Nicole D Urban

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Systematic evaluation of candidate blood markers for detecting ovarian cancer
    Chana Palmer
    Canary Foundation, Scientific Programs, San Jose, California, United States of America
    PLoS ONE 3:e2633. 2008
  2. pmc Interpretation of single and serial measures of HE4 and CA125 in asymptomatic women at high risk for ovarian cancer
    Nicole Urban
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2 B230, P O Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 21:2087-94. 2012
  3. pmc Use of cancer-specific yeast-secreted in vivo biotinylated recombinant antibodies for serum biomarker discovery
    Nathalie Scholler
    Center for Research on Early Detection and Cure of Ovarian Cancer, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Transl Med 6:41. 2008
  4. ncbi request reprint Ovarian cancer screening
    Nicole Urban
    Cancer Prevention Research Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, MP 900, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Hematol Oncol Clin North Am 17:989-1005, ix. 2003
  5. ncbi request reprint Current and future developments in screening for ovarian cancer
    Nicole Urban
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2 B230 Seattle, WA 98109, USA
    Womens Health (Lond Engl) 2:733-42. 2006
  6. pmc Designing early detection programs for ovarian cancer
    N Urban
    Molecular Diagnostics Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Ann Oncol 22:viii6-viii18. 2011
  7. pmc Computer-assisted mammography feedback program (CAMFP) an electronic tool for continuing medical education
    Nicole Urban
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B230, Seattle, WA 98109 1024, USA
    Acad Radiol 14:1036-42. 2007
  8. ncbi request reprint Developing measures of mammography performance
    Nicole Urban
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Med Care 40:III86-8. 2002
  9. pmc Potential role of HE4 in multimodal screening for epithelial ovarian cancer
    Nicole Urban
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 103:1630-4. 2011
  10. ncbi request reprint Comparing adaptive and non-adaptive algorithms for cancer early detection with novel biomarkers
    Alicia H Sato
    Fred Hutchinson Cancer Research Center, Seattle, WA 90109, USA
    Cancer Biomark 2:151-62. 2006

Research Grants

  1. Modeling ovarian cancer screening for CEA
    Nicole Urban; Fiscal Year: 2002
  2. Modeling ovarian cancer screening for CEA
    Nicole Urban; Fiscal Year: 2003
  3. Modeling ovarian cancer screening for CEA
    Nicole Urban; Fiscal Year: 2004
  4. Modeling ovarian cancer screening for CEA
    Nicole Urban; Fiscal Year: 2005
  5. Prevention of Ovarian Cancer in Women Participating in Mammography
    Nicole Urban; Fiscal Year: 2007

Detail Information

Publications61

  1. pmc Systematic evaluation of candidate blood markers for detecting ovarian cancer
    Chana Palmer
    Canary Foundation, Scientific Programs, San Jose, California, United States of America
    PLoS ONE 3:e2633. 2008
    ..We evaluated the performance of a set of candidate blood markers and combinations of these markers in detecting serous ovarian cancer...
  2. pmc Interpretation of single and serial measures of HE4 and CA125 in asymptomatic women at high risk for ovarian cancer
    Nicole Urban
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2 B230, P O Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 21:2087-94. 2012
    ..Human epididymis protein 4 (HE4) is approved for clinical use with CA125 to predict epithelial ovarian cancer in women with a pelvic mass or in remission after chemotherapy. Previously reported reference ranges for HE4 are inconsistent...
  3. pmc Use of cancer-specific yeast-secreted in vivo biotinylated recombinant antibodies for serum biomarker discovery
    Nathalie Scholler
    Center for Research on Early Detection and Cure of Ovarian Cancer, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Transl Med 6:41. 2008
    ..We developed a novel technology that permits us to isolate recombinant antibodies directed against the potential serum biomarkers, to facilitate the further development of affinity reagents necessary to construct diagnostic tests...
  4. ncbi request reprint Ovarian cancer screening
    Nicole Urban
    Cancer Prevention Research Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, MP 900, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Hematol Oncol Clin North Am 17:989-1005, ix. 2003
    ..Large, well-designed randomized controlled trials are under way to gauge the performance of existing screening methods...
  5. ncbi request reprint Current and future developments in screening for ovarian cancer
    Nicole Urban
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2 B230 Seattle, WA 98109, USA
    Womens Health (Lond Engl) 2:733-42. 2006
    ....
  6. pmc Designing early detection programs for ovarian cancer
    N Urban
    Molecular Diagnostics Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Ann Oncol 22:viii6-viii18. 2011
    ..Incorporation of symptoms in a screening strategy that includes CA125 and HE4 may warrant further research...
