STEPHEN TAPSCOTT

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206
    Miriam I Rosenberg
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 175:77-85. 2006
  2. pmc Intrinsic epigenetic regulation of the D4Z4 macrosatellite repeat in a transgenic mouse model for FSHD
    Yvonne D Krom
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Genet 9:e1003415. 2013
  3. pmc Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene
    Lauren Snider
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 6:e1001181. 2010
  4. pmc Comparison of endogenous and overexpressed MyoD shows enhanced binding of physiologically bound sites
    Zizhen Yao
    Human Biology Division, Seattle, WA, USA
    Skelet Muscle 3:8. 2013
  5. pmc miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells
    Kyle L MacQuarrie
    Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, C3 168, Seattle, WA, 98109, USA
    Skelet Muscle 2:7. 2012
  6. pmc Inhibition of CD26/DPP-IV enhances donor muscle cell engraftment and stimulates sustained donor cell proliferation
    Maura H Parker
    Program in Transplantation Biology, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Mailstop D1 100, Seattle, WA, 98109 1024, USA
    Skelet Muscle 2:4. 2012
  7. ncbi request reprint Deconstructing myotonic dystrophy
    S J Tapscott
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 289:1701-2. 2000
  8. ncbi request reprint Fragile-X syndrome and myotonic dystrophy: parallels and paradoxes
    S J Tapscott
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Curr Opin Genet Dev 8:245-53. 1998
  9. pmc Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters
    Yi Cao
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    EMBO J 25:502-11. 2006
  10. ncbi request reprint Large DNA palindromes as a common form of structural chromosome aberrations in human cancers
    Hisashi Tanaka
    Division of Basic Sciences, Fred Hitchinson Cancer Research Center, Seattle, Washington, USA
    Hum Cell 19:17-23. 2006

Research Grants

  1. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2004
  2. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2005
  3. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2005
  4. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2006
  5. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2006
  6. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2007
  7. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2007
  8. 2007 Myogenesis Gordon Conference
    STEPHEN TAPSCOTT; Fiscal Year: 2007
  9. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2009
  10. PRECLINICAL GENE THERAPY STUDIES IN CANINE MUSCULAR DYSTROPHY
    STEPHEN TAPSCOTT; Fiscal Year: 2009

