Research Topics
Genomes and Genes | Qing ZhangSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
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Detail Information
Publications
Contribution of protein fractionation to depth of analysis of the serum and plasma proteomesVitor Faca
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
J Proteome Res 6:3558-65. 2007....
A mouse plasma peptide atlas as a resource for disease proteomicsQing Zhang
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Genome Biol 9:R93. 2008..A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis...- Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progressionSharon J Pitteri
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Cancer Res 71:5090-100. 2011..Our findings offer an integrated view of tumor development relevant to plasma-based strategies to detect and diagnose cancer... - Lung cancer signatures in plasma based on proteome profiling of mouse tumor modelsAyumu Taguchi
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Cell 20:289-99. 2011..We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models... - Detection of elevated plasma levels of epidermal growth factor receptor before breast cancer diagnosis among hormone therapy usersSharon J Pitteri
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Cancer Res 70:8598-606. 2010..Further studies are warranted to examine the role of EGFR and to discover and validate other proteins that could potentially be used for early detection of breast cancer... - Plasma proteome profiles associated with inflammation, angiogenesis, and cancerKaren S Kelly-Spratt
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 6:e19721. 2011..This approach provides a basis for distinguishing between protein changes in plasma that are cancer-related and those that are part of a non-specific host response... 
Isoform analysis of LC-MS/MS data from multidimensional fractionation of the serum proteomeAlexei L Krasnoselsky
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Proteome Res 7:2546-52. 2008..Potential applications include identification of differentially expressed isoforms in disease states...- Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discoverySharon J Pitteri
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 4:e7916. 2009..The goal of this work is to evaluate the utility of an integrative strategy using these two approaches for biomarker discovery... - Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancerMark J Schliekelman
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Res 71:7670-82. 2011..Lastly, we identified ECM proteins and peptidases that were directly regulated by miR-200. Taken together, our results reveal how expression of miR-200 alters the tumor microenvironment to inhibit the processes of EMT and metastasis... - A mouse to human search for plasma proteome changes associated with pancreatic tumor developmentVitor M Faca
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Med 5:e123. 2008.... - Plasma proteome profiling of a mouse model of breast cancer identifies a set of up-regulated proteins in common with human breast cancer cellsSharon J Pitteri
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Proteome Res 7:1481-9. 2008.... - Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domainsVitor M Faca
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 3:e2425. 2008..We have characterized the cell surface proteome and the proteins released into the extra-cellular milieu of three ovarian cancer cell lines, CaOV3, OVCAR3 and ES2 and of ovarian tumor cells enriched from ascites fluid... - Concordant release of glycolysis proteins into the plasma preceding a diagnosis of ER+ breast cancerLynn M Amon
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, School of Medicine, University of Washington, Seattle, Washington 98109, USA
Cancer Res 72:1935-42. 2012..Together, our findings indicate that the concomitant release of glycolysis proteins into the plasma is a pathophysiologic event that precedes a diagnosis of ER(+) breast cancer... - Postmenopausal estrogen and progestin effects on the serum proteomeSharon J Pitteri
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Genome Med 1:121. 2009..The biologic mechanisms underlying these effects, and these differences, have yet to be fully elucidated... - Impact of protein stability, cellular localization, and abundance on proteomic detection of tumor-derived proteins in plasmaQiaojun Fang
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 6:e23090. 2011..This study provides quantitative support for a tumor-derived marker prioritization strategy that favors secreted and stable proteins over all but the most abundant intracellular proteins... - Quantitative serum proteomics using dual stable isotope coding and nano LC-MS/MSMSHong Wang
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Proteome Res 8:5412-22. 2009..e., Cysteine acrylamide labeling only). In contrast, using same criteria for identification, a total 185 proteins were identified and 174 proteins were quantified using the DSIC labeling technique... - Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in womenJon J Ladd
Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Cancer Prev Res (Phila) 5:655-64. 2012..A panel consisting of CEA, MAPRE1, IGFBP2, and LRG1 has predictive value in prediagnostic CRC plasmas... - Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findingsHiroyuki Katayama
Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Fairview Avenue North, Seattle, WA 98109, USA
Genome Med 1:47. 2009..CLINICAL TRIALS REGISTRATION : ClinicalTrials.gov identifier: NCT00000611... - Quantitative analysis of acrylamide labeled serum proteins by LC-MS/MSVitor Faca
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
J Proteome Res 5:2009-18. 2006..Overall, the use of acrylamide for differentially labeling intact proteins in complex mixtures, in combination with LC-MS/MS provides a robust method for quantitative analysis of complex proteomes... - Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancerSandra R Pereira-Faca
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Res 67:12000-6. 2007..5 proteins previously identified as associated with autoantibodies in lung cancer, gave a sensitivity of 55% at 95% specificity (area under the curve, 0.838) in discriminating lung cancer at the preclinical stage from matched controls... - The Molecular Biology Toolkit (MBT): a modular platform for developing molecular visualization applicationsJohn L Moreland
San Diego Supercomputer Center, 9500 Gilman Drive, La Jolla, CA 92093, USA
BMC Bioinformatics 6:21. 2005..Instead, new capabilities are needed that offer flexibility, rapid application development and deployment as standalone applications or available through the Web... - Interplay between mutagen sensitivity and epidemiological factors in modulatinglung cancer riskXifeng Wu
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Cancer 120:2687-95. 2007..This new integrative approach should facilitate identification of high-risk subgroups and has important implications in LC prevention... - Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinomaSufi Mary Thomas
Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Cancer Res 66:11831-9. 2006..Combined blockade of both EGFR and GPCRs may be a rational strategy to treat cancers, including HNSCC that shows cross-talk between GPCR and EGFR signaling pathways... - Effects of YC-1 on hypoxia-inducible factor 1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cellsQiu Zhao
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Pancreas 34:242-7. 2007..To investigate the effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) on HIF-1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells... - Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: roles of anoikisWei Aixinjueluo
Department of Biochemistry II and Oral and Maxillofacial Surgery, Nagoya University School of Medicine 65 Tsurumai, Showa-ku, Japan
J Biol Chem 280:29828-36. 2005.... - P518/Qrfp sequence polymorphisms in SAMP6 osteopenic mouseQing Zhang
Department of Discovery Technologies, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
Genomics 90:629-35. 2007..Tissue distribution of human, mouse, and rat P518/Qrfp and its receptors showed expression in bone and spinal cord. A direct role for P518/Qrfp function in maintaining bone mineral density is suggested... - Guided selection of an anti-gamma-seminoprotein human Fab for antibody directed enzyme prodrug therapy of prostate cancerQing Zhang
Department of Clinical Laboratory, Xijing Hospital, Fourth Military Medical University, Xi an 710032, People s Republic of China
Cancer Immunol Immunother 56:477-89. 2007..In this study we have achieved humanization of the anti-gamma-seminoprotein E(4)B(7) murine mAb by guided selection... - [Inhibition of survivin gene expression in PC-3 cells by RNAi]Jian-Jun Shen
Department of Clinical Laboratory, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China
Zhonghua Nan Ke Xue 12:890-5. 2006..1-SVV2 and pSilencer3. 1-SVV3) in the prostate cancer cell line PC-3. After transfected with pSilencer3. 1-SVV2 and pSilencer3. 1-SVV3 vectors, the apoptosis index of the PC-3 cells was increased and their growth inhibited... - Characterization and distribution of PAHs in surface sediments of Daliao River, ChinaJi X Zhang
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
J Environ Sci Health A Tox Hazard Subst Environ Eng 43:375-81. 2008..It showed that the PAHs in some sites of Daliao River would exert adverse biological effects... - [Deducing functional epitopes for GDNF proteins and its specific GFRalpha co-receptors using phylogenetic approach]Qing Zhang
Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:331-7. 2003.... - Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasionHiroshi Nozawa
Department of Oral and Maxillofacial Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
Clin Cancer Res 14:4336-44. 2008..The purpose of this study was to investigate the efficacy of combined inhibition of c-Src and PLCgamma-1 in the abrogation of HNSCC invasion... - Bioequivalence of two formulations of daidzein administered in a single dose to healthy Chinese volunteersJianchang He
Kunming General Hospital of Chengdu Military Command, Kunming, PR China
