Qing Zhang

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Contribution of protein fractionation to depth of analysis of the serum and plasma proteomes
    Vitor Faca
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    J Proteome Res 6:3558-65. 2007
  2. pmc A mouse plasma peptide atlas as a resource for disease proteomics
    Qing Zhang
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genome Biol 9:R93. 2008
  3. pmc Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression
    Sharon J Pitteri
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Res 71:5090-100. 2011
  4. pmc Lung cancer signatures in plasma based on proteome profiling of mouse tumor models
    Ayumu Taguchi
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Cell 20:289-99. 2011
  5. pmc Detection of elevated plasma levels of epidermal growth factor receptor before breast cancer diagnosis among hormone therapy users
    Sharon J Pitteri
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Res 70:8598-606. 2010
  6. pmc Plasma proteome profiles associated with inflammation, angiogenesis, and cancer
    Karen S Kelly-Spratt
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e19721. 2011
  7. doi request reprint Isoform analysis of LC-MS/MS data from multidimensional fractionation of the serum proteome
    Alexei L Krasnoselsky
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Proteome Res 7:2546-52. 2008
  8. pmc Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery
    Sharon J Pitteri
    Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 4:e7916. 2009
  9. pmc Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer
    Mark J Schliekelman
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 71:7670-82. 2011
  10. doi request reprint Plasma proteome profiling of a mouse model of breast cancer identifies a set of up-regulated proteins in common with human breast cancer cells
    Sharon J Pitteri
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Proteome Res 7:1481-9. 2008

Detail Information

Publications75

  1. ncbi request reprint Contribution of protein fractionation to depth of analysis of the serum and plasma proteomes
    Vitor Faca
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    J Proteome Res 6:3558-65. 2007
    ....
  2. pmc A mouse plasma peptide atlas as a resource for disease proteomics
    Qing Zhang
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genome Biol 9:R93. 2008
    ..A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis...
  3. pmc Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression
    Sharon J Pitteri
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Res 71:5090-100. 2011
    ..Our findings offer an integrated view of tumor development relevant to plasma-based strategies to detect and diagnose cancer...
  4. pmc Lung cancer signatures in plasma based on proteome profiling of mouse tumor models
    Ayumu Taguchi
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Cell 20:289-99. 2011
    ..We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models...
  5. pmc Detection of elevated plasma levels of epidermal growth factor receptor before breast cancer diagnosis among hormone therapy users
    Sharon J Pitteri
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Res 70:8598-606. 2010
    ..Further studies are warranted to examine the role of EGFR and to discover and validate other proteins that could potentially be used for early detection of breast cancer...
  6. pmc Plasma proteome profiles associated with inflammation, angiogenesis, and cancer
    Karen S Kelly-Spratt
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e19721. 2011
    ..This approach provides a basis for distinguishing between protein changes in plasma that are cancer-related and those that are part of a non-specific host response...
  7. doi request reprint Isoform analysis of LC-MS/MS data from multidimensional fractionation of the serum proteome
    Alexei L Krasnoselsky
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Proteome Res 7:2546-52. 2008
    ..Potential applications include identification of differentially expressed isoforms in disease states...
  8. pmc Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery
    Sharon J Pitteri
    Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 4:e7916. 2009
    ..The goal of this work is to evaluate the utility of an integrative strategy using these two approaches for biomarker discovery...
  9. pmc Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer
    Mark J Schliekelman
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 71:7670-82. 2011
    ..Lastly, we identified ECM proteins and peptidases that were directly regulated by miR-200. Taken together, our results reveal how expression of miR-200 alters the tumor microenvironment to inhibit the processes of EMT and metastasis...
  10. doi request reprint Plasma proteome profiling of a mouse model of breast cancer identifies a set of up-regulated proteins in common with human breast cancer cells
    Sharon J Pitteri
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Proteome Res 7:1481-9. 2008
    ....
  11. pmc A mouse to human search for plasma proteome changes associated with pancreatic tumor development
    Vitor M Faca
    Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 5:e123. 2008
    ....
  12. pmc Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains
    Vitor M Faca
    Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 3:e2425. 2008
    ..We have characterized the cell surface proteome and the proteins released into the extra-cellular milieu of three ovarian cancer cell lines, CaOV3, OVCAR3 and ES2 and of ovarian tumor cells enriched from ascites fluid...
