Hua Tang

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Estimation of individual admixture: analytical and study design considerations
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genet Epidemiol 28:289-301. 2005
  2. pmc Controlling for false positive findings of trans-hubs in expression quantitative trait loci mapping
    Jie Peng
    Department of Statistics, University of California, Davis, California 95616, USA
    BMC Proc 1:S157. 2007
  3. ncbi request reprint Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Genet 119:624-33. 2006
  4. pmc Combining multiple family-based association studies
    Hua Tang
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    BMC Proc 1:S162. 2007
  5. pmc Reconstructing genetic ancestry blocks in admixed individuals
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Hum Genet 79:1-12. 2006
  6. pmc Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Hum Genet 76:268-75. 2005
  7. pmc Genetic architecture of skin and eye color in an African-European admixed population
    Sandra Beleza
    Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 9:e1003372. 2013
  8. pmc Ethnicity and human genetic linkage maps
    Eric Jorgenson
    Department of Genetics, Stanford University, Stanford, CA, USA
    Am J Hum Genet 76:276-90. 2005
  9. doi request reprint African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Women's Health Initiative
    MARCO V PEREZ
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA Electronic address
    Am Heart J 166:566-72. 2013
  10. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009

Research Grants

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Estimation of individual admixture: analytical and study design considerations
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genet Epidemiol 28:289-301. 2005
    ..g., simulations) not possible by Bayesian methods. Our simulation results demonstrate that inclusion of ancestral populations or their surrogates in the analysis is required by any method of IA estimation to obtain reasonable results...
  2. pmc Controlling for false positive findings of trans-hubs in expression quantitative trait loci mapping
    Jie Peng
    Department of Statistics, University of California, Davis, California 95616, USA
    BMC Proc 1:S157. 2007
    ..After correlations among expressions were accounted for, the previously detected trans-hubs are no longer significant. Our results suggest that conclusions regarding regulation hot spots should be treated with great caution...
  3. ncbi request reprint Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Genet 119:624-33. 2006
    ..Excess obesity among Native Americans compared to whites is not consistent with a simple genetic explanation...
  4. pmc Combining multiple family-based association studies
    Hua Tang
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    BMC Proc 1:S162. 2007
    ....
  5. pmc Reconstructing genetic ancestry blocks in admixed individuals
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Hum Genet 79:1-12. 2006
    ..One application of our method is to perform admixture mapping without genotyping special ancestry-informative-marker panels...
  6. pmc Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Hum Genet 76:268-75. 2005
    ..S. population. Implications of this genetic structure for case-control association studies are discussed...
  7. pmc Genetic architecture of skin and eye color in an African-European admixed population
    Sandra Beleza
    Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 9:e1003372. 2013
    ....
  8. pmc Ethnicity and human genetic linkage maps
    Eric Jorgenson
    Department of Genetics, Stanford University, Stanford, CA, USA
    Am J Hum Genet 76:276-90. 2005
    ..The results of our investigation have implications for inferences of possible genetic influences on human recombination as well as for future linkage studies, especially those involving populations of nonwhite ethnicity...
  9. doi request reprint African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Women's Health Initiative
    MARCO V PEREZ
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA Electronic address
    Am Heart J 166:566-72. 2013
    ..Rates of AF are lower in African American subjects compared with European Americans, suggesting European ancestry could contribute to AF risk...
  10. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009
    ..To focus on African ancestry, we reduced the data to include only those genotypes in each African American determined statistically to be African in origin...
  11. pmc Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations
    Marc A Coram
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 92:904-16. 2013
    ....
  12. pmc Variation and genetic control of protein abundance in humans
    Linfeng Wu
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 499:79-82. 2013
    ..This study demonstrates the feasibility of high-throughput human proteome quantification that, when integrated with DNA variation and transcriptome information, adds a new dimension to the characterization of gene expression regulation. ..
  13. pmc Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations
    Sophie I Candille
    Department of Genetics, Stanford University, Stanford, California, United States of America
    PLoS ONE 7:e48294. 2012
    ..Interestingly, we also see that in each of these four populations, men are more lightly pigmented in the unexposed skin of the inner arm than women, a fact that is underappreciated and may vary across the world...
  14. pmc Joint testing of genotype and ancestry association in admixed families
    Hua Tang
    Department of Genetics, School of Medicine, Stanford University, Stanford, California 94305, USA
    Genet Epidemiol 34:783-91. 2010
    ..The efficiencies of the allele, ancestry and combined tests are compared in the context of a GWAS. We discuss the impact of population history and provide guidelines for future design and analysis of GWAS in admixed populations...
  15. pmc Estimating kinship in admixed populations
    Timothy Thornton
    Department of Biostatistics, University of Washington, Seattle, 98195, USA
    Am J Hum Genet 91:122-38. 2012
    ..We also apply REAP to the African American and Hispanic samples from the Women's Health Initiative SNP Health Association Resource (WHI-SHARe) study, in which hundreds of pairs of cryptically related individuals have been identified...