Arzneimittelforschung 58:211-4. 2008..Based on these statistical inferences it can be concluded that the two formulations of daidzein are likely to be bioequivalent... - The amphioxus genome illuminates vertebrate origins and cephalochordate biologyLinda Z Holland
Marine Biology Research Division, Scripps Institution of Oceanography, La Jolla, California 92093 0202, USA
Genome Res 18:1100-11. 2008..Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates... - Immune epitope database analysis resource (IEDB-AR)Qing Zhang
Immune Epitope Database and Analysis Resource IEDB AR, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
Nucleic Acids Res 36:W513-8. 2008..New functionalities have been added to most of the previously implemented tools, and a total of eight new tools were added, including two B-cell epitope prediction tools, four T-cell epitope prediction tools and two analysis tools... - Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1Christopher I Amos
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Nat Genet 40:616-22. 2008..Haplotype analysis was consistent with there being a single risk variant in this region. We conclude that variation in a region of 15q25.1 containing nicotinic acetylcholine receptors genes contributes to lung cancer risk... - Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapyJun Wang
Department of Otolaryngology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
J Natl Cancer Inst 100:502-12. 2008..Constitutive prosurvival signaling by the phosphoinositide-3 kinase/Akt pathway has been observed in SCCHN cells independent of epidermal growth factor receptor (EGFR) signaling... - VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400Arthur P Young
Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Cell Biol 10:361-9. 2008..Our results suggest that senescence induced by VHL inactivation is a tumour-suppressive mechanism that must be overcome to develop VHL-associated neoplasias... - A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factorQing Zhang
Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
Dev Cell 10:719-29. 2006..We provide evidence that HIB prevents aberrant Hh signaling posterior to the morphogenic furrow, which is essential for normal eye development... - Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activationQing Zhang
Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 103:6901-6. 2006..Furthermore, knockdown of PDK1 augmented the antitumor effects of the EGFR inhibitor erlotinib, indicating PDK1 as a therapeutic target to improve the clinical response to EGFR inhibitors... - Metastatic potential of mouse Lewis lung cancer cells is regulated via ganglioside GM1 by modulating the matrix metalloprotease-9 localization in lipid raftsQing Zhang
Department of Biochemistry II, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya 466 0065, Japan
J Biol Chem 281:18145-55. 2006.... - [Rotavirus surveillance data from Kunming Children's Hospital, 1998 - 2001]Li-jie Zhang
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
Zhonghua Liu Xing Bing Xue Za Zhi 25:396-9. 2004..2%). Another 7 uncommon P-G combinations were also identified. CONCLUSION: Rotavirus was the major cause of acute diarrhea in Kunming. An effective rotavirus vaccine for prevention and control of rotavirus diarrhea should be developed... - Prediction of soil organic carbon partition coefficients by soil column liquid chromatographyRongbo Guo
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 129 Street, PO Box 100, 116011 Dalian, PR China
J Chromatogr A 1035:31-6. 2004.... - Expression of the soluble extracellular domain of human thrombopoietin receptor using a maltose-binding protein-affinity fusion systemQing Zhang
Biotechnology Research Center, Key Laboratory of Gene Engineering of the Education Ministry, Zhongshan University, Guangzhou 510275, People's Republic of China
Biol Pharm Bull 27:219-21. 2004..We conclude that bacterial expression of MBP-Mpl-EC yields large amounts of protein with correct folding and that it can be used for further structure and function analyses... - Constitutive activation of Stat5b contributes to carcinogenesis in vivoSichuan Xi
Departments of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Cancer Res 63:6763-71. 2003..Thus, constitutive activation of Stat5b contributes to squamous cell tumorigenesis and may serve as a therapeutic target... - Identification of the key amino acids of glial cell line-derived neurotrophic factor family receptor alpha1 involved in its biological functionLi Mei Wang
Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
J Biol Chem 279:109-16. 2004..However N152A/N153A or S316A/N317A/S318A mutation in the GFRalpha1 molecule still retained the ability to bind with Ret. These findings suggest that distinct structural elements in GFRalpha1 may be involved in binding to GDNF and Ret... - Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)Wei Li
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Nat Genet 35:84-9. 2003.... - Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in ratsFeng Zuo
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing, China
