J L Stanford

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint A polymorphism in the CYP17 gene and risk of prostate cancer
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:243-7. 2002
  2. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
  3. pmc Breast implants following mastectomy in women with early-stage breast cancer: prevalence and impact on survival
    Gem M Le
    Northern California Cancer Center, Fremont, California, USA
    Breast Cancer Res 7:R184-93. 2005
  4. pmc Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer
    Liesel M FitzGerald
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    BMC Cancer 8:230. 2008
  5. pmc Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Am J Epidemiol 172:578-90. 2010
  6. ncbi request reprint Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study
    J L Stanford
    Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle 98109 1024, USA
    JAMA 283:354-60. 2000
  7. ncbi request reprint Vasectomy and risk of prostate cancer
    J L Stanford
    Division of Public Health Sciences, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 8:881-6. 1999
  8. pmc Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 18:1839-48. 2009
  9. ncbi request reprint Association of HPC2/ELAC2 polymorphisms with risk of prostate cancer in a population-based study
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:876-81. 2003
  10. ncbi request reprint Prostate cancer and genetic susceptibility: a genome scan incorporating disease aggressiveness
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Prostate 66:317-25. 2006

Research Grants

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint A polymorphism in the CYP17 gene and risk of prostate cancer
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:243-7. 2002
    ..It is also possible that CYP17 interacts with other genes that influence risk of familial prostate cancer...
  2. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
    ..Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive...
  3. pmc Breast implants following mastectomy in women with early-stage breast cancer: prevalence and impact on survival
    Gem M Le
    Northern California Cancer Center, Fremont, California, USA
    Breast Cancer Res 7:R184-93. 2005
    ..Few studies have examined the effect of breast implants after mastectomy on long-term survival in breast cancer patients, despite growing public health concern over potential long-term adverse health effects...
  4. pmc Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer
    Liesel M FitzGerald
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    BMC Cancer 8:230. 2008
    ..These associations suggest the hypothesis that the gene fusion may be used as a prognostic indicator for prostate cancer...
  5. pmc Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Am J Epidemiol 172:578-90. 2010
    ..These results contribute further evidence that aspirin may have chemopreventive activity against prostate cancer and highlight the need for additional research...
  6. ncbi request reprint Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study
    J L Stanford
    Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle 98109 1024, USA
    JAMA 283:354-60. 2000
    ..Patients with prostate cancer and their physicians need knowledge of treatment options and their potential complications, but limited data on complications are available in unselected population-based cohorts of patients...
  7. ncbi request reprint Vasectomy and risk of prostate cancer
    J L Stanford
    Division of Public Health Sciences, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 8:881-6. 1999
    ..This study suggests that vasectomy is not associated with the risk of developing prostate cancer. It also provides evidence that vasectomized men may be more likely to present with earlier-stage, lower-grade prostate tumors...
  8. pmc Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 18:1839-48. 2009
    ....
  9. ncbi request reprint Association of HPC2/ELAC2 polymorphisms with risk of prostate cancer in a population-based study
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:876-81. 2003
    ..We estimate that the Ser217Leu genotype may account for approximately 14% of less aggressive prostate cancer cases and 9% of all sporadic cases in the general United States population of white men <age 65 years...
  10. ncbi request reprint Prostate cancer and genetic susceptibility: a genome scan incorporating disease aggressiveness
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Prostate 66:317-25. 2006
    ..Linkage studies attempting to map genes for hereditary prostate cancer (HPC) have proved challenging, and one potential problem contributing to this challenge is the variability in disease phenotypes...
  11. ncbi request reprint Genetic linkage analysis of prostate cancer families to Xq27-28
    M A Peters
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Hum Hered 51:107-13. 2001
    ..Here we report on linkage analysis at this putative HPCX locus in an independent set of 186 prostate cancer families participating in the Prostate Cancer Genetic Research Study (PROGRESS)...
