Cornelia Ulrich

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc In silico experimentation with a model of hepatic mitochondrial folate metabolism
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Theor Biol Med Model 3:40. 2006
  2. pmc A mathematical model of glutathione metabolism
    Michael C Reed
    Department of Mathematics, Duke University, Durham, NC 27708, USA
    Theor Biol Med Model 5:8. 2008
  3. pmc UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R488-98. 2004
  4. pmc MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study
    Sonia S Maruti
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109 1024 USA
    Breast Cancer Res 11:R91. 2009
  5. ncbi Folate and cancer prevention--where to next? Counterpoint
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:2226-30. 2008
  6. doi Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:1822-31. 2008
  7. ncbi PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:616-9. 2005
  8. ncbi Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene
    C M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 9:1381-5. 2000
  9. ncbi Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, University of Washington, Seattle, Washington 98109 1024, USA
    Hum Mutat 26:394-5. 2005
  10. ncbi MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors
    C M Ulrich
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Nutr 135:2462-7. 2005

Detail Information

Publications79

  1. pmc In silico experimentation with a model of hepatic mitochondrial folate metabolism
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Theor Biol Med Model 3:40. 2006
    ....
  2. pmc A mathematical model of glutathione metabolism
    Michael C Reed
    Department of Mathematics, Duke University, Durham, NC 27708, USA
    Theor Biol Med Model 5:8. 2008
    ..Deficits in glutathione have been implicated in aging and a host of diseases including Alzheimer's disease, Parkinson's disease, cardiovascular disease, cancer, Down syndrome and autism...
  3. pmc UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R488-98. 2004
    ....
  4. pmc MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study
    Sonia S Maruti
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109 1024 USA
    Breast Cancer Res 11:R91. 2009
    ..Our aims were to investigate whether MTHFR C677T was associated with postmenopausal breast cancer risk and whether this relation was modified by intakes of folate, methionine, vitamins B(2), B(6), and B(12), and alcohol...
  5. ncbi Folate and cancer prevention--where to next? Counterpoint
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:2226-30. 2008
  6. doi Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:1822-31. 2008
    ..Although the proportional changes in biomarkers of risk with individual polymorphisms are frequently small, they may be quite relevant if present over an individual's lifetime...
  7. ncbi PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:616-9. 2005
    ....
  8. ncbi Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene
    C M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 9:1381-5. 2000
    ..The potential functional relevance of the common 6-bp deletion in the TS gene needs to be investigated, because this enzyme is plausibly of major importance not only in cancer treatment but also in cancer prevention...
  9. ncbi Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, University of Washington, Seattle, Washington 98109 1024, USA
    Hum Mutat 26:394-5. 2005
    ..Given the evolutionary evidence, these variants may be functional and therefore of relevance for disease endpoints related to inflammation and angiogenesis, as well as for the pharmacogenetics of non-steroidal anti-inflammatory drugs...
  10. ncbi MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors
    C M Ulrich
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Nutr 135:2462-7. 2005
    ..These results suggest a novel mechanism by which MTHFR polymorphisms can affect the risk of colon cancer...
  11. ncbi Nutrigenetics in cancer research--folate metabolism and colorectal cancer
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Nutr 135:2698-702. 2005
    ..This review illustrates knowledge that can be gained from molecular epidemiology in the context of nutrigenetics, and the questions that this approach can answer or raise...
  12. ncbi Folate supplementation: too much of a good thing?
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:189-93. 2006
  13. ncbi Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402 Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:2509-16. 2005
    ..A pathway-based approach to data analysis is needed to help discern the independent and combined effects of dietary intakes and genetic variability in folate metabolism...
  14. ncbi Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:889-93. 2004
    ..These preliminary findings require confirmation in larger studies of colorectal neoplasia...
  15. ncbi Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Rev Cancer 6:130-40. 2006
    ..These findings, and others that show that inherited genetic characteristics might determine preventive success, argue for new strategies that are tailored to individual medical history and genetic make-up...