  7. pmc Computer-assisted mammography feedback program (CAMFP) an electronic tool for continuing medical education
    Nicole Urban
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B230, Seattle, WA 98109 1024, USA
    Acad Radiol 14:1036-42. 2007
    ..Our goal was to develop and evaluate software to support a computer assisted mammography feedback program (CAMFP) to be used for continuing medical education (CME)...
  8. ncbi request reprint Developing measures of mammography performance
    Nicole Urban
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Med Care 40:III86-8. 2002
  9. pmc Potential role of HE4 in multimodal screening for epithelial ovarian cancer
    Nicole Urban
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 103:1630-4. 2011
    ..03). Serum HE4 levels were found to increase with age and smoking status, suggesting that a longitudinal algorithm might improve its performance...
  10. ncbi request reprint Comparing adaptive and non-adaptive algorithms for cancer early detection with novel biomarkers
    Alicia H Sato
    Fred Hutchinson Cancer Research Center, Seattle, WA 90109, USA
    Cancer Biomark 2:151-62. 2006
    ....
  11. doi request reprint Quantitative proteomics analysis integrated with microarray data reveals that extracellular matrix proteins, catenins, and p53 binding protein 1 are important for chemotherapy response in ovarian cancers
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington, USA
    OMICS 13:345-54. 2009
    ..Our results suggest that chemotherapy response may be determined by multiple and complex system properties involving extracellular-matrix, cell adhesion and junction proteins...
  12. pmc Assessing lead time of selected ovarian cancer biomarkers: a nested case-control study
    Garnet L Anderson
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, PO Box 19024, M3 A410, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 102:26-38. 2010
    ..Except for CA125, their behavior in the prediagnostic period has not been evaluated...
  13. pmc DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines
    Sahar Houshdaran
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 5:e9359. 2010
    ..This study applied recently developed methods for high-throughput DNA methylation profiling to characterize ovarian cancer cell lines and tumors, including representatives of three major histologies...
  14. pmc Influence of ovarian cancer risk status on the diagnostic performance of the serum biomarkers mesothelin, HE4, and CA125
    Chirag A Shah
    University of Washington, Seattle, WA 98195, USA
    Cancer Epidemiol Biomarkers Prev 18:1365-72. 2009
    ..To evaluate the effect of ovarian cancer risk on the performance of the serum biomarkers mesothelin, human epididymis protein 4 (HE4), and CA125...
  15. pmc Use of a single-chain antibody library for ovarian cancer biomarker discovery
    ARTURO B RAMIREZ
    Molecular Diagnostics Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Proteomics 9:1449-60. 2010
    ..Thus, our use of recombinant antibody microarrays for unbiased discovery found targets for ovarian cancer detection in multiple sample sets, supporting their further study for disease diagnosis...
  16. pmc Use of high density antibody arrays to validate and discover cancer serum biomarkers
    Christian M Loch
    Molecular Diagnostics Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Mol Oncol 1:313-20. 2007
    ..We demonstrate its performance by showing that known tumor markers behave as expected. We also identify several promising biomarkers from a candidate list and generate hypotheses to support new discovery studies...
  17. ncbi request reprint Development of an ovarian cancer symptom index: possibilities for earlier detection
    Barbara A Goff
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98196 6460, USA
    Cancer 109:221-7. 2007
    ..Currently, screening for ovarian cancer is not recommended for the general population. Targeting women with specific symptoms for screening has been evaluated only recently, because it was believed that symptoms had limited specificity...
  18. pmc Circulating microRNAs as stable blood-based markers for cancer detection
    Patrick S Mitchell
    Divisions of Human Biology, Clinical Research, and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 105:10513-8. 2008
    ..Our results establish the measurement of tumor-derived miRNAs in serum or plasma as an important approach for the blood-based detection of human cancer...
  19. ncbi request reprint Development and in vitro validation of anti-mesothelin biobodies that prevent CA125/Mesothelin-dependent cell attachment
    Lindsay Bergan
    Molecular Diagnositics Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Lett 255:263-74. 2007
    ..Anti-mesothelin Bbs derived from high affinity yeast-display scFv detected both membrane-bound and soluble mesothelins and inhibited CA125/mesothelin-dependent cell attachment...