  12. ncbi request reprint Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer
    Crystal N Holick
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, USA
    Cancer Epidemiol Biomarkers Prev 16:1990-9. 2007
    ..Our findings suggest that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer...
  13. ncbi request reprint Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer
    D C Farrow
    Fred Hutchinson Cancer Research Center, and University of Washington, School of Public Health and Community Medicine, Department of Epidemiology, Seattle 98109 1024, USA
    Cancer Causes Control 11:231-8. 2000
    ....
  14. ncbi request reprint Clinical characteristics of prostate cancer in an analysis of linkage to four putative susceptibility loci
    E L Goode
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, 98195-7236, USA
    Clin Cancer Res 7:2739-49. 2001
    ..Stratification by clinical characteristics may be a useful tool in prostate cancer linkage analyses and may increase our understanding of hereditary prostate cancer...
  15. ncbi request reprint Germline mutations in the p73 gene do not predispose to familial prostate-brain cancer
    M A Peters
    Division of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 48:292-6. 2001
    ..In 1997 a reported tumor suppressor with high homology to p53, termed p73, was mapped to the p36 region of chromosome one. Here, we examine the p73 gene as a potential candidate for CAPB...
  16. pmc Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis
    L M Fitzgerald
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Prostate Cancer Prostatic Dis 12:192-7. 2009
    ..Although our results confirm an association between FGFR4 and prostate cancer risk in radical prostatectomy cases, they suggest that the role of FGFR4 in disease risk and outcomes at a population-based level appears to be minor...
  17. pmc Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer
    I Agalliu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Br J Cancer 97:826-31. 2007
    ..However, we estimate that <1% of early-onset prostate cancers in the general US Caucasian population can be attributed to these rare disease-associated BRCA2 mutations...
  18. pmc Association of caveolin-1 and -2 genetic variants and post-treatment serum caveolin-1 with prostate cancer risk and outcomes
    Wendy J Langeberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 70:1020-35. 2010
    ..This study evaluated the relationship between post-treatment serum cav-1 levels and single nucleotide polymorphisms (SNPs) in the cav-1 and -2 genes with risk of PC, aggressive PC, PC recurrence or death...
  19. pmc CYP17 polymorphisms and prostate cancer outcomes
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Prostate 70:1094-101. 2010
    ..However, studies relating prostate cancer outcomes with CYP17 gene variants have conflicting results. In this study we analyzed Single Nucleotide Polymorphisms (SNPs) spanning the CYP17 gene for association with PCa survival...
  20. ncbi request reprint Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study
    Joanna M Lubieniecka
    Division of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 59:357-9. 2004
    ..The transmembrane serine protease 2 (TMPRSS2) gene encodes a type II transmembrane protein which, due to its cell surface localization, could be a potentially useful predictive marker for PCa...
  21. pmc Clinical utility of five genetic variants for predicting prostate cancer risk and mortality
    Claudia A Salinas
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 69:363-72. 2009
    ..3 and a family history of the disease may predict risk of prostate cancer. The present study tests the performance of these factors in prediction models for prostate cancer risk and prostate cancer-specific mortality...
  22. doi request reprint Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1203-13. 2008
    ....
  23. ncbi request reprint Glutathione S-transferase M1, T1, and P1 polymorphisms and prostate cancer risk in middle-aged men
    Ilir Agalliu
    Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 66:146-56. 2006
    ..The glutathione S-transferase (GST) enzymes detoxify several carcinogens. Genetic polymorphisms in GSTM1, T1, and P1 (Ile105Val) have been associated with prostate cancer, however, results have been inconsistent across studies...
  24. ncbi request reprint Family history of cancer and risk of esophageal and gastric cancers in the United States
    P K Dhillon
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Int J Cancer 93:148-52. 2001
    ..Our data point to the role of familial susceptibility to gastric cancer, but not to any form of esophageal cancer, in the United States...