  16. ncbi Cyclooxygenase 1 (COX1) polymorphisms in African-American and Caucasian populations
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, University of Washington, Seattle, WA 98109 1024, USA
    Hum Mutat 20:409-10. 2002
    ..More detailed phenotypic characterizations of these COX1 polymorphisms remain to be undertaken...
  17. ncbi Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 62:3361-4. 2002
    ..These findings raise questions regarding the molecular pathways linking folate metabolism and colorectal carcinogenesis, including whether high folate is beneficial in the presence of all metabolic genotypes...
  18. ncbi Cancer pharmacogenetics: polymorphisms, pathways and beyond
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nat Rev Cancer 3:912-20. 2003
  19. ncbi Pharmacogenetics and folate metabolism -- a promising direction
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 900, Seattle, WA 98109 1024, USA
    Pharmacogenomics 3:299-313. 2002
    ..Findings to date illustrate the potential for targeting therapy based on patients' genotypes with improved outcomes and reduced toxicity...
  20. ncbi Epoxide hydrolase Tyr113His polymorphism is associated with elevated risk of colorectal polyps in the presence of smoking and high meat intake
    C M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 10:875-82. 2001
    ....
  21. ncbi Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism
    C M Ulrich
    Public Health Sciences Division and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Blood 98:231-4. 2001
    ..23; 34% slower to 20 000/microL, P =.08). Patients with decreased MTHFR activity appear at risk of higher MTX toxicity. Because of the high prevalence of the TT genotype, these results may have implications for MTX dosage...
  22. ncbi Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps
    Elizabeth M Poole
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:502-8. 2006
    ..A more comprehensive investigation of genetic variability in prostaglandin synthesis in relation to risk of colorectal neoplasia and NSAID pharmacogenetics is warranted...
  23. ncbi Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy...
  24. pmc Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk
    Sonia S Maruti
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Clin Nutr 89:624-33. 2009
    ..Few epidemiologic studies have examined very high intakes of folate and whether consumption of nutrients involved in one-carbon metabolism is associated with breast cancer risk...
  25. ncbi Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk
    Ellen L Goode
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:157-62. 2004
    ..These findings add to what is known about the complexities of genetic variations in one-carbon-metabolizing enzymes in relation to colorectal carcinogenesis...
  26. pmc Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Carcinogenesis 28:1672-9. 2007
    ..1, 95% CI = 1.3-3.4 versus AA/high risk; P-interaction = 0.03). These results provide only limited support for a role of polymorphisms in one-carbon metabolism in the etiology of CIMP colon cancer...
  27. ncbi Associations between reproductive and menstrual factors and postmenopausal sex hormone concentrations
    Jessica Chubak
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:1296-301. 2004
    ....
  28. ncbi TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Int J Epidemiol 33:955-61. 2004
    ..A polymorphism in the signal peptide sequence of the TGFbeta1 gene (L10P) has been associated with increased levels of plasma TGFbeta1 in individuals with the P allele...
  29. doi DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps
    Audrey Y Jung
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:330-8. 2008
    ..01). These gene-diet interactions suggest that polymorphisms relevant to DNA methylation or alcohol metabolism may play a role in colorectal carcinogenesis in conjunction with a high-risk diet...
  30. pmc Genetic variation in calcium-sensing receptor and risk for colon cancer
    Linda M Dong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:2755-65. 2008
    ..We also examined interactions among CASR, calcium, and vitamin D intake and previously genotyped vitamin D-related genes...
  31. pmc C-reactive protein genotypes and haplotypes, polymorphisms in NSAID-metabolizing enzymes, and risk of colorectal polyps
    Elizabeth M Poole
    Fred Hutchinson Cancer Research Center, Seattle, University of Washington, Seattle, Washington, USA
    Pharmacogenet Genomics 19:113-20. 2009
    ..Polymorphisms in CRP have been associated with differential CRP concentrations among healthy adults, with some evidence for functional effects on CRP expression...
