Research Topics
| S GandySummaryCountry: USA Publications
Research Grants
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Detail Information
Publications
Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's diseaseAnastazija Gnjec
Centre of Excellence for Alzheimer s Disease Research and Care, Faculty of Computing, Health and Science, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, 6027, WA, Australia
J Neuroinflammation 5:36. 2008..In the current study TNFA and BAT1 promoter polymorphisms were analysed in AD and control cases and BAT1 mRNA levels were investigated in brain tissue from AD and control cases...- Alzheimer's disease. Molecular consequences of presenilin-1 mutationS Gandy
Sir James McCusker Alzheimer Research Unit, University of Western Australia, Perth, Australia and Department of Psychiatry, New York University School of Medicine, New York 10962, USA
Nature 411:654-6. 2001..Our findings do not support the conclusion of Russo et al. that pathogenic PS1 mutations may control cleavage of beta-APP by beta-secretase... - Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta)Sam Gandy
Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut St, Suite 467, Philadelphia, PA 19107, USA
Alzheimer Dis Assoc Disord 18:44-6. 2004..These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer A beta... - Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain sheddingS Parvathy
Farber Institute for Neurosciences of Thomas Jefferson University, Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
J Neurochem 90:1005-10. 2004..A systematic evaluation of the possible role of these protein kinases in statin-regulated APP ectodomain shedding is underway... - Toward modeling hemorrhagic and encephalitic complications of Alzheimer amyloid-beta vaccination in nonhuman primatesSam Gandy
Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Curr Opin Immunol 16:607-15. 2004.... - The role of cerebral amyloid beta accumulation in common forms of Alzheimer diseaseSam Gandy
Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Clin Invest 115:1121-9. 2005..Successful development of antiamyloid medications is critical for elucidating the role of Abeta in common AD... - Breaking up (amyloid) is hard to doSam Gandy
Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
PLoS Med 2:e417. 2005 - Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivoSam Gandy
Farber Institute for Neurosciences and the Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
J Neurochem 102:619-26. 2007..The chimera experiment suggests that TGN-enrichment of a beta-/gamma-secretase substrate may play an integral role in the action of mutant PS1 to elevate brain levels of Abeta42... - Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain sheddingAnnat F Ikin
Farber Institute for Neurosciences of Thomas Jefferson University, 900 Walnut Street, Philadelphia, 19107, PA, USA
Mol Neurodegener 2:23. 2007..Here, we examined the effects on APP ectodomain shedding of four phorbol-sensitive proteins involved in regulation of vesicular membrane trafficking of APP: Munc13-1, Munc18, NSF, and Eve-1... - Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta)Sam Gandy
Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
Mech Ageing Dev 125:149-51. 2004..These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta... - Molecular and cellular basis for anti-amyloid therapy in Alzheimer diseaseSam Gandy
Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Alzheimer Dis Assoc Disord 17:259-66. 2003 - Molecular basis for anti-amyloid therapy in the prevention and treatment of Alzheimer's diseaseSam Gandy
Farber Institute for Neurosciences, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA
Neurobiol Aging 23:1009-16. 2002 - Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCKSteve Pedrini
Farber Institute for Neurosciences, Thomas Jefferson University Philadelphia, Pennsylvania, USA
PLoS Med 2:e18. 2005..However, the possibility that these enzymes play a role in statin-stimulated shedding has been excluded, leading us to investigate whether the Rho/ROCK1 protein phosphorylation pathway might be involved... - Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosisTroy L Carter
Farber Institute for Neurosciences and Department of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, PA 19107, USA
Neurosci Lett 392:235-9. 2006..We conclude that aging- and strain-dependent differences in NEP specific activity may play a role in the differential susceptibility of some mouse strains for developing cerebral amyloidosis following human APP overexpression... - Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cellsTroy L Carter
Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
Alzheimer Dis Assoc Disord 18:261-3. 2004..Immunoprecipitation-mass spectrometry of AICD-L revealed its identity as the minor of the two known AICDs... - Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010.... - Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcriptionSimon M Laws