  25. ncbi request reprint Risk of recurrence after ductal carcinoma in situ of the breast
    L A Habel
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 7:689-96. 1998
    ..However, larger studies are needed to more clearly document predictors of disease recurrence after DCIS...
  26. ncbi request reprint Polymorphic repeats in the androgen receptor gene in high-risk sibships
    E A Miller
    Department of Urology, University of Washington, Seattle, Washington, USA
    Prostate 48:200-5. 2001
    ..06) compared to men with two long repeats [(CAG)n > or =22 and (GGN)n >16)]. CONCLUSIONS: These results suggest that the (CAG)n and (GGN)n repeats in the AR gene do not play a major role in familial prostate cancer...
  27. pmc Association of megalin genetic polymorphisms with prostate cancer risk and prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
    Clin Cancer Res 14:3823-31. 2008
    ..Genetic variation within megalin could potentially influence levels of steroid hormone uptake...
  28. ncbi request reprint Alcohol consumption and risk of prostate cancer in middle-aged men
    W Marieke Schoonen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Int J Cancer 113:133-40. 2005
    ..There may be, however, a reduced relative risk associated with increasing level of red wine consumption. Further research is needed to evaluate the potential negative association between red wine intake and prostate cancer risk...
  29. ncbi request reprint Vitamin D receptor gene polymorphisms and prostate cancer risk
    Mahesh B Keitheri Cheteri
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 59:409-18. 2004
    ..To further evaluate this relationship, we conducted a population-based case-control study of the VDR BsmI, FokI, and Poly-A polymorphisms, and prostate cancer...
  30. ncbi request reprint Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas
    Mary Beth Terry
    Mailman School of Public Health, Department of Epidemiology, Columbia University, 722 West 168th Street, Room 724A, New York, NY 10032, USA
    Cancer Causes Control 18:1039-46. 2007
    ..The alcohol dehydrogenase gene has several polymorphisms which may lead to faster conversion of ethanol to acetaldehyde, which may increase cancer risk...
  31. ncbi request reprint Oligogenic segregation analysis of hereditary prostate cancer pedigrees: evidence for multiple loci affecting age at onset
    Erin M Conlon
    Division of Medical Genetics, Department of Medicine, University of Washington, Box 357720, Seattle, WA 98195 7720, USA
    Int J Cancer 105:630-5. 2003
    ..Our findings for the number of QTLs contributing to HPC and the variance contribution of these QTLs will be instructive in mapping and identifying these genes...
  32. pmc Evaluation of 8q24 and 17q risk loci and prostate cancer mortality
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Harvard University, Cambridge, Massachusetts, USA
    Clin Cancer Res 15:3223-30. 2009
    ..We investigated whether the 8q24 and 17q risk variants are associated with clinical variables as well as prostate cancer mortality...
  33. pmc Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families
    Danielle M Friedrichsen
    Divisions of Clinical Research and Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 101:1939-44. 2004
    ..12 (P = 0.00007). These studies highlight the utility of analyzing defined sets of families with a common origin for reducing locus heterogeneity problems associated with studying complex traits...
  34. ncbi request reprint Germline mutations in the BRCA2 gene and susceptibility to hereditary prostate cancer
    Ilir Agalliu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, USA
    Clin Cancer Res 13:839-43. 2007
    ..However, studies of the contribution of BRCA2 mutations to the etiology of hereditary prostate cancer (HPC) have been inconsistent...
  35. pmc Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study
    Yong Zhu
    Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 69:9315-22. 2009
    ....
  36. pmc Population-based study of the association of variants in mismatch repair genes with prostate cancer risk and outcomes
    Wendy J Langeberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:258-64. 2010
    ..Mismatch repair (MMR) gene activity may be associated with prostate cancer risk and outcomes. This study evaluated whether single nucleotide polymorphisms (SNP) in key MMR genes are related to prostate cancer outcomes...