  20. pmc Bead-based ELISA for validation of ovarian cancer early detection markers
    Nathalie Scholler
    Translational Outcomes Research Laboratory, Fred Hutchinson Cancer Research Center, Public Health Sciences, and Harborview Medical Center, University of Washington, Seattle, Washington, USA
    Clin Cancer Res 12:2117-24. 2006
    ....
  21. ncbi request reprint The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma
    Ingegerd Hellstrom
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Cancer Res 63:3695-700. 2003
    ..However, the HE4 assay may have an advantage over the CA125 assay in that it is less frequently positive in patients with nonmalignant disease...
  22. pmc Combining a symptoms index with CA 125 to improve detection of ovarian cancer
    M Robyn Andersen
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer 113:484-9. 2008
    ....
  23. doi request reprint Breast cancer genomics: normal tissue and cancer markers
    Michel Schummer
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Ann N Y Acad Sci 1210:78-85. 2010
    ..Here we report the identification of potential breast cancer markers, including some that are overexpressed in aggressive disease...
  24. pmc Use of a Symptom Index, CA125, and HE4 to predict ovarian cancer
    M Robyn Andersen
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Gynecol Oncol 116:378-83. 2010
    ..Prior studies suggest that combining the Symptom Index (SI) with a serum HE4 test or a CA125 test may improve prediction of ovarian cancer. However, these three tests have not been evaluated in combination...
  25. pmc No effect of aspirin on mammographic density in a randomized controlled clinical trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:1524-30. 2009
    ....
  26. pmc Effects of personal characteristics on serum CA125, mesothelin, and HE4 levels in healthy postmenopausal women at high-risk for ovarian cancer
    Kimberly A Lowe
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:2480-7. 2008
    ..To evaluate if serum levels of candidate ovarian cancer biomarkers vary with individual characteristics of healthy women who are likely candidates for an ovarian cancer screening program...
  27. pmc Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: the Women's Health Initiative Dietary Modification Trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98019, USA
    Am J Clin Nutr 89:1864-76. 2009
    ..The effects of dietary changes on osteoporosis, low bone density, and frequent falls are unestablished...
  28. pmc Evaluating erythropoietin-associated tumor progression using archival tissues from a phase III clinical trial
    Chris P Miller
    Department of Medicine Hematology and the Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
    Stem Cells 27:2353-61. 2009
    ..Our results provide a framework for exploring the relationship between Epo, cancer progression, and survival using archival tumors from other Phase III clinical trials...
  29. pmc The temporal stability of the Symptom Index among women at high-risk for ovarian cancer
    Kimberly A Lowe
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Gynecol Oncol 114:225-30. 2009
    ..To evaluate the temporal stability of self-reported symptoms known to be associated with ovarian cancer...
  30. pmc Comparison of breast cancer to healthy control tissue discovers novel markers with potential for prognosis and early detection
    Michel Schummer
    Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 5:e9122. 2010
    ....
  31. pmc Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
    Wataru Sakai
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nature 451:1116-20. 2008
    ..Our results suggest that secondary mutations that restore the wild-type BRCA2 reading frame may be a major clinical mediator of acquired resistance to platinum-based chemotherapy...
  32. ncbi request reprint Examining the cost-effectiveness of cancer screening promotion
    M Robyn Andersen
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98102 1024, USA
    Cancer 101:1229-38. 2004
    ..The authors showed that CEA can be a valuable tool for understanding the merits of health promotion interventions and that CEA is particularly valuable in identifying screening strategies that might be promoted most cost-effectively...
  33. ncbi request reprint Compliance of average- and intermediate-risk women to semiannual ovarian cancer screening
    Charles W Drescher
    Swedish Hospital and Medical Center, 1101 Madison Street, Suite 1500, Seattle, WA 98104, USA
    Cancer Epidemiol Biomarkers Prev 13:600-6. 2004
    ....
  34. ncbi request reprint A parametric empirical Bayes method for cancer screening using longitudinal observations of a biomarker
    Martin W McIntosh
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue MP 900, Seattle, WA 98109, USA
    Biostatistics 4:27-40. 2003
    ..Our method was specifically developed for use in screening for cancer with a new biomarker, but it is appropriate whenever the pre-clinical behavior of the disease and/or biomarker is uncertain...
  35. ncbi request reprint The case for early detection
    Ruth Etzioni
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Rev Cancer 3:243-52. 2003
    ..been revitalized by the advent of novel molecular technologies that can identify cellular changes at the level of the genome or proteome, but how can we harness these new technologies to develop effective and practical screening tests?..