  13. doi request reprint Concordant release of glycolysis proteins into the plasma preceding a diagnosis of ER+ breast cancer
    Lynn M Amon
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, School of Medicine, University of Washington, Seattle, Washington 98109, USA
    Cancer Res 72:1935-42. 2012
    ..Together, our findings indicate that the concomitant release of glycolysis proteins into the plasma is a pathophysiologic event that precedes a diagnosis of ER(+) breast cancer...
  14. pmc Postmenopausal estrogen and progestin effects on the serum proteome
    Sharon J Pitteri
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Genome Med 1:121. 2009
    ..The biologic mechanisms underlying these effects, and these differences, have yet to be fully elucidated...
  15. pmc Impact of protein stability, cellular localization, and abundance on proteomic detection of tumor-derived proteins in plasma
    Qiaojun Fang
    Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e23090. 2011
    ..This study provides quantitative support for a tumor-derived marker prioritization strategy that favors secreted and stable proteins over all but the most abundant intracellular proteins...
  16. doi request reprint Quantitative serum proteomics using dual stable isotope coding and nano LC-MS/MSMS
    Hong Wang
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Proteome Res 8:5412-22. 2009
    ..e., Cysteine acrylamide labeling only). In contrast, using same criteria for identification, a total 185 proteins were identified and 174 proteins were quantified using the DSIC labeling technique...
  17. pmc Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women
    Jon J Ladd
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Prev Res (Phila) 5:655-64. 2012
    ..A panel consisting of CEA, MAPRE1, IGFBP2, and LRG1 has predictive value in prediagnostic CRC plasmas...
  18. pmc Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings
    Hiroyuki Katayama
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Fairview Avenue North, Seattle, WA 98109, USA
    Genome Med 1:47. 2009
    ..CLINICAL TRIALS REGISTRATION : ClinicalTrials.gov identifier: NCT00000611...
  19. ncbi request reprint Quantitative analysis of acrylamide labeled serum proteins by LC-MS/MS
    Vitor Faca
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Proteome Res 5:2009-18. 2006
    ..Overall, the use of acrylamide for differentially labeling intact proteins in complex mixtures, in combination with LC-MS/MS provides a robust method for quantitative analysis of complex proteomes...
  20. doi request reprint A Novel Soluble Form of Tim-3 Associated with Severe Graft-versus-Host Disease
    John A Hansen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington University of Washington School of Medicine, Seattle, Washington Department of Shared Resources, Fred Hutchinson Cancer Research Center, Seattle, Washington Electronic address
    Biol Blood Marrow Transplant 19:1323-30. 2013
    ..These findings have mechanistic implications for the development of novel strategies for targeting the Tim-3 immune regulatory pathway as an approach to improving control of GVHD. ..
  21. ncbi request reprint Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer
    Sandra R Pereira-Faca
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 67:12000-6. 2007
    ..5 proteins previously identified as associated with autoantibodies in lung cancer, gave a sensitivity of 55% at 95% specificity (area under the curve, 0.838) in discriminating lung cancer at the preclinical stage from matched controls...
  22. pmc The Molecular Biology Toolkit (MBT): a modular platform for developing molecular visualization applications
    John L Moreland
    San Diego Supercomputer Center, 9500 Gilman Drive, La Jolla, CA 92093, USA
    BMC Bioinformatics 6:21. 2005
    ..Instead, new capabilities are needed that offer flexibility, rapid application development and deployment as standalone applications or available through the Web...
  23. ncbi request reprint Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: roles of anoikis
    Wei Aixinjueluo
    Department of Biochemistry II and Oral and Maxillofacial Surgery, Nagoya University School of Medicine 65 Tsurumai, Showa Ku, Japan
    J Biol Chem 280:29828-36. 2005
    ....
  24. ncbi request reprint Effects of YC-1 on hypoxia-inducible factor 1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells
    Qiu Zhao
    Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Pancreas 34:242-7. 2007
    ..To investigate the effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) on HIF-1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells...