  32. ncbi Mismatch repair polymorphisms and colorectal polyps: hMLH1-93G>A variant modifies risk associated with smoking
    Joon Ho Yu
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109 1024, USA
    Am J Gastroenterol 101:1313-9. 2006
    ..The aim of our study was to determine if polymorphisms in the DNA MMR genes hMLH1 and hMSH6 are associated with an increased risk of colorectal polyps, and to evaluate interactions with exposures known to cause DNA damage...
  33. ncbi Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia
    Kim Robien
    Cancer Prevention Program, Public Health Division, University of Washington Cancer Center, Seattle, Washington, USA
    Biol Blood Marrow Transplant 12:973-80. 2006
    ..A direct trade-off between drug toxicity and drug efficacy may play a role. Alternatively, the systemic folate environment, regulated by host tissues, might influence donor T-cell growth and activity...
  34. pmc Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma
    Elizabeth M Poole
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 19:547-57. 2010
    ..Prostaglandins are metabolites of omega-6 and omega-3 polyunsaturated fatty acids; their biosynthesis is the primary target of nonsteroidal anti-inflammatory drugs (NSAID), which reduce colorectal neoplasia risk...
  35. ncbi Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women
    Charlotte Atkinson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:868-74. 2004
    ..Thus, this 12-month moderate intensity exercise intervention did not significantly alter urinary excretion of 2-OH E(1), 16alpha-OH E(1), or their ratio in this population of women...
  36. ncbi Pharmacogenetics of folate-related drug targets in cancer treatment
    Kim Robien
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
    Pharmacogenomics 6:673-89. 2005
    ..Findings to date illustrate a potential for targeting therapy based on patients' genotypes, in order to improve outcomes and reduce toxicity. However, larger, well-designed studies are needed to confirm these early findings...
  37. ncbi Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn, USA
    JAMA 289:323-30. 2003
    ..The increasing prevalence of obesity is a major public health concern. Physical activity may promote weight and body fat loss...
  38. ncbi Interindividual variation in nucleotide excision repair genes and risk of endometrial cancer
    Jocelyn M Weiss
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Occupational and Environmental Epidemiology Branch, 6120 Executive Boulevard, EPS 8123, MSC 7240, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 14:2524-30. 2005
    ..58; 95% CI, 0.35-0.96). Our data suggest that interindividual variation in XPA and XPC influences a woman's risk of endometrial cancer...
  39. ncbi MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer
    Karen Curtin
    University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Cancer Epidemiol Biomarkers Prev 13:285-92. 2004
    ..The possible interaction with hormone-replacement therapy warrants additional investigation...
  40. ncbi Polymorphisms predicted to alter function in prostaglandin E2 synthase and prostaglandin E2 receptors
    Jeannette Bigler
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Pharmacogenet Genomics 17:221-7. 2007
    ..Several lines of evidence implicate prostaglandin E2 in carcinogenesis; this study aimed to identify genetic variants in genes related to prostaglandin E2 synthesis and signaling...
  41. pmc Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors
    Page E Abrahamson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA, 98109 1024, USA
    Breast Cancer Res Treat 105:45-54. 2007
    ..These results provide little evidence that the CYP17, CYP1B1, and COMT polymorphisms are associated with different sex hormone levels in post-menopausal breast cancer survivors...
  42. ncbi Polymorphisms in DNA repair genes and associations with cancer risk
    Ellen L Goode
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:1513-30. 2002
    ..Such studies may benefit from analysis of multiple genes or polymorphisms and from the consideration of relevant exposures that may influence the likelihood of cancer in the presence of reduced DNA repair capacity...
  43. ncbi Predictors of diet quality among overweight and obese postmenopausal women
    Alanna Boynton
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA 98109 1024, USA
    J Am Diet Assoc 108:125-30. 2008
    ..In addition, these results suggest that the timing of smoking cessation is a possible teachable moment for food and nutrition professionals...
