Yingye Zheng

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Biometrics 62:279-87. 2006
  2. pmc Adopting nested case-control quota sampling designs for the evaluation of risk markers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA, 98109, USA
    Lifetime Data Anal 19:568-88. 2013
  3. pmc Evaluating incremental values from new predictors with net reclassification improvement in survival analysis
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Lifetime Data Anal 19:350-70. 2013
  4. pmc Evaluating prognostic accuracy of biomarkers under competing risk
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Biometrics 68:388-96. 2012
  5. ncbi request reprint Prospective accuracy for longitudinal markers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2 B500, P O Box 19024, Seattle, Washington 98109 1024, USA
    Biometrics 63:332-41. 2007
  6. pmc Semiparametric models of time-dependent predictive values of prognostic biomarkers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Biometrics 66:50-60. 2010
  7. pmc A practical multifaceted approach to selecting differentially expressed genes
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Inform 3:203-12. 2007
  8. pmc On combining family-based and population-based case-control data in association studies
    Yingye Zheng
    Biostatistics and Biomathematics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biometrics 66:1024-33. 2010
  9. ncbi request reprint Partly conditional survival models for longitudinal data
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B230, P O Box 19024, Seattle, Washington 98109 1024, USA
    Biometrics 61:379-91. 2005
  10. ncbi request reprint Assessing accuracy of mammography in the presence of verification bias and intrareader correlation
    Yingye Zheng
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, North Seattle, Washington 98109, USA
    Biometrics 61:259-68. 2005