Biol Pharm Bull 26:911-9. 2003..Therefore, they were more efficient and durable, making them promising to exerting pharmacological effects in vivo... - A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1Li-mei Wang
Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, China
Protein Pept Lett 10:61-72. 2003..The results suggest that the central domain of GFRalpha1 is a crucial determinant for ligand binding. This established a solid basis for further study to find the key amino acid mediating the binding of GDNF and GFRalpha1... - Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6Qing Zhang
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Nat Genet 33:145-53. 2003..Both genes are previously unknown and are found only in higher eukaryotes, and together represent a new class of genes that have evolved in higher organisms to govern the synthesis of highly specialized lysosome-related organelles... - [Role of the three-dimensional distribution of abl and bcr genes in the formation of bcr/abl fusion gene in interphase neucleus]Qing Zhang
Department of Hematology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
Di Yi Jun Yi Da Xue Xue Bao 22:197-9. 2002..To explore the mechanism of bcr/abl fusion gene formation in view of its biological stereology... - The expression of secretory leukocyte protease inhibitor (SLPI) in the fallopian tube: SLPI protects the acrosome reaction of sperm from inhibitory effects of elastaseYukinobu Ota
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita City, Japan
Hum Reprod 17:2517-22. 2002..The objective of the study was 2-fold, to evaluate (i) the presence of SLPI in the Fallopian tube, and (ii) the effect of SLPI on the acrosome reaction of sperm... - Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesityYanyun Chen
Division of Endocrinology, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
Endocrinology 143:2469-77. 2002..Our data firmly establish MCHR1 as a mediator of MCH effects on energy homeostasis and suggest that inactivation of MCHR1 alone is capable to counterbalance obesity induced by a high-fat diet... - A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genomeRichard J Mural
Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
Science 296:1661-71. 2002.... - Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal floraFeng Zuo
Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine, Beijing
Biol Pharm Bull 25:558-63. 2002..All the results suggested that the glycosides of many medicinal herbs could be converted to aglycones by HIF, and the metabolism of most glycosides was improved in the compound prescription... - Prediction of soil adsorption coefficients from retention parameters on three reversed-phase liquid chromatographic columnsRongbo Guo
Dalian Institute of Chemistry and Physics, Chinese Academy of Sciences
Anal Chem 74:655-60. 2002..The results showed that the multicolumn method was more promising than a single-column methpd was for the estimation of soil adsorption coefficients. The accuracy of the suggested model is identical with that of LSERs... - Investigation on the influence of methanol on adsorption and leaching of pesticides with soil column liquid chromatographyYuwen Ni
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 161 Zhongshan Road, 116011 Dalian, PR China
Chemosphere 56:1137-42. 2004..The predicted K(w) and the retardation factor (R(w)) in pure water system by solvophobic theory are thus possibly inaccurate... - Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell linesChristiane Houde
Department of Pathology, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL, USA
Blood 104:3697-704. 2004..Taken together, these results indicate that JAG2 overexpression may be an early event in the pathogenesis of multiple myeloma involving IL-6 production... - SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cellsQing Zhang
Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
Cancer Res 64:6166-73. 2004..These results suggest that Src family kinases contribute to GRP-mediated EGFR growth and invasion pathways by facilitating cleavage and release of TGF-alpha and amphiregulin in HNSCC... - Elevated glucose induction of thrombospondin-1 up-regulates fibronectin synthesis in proximal renal tubular epithelial cells through TGF-beta1 dependent and TGF-beta1 independent pathwaysSusan Yung
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
Nephrol Dial Transplant 21:1504-13. 2006..This study thus investigates the role of TSP-1 in mediating elevated glucose-induction of TGF-beta1 bioactivation and fibronectin (FN) synthesis in human proximal tubular epithelial cells... - Decreased STAT1 expression by promoter methylation in squamous cell carcinogenesisSichuan Xi
Department of Otolaryngology, University of Pittsburgh School of Medicine, Cancer Institute, Pittsburgh, PA, USA
J Natl Cancer Inst 98:181-9. 2006..3% versus 25.8%, difference = 35.5%, 95% CI = 24.5% to 43.4%; P = .028). CONCLUSION: STAT1 can function as a tumor suppressor in SCCHN cells. Silencing of the STAT1 gene via promoter methylation may contribute to SCCHN tumor cell growth... - Step-growth synthesis and interfacial friction properties of surface dendron coatingsQing Zhang