  44. ncbi Methylenetetrahydrofolate reductase genotype affects risk of relapse after hematopoietic cell transplantation for chronic myelogenous leukemia
    Kim Robien
    Cancer Prevention Program, Public Health Sciences Division and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Clin Cancer Res 10:7592-8. 2004
    ..We evaluated the association of these polymorphisms with risk of relapse and bcr-abl mRNA transcript detection among 336 Caucasian patients who underwent allogeneic hematopoietic cell transplantation for chronic myelogenous leukemia...
  45. pmc Frequent intentional weight loss is associated with higher ghrelin and lower glucose and androgen levels in postmenopausal women
    Laura E Hooper
    Department of Epidemiology, University of Washington, USA
    Nutr Res 30:163-70. 2010
    ..01). No independent associations between the concentrations of leptin or estrogens and weight cycling were observed. This study suggests that frequent intentional weight loss may affect hormones involved in energy regulation...
  46. ncbi Microsomal epoxide hydrolase polymorphisms are not associated with colon cancer risk
    Kim Robien
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1350-2. 2005
  47. ncbi Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential?
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:1012-8. 2002
    ..Overall, the similarity of the risk profiles of colorectal hyperplastic polyps, adenoma, and cancer provides additional support for the growing body of evidence that some hyperplastic polyps may have neoplastic potential...
  48. ncbi Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Int J Cancer 120:2226-32. 2007
    ..This study provides some support for associations between TS genotype and colon cancer tumor characteristics...
  49. ncbi Folate and cancer--timing is everything
    Cornelia M Ulrich
    JAMA 297:2408-9. 2007
  50. pmc The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Genes Chromosomes Cancer 47:835-44. 2008
    ....
  51. pmc Does folic acid supplementation prevent or promote colorectal cancer? Results from model-based predictions
    E Georg Luebeck
    Fred Hutchinson Cancer Research Center, Biostatistics and Biomathematics, 1100 Fairview Avenue North, M2 B500, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1360-7. 2008
    ..Experimental studies are needed to provide direct evidence for this dual role of folate in colorectal cancer and to validate and improve the model predictions...
  52. pmc Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors
    Marian L Neuhouser
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Clin Nutr 88:133-9. 2008
    ..Little is known about vitamin D status in breast cancer survivors. This issue is important because vitamin D influences pathways related to carcinogenesis...
  53. doi Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women
    Julie A Meyers
    Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
    J Endocrinol 199:51-60. 2008
    ..Our study does not support a link between leptin and other immune parameters among overweight or obese, but otherwise healthy postmenopausal women, perhaps because such effects are only present at low or deficient leptin concentrations...
  54. pmc No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women
    Kristin L Campbell
    Cancer Prevention Program, The Fred Hutchinson Cancer Research Center, Public Health Sciences, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1714-8. 2008
    ....
  55. ncbi The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women
    Shelley S Tworoger
    Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Obes Res 12:972-81. 2004
    ..These genes metabolize estrogens and androgens, which are important in body fat regulation...
  56. ncbi Frequent intentional weight loss is associated with lower natural killer cell cytotoxicity in postmenopausal women: possible long-term immune effects
    Erin D Shade
    University of Washington Medical Center, University of Washington, Seattle, WA, USA
    J Am Diet Assoc 104:903-12. 2004
    ..The question of whether this pattern has negative health effects is unresolved. The objective of this research was to investigate associations between weight-loss history and current measures of immune function...
  57. pmc A pilot study of sampling subcutaneous adipose tissue to examine biomarkers of cancer risk
    Kristin L Campbell
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Prev Res (Phila) 2:37-42. 2009
    ..Subcutaneous adipose tissue biopsies from healthy, overweight individuals provide adequate amounts for RNA extraction, gene expression, and other assays of relevance to cancer prevention research...
  58. pmc Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk
    Linda M Dong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:2540-8. 2009
    ..As this is the first study to evaluate these genes in relation to colon cancer, additional studies are needed to confirm these results...
  59. doi Intentional weight loss and risk of lymphohematopoietic cancers
    Anneclaire J De Roos
    Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 21:223-36. 2010
    ..We hypothesized that intentional weight loss may be associated with development of lymphohematopoietic cancers, based on observations of immune suppression following weight loss in short-term studies...
