Markus Welcker

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4
    Markus Welcker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 280:7654-8. 2005
  2. pmc FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
    Jennifer O'Neil
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 204:1813-24. 2007
  3. pmc Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase
    Jonathan E Grim
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 181:913-20. 2008
  4. pmc Fbw7/hCDC4 dimerization regulates its substrate interactions
    Markus Welcker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, Washington 98109, USA
    Cell Div 2:7. 2007
  5. ncbi request reprint FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
    Markus Welcker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Rev Cancer 8:83-93. 2008
  6. pmc Ras activity regulates cyclin E degradation by the Fbw7 pathway
    Alex C Minella
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:9649-54. 2005
  7. ncbi request reprint A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size
    Markus Welcker
    Divisions of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Curr Biol 14:1852-7. 2004
  8. ncbi request reprint Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation
    Markus Welcker
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell 12:381-92. 2003
  9. pmc Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3
    Markus Welcker
    Fred Hutchinson Cancer Research Center, Mailstop D2 100, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 31:1214-24. 2011
  10. pmc The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
    Markus Welcker
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 101:9085-90. 2004

Collaborators

  • Yong Chi
  • Ruedi Aebersold
  • Alexey G Ryazanov
  • David W Russell
  • ROBERT NEIL EISENMAN
  • Irwin D Bernstein
  • JEFFREY W HARPER
  • Hui Liu
  • Bruce E Clurman
  • Alex C Minella
  • Jherek Swanger
  • Michael P Gustafson
  • Asli A Hizli
  • Jonathan E Grim
  • James M Roberts
  • Jennifer O'Neil
  • Yan Geng
  • Harry C Hwang
  • Xin Ye
  • John H Carter
  • Yi Liao
  • Johan Ericsson
  • Andrea Knecht
  • Keith R Loeb
  • Barbara J Varnum-Finney
  • Roli K Hirata
  • Amanda C Hagar
  • Agnieszka Zagozdzon
  • Christopher Winter
  • Joel D Winer
  • Young Mi Lee
  • A Thomas Look
  • Rob Pieters
  • Giulio Draetta
  • Jules P Meijerink
  • Deanne Tibbitts
  • Rosalie Sears
  • James Hardwick
  • Sudhir Rao
  • Philipp Kaldis
  • Piotr Sicinski
  • Peter Strack
  • Jonathan Grim
  • Benedikt M Kessler
  • Eric Spooner
  • Jun Qin
  • Grzegorz Nalepa
  • Stephen J Elledge
  • Eileen Bryant
  • Harry Hwang

Detail Information

Publications19

  1. ncbi request reprint The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4
    Markus Welcker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 280:7654-8. 2005
    ..Our data suggest that LT competes with cellular proteins for Fbw7 binding in a substrate-like fashion...
  2. pmc FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
    Jennifer O'Neil
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 204:1813-24. 2007
    ....
  3. pmc Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase
    Jonathan E Grim
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 181:913-20. 2008
    ..Moreover, they highlight the utility of adeno-associated virus-mediated gene targeting in functional analyses of complex loci...
  4. pmc Fbw7/hCDC4 dimerization regulates its substrate interactions
    Markus Welcker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, Washington 98109, USA
    Cell Div 2:7. 2007
    ..The two fission yeast homologs of Fbw7, pop1 and pop2, have previously been shown to dimerize. In this study, we asked whether Fbw7 can also dimerize and how dimerization affects Fbw7 function...
  5. ncbi request reprint FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
    Markus Welcker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Rev Cancer 8:83-93. 2008
    ..This Review focuses on structural and functional aspects of FBW7 and its role in the development of cancer...
  6. pmc Ras activity regulates cyclin E degradation by the Fbw7 pathway
    Alex C Minella
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:9649-54. 2005
    ..Thus, we conclude that Ras activity regulates Fbw7-mediated cyclin E proteolysis and suggest that impaired cyclin E proteolysis is a mechanism through which Ras mutations promote tumorigenesis...
  7. ncbi request reprint A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size
    Markus Welcker
    Divisions of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Curr Biol 14:1852-7. 2004
    ..We suggest that interactions between c-Myc and Fbw7gamma within the nucleolus regulate c-Myc's growth-promoting function and that c-Myc activation is likely to be an important oncogenic consequence of Fbw7 loss in cancers...
  8. ncbi request reprint Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation
    Markus Welcker
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell 12:381-92. 2003
    ..Thus, cyclin E turnover is controlled by multiple biological inputs and cannot be understood in terms of autophosphorylation alone...
  9. pmc Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3
    Markus Welcker
    Fred Hutchinson Cancer Research Center, Mailstop D2 100, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 31:1214-24. 2011
    ..However, despite these canonical substrate-like interactions, Fbw7 binding is largely uncoupled from Ebp2 turnover in vivo. Ebp2 thus acts like a pseudosubstrate that directly recruits Fbw7 to nucleoli...
  10. pmc The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
    Markus Welcker
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 101:9085-90. 2004
    ..Because Fbw7 mediates the degradation of cyclin E, Notch, and c-Jun, as well as c-Myc, the loss of Fbw7 is likely to elicit profound effects on cell proliferation during tumorigenesis...
  11. pmc Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase
    Asli A Hizli
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Mol Cell Biol 33:596-604. 2013
    ..Because all known eEF2 regulation is exerted via eEF2K, S595 phosphorylation may globally couple the cell cycle machinery to regulatory pathways that impact eEF2K activity...
  12. pmc Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo
    Alex C Minella
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genes Dev 22:1677-89. 2008
    ..Overall these data show the critical role of both degrons in regulating cyclin E activity and reveal that complete loss of Fbw7-mediated cyclin E degradation causes spontaneous and cell type-specific proliferative anomalies...
  13. ncbi request reprint Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins
    Michael P Gustafson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biochem Biophys Res Commun 338:1359-67. 2005
    ..Moreover, we found that Zcchc8 interacts with proteins involved in RNA processing/degradation. We suggest that Zcchc8 is a GSK-3 substrate with a role in RNA metabolism...
  14. pmc Identification of CDK2 substrates in human cell lysates
    Yong Chi
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Genome Biol 9:R149. 2008
    ..However, despite intense study, only a limited number of mammalian CDK substrates are known. A comprehensive understanding of CDK function requires the identification of their substrate network...
  15. ncbi request reprint p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation
    Alex C Minella
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Curr Biol 12:1817-27. 2002
    ..Although deregulated cyclin E-cdk2 activity is believed to directly contribute to the neoplastic progression of these cancers, the mechanism of cyclin E-induced neoplasia is unknown...
  16. ncbi request reprint Cell cycle: how cyclin E got its groove back
    Markus Welcker
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Curr Biol 15:R810-2. 2005
    ..The new results shed light on a recent cell-cycle mystery, and provide another dramatic example of apparent functional redundancy among cyclins and cyclin-dependent kinases...
  17. pmc Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma
    Hui Liu
    Center for Hematologic Malignancies, Oregon Cancer Institute, Portland, OR 97239, USA
    J Exp Med 205:1843-58. 2008
    ..Furthermore, NPM short hairpin RNA produces a specific growth arrest in these cells. Our data demonstrate transvection in human cancer and suggest a functional role for CTCF and NPM...
  18. ncbi request reprint Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase
    Xin Ye
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:50110-9. 2004
    ....
  19. ncbi request reprint Kinase-independent function of cyclin E
    Yan Geng
    Department of Cancer Biology, Dana Farber Cancer Institute, USA
    Mol Cell 25:127-39. 2007
    ..Our work indicates that-in addition to their function as CDK activators-E cyclins play kinase-independent functions in cell-cycle progression...