  25. ncbi request reprint Interplay between mutagen sensitivity and epidemiological factors in modulatinglung cancer risk
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 120:2687-95. 2007
    ..This new integrative approach should facilitate identification of high-risk subgroups and has important implications in LC prevention...
  26. ncbi request reprint Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Cancer Res 66:11831-9. 2006
    ..Combined blockade of both EGFR and GPCRs may be a rational strategy to treat cancers, including HNSCC that shows cross-talk between GPCR and EGFR signaling pathways...
  27. ncbi request reprint [Inhibition of survivin gene expression in PC-3 cells by RNAi]
    Jian Jun Shen
    Department of Clinical Laboratory, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Zhonghua Nan Ke Xue 12:890-5. 2006
    ..To construct eukaryotic expression vectors by using the pSilencer3. 1-H1 neo vector for inhibiting human survivin gene by RNA interference, and to detect the effect of the silenced survivin gene on PC-3 cells...
  28. ncbi request reprint [Deducing functional epitopes for GDNF proteins and its specific GFRalpha co-receptors using phylogenetic approach]
    Qing Zhang
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:331-7. 2003
    ....
  29. ncbi request reprint Guided selection of an anti-gamma-seminoprotein human Fab for antibody directed enzyme prodrug therapy of prostate cancer
    Qing Zhang
    Department of Clinical Laboratory, Xijing Hospital, Fourth Military Medical University, Xi an 710032, People s Republic of China
    Cancer Immunol Immunother 56:477-89. 2007
    ..In this study we have achieved humanization of the anti-gamma-seminoprotein E(4)B(7) murine mAb by guided selection...
  30. ncbi request reprint P518/Qrfp sequence polymorphisms in SAMP6 osteopenic mouse
    Qing Zhang
    Department of Discovery Technologies, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Genomics 90:629-35. 2007
    ..Tissue distribution of human, mouse, and rat P518/Qrfp and its receptors showed expression in bone and spinal cord. A direct role for P518/Qrfp function in maintaining bone mineral density is suggested...
  31. pmc Immune epitope database analysis resource (IEDB-AR)
    Qing Zhang
    Immune Epitope Database and Analysis Resource IEDB AR, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Nucleic Acids Res 36:W513-8. 2008
    ..New functionalities have been added to most of the previously implemented tools, and a total of eight new tools were added, including two B-cell epitope prediction tools, four T-cell epitope prediction tools and two analysis tools...
  32. pmc Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion
    Hiroshi Nozawa
    Department of Oral and Maxillofacial Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Clin Cancer Res 14:4336-44. 2008
    ..The purpose of this study was to investigate the efficacy of combined inhibition of c-Src and PLCgamma-1 in the abrogation of HNSCC invasion...
  33. doi request reprint Characterization and distribution of PAHs in surface sediments of Daliao River, China
    Ji X Zhang
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
    J Environ Sci Health A Tox Hazard Subst Environ Eng 43:375-81. 2008
    ..It showed that the PAHs in some sites of Daliao River would exert adverse biological effects...
  34. doi request reprint VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
    Arthur P Young
    Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Cell Biol 10:361-9. 2008
    ..Our results suggest that senescence induced by VHL inactivation is a tumour-suppressive mechanism that must be overcome to develop VHL-associated neoplasias...
  35. doi request reprint Bioequivalence of two formulations of daidzein administered in a single dose to healthy Chinese volunteers
    Jianchang He
    Kunming General Hospital of Chengdu Military Command, Kunming, PR China
    Arzneimittelforschung 58:211-4. 2008
    ..Based on these statistical inferences it can be concluded that the two formulations of daidzein are likely to be bioequivalent...
  36. doi request reprint Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy
    Jun Wang
    Department of Otolaryngology, University of Pittsburgh Medical School, Pittsburgh, PA, USA
    J Natl Cancer Inst 100:502-12. 2008
    ..Constitutive prosurvival signaling by the phosphoinositide-3 kinase/Akt pathway has been observed in SCCHN cells independent of epidermal growth factor receptor (EGFR) signaling...
  37. pmc Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
    Christopher I Amos
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 40:616-22. 2008
    ..Haplotype analysis was consistent with there being a single risk variant in this region. We conclude that variation in a region of 15q25.1 containing nicotinic acetylcholine receptors genes contributes to lung cancer risk...
