Janet M Young

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Extreme variability among mammalian V1R gene families
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genome Res 20:10-8. 2010
  2. pmc Degeneration of the olfactory guanylyl cyclase D gene during primate evolution
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 2:e884. 2007
  3. pmc Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Genome Biol 4:R71. 2003
  4. pmc Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifs
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    BMC Genomics 12:561. 2011
  5. ncbi request reprint V2R gene families degenerated in primates, dog and cow, but expanded in opossum
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C3 168, Seattle, WA 98109 USA
    Trends Genet 23:212-5. 2007
  6. pmc Comparative sequence analysis of primate subtelomeres originating from a chromosome fission event
    M Katharine Rudd
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genome Res 19:33-41. 2009
  7. ncbi request reprint Different evolutionary processes shaped the mouse and human olfactory receptor gene families
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, C3 168, Seattle, WA 98109, USA
    Hum Mol Genet 11:535-46. 2002
  8. pmc Divergent V1R repertoires in five species: Amplification in rodents, decimation in primates, and a surprisingly small repertoire in dogs
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genome Res 15:231-40. 2005
  9. pmc Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication
    Elena V Linardopoulou
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3 168, Seattle, Washington 98109, USA
    Nature 437:94-100. 2005
  10. pmc Extensive copy-number variation of the human olfactory receptor gene family
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Hum Genet 83:228-42. 2008

Detail Information

Publications19

  1. pmc Extreme variability among mammalian V1R gene families
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genome Res 20:10-8. 2010
    ..V1Rs provide one of the most extreme examples observed to date of massive gene duplication in some genomes, with loss of all functional genes in other species...
  2. pmc Degeneration of the olfactory guanylyl cyclase D gene during primate evolution
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 2:e884. 2007
    ..Because GC-D is a pseudogene in humans, signaling through this system appears to have been lost at some point in primate evolution...
  3. pmc Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Genome Biol 4:R71. 2003
    ....
  4. pmc Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifs
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    BMC Genomics 12:561. 2011
    ..Mammalian olfactory receptors (ORs) are subject to a remarkable but poorly understood regime of transcriptional regulation, whereby individual olfactory neurons each express only one allele of a single member of the large OR gene family...
  5. ncbi request reprint V2R gene families degenerated in primates, dog and cow, but expanded in opossum
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C3 168, Seattle, WA 98109 USA
    Trends Genet 23:212-5. 2007
    ..One V2R gene subfamily with unusual biology evolved atypically, showing limited expansion in rodents and persistence of a single, albeit sometimes dysfunctional, ortholog in all other species examined...
  6. pmc Comparative sequence analysis of primate subtelomeres originating from a chromosome fission event
    M Katharine Rudd
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genome Res 19:33-41. 2009
    ..This gross structural difference places the subtelomeric defect underlying facioscapulohumeral muscular dystrophy (FSHD) much closer to the telomere in human 4q than in the hybrid 4q-15q subtelomere of chimpanzee...
  7. ncbi request reprint Different evolutionary processes shaped the mouse and human olfactory receptor gene families
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, C3 168, Seattle, WA 98109, USA
    Hum Mol Genet 11:535-46. 2002
    ..In addition to clarifying the evolutionary forces shaping this gene family, our study provides the basis for functional studies of the transcriptional regulation and ligand-binding capabilities of the OR gene family...
  8. pmc Divergent V1R repertoires in five species: Amplification in rodents, decimation in primates, and a surprisingly small repertoire in dogs
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genome Res 15:231-40. 2005
    ..The diminished V1R repertoire in dogs raises questions about the relative contributions of V1Rs versus other candidate pheromone receptor genes in the establishment of complex pheromone systems in mammals...
  9. pmc Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication
    Elena V Linardopoulou
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3 168, Seattle, Washington 98109, USA
    Nature 437:94-100. 2005
    ..More generally, our analyses suggest an evolutionary cycle between segmental polymorphisms and genome rearrangements...
  10. pmc Extensive copy-number variation of the human olfactory receptor gene family
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Hum Genet 83:228-42. 2008
    ..Finally, we show that both homology-based and homology-independent processes have played a recent role in remodeling the OR family...
  11. pmc Comparative analyses of chromosome alterations in soft-tissue metastases within and across patients with castration-resistant prostate cancer
    Ilona N Holcomb
    Divisions of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Cancer Res 69:7793-802. 2009
    ..Our investigation lays the foundation for a better understanding of and possible therapeutic targets for CR disease, the poorly responsive and final stage of prostate cancer...
  12. ncbi request reprint The sense of smell: genomics of vertebrate odorant receptors
    Janet M Young
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, C3 168, PO Box 19024, Seattle, Washington 98109, USA
    Hum Mol Genet 11:1153-60. 2002
    ..Sequence and copy number polymorphisms in OR genes have been described, which may account for interindividual differences in odorant detection thresholds...
  13. pmc Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
    Rebecca L Brunette
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 209:1969-83. 2012
    ..These findings validate ALRs as key activators of the antiviral response and provide an evolutionary and functional framework for understanding their roles in innate immunity...
  14. pmc DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy
    Linda N Geng
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 22:38-51. 2012
    ..These findings suggest specific mechanisms of FSHD pathology and identify candidate biomarkers for disease diagnosis and progression...
  15. pmc Genomic alterations indicate tumor origin and varied metastatic potential of disseminated cells from prostate cancer patients
    Ilona N Holcomb
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 68:5599-608. 2008
    ..Our analysis lays the foundation for elucidation of the relationship between DTC genomic alterations and progressive prostate cancer...
  16. pmc miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells
    Kyle L MacQuarrie
    Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, C3 168, Seattle, WA, 98109, USA
    Skelet Muscle 2:7. 2012
    ..abstract:..
  17. pmc Tissue-specific variation in DNA methylation levels along human chromosome 1
    Cecilia De Bustos
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Epigenetics Chromatin 2:7. 2009
    ..CONCLUSION: The varied patterns of methylation differences detected between tissues by our methylation profiling method reinforce the potential functional significance of regional differences in methylation levels outside of CpG islands...
  18. ncbi request reprint Genome sequence of the Brown Norway rat yields insights into mammalian evolution
    Richard A Gibbs
    Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, MS BCM226, One Baylor Plaza, Houston, Texas 77030, USA lt http www hgsc bcm tmc edu
    Nature 428:493-521. 2004
    ....
  19. ncbi request reprint Olfaction: diverse species, conserved principles
    Barry W Ache
    Whitney Lab for Marine Bioscience, Department of Zoology, Center for Smell and Taste and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Neuron 48:417-30. 2005
    ..These common features span a phylogenetically broad array of animals, implying that there is an optimal solution to the problem of detecting and discriminating odors...