford University, Stanford, California, USA
    Magn Reson Med 54:1286-9. 2005
    ..3 min and 4096 voxels in 8.5 min). The trajectories were insensitive to errors in timing and require only a modest (10 to 30%) penalty in SNR relative to conventional phase encoding using the same acquisition time...
  9. pmc Dynamic and high-resolution metabolic imaging of hyperpolarized [1-13C]-pyruvate in the rat brain using a high-performance gradient insert
    Dirk Mayer
    SRI International, Neuroscience Program, Menlo Park, California 94025, USA
    Magn Reson Med 65:1228-33. 2011
    ....
  10. doi request reprint Exchange-linked dissolution agents in dissolution-DNP (13)C metabolic imaging
    Ralph E Hurd
    GE Healthcare, California, USA
    Magn Reson Med 70:936-42. 2013
    ..The use of unlabeled exchange-linked dissolution agents in hyperpolarized metabolic imaging was studied to examine pool size limits and saturation relative to the availability of NADH...
  11. doi request reprint (13)C MR reporter probe system using dynamic nuclear polarization
    Albert P Chen
    GE Healthcare, Toronto, ON, Canada
    NMR Biomed 24:514-20. 2011
    ..The de-acetylation of the substrate was not observed in control cells...
  12. pmc Design of spectral-spatial outer volume suppression RF pulses for tissue specific metabolic characterization with hyperpolarized 13C pyruvate
    Albert P Chen
    GE Healthcare, Toronto, ON, Canada
    J Magn Reson 200:344-8. 2009
    ..Preliminary in vivo results showed that the suppression pulse did not prevent the pre-polarized pyruvate from being delivered throughout the animal while it saturated the metabolites within the targeted saturation region...
  13. pmc In vivo hyperpolarized 13C MR spectroscopic imaging with 1H decoupling
    Albert P Chen
    GE Healthcare, 11 Brunel Court, Suite 5116, Toronto, Ont, Canada M5V3Y3
    J Magn Reson 197:100-6. 2009
    ..Narrower linewidth for the [1-(13)C] lactate resonance was observed in hyperpolarized (13)C MRSI data in vivo with (1)H decoupling...
  14. ncbi request reprint 1H MR spectroscopy using TE averaged PRESS: a more sensitive technique to detect neurodegeneration associated with Alzheimer's disease
    Ileana Hancu
    GE Global Research Center, One Research Circle, K1 NMR138, Niskayuna, NY 12309, USA
    Magn Reson Med 53:777-82. 2005
    ..This increased sensitivity enables new MR applications and, among other benefits, allows for smaller group sizes in drug trials, which can significantly reduce the cost of such trials...
  15. ncbi request reprint Design of symmetric-sweep spectral-spatial RF pulses for spectral editing
    Charles H Cunningham
    Department of Electrical Engineering, Stanford University, Stanford, California, USA
    Magn Reson Med 52:147-53. 2004
    ..5 T and 3 T. The spectral and spatial spin-echo profiles of the new pulses were measured experimentally. Spectra acquired in phantom experiments showed a well-resolved, edited lactate doublet, with 91% to 93% editing efficiency...