  37. pmc Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36
    M Gibbs
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, D2 190, Seattle, WA 98109 1024, USA
    Am J Hum Genet 64:776-87. 1999
    ..74 at straight theta = .0, with marker D1S407. We conclude that a significant proportion of these families with both a high risk for PC and a family member with BC show linkage to the 1p36 region...
  38. ncbi request reprint Lactose metabolism and time to pregnancy
    L J Herrinton
    University of Washington, Fred Hutchinson Cancer Research Center, Seattle, USA
    Fertil Steril 66:384-8. 1996
    ..To investigate whether, in the absence of galactosemia, relatively high intestinal lactase activity or low activity of an enzyme involved in galactose catabolism reduces fertility, as it does in the presence of galactosemia...
  39. ncbi request reprint The association of fatty acids with prostate cancer risk
    L M Newcomer
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA
    Prostate 47:262-8. 2001
    ..Contrary to animal studies, alpha-linolenic acid was also positively associated with risk. Further research will be required to clarify the role of these fatty acids in human prostate cancer...
  40. pmc Association of hepsin gene variants with prostate cancer risk and prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 70:1012-9. 2010
    ..We report results from a population-based case-control genetic association study for six tagging single nucleotide polymorphisms (tagSNPs) in the HPN gene...
  41. pmc Vasectomy and the risk of prostate cancer
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Urol 180:2565-7; discussion 2567-8. 2008
    ..Studies of risk with long latency periods have been hampered by small sample sizes in subgroups since vasectomy only became widely used in the 1960s and generally prostate cancer has a long latency period...
  42. ncbi request reprint Risk of subsequent breast cancer in relation to characteristics of screening mammograms from women less than 50 years of age
    David B Thomas
    Program in Epidemiology, The Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:565-71. 2002
    ..Women <50 years of age with class 1 or 2 calcifications or mammographically dense breasts, or both, should receive high priority for further evaluation and regular breast cancer screening...
  43. ncbi request reprint Some further results on incorporating risk factor information in assessing the dependence between paired failure times arising from case-control family studies: an application to prostate cancer
    Li Hsu
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 665, P O Box 19024, Seattle, Washington 98109 1024, U S A
    Stat Med 21:863-76. 2002
    ..Finally we illustrate various analyses using a case-control family study of early onset prostate cancer...
  44. pmc Vitamin D pathway gene variants and prostate cancer risk
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:1929-33. 2009
    ....
  45. pmc Vitamin D pathway gene variants and prostate cancer prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 70:1448-60. 2010
    ..Increased understanding of relevant germline genetic variation with disease outcome could aid in the development of vitamin-D-based therapies...
  46. pmc Evaluation of a variant in the transcription factor 7-like 2 (TCF7L2) gene and prostate cancer risk in a population-based study
    Ilir Agalliu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 68:740-7. 2008
    ..Specifically, the same risk allele of single nucleotide polymorphism (SNP) rs12255372 that is associated with diabetes (T allele) has recently been associated with an increased risk of breast cancer...
  47. ncbi request reprint Genomic scan of 254 hereditary prostate cancer families
    Marta Janer
    Institute for Systems Biology, Seattle, Washington, USA
    Prostate 57:309-19. 2003
    ..These analyses support the existence of multiple HPC loci, whose presence may be best identified by analyses of large, including pooled, datasets which consider locus heterogeneity...
  48. pmc Association between the peroxisome proliferator-activated receptor gamma Pro12Ala variant and haplotype and pancreatic cancer in a high-risk cohort of smokers: a pilot study
    Megan Dann Fesinmeyer
    Institute for Public Health Genetics, University of Washington, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, Seattle, WA 98195, USA
    Pancreas 38:631-7. 2009
    ..This pilot study tested for the association between Pro12Ala and pancreatic cancer risk in a high-risk sample of smokers...
  49. ncbi request reprint Obesity and the risk of prostate cancer
    Michael P Porter
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Prostate 62:316-21. 2005
    ..Prostate cancer and obesity are common diseases among men in the United States. A link between obesity and prostate cancer risk has potential implications in understanding prostate cancer genesis and screening strategies...