Collaborators

Detail Information

Publications51

  1. pmc MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206
    Miriam I Rosenberg
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 175:77-85. 2006
    ..These findings demonstrate that MyoD, in addition to activating muscle-specific genes, induces miRNAs that repress gene expression during skeletal muscle differentiation...
  2. pmc Intrinsic epigenetic regulation of the D4Z4 macrosatellite repeat in a transgenic mouse model for FSHD
    Yvonne D Krom
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Genet 9:e1003415. 2013
    ..These transgenic mice therefore represent a valuable animal model for FSHD and will be a useful resource to study the molecular mechanisms underlying FSHD and to test new therapeutic intervention strategies...
  3. pmc Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene
    Lauren Snider
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 6:e1001181. 2010
    ..Therefore, FSHD represents the first human disease to be associated with the incomplete developmental silencing of a retrogene array normally expressed early in development...
  4. pmc Comparison of endogenous and overexpressed MyoD shows enhanced binding of physiologically bound sites
    Zizhen Yao
    Human Biology Division, Seattle, WA, USA
    Skelet Muscle 3:8. 2013
    ....
  5. pmc miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells
    Kyle L MacQuarrie
    Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, C3 168, Seattle, WA, 98109, USA
    Skelet Muscle 2:7. 2012
    ..abstract:..
  6. pmc Inhibition of CD26/DPP-IV enhances donor muscle cell engraftment and stimulates sustained donor cell proliferation
    Maura H Parker
    Program in Transplantation Biology, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Mailstop D1 100, Seattle, WA, 98109 1024, USA
    Skelet Muscle 2:4. 2012
    ..abstract:..
  7. ncbi request reprint Deconstructing myotonic dystrophy
    S J Tapscott
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 289:1701-2. 2000
    ..In a Perspective, Tapscott explains how findings from a new mouse model of DM (Mankodi et al.) could solve this paradox...
  8. ncbi request reprint Fragile-X syndrome and myotonic dystrophy: parallels and paradoxes
    S J Tapscott
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Curr Opin Genet Dev 8:245-53. 1998
    ..At both loci, expansion is associated with altered chromatin, aberrant methylation, and suppressed expression of the adjacent FMR1 and DMAHP genes, implicating epigenetic mediation of these genetic diseases...
  9. pmc Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters
    Yi Cao
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    EMBO J 25:502-11. 2006
    ..Therefore, the role of Myog in mediating terminal differentiation is, in part, to enhance expression of a subset of genes previously initiated by Myod...
  10. ncbi request reprint Large DNA palindromes as a common form of structural chromosome aberrations in human cancers
    Hisashi Tanaka
    Division of Basic Sciences, Fred Hitchinson Cancer Research Center, Seattle, Washington, USA
    Hum Cell 19:17-23. 2006
    ..A subset of loci containing palindromes is associated with gene amplification in Colo320DM, indicating that the location of palindromes in the cancer genome serves as a structural platform that supports subsequent gene amplification...
  11. ncbi request reprint Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Development 134:3371-82. 2007
    ..Our results reveal that Pbx proteins modulate Myod activity to drive fast-muscle gene expression, thus showing that homeodomain proteins can direct bHLH proteins to establish a specific cell-type identity...
  12. pmc Pbx acts with Hand2 in early myocardial differentiation
    Lisa Maves
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 333:409-18. 2009
    ..Our findings demonstrate new roles for Pbx proteins in vertebrate cardiac development and also provide new insight into connections between the transcriptional regulation of skeletal and cardiac muscle differentiation programs...
  13. pmc Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming
    Yi Cao
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 18:662-74. 2010
    ..Therefore, in addition to regulating muscle gene expression, MyoD binds genome wide and has the ability to broadly alter the epigenome in myoblasts and myotubes...
  14. ncbi request reprint Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential
    Charlotte A Berkes
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell 14:465-77. 2004
    ..This demonstrates a specific mechanism of targeting MyoD to loci in inactive chromatin and reveals a critical role of homeodomain proteins in marking specific genes for activation in the muscle lineage...
  15. ncbi request reprint Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression
    Donald A Bergstrom
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell 9:587-600. 2002
    ..The identification of distinct molecular mechanisms that regulate discrete subprograms of myogenesis should facilitate analyses of differentiation in normal development and disease...
  16. ncbi request reprint Gene expression in Huntington's disease skeletal muscle: a potential biomarker
    Andrew D Strand
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 14:1863-76. 2005
    ..Furthermore, an understanding of the molecular basis of muscle dysfunction in HD should provide insight into mechanisms involved in neuronal abnormalities and neurodegeneration...
  17. pmc RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy
    Lauren Snider
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 18:2414-30. 2009
    ..Together, we have identified new sense and anti-sense RNA transcripts, novel mRNAs and mi/siRNA-sized RNA fragments generated from the D4Z4 units that are new candidates for the pathophysiology of FSHD...
  18. ncbi request reprint Widespread and nonrandom distribution of DNA palindromes in cancer cells provides a structural platform for subsequent gene amplification
    Hisashi Tanaka
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nat Genet 37:320-7. 2005
    ..Genome-wide analysis of palindrome formation is a new approach to identify structural chromosome aberrations associated with cancer...
  19. ncbi request reprint Emerging parallels in the generation and regeneration of skeletal muscle
    Lauren Snider
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cell 113:811-2. 2003
    ..show that Wnt signaling induces myogenesis in adult muscle stem cells in a manner analogous to muscle induction in the somite...
  20. pmc Cell-lineage regulated myogenesis for dystrophin replacement: a novel therapeutic approach for treatment of muscular dystrophy
    En Kimura
    Department of Neurology, University of Washington School of Medicine, Seattle, WA 98195 7720, USA
    Hum Mol Genet 17:2507-17. 2008
    ..Our study provides a proof of concept for a novel gene/stem cell therapy technique and opens another potential therapeutic approach for degenerative muscle disorders...
  21. pmc Intrastrand annealing leads to the formation of a large DNA palindrome and determines the boundaries of genomic amplification in human cancer
    Hisashi Tanaka
    Fred Hutchinson Cancer Reserach Center, Seattle, WA 98109, USA
    Mol Cell Biol 27:1993-2002. 2007
    ..Therefore, an early step of gene amplification is a regulated process that is facilitated by DNA inverted repeats in the genome...
  22. pmc XIC is required for Siamois activity and dorsoanterior development
    Lauren Snider
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Mol Cell Biol 25:5061-72. 2005
    ..The data indicate a role for XIC in limiting Tcf3-dependent repression of Siamois activities that are required for goosecoid transcription and for dorsal organizer formation...
  23. ncbi request reprint Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs
    Chiara Dell'agnola
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 104:4311-8. 2004
    ..1% donor contribution...
  24. ncbi request reprint BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect
    Andrew R Hallahan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nat Med 9:1033-8. 2003
    ....
  25. ncbi request reprint The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription
    Stephen J Tapscott
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Development 132:2685-95. 2005
    ..These studies are beginning to merge our understanding of how lineage-specific information is encoded in chromatin with how master regulatory factors drive programs of cell differentiation...
  26. pmc A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation
    Bennett H Penn
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 18:2348-53. 2004
    ....
  27. pmc RNA-binding protein Muscleblind-like 3 (MBNL3) disrupts myocyte enhancer factor 2 (Mef2) {beta}-exon splicing
    Kyung Soon Lee
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 2780, USA
    J Biol Chem 285:33779-87. 2010
    ..These studies suggest that elevating MBNL3 activity in myogenic cells could lead to muscle degeneration disorders such as myotonic dystrophy...
  28. pmc DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences
    Scott J Diede
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 107:234-9. 2010
    ..This finding warrants strong consideration for DNA demethylating agents in future clinical trials for children with this disease...
  29. pmc MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state
    Zhihong Yang
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 23:694-707. 2009
    ....
  30. pmc Networking the nucleus
    Indika Rajapakse
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Syst Biol 6:395. 2010
    ..Studying the interaction within and among networks provides a useful framework for investigating the complex organization and dynamic function of the nucleus...
  31. pmc Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice
    Olga Klezovitch
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 18:559-71. 2004
    ....
  32. ncbi request reprint Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppression
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Ther 15:1160-6. 2007
    ..This protocol has potential applications to human clinical trials to enhance AAV-mediated therapies...
  33. pmc Immune responses to AAV in canine muscle monitored by cellular assays and noninvasive imaging
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Ther 18:617-24. 2010
    ..These assays should be incorporated into future human clinical trials of AAV gene therapy to monitor immune responses...
  34. pmc Expression of human alpha1-antitrypsin in mice and dogs following AAV6 vector-mediated gene transfer to the lungs
    Christine L Halbert
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Mol Ther 18:1165-72. 2010
    ....
  35. pmc In vitro transcription system delineates the distinct roles of the coactivators pCAF and p300 during MyoD/E47-dependent transactivation
    F Jeffrey Dilworth
    Division of Human Biology, Fred Hutchinson Cancer Research Center, and Department of Pathology, University of Washington School of Medicine, 1100 Fairview Avenue North C3 168, P O Box 19024, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 101:11593-8. 2004