  60. ncbi Mailing strategies and recruitment into an intervention trial of the exercise effect on breast cancer biomarkers
    Shelley S Tworoger
    Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:73-7. 2002
    ..Our study indicates that bulk mail may be more cost-effective than first-class mail for recruitment into intervention trials and that older women are willing to participate in such studies...
  61. ncbi Prostaglandin H synthases: members of a class of quasi-linear threshold switches
    William D Hazelton
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2 B500 Seattle, WA 98109 1024, USA
    Biochem Pharmacol 68:423-32. 2004
    ..Mathematical modeling helps explain how these adaptations enable the PTGS1 and PTGS2 enzymes to maintain their physiological roles while avoiding potentially damaging consequences...
  62. ncbi Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
    Cancer Epidemiol Biomarkers Prev 13:1099-105. 2004
    ..The association between exercise and breast cancer risk may be partly explained by the effects of exercise on these hormones...
  63. ncbi DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps
    Jeannette Bigler
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M5 A864, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:2501-8. 2005
    ..38; 95% CI, 0.25-7.65). Our data suggest that polymorphisms in DNA repair genes may be risk factors for colorectal neoplasia and that they may exacerbate the effects of exposures to carcinogens...
  64. ncbi Associations between reproductive and menstrual factors and postmenopausal androgen concentrations
    Jessica Chubak
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Womens Health (Larchmt) 14:704-12. 2005
    ....
  65. ncbi COX-2 and gastric cancer: More on inflammation and neoplasia
    John D Potter
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Gastroenterology 130:2198-200. 2006
  66. ncbi Nucleotide excision repair genotype and the incidence of endometrial cancer: effect of other risk factors on the association
    Jocelyn M Weiss
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Gynecol Oncol 103:891-6. 2006
    ..Certain nucleotide excision repair (NER) genotypes appear to be associated with an altered risk of endometrial cancer. These associations could be modified by characteristics and exposures that themselves influence risk of disease...
  67. ncbi Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial
    Laura Lewis Frank
    Fred Hutchinson Cancer Research Center, Cancer Prevention, Seattle, WA 98109 1024, USA
    Obes Res 13:615-25. 2005
    ..This study examined the effects of exercise on metabolic risk variables insulin, leptin, glucose, and triglycerides in overweight/obese postmenopausal women...
  68. ncbi No effect of exercise on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1020-1. 2005
  69. pmc DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas?
    William M Grady
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Gut 56:318-20. 2007
  70. doi Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review
    Christine M Velicer
    Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
    J Clin Oncol 26:665-73. 2008
    ....
  71. ncbi Associations between healthy eating patterns and immune function or inflammation in overweight or obese postmenopausal women
    Alanna Boynton
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA 98109 1024, USA
    Am J Clin Nutr 86:1445-55. 2007
    ..The link between poor nutritional status and impaired immune function is well established; however, most studies have focused on individual nutrients instead of overall dietary patterns...
  72. pmc Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer
    Anna E Coghill
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Gut 60:491-8. 2011
    ..The role of prediagnostic NSAID use was therefore examined in relation to colorectal cancer-specific survival among cases from the Seattle Colon Cancer Family Registry (Seattle Colon CFR)...
  73. ncbi Influence of demographic, physiologic, and psychosocial variables on adherence to a yearlong moderate-intensity exercise trial in postmenopausal women
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Prev Med 39:1080-6. 2004
    ..We examined the patterns of adherence to a yearlong exercise intervention and the influence of demographic, physiologic, and psychosocial variables on patterns of adherence among 173 sedentary, overweight, postmenopausal women...
  74. ncbi A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism
    Michael C Reed
    Department of Mathematics, Duke University, Durham, NC 27708, USA
    J Nutr 136:2653-61. 2006
    ..These mathematical simulations of folate-mediated 1-carbon metabolism provide a cost-efficient approach to in silico experimentation that can complement and help guide laboratory studies...