  36. ncbi request reprint Serologic analysis of ovarian tumor antigens reveals a bias toward antigens encoded on 17q
    Brad Stone
    Benaroya Research Institute at Virginia Mason Research Center, Seattle, WA 98101 2795, USA
    Int J Cancer 104:73-84. 2003
    ..Thus, these abnormal expression patterns combined with the endogenous immune response suggests that these antigens represent potential targets for immunotherapy...
  37. ncbi request reprint Analysis of the cost-effectiveness of mammography promotion by volunteers in rural communities
    M Robyn Andersen
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Health Educ Behav 29:755-70. 2002
    ..Exploratory analyses suggest that the most cost-effective method of promoting mammography use may vary with the target population...
  38. ncbi request reprint Costs and cost-effectiveness of a clinical intervention to increase mammography utilization in an inner city public health hospital
    Beti Thompson
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 702, Seattle, Washington 98109 1024, USA
    Prev Med 35:87-96. 2002
    ..Studies have demonstrated the cost-effectiveness of screening women for breast cancer; however, the cost-effectiveness of strategies to motivate women to receive breast cancer screening has been less well studied...
  39. ncbi request reprint Generating longitudinal screening algorithms using novel biomarkers for disease
    Martin W McIntosh
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:159-66. 2002
    ..The algorithm is particularly useful when screening with a new marker of which the behavior in the preclinical period is not well known...
  40. ncbi request reprint Using a population-based cancer registry for recruitment of newly diagnosed patients with ovarian cancer
    M Robyn Andersen
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Clin Oncol 28:17-20. 2005
    ..This information can be used to identify patients eligible for intervention trials...
  41. ncbi request reprint Worry about ovarian cancer risk and use of screening by high-risk women: how you recruit affects what you find
    M Robyn Andersen
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Med Genet A 129:130-5. 2004
    ..High-risk women recruited via mass mailing were less likely than those recruited via physicians or affected relatives to report either worry about their risk or use of ovarian cancer screening tests...
  42. ncbi request reprint Assertiveness with physicians is related to women's perceived roles in the medical encounter
    M Robyn Andersen
    Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
    Women Health 42:15-33. 2005
    ..Data are also presented on the development of a scale designed to assess assertiveness with physicians for use in studies of medical care...
  43. pmc Method for generation of in vivo biotinylated recombinant antibodies by yeast mating
    Nathalie Scholler
    Translational Outcomes Research Group, Molecular Diagnostics Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Immunol Methods 317:132-43. 2006
    ..8 x 10(-9) M and K(d)=5.1 x 10(-9) M before and after Ni-purification respectively. Thus, yeast mating permits cost-effective generation of biotinylated recombinant antibodies of high affinity...
  44. ncbi request reprint Changes in cancer worry associated with participation in ovarian cancer screening
    M Robyn Andersen
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Psychooncology 16:814-20. 2007
    ..Further research will be required to examine the possibility that screening reduces worry when women receive only normal, presumably reassuring, results...
  45. ncbi request reprint Validation and characterization of human kallikrein 11 as a serum marker for diagnosis of ovarian carcinoma
    Martin W McIntosh
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Clin Cancer Res 13:4422-8. 2007
    ..The human kallikrein 11 (hK11) marker has been reported to have favorable predictive value for ovarian cancer, although, by itself, it may be inferior to CA 125...
  46. pmc Development of a CA125-mesothelin cell adhesion assay as a screening tool for biologics discovery
    Nathalie Scholler
    Molecular Diagnostics Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109 1024, USA
    Cancer Lett 247:130-6. 2007
    ..We finally demonstrated that a mesothelin chimeric protein and anti-CA125 antibodies block CA125/mesothelin-dependent cell attachment...
  47. pmc Effects of blood collection conditions on ovarian cancer serum markers
    Jason D Thorpe
    Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 2:e1281. 2007
    ..By measuring the effects of differences in collection conditions on three different markers, we investigated the potential of these effects to bias validation studies...
  48. pmc An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription
    Emily C Knouf
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nucleic Acids Res 40:499-510. 2012
    ..This study delineates an integrative approach that can be applied to discover transcriptional regulatory mechanisms in other biological settings where analogous genomic data are available...
  49. pmc Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries
    Stacia K Wyman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 4:e5311. 2009
    ..A critical step toward these goals is to establish a comprehensive view of miRNAs expressed in epithelial ovarian cancer tissues as well as in normal ovarian surface epithelial cells...
  50. pmc Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery
    Sharon J Pitteri
    Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 4:e7916. 2009
    ..The goal of this work is to evaluate the utility of an integrative strategy using these two approaches for biomarker discovery...