Sir James McCusker Alzheimer's Disease Research Unit, School of Psychiatry and Neuroscience, University of Western Australia, Hollywood Private Hospital, Perth, Western Australia, Australia
J Neurochem 84:1215-36. 2003..Here we review the genetic and biochemical evidence supporting the hypothesis that regulation of apoE protein levels may contribute to the risk of AD, distinct from the well known polymorphisms at the epsilon2/epsilon3/epsilon4 locus... - Estrogen and neurodegenerationSam Gandy
Faber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5587, USA
Neurochem Res 28:1003-8. 2003.... - Mature glycosylation and trafficking of nicastrin modulate its binding to presenilinsDun Sheng Yang
Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, Toronto, Ontario M5S 3H2, Canada
J Biol Chem 277:28135-42. 2002.... - Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysisHanna Laudon
Department of Neurotec, Division of Experimental Geriatrics, Karolinska Institutet, Novum, SE 141 86 Huddinge, Sweden
J Biol Chem 279:23925-32. 2004..Thus, mutations at Tyr-288 do not affect gamma-secretase complex assembly but can differentially control endoproteolysis and gamma-secretase activity... - The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidGiuseppe Verdile
Centre of Excellence for Alzheimer s Disease Research and Care, and the Sir James McCusker Alzheimer s Disease Research Unit, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, 100 Joondalup Drive, Joondalup, 6027 WA, Australia
Neurochem Res 32:609-23. 2007..This review will discuss the components of the gamma-secretase complex and the role of presenilin interacting proteins on gamma-secretase activity... - Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophyJohn B J Kwok
Garvan Institute of Medical Research, Darlinghurst, Sydney 2010, Australia
J Biol Chem 278:6748-54. 2003..We postulate that variant plaques observed in this family are due in part to the effects of PS-1deltaexon8 and that interaction between PS-1 and various protein complexes are necessary for neuritic plaque formation... - Plasma Abeta42 correlates positively with increased body fat in healthy individualsKelvin Balakrishnan
The Sir James McCusker Alzheimer's Disease Research Unit, C/- Hollywood Private Hospital, Monash Avenue, Nedlands WA 6009, Australia
J Alzheimers Dis 8:269-82. 2005..Longitudinal studies involving larger cohorts are required to determine if elevated body fat may predispose individuals to AD through increasing Abeta42 levels throughout early to late adulthood... - Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotypeElizabeth A Thomas
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Biol Psychiatry 54:136-41. 2003..Progressive cognitive decline is the core clinical feature of AD and is associated with disturbances in the prefrontal cortex... - The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?Giuseppe Verdile
Sir James McCusker Alzheimer s Disease Research Unit, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Hollywood Private Hospital, Monash Avenue, Nedlands, WA 6009, Australia
Pharmacol Res 50:397-409. 2004..This research has led to the development of therapeutic agents, currently in human clinical trials, which target A beta... - Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length proteinHanna Laudon
Karolinska Institutet, Neurotec, Section for Experimental Geriatrics, Novum, Huddinge, Sweden
J Neurochem 89:44-53. 2004..Taken together, our findings indicate that ectopically expressed NTF and CTF restore functional gamma-secretase complexes and that the presence of full-length PS1 is not a requirement for proper complex assembly... - Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophreniaBrian Dean
Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
Biol Psychiatry 54:616-22. 2003..It is unclear whether altered expression of a specific isoform of apolipoprotein E (apoE) is associated with the pathology of schizophrenia... - A phase 2 study of tramiprosate for cerebral amyloid angiopathySteven M Greenberg
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Alzheimer Dis Assoc Disord 20:269-74. 2006..Tramiprosate (3-amino-1-propanesulfonic acid) is a candidate molecule shown in preclinical studies to reduce CAA in a transgenic mouse model... - Association of interleukin-1 polymorphisms with Alzheimer's disease in AustraliaRoss Hedley
Ann Neurol 51:795-7. 2002
Research Grants
- TRANSMITTER NEUROANATOMY IN ALZHEIMERS DISEASESamuel Gandy; Fiscal Year: 2002....
- BABAA RECEPTORS IN AGING & ALZHEIMER'S DISEASESamuel Gandy; Fiscal Year: 2002....
- PRESENILIN DOMAINS AND RECONSTITUTION OF CATALYSISSamuel Gandy; Fiscal Year: 2007..This investigation will permit the identification of the minimal functional unit for gamma-secretase activity and potentially support the notion that PS1 is indeed the catalytic component of the gamma-secretase complex. ..