Yingye Zheng

..Our results indicate the proposed methods are both flexible and efficient. We contrast these methods with an application concerning the prognostic accuracies of expression levels of six genes...

..The proposed procedures are illustrated with data from a prostate cancer prognostic study...

..They are simply descriptive in nature. We contrast the mp-values with multiple testing p-values in the context of data from a breast cancer prognosis study and from a simulation model...

..The proposed methods allow a flexible characterization of the association between a longitudinal covariate process and a survival time, and facilitate the direct prediction of survival probabilities in the time-varying covariate setting...

..We apply the methodology to mammography as performed by community radiologists...

..Efficiencies of different designs are contrasted in the simulation. We applied the methods to data from the Colorectal Cancer Family Registry...

..1999, Medical Decision Making, 19, 242-251) suggests that the ability to relax distributional assumptions may be important in practice...

..We illustrate our approach with numerical studies and a dataset from a prostate cancer study...

..We illustrate the new methods by analyzing a well-known data set from HIV research, the Multicenter AIDS Cohort Study data...

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..The methods are demonstrated with data on prostate-specific antigen and risk factors from the Prostate Cancer Prevention Trial, 1993-2003...

..Semiparametric estimation methods appropriate for both proportional and nonproportional hazards data are introduced, evaluated in simulations, and illustrated using two familiar survival data sets...

..Applications to two datasets are presented...

..33-5.37] and each minor allele of rs4464148 was associated with better survival (HR = 0.41, CI 0.18-0.94). SMAD7 variants known to be important for CRC risk were associated with disease-specific survival among prediagnostic NSAID users...

..The EDRN has developed a robust triage and validation system that serves the roles of both "facilitator" and "brake."..

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..Further research will be required to examine the possibility that screening reduces worry when women receive only normal, presumably reassuring, results...

..Progestin may enhance the estrogenic effect of conjugated estrogen so the combination may be more biologically active in the colon than E alone...

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..Interindividual variation in aspirin (ASA) metabolism is attributed to concomitant use of drugs or alcohol, urine pH, ethnicity, sex, and genetic variants in UDP-glucuronosyltransferases (UGT). Little is known about the effects of diet...

..Extensive simulation experiments demonstrate that the proposed estimation and inferential methods perform well in realistic settings. We illustrate the method by an application to a study of testicular cancer...

..Such information may be useful for generating hypothesis in future studies...

..We illustrate new procedures using data from Framingham Offspring Study to evaluate the accuracy of a recently developed risk score incorporating biomarker information for predicting cardiovascular disease...

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..We derive asymptotic null distributions for the residual processes and discuss resampling procedures to approximate these distributions in practice. We illustrate our methods with a dataset from the cystic fibrosis registry...

..We illustrate our methods with data from the Cardiovascular Health Study, relating the FR-score measured at enrollment to subsequent risk of cardiovascular events...

..We evaluated whether age, breast density, self-reported breast lump, and previous mammography influence the performance of diagnostic mammography...

..Here, we examined the clinical value of 11 members of the tissue kallikrein family as potential biomarkers for lung cancer diagnosis...

..Our study constitutes the most comprehensive methylation profile of CRCs, demonstrates that methylation commences early during CRC pathogenesis and is an age-related phenomenon...

..CONCLUSIONS: The three major forms of lymphoid/hematopoietic malignancies show overlapping but individual patterns of methylation...

..Given uncertainty about the natural history of DCIS, the clinical significance of screen-detected DCIS needs further investigation...

..To examine whether mammographic assessments and recommendations are linked as expected, based on the Breast Imaging Reporting and Data System (BI-RADS), for the evaluation of women with signs and symptoms of breast disease...

..The research will demonstrate lasting usefulness as more biomarkers are developed and studied for potential impact on public health. ..