Research Topics
Species | Janet M YoungSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Extreme variability among mammalian V1R gene familiesJanet M Young
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genome Res 20:10-8. 2010..V1Rs provide one of the most extreme examples observed to date of massive gene duplication in some genomes, with loss of all functional genes in other species...- Degeneration of the olfactory guanylyl cyclase D gene during primate evolutionJanet M Young
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 2:e884. 2007..Because GC-D is a pseudogene in humans, signaling through this system appears to have been lost at some point in primate evolution... - Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levelsJanet M Young
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Genome Biol 4:R71. 2003.... - Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifsJanet M Young
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
BMC Genomics 12:561. 2011..Mammalian olfactory receptors (ORs) are subject to a remarkable but poorly understood regime of transcriptional regulation, whereby individual olfactory neurons each express only one allele of a single member of the large OR gene family... 
V2R gene families degenerated in primates, dog and cow, but expanded in opossumJanet M Young
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C3 168, Seattle, WA 98109 USA
Trends Genet 23:212-5. 2007..One V2R gene subfamily with unusual biology evolved atypically, showing limited expansion in rodents and persistence of a single, albeit sometimes dysfunctional, ortholog in all other species examined...- Comparative sequence analysis of primate subtelomeres originating from a chromosome fission eventM Katharine Rudd
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genome Res 19:33-41. 2009..This gross structural difference places the subtelomeric defect underlying facioscapulohumeral muscular dystrophy (FSHD) much closer to the telomere in human 4q than in the hybrid 4q-15q subtelomere of chimpanzee... - Different evolutionary processes shaped the mouse and human olfactory receptor gene familiesJanet M Young
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, C3-168, Seattle, WA 98109, USA
Hum Mol Genet 11:535-46. 2002..In addition to clarifying the evolutionary forces shaping this gene family, our study provides the basis for functional studies of the transcriptional regulation and ligand-binding capabilities of the OR gene family... - Divergent V1R repertoires in five species: Amplification in rodents, decimation in primates, and a surprisingly small repertoire in dogsJanet M Young
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genome Res 15:231-40. 2005..The diminished V1R repertoire in dogs raises questions about the relative contributions of V1Rs versus other candidate pheromone receptor genes in the establishment of complex pheromone systems in mammals... - Human subtelomeres are hot spots of interchromosomal recombination and segmental duplicationElena V Linardopoulou
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3-168, Seattle, Washington 98109, USA
Nature 437:94-100. 2005..More generally, our analyses suggest an evolutionary cycle between segmental polymorphisms and genome rearrangements... - Extensive copy-number variation of the human olfactory receptor gene familyJanet M Young
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Am J Hum Genet 83:228-42. 2008..Finally, we show that both homology-based and homology-independent processes have played a recent role in remodeling the OR family... - Comparative analyses of chromosome alterations in soft-tissue metastases within and across patients with castration-resistant prostate cancerIlona N Holcomb
Divisions of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
Cancer Res 69:7793-802. 2009..Our investigation lays the foundation for a better understanding of and possible therapeutic targets for CR disease, the poorly responsive and final stage of prostate cancer... - The sense of smell: genomics of vertebrate odorant receptorsJanet M Young
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, C3-168, PO Box 19024, Seattle, Washington 98109, USA
Hum Mol Genet 11:1153-60. 2002..Sequence and copy number polymorphisms in OR genes have been described, which may account for interindividual differences in odorant detection thresholds... - Extensive evolutionary and functional diversity among mammalian AIM2-like receptorsRebecca L Brunette
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
J Exp Med 209:1969-83. 2012..These findings validate ALRs as key activators of the antiviral response and provide an evolutionary and functional framework for understanding their roles in innate immunity... - DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophyLinda N Geng
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Dev Cell 22:38-51. 2012..These findings suggest specific mechanisms of FSHD pathology and identify candidate biomarkers for disease diagnosis and progression... - Genomic alterations indicate tumor origin and varied metastatic potential of disseminated cells from prostate cancer patientsIlona N Holcomb
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Res 68:5599-608. 2008..Our analysis lays the foundation for elucidation of the relationship between DTC genomic alterations and progressive prostate cancer... - miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cellsKyle L MacQuarrie
Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, C3 168, Seattle, WA, 98109, USA
Skelet Muscle 2:7. 2012..abstract:.. - Tissue-specific variation in DNA methylation levels along human chromosome 1Cecilia De Bustos
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Epigenetics Chromatin 2:7. 2009..CONCLUSION: The varied patterns of methylation differences detected between tissues by our methylation profiling method reinforce the potential functional significance of regional differences in methylation levels outside of CpG islands... - Genome sequence of the Brown Norway rat yields insights into mammalian evolutionRichard A Gibbs
Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, MS BCM226, One Baylor Plaza, Houston, Texas 77030, USA <http://www.hgsc.bcm.tmc.edu
Nature 428:493-521. 2004.... - Olfaction: diverse species, conserved principlesBarry W Ache
Whitney Lab for Marine Bioscience, Department of Zoology, Center for Smell and Taste and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
Neuron 48:417-30. 2005..These common features span a phylogenetically broad array of animals, implying that there is an optimal solution to the problem of detecting and discriminating odors...