Zejing Wang

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. doi request reprint Analyzing cellular immunity to AAV in a canine model using ELISPOT assay
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Methods Mol Biol 792:65-74. 2012
  2. pmc Successful regional delivery and long-term expression of a dystrophin gene in canine muscular dystrophy: a preclinical model for human therapies
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Mol Ther 20:1501-7. 2012
  3. ncbi request reprint Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppression
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Ther 15:1160-6. 2007
  4. pmc Expression of human alpha1-antitrypsin in mice and dogs following AAV6 vector-mediated gene transfer to the lungs
    Christine L Halbert
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Mol Ther 18:1165-72. 2010
  5. ncbi request reprint Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophy
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Gene Ther 18:18-26. 2007
  6. doi request reprint Local gene delivery and methods to control immune responses in muscles of normal and dystrophic dogs
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Fairview Av N, D1 100, Seattle, WA, USA
    Methods Mol Biol 709:265-75. 2011
  7. pmc Gene therapy in large animal models of muscular dystrophy
    Zejing Wang
    Division of Clinical Research, Fred Hutchinson Cancer Research Center in Seattle, Washington 98109, USA
    ILAR J 50:187-98. 2009
  8. pmc Immune responses to AAV in canine muscle monitored by cellular assays and noninvasive imaging
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Ther 18:617-24. 2010
  9. ncbi request reprint Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs
    Chiara Dell'agnola
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 104:4311-8. 2004
  10. pmc Immunity and AAV-Mediated Gene Therapy for Muscular Dystrophies in Large Animal Models and Human Trials
    Zejing Wang
    Division of Clinical Research, Fred Hutchinson Cancer Research Center Seattle, WA, USA
    Front Microbiol 2:201. 2011

Collaborators

Detail Information

Publications13

  1. doi request reprint Analyzing cellular immunity to AAV in a canine model using ELISPOT assay
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Methods Mol Biol 792:65-74. 2012
    ..This high-throughput method allows the identification of T-cell epitopes without the need for large cell numbers and the need for major histocompatibility complex molecule-matched cell lines...
  2. pmc Successful regional delivery and long-term expression of a dystrophin gene in canine muscular dystrophy: a preclinical model for human therapies
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Mol Ther 20:1501-7. 2012
    ....
  3. ncbi request reprint Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppression
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Ther 15:1160-6. 2007
    ..This protocol has potential applications to human clinical trials to enhance AAV-mediated therapies...
  4. pmc Expression of human alpha1-antitrypsin in mice and dogs following AAV6 vector-mediated gene transfer to the lungs
    Christine L Halbert
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Mol Ther 18:1165-72. 2010
    ....
  5. ncbi request reprint Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophy
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Gene Ther 18:18-26. 2007
    ..Our data indicate that AAV2 and AAV6 capsid proteins can elicit primary cellular immune responses when injected into the skeletal muscle of random-bred dogs, and suggest the possibility of cellular immunity to AAV vectors in humans...
  6. doi request reprint Local gene delivery and methods to control immune responses in muscles of normal and dystrophic dogs
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Fairview Av N, D1 100, Seattle, WA, USA
    Methods Mol Biol 709:265-75. 2011
    ..Here, we describe in detail the immunosuppressive regimens employed in both normal and DMD dogs and provide methods for evaluating the efficiency of the regimens following intramuscular injection of AAV in dogs...
  7. pmc Gene therapy in large animal models of muscular dystrophy
    Zejing Wang
    Division of Clinical Research, Fred Hutchinson Cancer Research Center in Seattle, Washington 98109, USA
    ILAR J 50:187-98. 2009
    ..Because of the complex nature of these diseases, it may be necessary to combine multiple approaches to achieve a successful treatment...
  8. pmc Immune responses to AAV in canine muscle monitored by cellular assays and noninvasive imaging
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Ther 18:617-24. 2010
    ..These assays should be incorporated into future human clinical trials of AAV gene therapy to monitor immune responses...
  9. ncbi request reprint Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs
    Chiara Dell'agnola
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 104:4311-8. 2004
    ..1% donor contribution...
  10. pmc Immunity and AAV-Mediated Gene Therapy for Muscular Dystrophies in Large Animal Models and Human Trials
    Zejing Wang
    Division of Clinical Research, Fred Hutchinson Cancer Research Center Seattle, WA, USA
    Front Microbiol 2:201. 2011
    ....
  11. pmc Mapping contrast agent uptake and retention in MRI studies of myocardial perfusion: case control study of dogs with Duchenne muscular dystrophy
    William S Kerwin
    Department of Radiology, University of Washington, Seattle, WA, 98109, USA
    Int J Cardiovasc Imaging 29:819-26. 2013
    ..2 ± 5.8 % in dogs with DMD compared to 90.5 ± 6.6 % in controls (p = 0.12). A discrete-time kinetic model of uptake and retention of contrast agent in perfusion CMRI shows potential for the study of DMD...
  12. pmc The impact of donor type and ABO incompatibility on transfusion requirements after nonmyeloablative haematopoietic cell transplantation
    Zejing Wang
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
    Br J Haematol 149:101-10. 2010
    ..ABO incompatibility did not affect nonmyeloablative HCT outcomes...
  13. pmc Immune Responses to rAAV6: The Influence of Canine Parvovirus Vaccination and Neonatal Administration of Viral Vector
    Andrea L H Arnett
    Medical Scientist Training Program, University of Washington School of Medicine Seattle, WA, USA
    Front Microbiol 2:220. 2011
    ..Taken together, these data demonstrate that the immune response raised against rAAV6 is distinct from that which is elicited by the standard parvoviral vaccines and is sufficient to prevent stable tolerization in neonatal mice...