  75. ncbi Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps
    Elizabeth M Poole
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Carcinogenesis 28:1259-63. 2007
    ..33-1.09). The opposite association was observed among those with COX-1 17PL or LL genotypes (p-interaction = 0.04). Our results suggest that the effects of dietary n-3 PUFA intake and NSAID use may differ by genetic variation in COX-1...
  76. ncbi Moderate-intensity exercise reduces the incidence of colds among postmenopausal women
    Jessica Chubak
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, Wash 98109 1024, USA
    Am J Med 119:937-42. 2006
    ..Our aim was to assess the effect of a moderate-intensity, year-long exercise program on the risk of colds and other upper respiratory tract infections in postmenopausal women...
  77. ncbi Effects of an exercise intervention on other health behaviors in overweight/obese post-menopausal women
    Isaac Rhew
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, University of Washington, School of Public Health and Community Medicine, Department of Epidemiology, Seattle, WA, 98109 1024, United States
    Contemp Clin Trials 28:472-81. 2007
    ..If other behaviors do change with increasing physical activity, this would complicate interpretation of differences in study outcomes in exercise intervention trials...
  78. pmc Correlates of circulating C-reactive protein and serum amyloid A concentrations in breast cancer survivors
    Brandon L Pierce
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 114:155-67. 2009
    ..Inflammatory status may be an important prognostic factor for breast cancer. Correlates of markers of inflammation in breast cancer survivors have not been thoroughly evaluated...
  79. ncbi Folate and cancer prevention: a closer look at a complex picture
    Cornelia M Ulrich
    Am J Clin Nutr 86:271-3. 2007

Research Grants23

  1. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia Ulrich; Fiscal Year: 2009
    ..Through this research, we will learn more about how to prevent colorectal cancer and about possible public health recommendations based on genetic characteristics. ..
  2. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia M Ulrich; Fiscal Year: 2010
    ..Through this research, we will learn more about how to prevent colorectal cancer and about possible public health recommendations based on genetic characteristics. ..
  3. Prostaglandin Synthesis, Genetics and Colorectal Cancer
    Cornelia M Ulrich; Fiscal Year: 2010
    ..They will also advance tailoring of chemoprevention in a way that maximizes benefit and minimizes toxicity. ..
  4. Exercise effects on oxidative damage among women
    Cornelia Ulrich; Fiscal Year: 2007
    ..In summary, this application builds on existing high quality data from a previously established randomized controlled trial to examine the effect of a 1-year of moderate-intensity exercise program on a novel biomarker of cancer risk. ..
  5. Genetic Study of Prostaglandin Synthesis/EGFR and Risk of Colorectal Neoplasia
    Cornelia Ulrich; Fiscal Year: 2007
    ..This study of genetic variation in the prostaglandin/EGFR pathway will provide insights into the complex process of colorectal carcinogenesis, and increase understanding of the pharmacogenetics of NSAID chemoprevention. ..
  6. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2003
    ..Finally, we plan to develop a model for integrating information on genetic variability at multiple points in this metabolic pathway. ..
  7. Prostaglandin Synthesis, Genetics and Colorectal Cancer
    Cornelia Ulrich; Fiscal Year: 2006
    ..They will also advance tailoring of chemoprevention in a way that maximizes benefit and minimizes toxicity. ..
  8. Prostaglandin Synthesis, Genetics and Colorectal Cancer
    Cornelia Ulrich; Fiscal Year: 2007
    ..They will also advance tailoring of chemoprevention in a way that maximizes benefit and minimizes toxicity. ..
  9. Modeling Folate, One-Carbon Metabolism & DNA Methylation
    Cornelia Ulrich; Fiscal Year: 2007
    ..We plan to make the model generally available to the research community, and anticipate that it will become a useful tool that can be used as an adjunct to experimental investigations and as an aid to study design. ..
  10. NSAID and COX/PG Metabolism and Colorectal Cancer
    Cornelia Ulrich; Fiscal Year: 2009
    ..Ultimately, such information on the metabolic variation will be useful in optimizing NSAIDs and NSAID regimens and will allow individual tailoring of chemoprevention. ..