S Gandy

Summary

Country: USA

Publications

  1. ncbi request reprint Alzheimer's disease. Molecular consequences of presenilin-1 mutation
    S Gandy
    Sir James McCusker Alzheimer Research Unit, University of Western Australia, Perth, Australia and Department of Psychiatry, New York University School of Medicine, New York 10962, USA
    Nature 411:654-6. 2001
  2. pmc Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP
    Yoshitake Sano
    RIKEN, Brain Science Institute, Behavioral Genetics, Wako, Japan
    PLoS ONE 1:e51. 2006
  3. pmc Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease
    Anastazija Gnjec
    Centre of Excellence for Alzheimer s Disease Research and Care, Faculty of Computing, Health and Science, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, 6027, WA, Australia
    J Neuroinflammation 5:36. 2008
  4. ncbi request reprint Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding
    S Parvathy
    Farber Institute for Neurosciences of Thomas Jefferson University, Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    J Neurochem 90:1005-10. 2004
  5. ncbi request reprint Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta)
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut St, Suite 467, Philadelphia, PA 19107, USA
    Alzheimer Dis Assoc Disord 18:44-6. 2004
  6. ncbi request reprint Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta)
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mech Ageing Dev 125:149-51. 2004
  7. ncbi request reprint Molecular and cellular basis for anti-amyloid therapy in Alzheimer disease
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Alzheimer Dis Assoc Disord 17:259-66. 2003
  8. pmc The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 115:1121-9. 2005
  9. pmc Breaking up (amyloid) is hard to do
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS Med 2:e417. 2005
  10. ncbi request reprint Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo
    Sam Gandy
    Farber Institute for Neurosciences and the Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Neurochem 102:619-26. 2007

