Research Topics
Species | Zejing WangSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
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Detail Information
Publications
Successful regional delivery and long-term expression of a dystrophin gene in canine muscular dystrophy: a preclinical model for human therapiesZejing Wang
Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Mol Ther 20:1501-7. 2012....
Analyzing cellular immunity to AAV in a canine model using ELISPOT assayZejing Wang
Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Methods Mol Biol 792:65-74. 2012..This high-throughput method allows the identification of T-cell epitopes without the need for large cell numbers and the need for major histocompatibility complex molecule-matched cell lines...
Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppressionZejing Wang
Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Mol Ther 15:1160-6. 2007..This protocol has potential applications to human clinical trials to enhance AAV-mediated therapies...- Expression of human alpha1-antitrypsin in mice and dogs following AAV6 vector-mediated gene transfer to the lungsChristine L Halbert
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Mol Ther 18:1165-72. 2010.... - Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophyZejing Wang
Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Hum Gene Ther 18:18-26. 2007..Our data indicate that AAV2 and AAV6 capsid proteins can elicit primary cellular immune responses when injected into the skeletal muscle of random-bred dogs, and suggest the possibility of cellular immunity to AAV vectors in humans... - Local gene delivery and methods to control immune responses in muscles of normal and dystrophic dogsZejing Wang
Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Fairview Av N, D1 100, Seattle, WA, USA
Methods Mol Biol 709:265-75. 2011..Here, we describe in detail the immunosuppressive regimens employed in both normal and DMD dogs and provide methods for evaluating the efficiency of the regimens following intramuscular injection of AAV in dogs... - Gene therapy in large animal models of muscular dystrophyZejing Wang
Division of Clinical Research, Fred Hutchinson Cancer Research Center in Seattle, Washington 98109, USA
ILAR J 50:187-98. 2009..Because of the complex nature of these diseases, it may be necessary to combine multiple approaches to achieve a successful treatment... - Immune responses to AAV in canine muscle monitored by cellular assays and noninvasive imagingZejing Wang
Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Mol Ther 18:617-24. 2010..These assays should be incorporated into future human clinical trials of AAV gene therapy to monitor immune responses... - Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogsChiara Dell'agnola
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
Blood 104:4311-8. 2004..1% donor contribution... - Immunity and AAV-Mediated Gene Therapy for Muscular Dystrophies in Large Animal Models and Human TrialsZejing Wang
Division of Clinical Research, Fred Hutchinson Cancer Research Center Seattle, WA, USA
Front Microbiol 2:201. 2011.... - Mapping contrast agent uptake and retention in MRI studies of myocardial perfusion: case control study of dogs with Duchenne muscular dystrophyWilliam S Kerwin
Department of Radiology, University of Washington, Seattle, WA, 98109, USA
Int J Cardiovasc Imaging 29:819-26. 2013..2 ± 5.8 % in dogs with DMD compared to 90.5 ± 6.6 % in controls (p = 0.12). A discrete-time kinetic model of uptake and retention of contrast agent in perfusion CMRI shows potential for the study of DMD... - The impact of donor type and ABO incompatibility on transfusion requirements after nonmyeloablative haematopoietic cell transplantationZejing Wang
Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
Br J Haematol 149:101-10. 2010..ABO incompatibility did not affect nonmyeloablative HCT outcomes... - Immune Responses to rAAV6: The Influence of Canine Parvovirus Vaccination and Neonatal Administration of Viral VectorAndrea L H Arnett
Medical Scientist Training Program, University of Washington School of Medicine Seattle, WA, USA
Front Microbiol 2:220. 2011..Taken together, these data demonstrate that the immune response raised against rAAV6 is distinct from that which is elicited by the standard parvoviral vaccines and is sufficient to prevent stable tolerization in neonatal mice...