  16. pmc Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women
    Alex P Reiner
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Hum Genet 91:502-12. 2012
    ..The genetic architecture underlying the CRP phenotype in AA women is complex and involves genetic variants shared across populations, as well as variants specific to populations of African descent...
  17. ncbi request reprint A statistical method for chromatographic alignment of LC-MS data
    Pei Wang
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Biostatistics 8:357-67. 2007
    ..We illustrate the performance of PETAL on example data sets...
  18. ncbi request reprint Quality control metrics for LC-MS feature detection tools demonstrated on Saccharomyces cerevisiae proteomic profiles
    Brian D Piening
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, Washington, 98109, USA
    J Proteome Res 5:1527-34. 2006
    ..This work is done on complex LC-MS profiles of Saccharomyces cerevisiae which present a significant challenge to peptide feature detection algorithms...
  19. pmc Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    Hum Mol Genet 17:2320-8. 2008
    ..Further investigations in other populations are needed to confirm or refute our findings...
  20. pmc Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project
    Paul L Auer
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Am J Hum Genet 91:794-808. 2012
    ....
  21. pmc Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe)
    Cara L Carty
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 21:711-20. 2012
    ..Specifically, we identify new loci that may reflect population-specific regulation of height and report several known height loci that are important in determining height in African-descent populations...
  22. pmc Locally weighted transmission/disequilibrium test for genetic association analysis
    Li Hsu
    Modeling and Methods, Biostatistics Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA
    BMC Genet 6:S60. 2005
    ..As an illustration, we applied the method to the simulated Aipotu data...
  23. doi request reprint Worldwide human relationships inferred from genome-wide patterns of variation
    Jun Z Li
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Science 319:1100-4. 2008
    ..This data set allows the most comprehensive characterization to date of human genetic variation...
  24. pmc Detecting genomic aberrations using products in a multiscale analysis
    Xuesong Yu
    Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biometrics 66:684-93. 2010
    ..A simulation study investigates the finite sample performance of the proposed method and compares it with a more standard sequential testing method. The method is illustrated using two real data sets...
  25. pmc Molecular and evolutionary history of melanism in North American gray wolves
    Tovi M Anderson
    Departments of Genetics and Pediatrics, Stanford University, Stanford, CA 94305, USA
    Science 323:1339-43. 2009
    ....
  26. pmc Human genetic variation altering anthrax toxin sensitivity
    Mikhail Martchenko
    Department of Genetics and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:2972-7. 2012
    ..Testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility...
  27. pmc Categorization of humans in biomedical research: genes, race and disease
    Neil Risch
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Genome Biol 3:comment2007. 2002
    ..An epidemiologic perspective on the issue of human categorization in biomedical and genetic research strongly supports the continued use of self-identified race and ethnicity...
  28. pmc Geographic distribution of disease mutations in the Ashkenazi Jewish population supports genetic drift over selection
    Neil Risch
    Department of Genetics, Stanford University, Standford, CA 94305, USA
    Am J Hum Genet 72:812-22. 2003
    ....
  29. pmc Genomewide evolutionary rates in laboratory and wild yeast
    James Ronald
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genetics 174:541-4. 2006
    ..It has been suggested that a commonly used S. cerevisiae strain has rapidly accumulated mutations in the lab. We report a low-to-intermediate rate of protein evolution in this strain relative to wild isolates...
  30. pmc Recent genetic selection in the ancestral admixture of Puerto Ricans
    Hua Tang
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
    Am J Hum Genet 81:626-33. 2007
    ..Two of these regions harbor genes for olfactory receptors. Interestingly, all three regions exhibit deficiencies in the European-ancestry proportion...
  31. pmc Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94304 1334, USA
    J Am Coll Cardiol 56:1552-63. 2010
    ..We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD)...
  32. pmc Frequentist estimation of coalescence times from nucleotide sequence data using a tree-based partition
    Hua Tang
    Department of Statistics, Stanford University, Stanford, California 94305, USA
    Genetics 161:447-59. 2002
    ..Performance of this estimator is compared with existing methods based on the coalescence theory. The method is applied to sequences of Y chromosomes and mtDNAs to estimate the coalescent times of human male and female populations...
  33. pmc Reduced selection leads to accelerated gene loss in Shigella
    Ruth Hershberg
    Department of Biological Sciences, Stanford University, Serra Mall, Stanford, CA 94305, USA
    Genome Biol 8:R164. 2007
    ..It was suggested that the increased gene loss in obligate pathogens may be due to a reduction in the effectiveness of purifying selection. Less attention has been given to the causes of increased gene loss in facultative pathogens...
  34. ncbi request reprint Confronting ethnicity-specific disease risk
    Hua Tang
    Nat Genet 38:13-5. 2006
  35. ncbi request reprint Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics
    Keyan Salari
    Department of Medicine, University of California, San Francisco, California 94143 1732, USA
    Genet Epidemiol 29:76-86. 2005
    ..These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation...
  36. ncbi request reprint A classical likelihood based approach for admixture mapping using EM algorithm