School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853-5201, USA
Langmuir 22:717-22. 2006..Structural variations in the canopy layer are found to play a crucial role in interfacial friction properties of these coatings... - Optimal design of Ig 5' primers for construction of diverse phage antibody library established to select anti-HAb18GEF and anti-DOTA-Y Fabs for hepatoma pretargeting RITSihe Zhang
Cell Engineer Research Center, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an 710032, P R China
Front Biosci 11:1733-49. 2006..This novel Fab primers set can be applied to the construction of diverse phage antibody library and the anti-HAb18GEF and anti-DOTA-Y Fab antibodies lay a solid foundation for radioimmunotherapy of hepatoma... - Secretory leukocyte protease inhibitor levels in cervicovaginal secretion of elderly womenKoichiro Shimoya
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita City, Osaka 565 0871, Japan
Maturitas 54:141-8. 2006..The aim of the present study was to examine whether there is an association between the SLPI concentration in the cervicovaginal secretion (CS) and vaginal complaints of post-menopausal women... - Never smokers and lung cancer risk: a case-control study of epidemiological factorsOlga Y Gorlova
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Cancer 118:1798-804. 2006..35-0.92]). In the multivariate analysis, exposure to ETS and dusts, and family history of cancer with onset before age 50 were significant risk factors, while a history of hay fever (occurring without asthma) was significantly protective... - Trypanosomal TBP functions with the multisubunit transcription factor tSNAP to direct spliced-leader RNA gene expressionAnish Das
Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, 07103, USA
Mol Cell Biol 25:7314-22. 2005..These findings provide the first view of the architecture of a transcriptional complex that assembles at an RNA polymerase II-dependent gene promoter in a highly divergent eukaryote... - Alteration of SMRT tumor suppressor function in transformed non-Hodgkin lymphomasLynda Song
Department of Medicine, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, Illinois, USA
Cancer Res 65:4554-61. 2005..Assessment of cDNA array profiles should further help us to design a working model for SMRT involvement in non-Hodgkin lymphoma transformation as a novel, nonclassical tumor suppressor... - Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1Jun Zhou
Department of Clinical Immunology, First Affiliated Hospital, Fourth Military Medical University, 17 Changlexilu, Xi an 710032, Shaanxi, P R China
BMC Cell Biol 6:25. 2005..We found in our study that CD147 played a very important role in this process... - Searching for potential drug targets in two-component and phosphorelay signal-transduction systems using three-dimensional cluster analysisXiao-hui Cai
Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Acta Biochim Biophys Sin (Shanghai) 37:293-302. 2005.... - [Prediction of soil adsorption coefficients of organic compounds in a wide range of soil types by soil column liquid chromatography]Rongbo Guo
Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116012, China
Se Pu 22:57-60. 2004..However, a good correlation was obtained using a methanol-buffer mixture with pH 3 as the mobile phase. This study proved that the SCLC is suitable for the prediction of soil adsorption coefficients... - [Survey of the utilization and adverse effects of antibacterial drugs in patients admitted for respiratory diseases]Qing Zhang
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Di Yi Jun Yi Da Xue Xue Bao 25:236-8. 2005..More careful application of these drugs in old patients is stressed... - [Clinical study on treatment of advanced stage non-small cell lung cancer by guben xiaoliu capsule]Xiao Min Wang
Department of Oncology, Beijing Hospital of TCM, Beijing
Zhongguo Zhong Xi Yi Jie He Za Zhi 24:986-8. 2004..To observe the therapeutic effect of Guben Xiaoliu Capsule (GXC) in treating advanced stage non-small cell lung cancer (NSCLC)... - The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schemaNita Deshpande
San Diego Supercomputer Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Nucleic Acids Res 33:D233-7. 2005..The current capabilities of the re-engineered site, which will become the RCSB production site at http://www.pdb.org in late 2005, are described... - Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutationsXiao-hui Cai
Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Acta Pharmacol Sin 25:1712-818. 2004..The results presented here provided quantitative structural and functional information concerning the role of the charge-charge interactions in the binding of furin/kexin and their inhibitors... - Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear geneTamio Suzuki
Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Nat Genet 30:321-4. 2002..In addition, the HPS1 protein is absent in tissues of le mutant mice. These results suggest that the HPS4 and HPS1 proteins may function in the same pathway of organelle biogenesis...