  50. pmc Semiparametric models of time-dependent predictive values of prognostic biomarkers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Biometrics 66:50-60. 2010
    ..We illustrate our approach with numerical studies and a dataset from a prostate cancer study...
  51. ncbi request reprint Finding prostate cancer susceptibility genes
    Elaine A Ostrander
    Division of Clinical Research1, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Annu Rev Genomics Hum Genet 5:151-75. 2004
    ..To increase the ability to find disease-associated loci, much denser genome-wide scans must be undertaken in multiple ethnic groups. In addition, new ways of defining homogenous subsets of families need to be developed...
  52. ncbi request reprint Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers
    Katrina F Trivers
    Department of Epidemiology, University of North Carolina at Chapel Hill, CB 7435, Chapel Hill, North Carolina 27599 7435, USA
    Clin Gastroenterol Hepatol 3:225-30. 2005
    ..Risk factors for subtypes of esophageal and gastric cancer recently have been identified, but their effect on survival is unknown...
  53. ncbi request reprint Polymorphisms in the glutathione S-transferase M1, T1, and P1 genes and prostate cancer prognosis
    Ilir Agalliu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 66:1535-41. 2006
    ..The aim of this study was to examine associations between GSTM1, T1, or P1 genetic variants and prostate cancer outcomes...
  54. ncbi request reprint Fruit and vegetable intakes and prostate cancer risk
    J H Cohen
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 92:61-8. 2000
    ..We studied the associations of fruit and vegetable intakes with prostate cancer risk in a population-based, case-control study of men under 65 years of age...
  55. ncbi request reprint Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer
    Brandon L Pierce
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 67:410-5. 2007
    ....
  56. doi request reprint Diabetes mellitus and prostate cancer risk
    Brandon L Pierce
    Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 68:1126-32. 2008
    ..The objective of this study was to examine the association between PCa risk and several characteristics of DM (duration, age at diagnosis, treatment) in data from two population-based, case-control studies of PCa...
  57. ncbi request reprint Prostate cancer mortality in relation to screening by prostate-specific antigen testing and digital rectal examination: a population-based study in middle-aged men
    Ilir Agalliu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B874, Seattle, WA 98109, USA
    Cancer Causes Control 18:931-7. 2007
    ....
  58. ncbi request reprint The distribution of serum prostate-specific antigen levels among American men: implications for prostate cancer prevalence and screening
    Michael P Porter
    Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA
    Prostate 66:1044-51. 2006
    ..The purpose of this study was to describe the distribution of serum prostate-specific antigen (PSA) among American men and to estimate the number of prevalent cases of biopsy detectable prostate cancer among men with normal serum PSA...
  59. ncbi request reprint IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer
    Danielle M Friedrichsen
    Division of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 65:44-51. 2005
    ..Several polymorphisms within the IGF-I and IGFBP-3 coding regions have been associated with increased serum protein levels...
  60. pmc C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older
    Brandon L Pierce
    Institute for Public Health Genetics, University of Washington, Seattle, WA, USA
    Cancer Causes Control 20:1193-203. 2009
    ..21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation...
  61. ncbi request reprint Nonsteroidal anti-inflammatory drug use associated with reduced incidence of adenocarcinomas of the esophagus and gastric cardia that overexpress cyclin D1: a population-based study
    Marilie D Gammon
    University of North Carolina, School of Public Health, Department of Epidemiology, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 13:34-9. 2004
    ..These data suggest that the reduction in risk associated with NSAID use may be restricted to those esophageal and gastric cardia adenocarcinomas that overexpress cyclin D1...
  62. ncbi request reprint Associations of energy, fat, calcium, and vitamin D with prostate cancer risk
    Alan R Kristal
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 981091024, USA
    Cancer Epidemiol Biomarkers Prev 11:719-25. 2002
    ..These results are consistent with general dietary guidelines to moderate consumption of total energy and fat, and they motivate further research to consider the potential benefits and risks of high calcium intake...