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 2160 S First Ave, Maywood, IL 60153, USA
    Hum Genet 120:431-45. 2006
    ..The software ADMIXPROGRAM for performing admixture mapping is available from authors...
  37. pmc Genome-wide distribution of ancestry in Mexican Americans
    Analabha Basu
    Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Ave, Room 901H HSW, San Francisco, CA 94143, USA
    Hum Genet 124:207-14. 2008
    ..These locations may harbor genes that have been subjected to natural selection after the ancestral mixing giving rise to Mexicans...
  38. ncbi request reprint Studies on repository compound stability in DMSO under various conditions
    Xueheng Cheng
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    J Biomol Screen 8:292-304. 2003
    ..Compound recovery was also measured from glass and polypropylene containers for 5 months at room temperature, and no significant difference was found for these 2 types of containers...
  39. doi request reprint Admixture mapping and the role of population structure for localizing disease genes
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Adv Genet 60:547-69. 2008
    ..In this chapter, we describe the recent methodology and software development, review successful applications, and comment on the future of this approach...
  40. ncbi request reprint Prediction of steady-state skin permeabilities of polar and nonpolar permeants across excised pig skin based on measurements of transient diffusion: characterization of hydration effects on the skin porous pathway
    Hua Tang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge 02139 4307, USA
    J Pharm Sci 91:1891-907. 2002
    ....
  41. ncbi request reprint The importance of race and ethnic background in biomedical research and clinical practice
    Esteban Gonzalez Burchard
    Lung Biology Center, University of California, San Francisco, CA 94143 0833, USA
    N Engl J Med 348:1170-5. 2003
  42. ncbi request reprint [Genetic analysis of segregation distortion of molecular markers in maize F2 population]
    Jian Bing Yan
    National Key Lab of Crop Genetic Improvement, Huanzhong Agricultural University, Wuhan 430070, China
    Yi Chuan Xue Bao 30:913-8. 2003
    ..Regarding to QTL analysis with single locus, segregation distortion would not affect QTL mapping, but regarding to analysis of digenic interactions for epistasis, the fewer distortion markers and larger size population would be needed...
  43. ncbi request reprint A universal evolutionary index for amino acid changes
    Hua Tang
    Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA
    Mol Biol Evol 21:1548-56. 2004
    ..The codon-based, empirically determined EI (i.e., U*R) makes much better predictions on protein evolution than do previous methods...
  44. ncbi request reprint Admixture mapping for hypertension loci with genome-scan markers
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 2160 S First Ave, Maywood, Illinois 60153, USA
    Nat Genet 37:177-81. 2005
    ..These results suggest that chromosome 6q24 and 21q21 may contain genes influencing risk of hypertension in African Americans...
  45. pmc Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human
    Huai Dong Song
    State Key Laboratory for Medical Genomics Pôle Sino Français de Recherche en Sciences du Vivant et Génomique, Ruijin Hospital Affiliated to Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China
    Proc Natl Acad Sci U S A 102:2430-5. 2005
    ....
  46. ncbi request reprint A newly discovered founder population: the Roma/Gypsies
    Luba Kalaydjieva
    Western Australian Institute for Medical Research and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, Australia
    Bioessays 27:1084-94. 2005
    ..The string of population bottlenecks and founder effects have shaped a unique genetic profile, whose potential for genetic research can be met only by study designs that acknowledge cultural tradition and self-identity...
  47. ncbi request reprint A new method for estimating nonsynonymous substitutions and its applications to detecting positive selection
    Hua Tang
    Department of Ecology and Evolution, University of Chicago, USA
    Mol Biol Evol 23:372-9. 2006
    ..Many genes with Ka/Ks > 0.5 can now be shown to have Kh/Ks > 1 and to have evolved adaptively, at least for the high-exchangeability group of amino acid changes...
  48. ncbi request reprint Population stratification confounds genetic association studies among Latinos
    Shweta Choudhry
    University of California, San Francisco, 94143 0833, USA
    Hum Genet 118:652-64. 2006
    ..Our findings suggest that empirical assessment of the effects of stratification is critical to appropriately interpret the results of case-control studies in admixed populations...
  49. pmc Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution
    Jun Gojobori
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 104:3907-12. 2007
    ..These patterns suggest that negative and positive selection operate more effectively on the same set of amino acid changes and that approximately 10-13% of amino acid substitutions between humans and chimpanzee may be adaptive...
  50. pmc Dissecting complex diseases in complex populations: asthma in latino americans
    Shweta Choudhry
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2911, USA
    Proc Am Thorac Soc 4:226-33. 2007
    ....
  51. ncbi request reprint Effect of linkage disequilibrium between markers in linkage and association analyses
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Genet Epidemiol 31:S139-48. 2007
    ....
  52. ncbi request reprint Effects of low-frequency ultrasound on the transdermal permeation of mannitol: comparative studies with in vivo and in vitro skin
    Hua Tang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge 02139 4307, USA
    J Pharm Sci 91:1776-94. 2002
    ..This result suggests that LFS represents a good method of enhancing the systemic absorption of hydrophilic permeants, while it does not significantly alter the vehicle-to-skin partition coefficient for the same class of permeants...

Research Grants1

  1. Genetic Admixture and Confounding in Association Studies
    Hua Tang; Fiscal Year: 2007
    ..Genotypic data from various multiethnic studies will be used together with extensive simulation experiments to test and refine the methodology for real-world applications. ..