Research Grants

Detail Information

Publications30

  1. ncbi request reprint Alzheimer's disease. Molecular consequences of presenilin-1 mutation
    S Gandy
    Sir James McCusker Alzheimer Research Unit, University of Western Australia, Perth, Australia and Department of Psychiatry, New York University School of Medicine, New York 10962, USA
    Nature 411:654-6. 2001
    ..Our findings do not support the conclusion of Russo et al. that pathogenic PS1 mutations may control cleavage of beta-APP by beta-secretase...
  2. pmc Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP
    Yoshitake Sano
    RIKEN, Brain Science Institute, Behavioral Genetics, Wako, Japan
    PLoS ONE 1:e51. 2006
    ..Some investigators have recently proposed that the phosphorylation state of Thr668 plays a pivotal role in governing brain Abeta levels, prompting the current study...
  3. pmc Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease
    Anastazija Gnjec
    Centre of Excellence for Alzheimer s Disease Research and Care, Faculty of Computing, Health and Science, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, 6027, WA, Australia
    J Neuroinflammation 5:36. 2008
    ..In the current study TNFA and BAT1 promoter polymorphisms were analysed in AD and control cases and BAT1 mRNA levels were investigated in brain tissue from AD and control cases...
  4. ncbi request reprint Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding
    S Parvathy
    Farber Institute for Neurosciences of Thomas Jefferson University, Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    J Neurochem 90:1005-10. 2004
    ..A systematic evaluation of the possible role of these protein kinases in statin-regulated APP ectodomain shedding is underway...
  5. ncbi request reprint Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta)
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut St, Suite 467, Philadelphia, PA 19107, USA
    Alzheimer Dis Assoc Disord 18:44-6. 2004
    ..These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer A beta...
  6. ncbi request reprint Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta)
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mech Ageing Dev 125:149-51. 2004
    ..These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta...
  7. ncbi request reprint Molecular and cellular basis for anti-amyloid therapy in Alzheimer disease
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Alzheimer Dis Assoc Disord 17:259-66. 2003
  8. pmc The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 115:1121-9. 2005
    ..Successful development of antiamyloid medications is critical for elucidating the role of Abeta in common AD...
  9. pmc Breaking up (amyloid) is hard to do
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS Med 2:e417. 2005
  10. ncbi request reprint Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo
    Sam Gandy
    Farber Institute for Neurosciences and the Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Neurochem 102:619-26. 2007
    ..The chimera experiment suggests that TGN-enrichment of a beta-/gamma-secretase substrate may play an integral role in the action of mutant PS1 to elevate brain levels of Abeta42...
  11. ncbi request reprint Molecular basis for anti-amyloid therapy in the prevention and treatment of Alzheimer's disease
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA
    Neurobiol Aging 23:1009-16. 2002
  12. pmc Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding
    Annat F Ikin
    Farber Institute for Neurosciences of Thomas Jefferson University, 900 Walnut Street, Philadelphia, 19107, PA, USA
    Mol Neurodegener 2:23. 2007
    ..Here, we examined the effects on APP ectodomain shedding of four phorbol-sensitive proteins involved in regulation of vesicular membrane trafficking of APP: Munc13-1, Munc18, NSF, and Eve-1...
  13. ncbi request reprint Toward modeling hemorrhagic and encephalitic complications of Alzheimer amyloid-beta vaccination in nonhuman primates
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Immunol 16:607-15. 2004
    ....
  14. pmc Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK
    Steve Pedrini
    Farber Institute for Neurosciences, Thomas Jefferson University Philadelphia, Pennsylvania, USA
    PLoS Med 2:e18. 2005
    ..However, the possibility that these enzymes play a role in statin-stimulated shedding has been excluded, leading us to investigate whether the Rho/ROCK1 protein phosphorylation pathway might be involved...
  15. ncbi request reprint Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis
    Troy L Carter
    Farber Institute for Neurosciences and Department of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, PA 19107, USA
    Neurosci Lett 392:235-9. 2006
    ..We conclude that aging- and strain-dependent differences in NEP specific activity may play a role in the differential susceptibility of some mouse strains for developing cerebral amyloidosis following human APP overexpression...
  16. ncbi request reprint Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells
    Troy L Carter
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Alzheimer Dis Assoc Disord 18:261-3. 2004
    ..Immunoprecipitation-mass spectrometry of AICD-L revealed its identity as the minor of the two known AICDs...
  17. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  18. ncbi request reprint Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription
    Simon M Laws
    Sir James McCusker Alzheimer s Disease Research Unit, School of Psychiatry and Neuroscience, University of Western Australia, Hollywood Private Hospital, Perth, Western Australia, Australia
    J Neurochem 84:1215-36. 2003
    ..Here we review the genetic and biochemical evidence supporting the hypothesis that regulation of apoE protein levels may contribute to the risk of AD, distinct from the well known polymorphisms at the epsilon2/epsilon3/epsilon4 locus...
  19. ncbi request reprint Estrogen and neurodegeneration
    Sam Gandy
    Faber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5587, USA
    Neurochem Res 28:1003-8. 2003
    ....
  20. ncbi request reprint Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
    Dun Sheng Yang
    Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 277:28135-42. 2002
    ....
  21. ncbi request reprint Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy
    John B J Kwok
    Garvan Institute of Medical Research, Darlinghurst, Sydney 2010, Australia
    J Biol Chem 278:6748-54. 2003
    ..We postulate that variant plaques observed in this family are due in part to the effects of PS-1deltaexon8 and that interaction between PS-1 and various protein complexes are necessary for neuritic plaque formation...
  22. pmc The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid
    Giuseppe Verdile
    Centre of Excellence for Alzheimer s Disease Research and Care, and the Sir James McCusker Alzheimer s Disease Research Unit, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, 100 Joondalup Drive, Joondalup, 6027 WA, Australia
    Neurochem Res 32:609-23. 2007
    ..This review will discuss the components of the gamma-secretase complex and the role of presenilin interacting proteins on gamma-secretase activity...
  23. ncbi request reprint Plasma Abeta42 correlates positively with increased body fat in healthy individuals
    Kelvin Balakrishnan
    The Sir James McCusker Alzheimer s Disease Research Unit, C Hollywood Private Hospital, Monash Avenue, Nedlands WA 6009, Australia
    J Alzheimers Dis 8:269-82. 2005
    ..Longitudinal studies involving larger cohorts are required to determine if elevated body fat may predispose individuals to AD through increasing Abeta42 levels throughout early to late adulthood...
  24. ncbi request reprint Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:136-41. 2003
    ..Progressive cognitive decline is the core clinical feature of AD and is associated with disturbances in the prefrontal cortex...
  25. ncbi request reprint Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
    Hanna Laudon
    Karolinska Institutet, Neurotec, Section for Experimental Geriatrics, Novum, Huddinge, Sweden
    J Neurochem 89:44-53. 2004
    ..Taken together, our findings indicate that ectopically expressed NTF and CTF restore functional gamma-secretase complexes and that the presence of full-length PS1 is not a requirement for proper complex assembly...
  26. ncbi request reprint Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis
    Hanna Laudon
    Department of Neurotec, Division of Experimental Geriatrics, Karolinska Institutet, Novum, SE 141 86 Huddinge, Sweden
    J Biol Chem 279:23925-32. 2004
    ..Thus, mutations at Tyr-288 do not affect gamma-secretase complex assembly but can differentially control endoproteolysis and gamma-secretase activity...
  27. ncbi request reprint The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?
    Giuseppe Verdile
    Sir James McCusker Alzheimer s Disease Research Unit, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Hollywood Private Hospital, Monash Avenue, Nedlands, WA 6009, Australia
    Pharmacol Res 50:397-409. 2004
    ..This research has led to the development of therapeutic agents, currently in human clinical trials, which target A beta...
  28. ncbi request reprint A phase 2 study of tramiprosate for cerebral amyloid angiopathy
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Alzheimer Dis Assoc Disord 20:269-74. 2006
    ..Tramiprosate (3-amino-1-propanesulfonic acid) is a candidate molecule shown in preclinical studies to reduce CAA in a transgenic mouse model...
  29. ncbi request reprint Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia
    Brian Dean
    Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Biol Psychiatry 54:616-22. 2003
    ..It is unclear whether altered expression of a specific isoform of apolipoprotein E (apoE) is associated with the pathology of schizophrenia...
  30. ncbi request reprint Association of interleukin-1 polymorphisms with Alzheimer's disease in Australia
    Ross Hedley
    Ann Neurol 51:795-7. 2002

Research Grants4

  1. TRANSMITTER NEUROANATOMY IN ALZHEIMERS DISEASE
    Samuel Gandy; Fiscal Year: 2002
    ....
  2. BABAA RECEPTORS IN AGING & ALZHEIMER'S DISEASE
    Samuel Gandy; Fiscal Year: 2002
    ....
  3. PRESENILIN DOMAINS AND RECONSTITUTION OF CATALYSIS
    Samuel Gandy; Fiscal Year: 2007
    ..This investigation will permit the identification of the minimal functional unit for gamma-secretase activity and potentially support the notion that PS1 is indeed the catalytic component of the gamma-secretase complex. ..