  51. ncbi request reprint Use of the American College of Radiology BI-RADS guidelines by community radiologists: concordance of assessments and recommendations assigned to screening mammograms
    Constance Lehman
    Department of Radiology, University of Washington, Seattle Cancer Care Alliance, 825 Eastlake Ave, G4 830, Seattle, WA 98109 1023, USA
    AJR Am J Roentgenol 179:15-20. 2002
    ....
  52. ncbi request reprint Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial
    Lesley F Tinker
    Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
    Arch Intern Med 168:1500-11. 2008
    ..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women...
  53. ncbi request reprint Antibody immunity to the p53 oncogenic protein is a prognostic indicator in ovarian cancer
    Vivian Goodell
    Center for Translational Medicine in Women s Health, Tumor Vaccine Group, University of Washington, and the Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Clin Oncol 24:762-8. 2006
    ..We questioned whether antibody immunity specific for ovarian cancer tumor antigens would predict disease outcome. We evaluated humoral immune responses against ovarian cancer antigens p53, HER-2/neu, and topoisomerase IIalpha...
  54. pmc Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition
    Ausra Bendoraite
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Gynecol Oncol 116:117-25. 2010
    ..Our objective was to characterize the expression and function of the miR-200 family of microRNAs (miRNA) in ovarian carcinogenesis...
  55. ncbi request reprint Concordance of breast imaging reporting and data system assessments and management recommendations in screening mammography
    Stephen H Taplin
    Center for Health Studies, Group Health Cooperative of Puget Sound, 1730 Minor Ave, Suite 1600, Seattle, WA 98101, USA
    Radiology 222:529-35. 2002
    ..To examine how frequently Breast Imaging Reporting and Data System (BI-RADS) mammographic screening assessments were associated with expected clinical management recommendations...
  56. ncbi request reprint Proteins associated with Cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels
    Jennifer J Stewart
    The Institute for Systems Biology, Seattle, Washington 98103, USA
    Mol Cell Proteomics 5:433-43. 2006
    ..Several proteins may be involved in modulating response to cisplatin and have potential as markers of treatment response or treatment targets...
  57. pmc A mouse to human search for plasma proteome changes associated with pancreatic tumor development
    Vitor M Faca
    Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 5:e123. 2008
    ....
  58. pmc DNA hypermethylation, Her-2/neu overexpression and p53 mutations in ovarian carcinoma
    Qinghua Feng
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington, USA
    Gynecol Oncol 111:320-9. 2008
    ....
  59. pmc Epithelial phenotype confers resistance of ovarian cancer cells to oncolytic adenoviruses
    Robert Strauss
    Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Cancer Res 69:5115-25. 2009
    ..Our study provides a venue for improved virotherapy of cancer as well as new insights into cancer cell biology...
  60. pmc Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
    Elizabeth M Swisher
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA
    Cancer Res 68:2581-6. 2008
    ..Our results suggest that secondary mutations in BRCA1 can mediate resistance to platinum in BRCA1-mutated ovarian tumors...
  61. ncbi request reprint 10th Biennial Helene Harris Memorial Trust meeting
    Frances R Balkwill
    Barts and The London Queen Mary s School of Medicine and Dentistry, UK
    Cancer Res 66:2904-6. 2006
    ....

Research Grants8

  1. Modeling ovarian cancer screening for CEA
    Nicole Urban; Fiscal Year: 2002
    ..Ultimately, an enhanced microsimulation model that incorporates new developments, innovations of the future as well as those we recognize today, will help guide policy and research investment decisions. ..
  2. Modeling ovarian cancer screening for CEA
    Nicole Urban; Fiscal Year: 2003
    ..Ultimately, an enhanced microsimulation model that incorporates new developments, innovations of the future as well as those we recognize today, will help guide policy and research investment decisions. ..
  3. Modeling ovarian cancer screening for CEA
    Nicole Urban; Fiscal Year: 2004
    ..Ultimately, an enhanced microsimulation model that incorporates new developments, innovations of the future as well as those we recognize today, will help guide policy and research investment decisions. ..
  4. Modeling ovarian cancer screening for CEA
    Nicole Urban; Fiscal Year: 2005
    ..Ultimately, an enhanced microsimulation model that incorporates new developments, innovations of the future as well as those we recognize today, will help guide policy and research investment decisions. ..
  5. Prevention of Ovarian Cancer in Women Participating in Mammography
    Nicole Urban; Fiscal Year: 2007
    ....