  38. pmc The amphioxus genome illuminates vertebrate origins and cephalochordate biology
    Linda Z Holland
    Marine Biology Research Division, Scripps Institution of Oceanography, La Jolla, California 92093 0202, USA
    Genome Res 18:1100-11. 2008
    ..Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates...
  39. ncbi request reprint A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
    Qing Zhang
    Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Cell 10:719-29. 2006
    ..We provide evidence that HIB prevents aberrant Hh signaling posterior to the morphogenic furrow, which is essential for normal eye development...
  40. pmc Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation
    Qing Zhang
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 103:6901-6. 2006
    ..Furthermore, knockdown of PDK1 augmented the antitumor effects of the EGFR inhibitor erlotinib, indicating PDK1 as a therapeutic target to improve the clinical response to EGFR inhibitors...
  41. ncbi request reprint Investigation on the influence of methanol on adsorption and leaching of pesticides with soil column liquid chromatography
    Yuwen Ni
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 161 Zhongshan Road, 116011 Dalian, PR China
    Chemosphere 56:1137-42. 2004
    ..The predicted K(w) and the retardation factor (R(w)) in pure water system by solvophobic theory are thus possibly inaccurate...
  42. ncbi request reprint [Rotavirus surveillance data from Kunming Children's Hospital, 1998 - 2001]
    Li Jie Zhang
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
    Zhonghua Liu Xing Bing Xue Za Zhi 25:396-9. 2004
    ..To study the epidemiological status on rotavirus diarrhea in Kunming to improve the rotavirus vaccine immunization program...
  43. ncbi request reprint Prediction of soil organic carbon partition coefficients by soil column liquid chromatography
    Rongbo Guo
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 129 Street, PO Box 100, 116011 Dalian, PR China
    J Chromatogr A 1035:31-6. 2004
    ....
  44. ncbi request reprint Expression of the soluble extracellular domain of human thrombopoietin receptor using a maltose-binding protein-affinity fusion system
    Qing Zhang
    Biotechnology Research Center, Key Laboratory of Gene Engineering of the Education Ministry, Zhongshan University, Guangzhou 510275, People s Republic of China
    Biol Pharm Bull 27:219-21. 2004
    ..We conclude that bacterial expression of MBP-Mpl-EC yields large amounts of protein with correct folding and that it can be used for further structure and function analyses...
  45. ncbi request reprint Constitutive activation of Stat5b contributes to carcinogenesis in vivo
    Sichuan Xi
    Departments of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 63:6763-71. 2003
    ..Thus, constitutive activation of Stat5b contributes to squamous cell tumorigenesis and may serve as a therapeutic target...
  46. ncbi request reprint Identification of the key amino acids of glial cell line-derived neurotrophic factor family receptor alpha1 involved in its biological function
    Li Mei Wang
    Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    J Biol Chem 279:109-16. 2004
    ..However N152A/N153A or S316A/N317A/S318A mutation in the GFRalpha1 molecule still retained the ability to bind with Ret. These findings suggest that distinct structural elements in GFRalpha1 may be involved in binding to GDNF and Ret...
  47. pmc Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)
    Wei Li
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Genet 35:84-9. 2003
    ....
  48. ncbi request reprint Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats
    Feng Zuo
    Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing, China
    Biol Pharm Bull 26:911-9. 2003
    ..Therefore, they were more efficient and durable, making them promising to exerting pharmacological effects in vivo...
  49. ncbi request reprint A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1
    Li Mei Wang
    Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, China
    Protein Pept Lett 10:61-72. 2003
    ..The results suggest that the central domain of GFRalpha1 is a crucial determinant for ligand binding. This established a solid basis for further study to find the key amino acid mediating the binding of GDNF and GFRalpha1...
  50. ncbi request reprint Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6
    Qing Zhang
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Genet 33:145-53. 2003
    ..Both genes are previously unknown and are found only in higher eukaryotes, and together represent a new class of genes that have evolved in higher organisms to govern the synthesis of highly specialized lysosome-related organelles...
  51. ncbi request reprint [Role of the three-dimensional distribution of abl and bcr genes in the formation of bcr/abl fusion gene in interphase neucleus]
    Qing Zhang
    Department of Hematology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 22:197-9. 2002
    ..To explore the mechanism of bcr/abl fusion gene formation in view of its biological stereology...