    ..Further dissection of this in vitro transcription system should be highly useful toward elucidating the mechanism by which coactivators facilitate differential gene expression by MyoD...
  36. ncbi request reprint Selective instability: maternal effort and the evolution of gene activation and deactivation rates
    Carlo C Maley
    Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109 1024, USA
    Artif Life 9:317-26. 2003
    ....
  37. ncbi request reprint Regulation of neuroD2 expression in mouse brain
    Chin Hsing Lin
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 265:234-45. 2004
    ....
  38. pmc Short inverted repeats initiate gene amplification through the formation of a large DNA palindrome in mammalian cells
    Hisashi Tanaka
    Division of Basic Sciences and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 99:8772-7. 2002
    ..This finding suggests that short inverted repeats in the mammalian genome can have a critical role in the initiation of gene amplification. This specific mechanism may provide a novel target for cancer therapies...
  39. pmc Gene therapy in large animal models of muscular dystrophy
    Zejing Wang
    Division of Clinical Research, Fred Hutchinson Cancer Research Center in Seattle, Washington 98109, USA
    ILAR J 50:187-98. 2009
    ..Because of the complex nature of these diseases, it may be necessary to combine multiple approaches to achieve a successful treatment...
  40. pmc CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination
    Randell T Libby
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, USA
    PLoS Genet 4:e1000257. 2008
    ....
  41. ncbi request reprint Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophy
    Zejing Wang
    Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Gene Ther 18:18-26. 2007
    ..Our data indicate that AAV2 and AAV6 capsid proteins can elicit primary cellular immune responses when injected into the skeletal muscle of random-bred dogs, and suggest the possibility of cellular immunity to AAV vectors in humans...
  42. ncbi request reprint Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF
    Diane H Cho
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell 20:483-9. 2005
    ....
  43. ncbi request reprint Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain
    Ruth Luthi-Carter
    Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Hum Mol Genet 11:1911-26. 2002
    ..The complete dataset is available at www.neumetrix.info...
  44. ncbi request reprint Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1
    Shigeru Sato
    Department of Biology, Jichi Medical School, Minamikawachi, Tochigi 329 0498, Japan
    Hum Mol Genet 11:1045-58. 2002
    ..Our results not only identify Six5 as an activator that directs Igfbp5 expression but also suggest that reduced SIX5 expression in DM1 might contribute to specific aspects of the DM1 phenotype...
  45. ncbi request reprint MyoD and the transcriptional control of myogenesis
    Charlotte A Berkes
    Colorado College, Colorado Springs, CO 80903, USA
    Semin Cell Dev Biol 16:585-95. 2005
    ..This review highlights recent studies regarding the molecular mechanisms by which the muscle-specific myogenic bHLH proteins interact with other regulatory factors to coordinate gene expression in a controlled and ordered manner...
  46. ncbi request reprint Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation
    Sara T Winokur
    Department of Biological Chemistry, 202 Sprague Hall, University of California, Irvine, CA 92697, USA
    Hum Mol Genet 12:2895-907. 2003
    ..Improper nuclear localization of 4qter is discussed as an alternative model for FSHD gene regulation and pathogenesis...
  47. pmc Reciprocal inhibition between Pax7 and muscle regulatory factors modulates myogenic cell fate determination
    Hugo C Olguin
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Biol 177:769-79. 2007
    ..This could represent an additional mechanism for the control of satellite cell fate decisions resulting in proliferation, differentiation, and self-renewal, necessary for skeletal muscle maintenance and repair...
  48. pmc MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex
    Ivana L de la Serna
    University of Massachusetts Medical School, Department of Cell Biology, 55 Lake Avenue North, Worcester, MA 01655, USA
    Mol Cell Biol 25:3997-4009. 2005
    ....
  49. ncbi request reprint Regulation of thalamocortical patterning and synaptic maturation by NeuroD2
    Gulayse Ince-Dunn
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 49:683-95. 2006
    ..These observations indicate that NeuroD2 plays a critical role in regulating synaptic maturation and the patterning of thalamocortical connections...
  50. ncbi request reprint The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation
    Giuseppina Caretti
    Muscle Gene Expression Group, Laboratory of Muscle Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20829, USA
    Dev Cell 11:547-60. 2006
    ..These findings reveal that p68/p72 play a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling...
  51. pmc Essential role for Dicer during skeletal muscle development
    Jason R O'Rourke
    Department of Molecular Genetics and Microbiology and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32610 0266, USA
    Dev Biol 311:359-68. 2007
    ..These observations demonstrate key roles for Dicer in skeletal muscle and implicate miRNAs as critical components required for embryonic myogenesis...