Detail Information

Publications38

  1. ncbi request reprint Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Biometrics 62:279-87. 2006
    ..Our results indicate the proposed methods are both flexible and efficient. We contrast these methods with an application concerning the prognostic accuracies of expression levels of six genes...
  2. pmc Adopting nested case-control quota sampling designs for the evaluation of risk markers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA, 98109, USA
    Lifetime Data Anal 19:568-88. 2013
    ..Simulation results indicate that the proposed procedures perform well in finite samples. Application is made to the evaluation of a new risk model for predicting the onset of cardiovascular disease. ..
  3. pmc Evaluating incremental values from new predictors with net reclassification improvement in survival analysis
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Lifetime Data Anal 19:350-70. 2013
    ..Simulation results indicate that the proposed procedures perform well in finite samples. We illustrate these procedures by evaluating a new risk model for predicting the onset of cardiovascular disease. ..
  4. pmc Evaluating prognostic accuracy of biomarkers under competing risk
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Biometrics 68:388-96. 2012
    ..The proposed procedures are illustrated with data from a prostate cancer prognostic study...
  5. ncbi request reprint Prospective accuracy for longitudinal markers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2 B500, P O Box 19024, Seattle, Washington 98109 1024, USA
    Biometrics 63:332-41. 2007
    ..We illustrate the new methods by analyzing a well-known data set from HIV research, the Multicenter AIDS Cohort Study data...
  6. pmc Semiparametric models of time-dependent predictive values of prognostic biomarkers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Biometrics 66:50-60. 2010
    ..We illustrate our approach with numerical studies and a dataset from a prostate cancer study...
  7. pmc A practical multifaceted approach to selecting differentially expressed genes
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Inform 3:203-12. 2007
    ..They are simply descriptive in nature. We contrast the mp-values with multiple testing p-values in the context of data from a breast cancer prognosis study and from a simulation model...
  8. pmc On combining family-based and population-based case-control data in association studies
    Yingye Zheng
    Biostatistics and Biomathematics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biometrics 66:1024-33. 2010
    ..Efficiencies of different designs are contrasted in the simulation. We applied the methods to data from the Colorectal Cancer Family Registry...
  9. ncbi request reprint Partly conditional survival models for longitudinal data
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B230, P O Box 19024, Seattle, Washington 98109 1024, USA
    Biometrics 61:379-91. 2005
    ..The proposed methods allow a flexible characterization of the association between a longitudinal covariate process and a survival time, and facilitate the direct prediction of survival probabilities in the time-varying covariate setting...
  10. ncbi request reprint Assessing accuracy of mammography in the presence of verification bias and intrareader correlation
    Yingye Zheng
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, North Seattle, Washington 98109, USA
    Biometrics 61:259-68. 2005
    ..We apply the methodology to mammography as performed by community radiologists...
  11. ncbi request reprint Semiparametric estimation of time-dependent ROC curves for longitudinal marker data
    Yingye Zheng
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Biostatistics 5:615-32. 2004
    ..1999, Medical Decision Making, 19, 242-251) suggests that the ability to relax distributional assumptions may be important in practice...
  12. pmc Vitamin D intake determines vitamin d status of postmenopausal women, particularly those with limited sun exposure
    Ting Yuan David Cheng
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA
    J Nutr 144:681-9. 2014
    ..In conclusion, dietary factors and sun exposure remain important determinants of vitamin D status in postmenopausal women. Vitamin D intake should be emphasized for those with limited sun exposure. ..
  13. pmc Integrating the predictiveness of a marker with its performance as a classifier
    Margaret S Pepe
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Epidemiol 167:362-8. 2008
    ..The methods are demonstrated with data on prostate-specific antigen and risk factors from the Prostate Cancer Prevention Trial, 1993-2003...
  14. pmc Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps
    Karen J Wernli
    Program in Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Growth Horm IGF Res 20:305-9. 2010
    ....
  15. ncbi request reprint Survival model predictive accuracy and ROC curves
    Patrick J Heagerty
    Department of Biostatistics, University of Washington, P O Box 357232, Seattle, Washington 98195 7232, USA
    Biometrics 61:92-105. 2005
    ..Semiparametric estimation methods appropriate for both proportional and nonproportional hazards data are introduced, evaluated in simulations, and illustrated using two familiar survival data sets...
  16. ncbi request reprint Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers
    Ting Yuan David Cheng
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Epidemiology, University of Washington, Seattle, WA
    Int J Cancer 135:2135-45. 2014
    ..02 for current smokers). Our observation suggests that vitamin A may assist vitamin D in preventing lung cancer among smokers. ..
  17. ncbi request reprint Evaluating the ROC performance of markers for future events
    Margaret S Pepe
    Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2 B500, Seattle, WA 98109, USA
    Lifetime Data Anal 14:86-113. 2008
    ..Applications to two datasets are presented...
  18. pmc Common colorectal cancer risk variants in SMAD7 are associated with survival among prediagnostic nonsteroidal anti-inflammatory drug users: a population-based study of postmenopausal women
    Michael N Passarelli
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Genes Chromosomes Cancer 50:875-86. 2011
    ..33-5.37] and each minor allele of rs4464148 was associated with better survival (HR = 0.41, CI 0.18-0.94). SMAD7 variants known to be important for CRC risk were associated with disease-specific survival among prediagnostic NSAID users...
  19. pmc A unified mixed-effects model for rare-variant association in sequencing studies
    Jianping Sun
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Genet Epidemiol 37:334-44. 2013
    ..Such information may be useful for generating hypothesis in future studies...
  20. pmc Vitamin D intake and lung cancer risk in the Women's Health Initiative
    Ting Yuan David Cheng
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA and Biostatistics, University of Washington, Seattle, WA Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA
    Am J Clin Nutr 98:1002-11. 2013
    ..Prior research suggests that vitamin D protects against lung cancer only among certain subgroups...
