Barbara Varnum-Finney

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
    B Varnum-Finney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2 373, Seattle, Washington 98109, USA
    Nat Med 6:1278-81. 2000
  2. ncbi request reprint Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling
    B Varnum-Finney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Cell Sci 113:4313-8. 2000
  3. pmc Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus
    Barbara Varnum-Finney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Blood 111:2615-20. 2008
  4. pmc Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1
    Mari H Dallas
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Blood 109:3579-87. 2007
  5. pmc Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells
    Kohshi Ohishi
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, Washington 98195, USA
    J Clin Invest 110:1165-74. 2002
  6. pmc Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells
    Mari H Dallas
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Exp Med 201:1361-6. 2005
  7. ncbi request reprint Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability
    Barbara Varnum-Finney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 101:1784-9. 2003
  8. pmc Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells
    Colleen Delaney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2 373, Seattle, WA 98109, USA
    Blood 106:2693-9. 2005
  9. pmc SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
    Vid Leko
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 119:1856-60. 2012
  10. ncbi request reprint The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation
    Keisuke Aoyama
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2 373, Seattle, Washington 98109, USA
    Stem Cells 25:2488-97. 2007

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
    B Varnum-Finney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2 373, Seattle, Washington 98109, USA
    Nat Med 6:1278-81. 2000
    ....
  2. ncbi request reprint Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling
    B Varnum-Finney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Cell Sci 113:4313-8. 2000
    ..These results imply that ligand stabilization may be essential for Notch activation...
  3. pmc Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus
    Barbara Varnum-Finney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Blood 111:2615-20. 2008
    ..Together, our results suggest that to ensure an appropriate outcome in the thymus in response to a lower threshold of induced Notch signaling, induction of the additional target Hes5 is required...
  4. pmc Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1
    Mari H Dallas
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Blood 109:3579-87. 2007
    ..These findings demonstrate the potential of Delta1(ext-IgG)-cultured cells for accelerating early immune reconstitution after hematopoietic cell transplantation...
  5. pmc Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells
    Kohshi Ohishi
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, Washington 98195, USA
    J Clin Invest 110:1165-74. 2002
    ..These data suggest that Delta-1 can enhance myeloid and lymphoid marrow-repopulating ability and promote the generation of thymus-repopulating T cell precursors...
  6. pmc Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells
    Mari H Dallas
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Exp Med 201:1361-6. 2005
    ....
  7. ncbi request reprint Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability
    Barbara Varnum-Finney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 101:1784-9. 2003
    ....
  8. pmc Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells
    Colleen Delaney
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2 373, Seattle, WA 98109, USA
    Blood 106:2693-9. 2005
    ..Moreover, these findings contribute to the development of methodology for manipulation of hematopoietic precursors for therapeutic purposes...
  9. pmc SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
    Vid Leko
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 119:1856-60. 2012
    ..The results of the present study rule out an essential physiologic role for cell-autonomous SIRT1 signaling in the maintenance of the adult HSC compartment in mice...
  10. ncbi request reprint The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation
    Keisuke Aoyama
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2 373, Seattle, Washington 98109, USA
    Stem Cells 25:2488-97. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  11. pmc Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells
    Barbara Varnum-Finney
    Pediatric Oncology, Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Clin Invest 121:1207-16. 2011
    ..These data indicate a Notch2-dependent role in assuring orderly repopulation by HSCs, MPPs, myeloid cells, and lymphoid cells during BM regeneration...