Anne M Stevens

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Polymyositis as a manifestation of chronic graft-versus-host disease
    A M Stevens
    Immunogenetics D2 100, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue NE, Seattle, WA 98109, USA
    Rheumatology (Oxford) 42:34-9. 2003
  2. ncbi request reprint Foreign cells in polymyositis: could stem cell transplantation and pregnancy-derived chimerism lead to the same disease?
    Anne M Stevens
    Immunogenetics Department, Fred Hutchinson Cancer Research Center, PO Box 19024, D2 100, 1100 Fairview Avenue NE, Seattle, WA 98109, USA
    Curr Rheumatol Rep 5:437-44. 2003
  3. ncbi request reprint Myocardial-tissue-specific phenotype of maternal microchimerism in neonatal lupus congenital heart block
    Anne M Stevens
    Fred Hutchinson Cancer Research Center, Immunogenetics, Seattle, WA 98109, USA
    Lancet 362:1617-23. 2003
  4. ncbi request reprint Liver biopsies from human females contain male hepatocytes in the absence of transplantation
    Anne M Stevens
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Lab Invest 84:1603-9. 2004
  5. ncbi request reprint Maternal and sibling microchimerism in twins and triplets discordant for neonatal lupus syndrome-congenital heart block
    A M Stevens
    Immunogenetics, D2 100, P O Box 19024, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109, USA
    Rheumatology (Oxford) 44:187-91. 2005
  6. pmc Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism
    J Lee Nelson
    Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 104:1637-42. 2007
  7. pmc Chimeric maternal cells with tissue-specific antigen expression and morphology are common in infant tissues
    Anne M Stevens
    Center for Immunity and Immunotherapy, Children s Hospital Research Institute, Seattle, WA 98101, USA
    Pediatr Dev Pathol 12:337-46. 2009
  8. ncbi request reprint Maternal HLA class II compatibility in men with systemic lupus erythematosus
    Anne M Stevens
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
    Arthritis Rheum 52:2768-73. 2005
  9. pmc NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease
    Nobuyoshi Hanaoka
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 185:5732-42. 2010
  10. ncbi request reprint Male microchimerism in women without sons: quantitative assessment and correlation with pregnancy history
    Zhen Yan
    Program in Human Immunogenetics, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
    Am J Med 118:899-906. 2005

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Polymyositis as a manifestation of chronic graft-versus-host disease
    A M Stevens
    Immunogenetics D2 100, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue NE, Seattle, WA 98109, USA
    Rheumatology (Oxford) 42:34-9. 2003
    ..To investigate the relationship between chronic GVHD and idiopathic myositis we conducted a detailed analysis of all cases of myositis occurring in a large series of HSCT patients...
  2. ncbi request reprint Foreign cells in polymyositis: could stem cell transplantation and pregnancy-derived chimerism lead to the same disease?
    Anne M Stevens
    Immunogenetics Department, Fred Hutchinson Cancer Research Center, PO Box 19024, D2 100, 1100 Fairview Avenue NE, Seattle, WA 98109, USA
    Curr Rheumatol Rep 5:437-44. 2003
    ..Thus, PM can be added to the list of potentially allo-autoimmune diseases in which pregnancy-derived microchimerism may play a role...
  3. ncbi request reprint Myocardial-tissue-specific phenotype of maternal microchimerism in neonatal lupus congenital heart block
    Anne M Stevens
    Fred Hutchinson Cancer Research Center, Immunogenetics, Seattle, WA 98109, USA
    Lancet 362:1617-23. 2003
    ..The most serious complication of NLS is inflammation of the atrioventricular node leading to congenital heart block (CHB)...
  4. ncbi request reprint Liver biopsies from human females contain male hepatocytes in the absence of transplantation
    Anne M Stevens
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Lab Invest 84:1603-9. 2004
    ..Whether fetal cells play a role in autoimmune diseases like PBC merits further investigation...
  5. ncbi request reprint Maternal and sibling microchimerism in twins and triplets discordant for neonatal lupus syndrome-congenital heart block
    A M Stevens
    Immunogenetics, D2 100, P O Box 19024, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109, USA
    Rheumatology (Oxford) 44:187-91. 2005
    ..In this study we asked whether levels of microchimerism in the blood are associated with NLS-CHB in discordant twins and triplets...
