Genomes and Genes
Anne M Stevens
Affiliation: Fred Hutchinson Cancer Research Center
- Polymyositis as a manifestation of chronic graft-versus-host diseaseA M Stevens
Immunogenetics D2 100, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue NE, Seattle, WA 98109, USA
Rheumatology (Oxford) 42:34-9. 2003..To investigate the relationship between chronic GVHD and idiopathic myositis we conducted a detailed analysis of all cases of myositis occurring in a large series of HSCT patients...
- Foreign cells in polymyositis: could stem cell transplantation and pregnancy-derived chimerism lead to the same disease?Anne M Stevens
Immunogenetics Department, Fred Hutchinson Cancer Research Center, PO Box 19024, D2 100, 1100 Fairview Avenue NE, Seattle, WA 98109, USA
Curr Rheumatol Rep 5:437-44. 2003..Thus, PM can be added to the list of potentially allo-autoimmune diseases in which pregnancy-derived microchimerism may play a role...
- Myocardial-tissue-specific phenotype of maternal microchimerism in neonatal lupus congenital heart blockAnne M Stevens
Fred Hutchinson Cancer Research Center, Immunogenetics, Seattle, WA 98109, USA
Lancet 362:1617-23. 2003..The most serious complication of NLS is inflammation of the atrioventricular node leading to congenital heart block (CHB)...
- Liver biopsies from human females contain male hepatocytes in the absence of transplantationAnne M Stevens
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Lab Invest 84:1603-9. 2004..Whether fetal cells play a role in autoimmune diseases like PBC merits further investigation...
- Maternal and sibling microchimerism in twins and triplets discordant for neonatal lupus syndrome-congenital heart blockA M Stevens
Immunogenetics, D2 100, P O Box 19024, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109, USA
Rheumatology (Oxford) 44:187-91. 2005..In this study we asked whether levels of microchimerism in the blood are associated with NLS-CHB in discordant twins and triplets...
- Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerismJ Lee Nelson
Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 104:1637-42. 2007..Thus, T1D patients have higher levels of MMc in their circulation than unaffected siblings and healthy individuals, and MMc contributes to islet beta cells in a mother's progeny...
- Chimeric maternal cells with tissue-specific antigen expression and morphology are common in infant tissuesAnne M Stevens
Center for Immunity and Immunotherapy, Children s Hospital Research Institute, Seattle, WA 98101, USA
Pediatr Dev Pathol 12:337-46. 2009..Loss of tolerance to maternal parenchymal cells could lead to organ-specific "auto" inflammatory disease and elimination of maternal cells in areas of inflammation...
- Maternal HLA class II compatibility in men with systemic lupus erythematosusAnne M Stevens
Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
Arthritis Rheum 52:2768-73. 2005..Male subjects were selected in order to avoid confounding due to fetal microchimerism, which may occur in women...
- NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune diseaseNobuyoshi Hanaoka
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Immunol 185:5732-42. 2010....
- Male microchimerism in women without sons: quantitative assessment and correlation with pregnancy historyZhen Yan
Program in Human Immunogenetics, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
Am J Med 118:899-906. 2005..We investigated male microchimerism in women without sons and examined correlation with prior pregnancy history. Immunologic consequences of microchimerism are unknown. We studied healthy women and women with rheumatoid arthritis (RA)...
- Microchimeric cells in systemic lupus erythematosus: targets or innocent bystanders?A M Stevens
Department of Pediatrics, University of Washington, Childrens Hospital and Regional Medical Center, 307 Westlake Ave N, Suite 300, Seattle, WA 98109, Washington, USA
Lupus 15:820-6. 2006..Future studies will address how the host immune system normally tolerates maternal and fetal cells or how the balance may change during autoimmunity...
- From the simple detection of microchimerism in patients with autoimmune diseases to its implication in pathogenesisN C Lambert
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Ann N Y Acad Sci 945:164-71. 2001..Detection of microchimerism has to be quantitatively studied in the context of genetic factors in order to study its relationship to the pathogenesis of autoimmune diseases...
- TNF-α and TGF-β counter-regulate PD-L1 expression on monocytes in systemic lupus erythematosusJing Ni Ou
Seattle Children s Research Institute University of Washington, Seattle, WA, USA
Sci Rep 2:295. 2012..As PD-L1 functions to fine tune lymphocyte activation, dysregulation of cytokines resulting in reduced expression could lead to loss of peripheral T cell tolerance...
- Are pediatric autoimmune diseases primarily genetic diseases?Elizabeth A Shaw
Division of Rheumatology, Department of Pediatrics, University of Washington, Children s Hospital and Regional Medical Center, Seattle, Washington, USA
Curr Opin Rheumatol 20:589-94. 2008..We also introduce novel concepts for nontraditional modes of genetic inheritance that may be important in the pathogenesis of autoimmunity...
- Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupusZhenpeng Dai
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Exp Med 206:793-805. 2009..As classical regulatory T cell functions are typically impaired in SLE, it may be clinically significant that the immunosuppressive NKG2D(+)CD4(+) T cells appear functionally uncompromised in this disease...
- Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1N Mozaffarian
Seattle Children s Hospital Research Institute, 1900 Ninth Avenue, 7th Floor, Seattle, WA 98101, USA
Rheumatology (Oxford) 47:1335-41. 2008..Several studies have strongly linked dysfunction of APC, including mDC, to the pathogenesis of SLE. The objective of this study was to determine whether APC expressed PD-L1 protein at normal levels during active lupus...
- The changing maternal "self" hypothesis: a mechanism for maternal tolerance of the fetusK M Adams
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, P O Box 19024, Seattle, WA 98109 1024, USA
Placenta 28:378-82. 2007..Thus, during pregnancy maternal immunologic "self" includes fetal HLA Class II as a result of apoptotic syncytiotrophoblast uptake by maternal tolerogenic dendritic cells...