  52. ncbi request reprint The expression of secretory leukocyte protease inhibitor (SLPI) in the fallopian tube: SLPI protects the acrosome reaction of sperm from inhibitory effects of elastase
    Yukinobu Ota
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita City, Japan
    Hum Reprod 17:2517-22. 2002
    ..The objective of the study was 2-fold, to evaluate (i) the presence of SLPI in the Fallopian tube, and (ii) the effect of SLPI on the acrosome reaction of sperm...
  53. ncbi request reprint Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity
    Yanyun Chen
    Division of Endocrinology, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Endocrinology 143:2469-77. 2002
    ..Our data firmly establish MCHR1 as a mediator of MCH effects on energy homeostasis and suggest that inactivation of MCHR1 alone is capable to counterbalance obesity induced by a high-fat diet...
  54. ncbi request reprint A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome
    Richard J Mural
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 296:1661-71. 2002
    ....
  55. ncbi request reprint Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora
    Feng Zuo
    Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine, Beijing
    Biol Pharm Bull 25:558-63. 2002
    ..All the results suggested that the glycosides of many medicinal herbs could be converted to aglycones by HIF, and the metabolism of most glycosides was improved in the compound prescription...
  56. ncbi request reprint Prediction of soil adsorption coefficients from retention parameters on three reversed-phase liquid chromatographic columns
    Rongbo Guo
    Dalian Institute of Chemistry and Physics, Chinese Academy of Sciences
    Anal Chem 74:655-60. 2002
    ..The results showed that the multicolumn method was more promising than a single-column methpd was for the estimation of soil adsorption coefficients. The accuracy of the suggested model is identical with that of LSERs...
  57. ncbi request reprint Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines
    Christiane Houde
    Department of Pathology, Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL, USA
    Blood 104:3697-704. 2004
    ..Taken together, these results indicate that JAG2 overexpression may be an early event in the pathogenesis of multiple myeloma involving IL-6 production...
  58. ncbi request reprint SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells
    Qing Zhang
    Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 64:6166-73. 2004
    ..These results suggest that Src family kinases contribute to GRP-mediated EGFR growth and invasion pathways by facilitating cleavage and release of TGF-alpha and amphiregulin in HNSCC...
  59. ncbi request reprint Metastatic potential of mouse Lewis lung cancer cells is regulated via ganglioside GM1 by modulating the matrix metalloprotease-9 localization in lipid rafts
    Qing Zhang
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 281:18145-55. 2006
    ....
  60. ncbi request reprint Elevated glucose induction of thrombospondin-1 up-regulates fibronectin synthesis in proximal renal tubular epithelial cells through TGF-beta1 dependent and TGF-beta1 independent pathways
    Susan Yung
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
    Nephrol Dial Transplant 21:1504-13. 2006
    ..This study thus investigates the role of TSP-1 in mediating elevated glucose-induction of TGF-beta1 bioactivation and fibronectin (FN) synthesis in human proximal tubular epithelial cells...
  61. ncbi request reprint Decreased STAT1 expression by promoter methylation in squamous cell carcinogenesis
    Sichuan Xi
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Cancer Institute, Pittsburgh, PA, USA
    J Natl Cancer Inst 98:181-9. 2006
    ..Dysregulation of signal transducers and activators of transcription (STATs) is associated with many cancers, but no role of STAT1 in human tumor progression has been demonstrated...
  62. ncbi request reprint Step-growth synthesis and interfacial friction properties of surface dendron coatings
    Qing Zhang
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853 5201, USA
    Langmuir 22:717-22. 2006
    ..Structural variations in the canopy layer are found to play a crucial role in interfacial friction properties of these coatings...
  63. ncbi request reprint Optimal design of Ig 5' primers for construction of diverse phage antibody library established to select anti-HAb18GEF and anti-DOTA-Y Fabs for hepatoma pretargeting RIT
    Sihe Zhang
    Cell Engineer Research Center, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an 710032, P R China
    Front Biosci 11:1733-49. 2006
    ..This novel Fab primers set can be applied to the construction of diverse phage antibody library and the anti-HAb18GEF and anti-DOTA-Y Fab antibodies lay a solid foundation for radioimmunotherapy of hepatoma...