  6. pmc Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism
    J Lee Nelson
    Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 104:1637-42. 2007
    ..Thus, T1D patients have higher levels of MMc in their circulation than unaffected siblings and healthy individuals, and MMc contributes to islet beta cells in a mother's progeny...
  7. pmc Chimeric maternal cells with tissue-specific antigen expression and morphology are common in infant tissues
    Anne M Stevens
    Center for Immunity and Immunotherapy, Children s Hospital Research Institute, Seattle, WA 98101, USA
    Pediatr Dev Pathol 12:337-46. 2009
    ..Loss of tolerance to maternal parenchymal cells could lead to organ-specific "auto" inflammatory disease and elimination of maternal cells in areas of inflammation...
  8. ncbi request reprint Maternal HLA class II compatibility in men with systemic lupus erythematosus
    Anne M Stevens
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
    Arthritis Rheum 52:2768-73. 2005
    ..Male subjects were selected in order to avoid confounding due to fetal microchimerism, which may occur in women...
  9. pmc NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease
    Nobuyoshi Hanaoka
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 185:5732-42. 2010
    ....
  10. ncbi request reprint Male microchimerism in women without sons: quantitative assessment and correlation with pregnancy history
    Zhen Yan
    Program in Human Immunogenetics, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
    Am J Med 118:899-906. 2005
    ..We investigated male microchimerism in women without sons and examined correlation with prior pregnancy history. Immunologic consequences of microchimerism are unknown. We studied healthy women and women with rheumatoid arthritis (RA)...
  11. ncbi request reprint Microchimeric cells in systemic lupus erythematosus: targets or innocent bystanders?
    A M Stevens
    Department of Pediatrics, University of Washington, Childrens Hospital and Regional Medical Center, 307 Westlake Ave N, Suite 300, Seattle, WA 98109, Washington, USA
    Lupus 15:820-6. 2006
    ..Future studies will address how the host immune system normally tolerates maternal and fetal cells or how the balance may change during autoimmunity...
  12. ncbi request reprint From the simple detection of microchimerism in patients with autoimmune diseases to its implication in pathogenesis
    N C Lambert
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Ann N Y Acad Sci 945:164-71. 2001
    ..Detection of microchimerism has to be quantitatively studied in the context of genetic factors in order to study its relationship to the pathogenesis of autoimmune diseases...
  13. pmc TNF-α and TGF-β counter-regulate PD-L1 expression on monocytes in systemic lupus erythematosus
    Jing Ni Ou
    Seattle Children s Research Institute University of Washington, Seattle, WA, USA
    Sci Rep 2:295. 2012
    ..As PD-L1 functions to fine tune lymphocyte activation, dysregulation of cytokines resulting in reduced expression could lead to loss of peripheral T cell tolerance...
  14. ncbi request reprint Are pediatric autoimmune diseases primarily genetic diseases?
    Elizabeth A Shaw
    Division of Rheumatology, Department of Pediatrics, University of Washington, Children s Hospital and Regional Medical Center, Seattle, Washington, USA
    Curr Opin Rheumatol 20:589-94. 2008
    ..We also introduce novel concepts for nontraditional modes of genetic inheritance that may be important in the pathogenesis of autoimmunity...
  15. pmc Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus
    Zhenpeng Dai
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Exp Med 206:793-805. 2009
    ..As classical regulatory T cell functions are typically impaired in SLE, it may be clinically significant that the immunosuppressive NKG2D(+)CD4(+) T cells appear functionally uncompromised in this disease...
  16. pmc Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1
    N Mozaffarian
    Seattle Children s Hospital Research Institute, 1900 Ninth Avenue, 7th Floor, Seattle, WA 98101, USA
    Rheumatology (Oxford) 47:1335-41. 2008
    ..Several studies have strongly linked dysfunction of APC, including mDC, to the pathogenesis of SLE. The objective of this study was to determine whether APC expressed PD-L1 protein at normal levels during active lupus...
  17. ncbi request reprint The changing maternal "self" hypothesis: a mechanism for maternal tolerance of the fetus
    K M Adams
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, P O Box 19024, Seattle, WA 98109 1024, USA
    Placenta 28:378-82. 2007
    ..Thus, during pregnancy maternal immunologic "self" includes fetal HLA Class II as a result of apoptotic syncytiotrophoblast uptake by maternal tolerogenic dendritic cells...