  21. pmc The Early Detection Research Network's Specimen reference sets: paving the way for rapid evaluation of potential biomarkers
    Ziding Feng
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Chem 59:68-74. 2013
    ..The EDRN has developed a robust triage and validation system that serves the roles of both "facilitator" and "brake."..
  22. pmc The relationship between gravidity and parity and colorectal cancer risk
    Karen J Wernli
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Womens Health (Larchmt) 18:995-1001. 2009
    ....
  23. ncbi request reprint Changes in cancer worry associated with participation in ovarian cancer screening
    M Robyn Andersen
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Psychooncology 16:814-20. 2007
    ..Further research will be required to examine the possibility that screening reduces worry when women receive only normal, presumably reassuring, results...
  24. pmc Should modest elevations in prostate-specific antigen, International Prostate Symptom Score, or their rates of increase over time be used as surrogate measures of incident benign prostatic hyperplasia?
    Jeannette M Schenk
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA 98109 1024, USA
    Am J Epidemiol 178:741-51. 2013
    ..61, 0.65); however there were no cut points at which sensitivity and specificity were both above 75%. We concluded that moderate elevations in PSA, IPSS, or their rates of change should not be used as surrogate measures of incident BPH. ..
  25. pmc Determinants of aspirin metabolism in healthy men and women: effects of dietary inducers of UDP-glucuronosyltransferases
    Sandi L Navarro
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Wash, USA
    J Nutrigenet Nutrigenomics 4:110-8. 2011
    ..Interindividual variation in aspirin (ASA) metabolism is attributed to concomitant use of drugs or alcohol, urine pH, ethnicity, sex, and genetic variants in UDP-glucuronosyltransferases (UGT). Little is known about the effects of diet...
  26. doi request reprint Reproducibility of serum leptin, insulin-like growth factor-I, and insulin-like growth factor-binding protein-3 measurements
    Victoria M Chia
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
    Horm Res 69:295-300. 2008
    ....
  27. ncbi request reprint Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, Washington 98109, USA
    Cancer Res 67:7534-9. 2007
    ..Progestin may enhance the estrogenic effect of conjugated estrogen so the combination may be more biologically active in the colon than E alone...
  28. pmc On combining triads and unrelated subjects data in candidate gene studies: an application to data on testicular cancer
    Li Hsu
    Biostatistics and Biomathematics Program, Fred Hutchinson Cancer Research Center, Seattle, Wash, USA
    Hum Hered 67:88-103. 2009
    ..Extensive simulation experiments demonstrate that the proposed estimation and inferential methods perform well in realistic settings. We illustrate the method by an application to a study of testicular cancer...
  29. pmc Evaluating the predictive value of biomarkers with stratified case-cohort design
    Dandan Liu
    Department of Biostatistics, Vanderbilt University, Nashville, TN 37232, USA
    Biometrics 68:1219-27. 2012
    ..We illustrate new procedures using data from Framingham Offspring Study to evaluate the accuracy of a recently developed risk score incorporating biomarker information for predicting cardiovascular disease...
  30. ncbi request reprint A multiparametric panel for ovarian cancer diagnosis, prognosis, and response to chemotherapy
    Yingye Zheng
    The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Clin Cancer Res 13:6984-92. 2007
    ....
  31. ncbi request reprint Model checking for ROC regression analysis
    Tianxi Cai
    Department of Biostatistics, Harvard University, Boston, Massachusetts 02115, USA
    Biometrics 63:152-63. 2007
    ..We derive asymptotic null distributions for the residual processes and discuss resampling procedures to approximate these distributions in practice. We illustrate our methods with a dataset from the cystic fibrosis registry...
  32. ncbi request reprint The sensitivity and specificity of markers for event times
    Tianxi Cai
    Department of Biostatistics, Harvard University, Boston, MA 02115, USA
    Biostatistics 7:182-97. 2006
    ..We illustrate our methods with data from the Cardiovascular Health Study, relating the FR-score measured at enrollment to subsequent risk of cardiovascular events...
  33. ncbi request reprint Performance of diagnostic mammography for women with signs or symptoms of breast cancer
    William E Barlow
    W E Barlow, Center for Health Studies, Group Health Cooperative, Department of Biostatistics, University of Washington, Seattle 98101 1448, USA
    J Natl Cancer Inst 94:1151-9. 2002
    ..We evaluated whether age, breast density, self-reported breast lump, and previous mammography influence the performance of diagnostic mammography...
  34. ncbi request reprint A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma
    Chris Planque
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 14:1355-62. 2008
    ..Here, we examined the clinical value of 11 members of the tissue kallikrein family as potential biomarkers for lung cancer diagnosis...
  35. ncbi request reprint Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers
    Takao Takahashi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Int J Cancer 118:924-31. 2006
    ..Our study constitutes the most comprehensive methylation profile of CRCs, demonstrates that methylation commences early during CRC pathogenesis and is an age-related phenomenon...
  36. ncbi request reprint DNA methylation profiles of lymphoid and hematopoietic malignancies
    Takao Takahashi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Clin Cancer Res 10:2928-35. 2004
    ....
  37. ncbi request reprint Detection of ductal carcinoma in situ in women undergoing screening mammography
    Virginia L Ernster
    Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, USA
    J Natl Cancer Inst 94:1546-54. 2002
    ..We pooled data from seven regional mammography registries to determine the percentage of mammographically detected cancers that are DCIS and the rate of DCIS per 1000 mammograms...
  38. ncbi request reprint Use of the American College of Radiology BI-RADS to report on the mammographic evaluation of women with signs and symptoms of breast disease
    Berta M Geller
    Dept of Health Promotion Research, Univ of Vermont, 1 S Prospect St, Burlington, VT 05401 3444, USA
    Radiology 222:536-42. 2002
    ..To examine whether mammographic assessments and recommendations are linked as expected, based on the Breast Imaging Reporting and Data System (BI-RADS), for the evaluation of women with signs and symptoms of breast disease...

Research Grants2

  1. Statistical Methods for Prospective Evaluation of Biomarkers
    Yingye Zheng; Fiscal Year: 2010
    ..The research will demonstrate lasting usefulness as more biomarkers are developed and studied for potential impact on public health. ..
  2. Statistical Methods for Prospective Evaluation of Biomarkers
    Yingye Zheng; Fiscal Year: 2009
    ..The research will demonstrate lasting usefulness as more biomarkers are developed and studied for potential impact on public health. ..