  64. ncbi request reprint Secretory leukocyte protease inhibitor levels in cervicovaginal secretion of elderly women
    Koichiro Shimoya
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita City, Osaka 565 0871, Japan
    Maturitas 54:141-8. 2006
    ..The aim of the present study was to examine whether there is an association between the SLPI concentration in the cervicovaginal secretion (CS) and vaginal complaints of post-menopausal women...
  65. ncbi request reprint Never smokers and lung cancer risk: a case-control study of epidemiological factors
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 118:1798-804. 2006
    ..35-0.92]). In the multivariate analysis, exposure to ETS and dusts, and family history of cancer with onset before age 50 were significant risk factors, while a history of hay fever (occurring without asthma) was significantly protective...
  66. pmc Trypanosomal TBP functions with the multisubunit transcription factor tSNAP to direct spliced-leader RNA gene expression
    Anish Das
    Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, 07103, USA
    Mol Cell Biol 25:7314-22. 2005
    ..These findings provide the first view of the architecture of a transcriptional complex that assembles at an RNA polymerase II-dependent gene promoter in a highly divergent eukaryote...
  67. ncbi request reprint Alteration of SMRT tumor suppressor function in transformed non-Hodgkin lymphomas
    Lynda Song
    Department of Medicine, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, Illinois, USA
    Cancer Res 65:4554-61. 2005
    ..Assessment of cDNA array profiles should further help us to design a working model for SMRT involvement in non-Hodgkin lymphoma transformation as a novel, nonclassical tumor suppressor...
  68. pmc Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1
    Jun Zhou
    Department of Clinical Immunology, First Affiliated Hospital, Fourth Military Medical University, 17 Changlexilu, Xi an 710032, Shaanxi, P R China
    BMC Cell Biol 6:25. 2005
    ..We found in our study that CD147 played a very important role in this process...
  69. ncbi request reprint Searching for potential drug targets in two-component and phosphorelay signal-transduction systems using three-dimensional cluster analysis
    Xiao hui Cai
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Acta Biochim Biophys Sin (Shanghai) 37:293-302. 2005
    ....
  70. ncbi request reprint [Prediction of soil adsorption coefficients of organic compounds in a wide range of soil types by soil column liquid chromatography]
    Rongbo Guo
    Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116012, China
    Se Pu 22:57-60. 2004
    ..However, a good correlation was obtained using a methanol-buffer mixture with pH 3 as the mobile phase. This study proved that the SCLC is suitable for the prediction of soil adsorption coefficients...
  71. ncbi request reprint [Survey of the utilization and adverse effects of antibacterial drugs in patients admitted for respiratory diseases]
    Qing Zhang
    Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 25:236-8. 2005
    ..To evaluate the utilization of antibacterial drugs and their adverse effects in patients admitted for respiratory disease based on medical record review...
  72. ncbi request reprint [Clinical study on treatment of advanced stage non-small cell lung cancer by guben xiaoliu capsule]
    Xiao Min Wang
    Department of Oncology, Beijing Hospital of TCM, Beijing
    Zhongguo Zhong Xi Yi Jie He Za Zhi 24:986-8. 2004
    ..To observe the therapeutic effect of Guben Xiaoliu Capsule (GXC) in treating advanced stage non-small cell lung cancer (NSCLC)...
  73. pmc The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema
    Nita Deshpande
    San Diego Supercomputer Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Nucleic Acids Res 33:D233-7. 2005
    ..The current capabilities of the re-engineered site, which will become the RCSB production site at http://www.pdb.org in late 2005, are described...
  74. ncbi request reprint Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutations
    Xiao hui Cai
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Acta Pharmacol Sin 25:1712-818. 2004
    ..To model the three-dimensional structure and investigate the interaction mechanism of the proprotein convertase furin/kexin and their inhibitors (eglin c mutants)...
  75. ncbi request reprint Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene
    Tamio Suzuki
    Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nat Genet 30:321-4. 2002
    ..In addition, the HPS1 protein is absent in tissues of le mutant mice. These results suggest that the HPS4 and HPS1 proteins may function in the same pathway of organelle biogenesis...