Research Grants34

  1. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2004
    ..The health relatedness is that understanding the normal role of CTG/CAG repeats in the genome will give new insight into their role in generating tissue specific diseases. ..
  2. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2005
    ..abstract_text> ..
  3. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2005
    ..The health relatedness is that understanding the normal role of CTG/CAG repeats in the genome will give new insight into their role in generating tissue specific diseases. ..
  4. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2006
    ..abstract_text> ..
  5. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2006
    ..The health relatedness is that understanding the normal role of CTG/CAG repeats in the genome will give new insight into their role in generating tissue specific diseases. ..
  6. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2007
    ..abstract_text> ..
  7. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2007
    ..The health relatedness is that understanding the normal role of CTG/CAG repeats in the genome will give new insight into their role in generating tissue specific diseases. ..
  8. 2007 Myogenesis Gordon Conference
    STEPHEN TAPSCOTT; Fiscal Year: 2007
    ..abstract_text> ..
  9. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2009
    ..The knowledge from these studies will identify new therapeutic targets and strategies for the development of novel, differentiation based therapies. ..
  10. PRECLINICAL GENE THERAPY STUDIES IN CANINE MUSCULAR DYSTROPHY
    STEPHEN TAPSCOTT; Fiscal Year: 2009
    ..better understanding of the immunogenicity of AAV and developing even better and less toxic immunosuppression regimens will increase the likelihood of achieving the goal of effective gene therapy for human Duchenne muscular dystrophy ..
  11. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2009
    ..This will provide new insight into the network mechanisms that regulate transitional states in mammalian cell differentiation. ..
  12. D4Z4 Coding Transcripts and FSHD
    Stephen J Tapscott; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The human health relatedness of this proposal is that it will identify possible molecular causes of FSHD and provide a basis for future therapeutic development. ..
  13. LINEAGE DETERMINATION IN MUSCLE
    Stephen J Tapscott; Fiscal Year: 2010
    ..The knowledge from these studies will identify new therapeutic targets and strategies for the development of novel, differentiation based therapies. ..
  14. PRECLINICAL GENE THERAPY STUDIES IN CANINE MUSCULAR DYSTROPHY
    Stephen J Tapscott; Fiscal Year: 2010
    ..better understanding of the immunogenicity of AAV and developing even better and less toxic immunosuppression regimens will increase the likelihood of achieving the goal of effective gene therapy for human Duchenne muscular dystrophy ..
  15. Gordon Research Conference on Myogenesis
    STEPHEN TAPSCOTT; Fiscal Year: 2004
    ..abstract_text> ..
  16. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2004
    ..abstract_text> ..
  17. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 1999
    ....
  18. NEUROD AND NEUROGENESIS
    STEPHEN TAPSCOTT; Fiscal Year: 1999
    ..Th health relatedness of this work is that the ability to generate neurons and neuroendocrine cells will be critical for the treatment of numerous human diseases. ..
  19. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 1999
    ....
  20. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2000
    ....
  21. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2000
    ....
  22. NEUROD AND NEUROGENESIS
    STEPHEN TAPSCOTT; Fiscal Year: 2000
    ..Th health relatedness of this work is that the ability to generate neurons and neuroendocrine cells will be critical for the treatment of numerous human diseases. ..
  23. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2001
    ....
  24. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2001
    ....
  25. NEUROD AND NEUROGENESIS
    STEPHEN TAPSCOTT; Fiscal Year: 2001
    ..Th health relatedness of this work is that the ability to generate neurons and neuroendocrine cells will be critical for the treatment of numerous human diseases. ..
  26. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2002
    ....
  27. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2002
    ....
  28. LINEAGE DETERMINATION IN MUSCLE
    STEPHEN TAPSCOTT; Fiscal Year: 2003
    ..abstract_text> ..
  29. MYOTONIC DYSTROPHY LOCUS CONTROL
    STEPHEN TAPSCOTT; Fiscal Year: 2003
    ..The health relatedness is that understanding the normal role of CTG/CAG repeats in the genome will give new insight into their role in generating tissue specific diseases. ..
  30. PRECLINICAL GENE THERAPY STUDIES IN CANINE MUSCULAR DYSTROPHY
    Stephen J Tapscott; Fiscal Year: 2010
    ..Reducing the immunogenicity of AAV vectors and developing better and less toxic immunosuppression regimens will increase the likelihood of achieving the goal of effective gene therapy for human DMD. ..