  63. ncbi request reprint Breast cancer risk and "delayed" primary Epstein-Barr virus infection
    Y Yasui
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 10:9-16. 2001
    ..018). Adjusting for additional potential confounders did not modify the associations appreciably. The implications of the findings and a potential biological mechanism are presented...
  64. pmc The impact of patents on the development of genome-based clinical diagnostics: an analysis of case studies
    Brandon L Pierce
    Institute for Public Health Genetics, University of Washington, Seattle, WA, USA
    Genet Med 11:202-9. 2009
    ....
  65. pmc Statin use and risk of prostate cancer: results from a population-based epidemiologic study
    Ilir Agalliu
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 168:250-60. 2008
    ..Although statin use was not associated with overall prostate cancer risk, the finding of an increased risk associated with statin use among obese men, particularly use for extended durations, warrants further investigation...
  66. pmc Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, WA, USA
    Cancer Causes Control 20:1617-22. 2009
    ..In this study, we explore the relationship between metformin use and PCa risk in a population-based case-control study...
  67. ncbi request reprint Cigarette smoking and risk of prostate cancer in middle-aged men
    Lora A Plaskon
    Department of Urology, University of Washington, Seattle, USA
    Cancer Epidemiol Biomarkers Prev 12:604-9. 2003
    ..Given that smoking cessation seems to reduce these risks, results from this study have public health ramifications and suggest that prostate cancer should be added to the list of tumors for which cigarette smoking is a risk factor...
  68. ncbi request reprint Polymorphisms in the androgen receptor and the prostate-specific antigen genes and prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 65:58-65. 2005
    ..Polymorphic CAG and GGC microsatellites in the androgen receptor (AR) can alter transactivation of androgen-responsive genes in in vitro studies. Potentially, this may influence PCa risk...
  69. pmc Positive surgical margins at radical prostatectomy predict prostate cancer specific mortality
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA
    J Urol 183:2213-8. 2010
    ..Using a large, population based national cancer registry we evaluated the risk of prostate cancer specific mortality associated with margin status...
  70. ncbi request reprint Genetic etiology of hereditary prostate cancer
    Wendy J Langeberg
    Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Front Biosci 12:4101-10. 2007
    ..This chapter will review these studies, describe the challenges of this endeavor, and describe efforts to confront these challenges, such as using larger sets of families and more homogeneous subgroups...
  71. pmc Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality
    Daniel W Lin
    Department of Urology, University of Washington School of Medicine, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 20:1928-36. 2011
    ..The purpose of this study was to test whether variation in selected candidate genes in biological pathways of interest for prostate cancer progression could help distinguish patients at higher risk for fatal prostate cancer...
  72. pmc Oral contraceptives and breast cancer: results from an expanded case-control study
    J L Stanford
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98104
    Br J Cancer 60:375-81. 1989
    ..5 and 1.4 respectively for small and large lesions). These data suggest that oral contraceptive effects may vary by stage of disease, but provide no overall evidence of an association between oral contraceptives and breast cancer...
  73. pmc Genome-wide association study identifies a genetic variant associated with risk for more aggressive prostate cancer
    Liesel M FitzGerald
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 20:1196-203. 2011
    ..We therefore undertook a search for genetic variants associated with risk of more aggressive disease...
  74. ncbi request reprint Obesity is associated with increased risks of prostate cancer metastasis and death after initial cancer diagnosis in middle-aged men
    Zhihong Gong
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer 109:1192-202. 2007
    ..The objective of this study was to examine associations between obesity and the risks of developing metastasis or prostate cancer-specific mortality in a population-based cohort of men with prostate cancer...
  75. ncbi request reprint General quality of life 2 years following treatment for prostate cancer: what influences outcomes? Results from the prostate cancer outcomes study
    David F Penson
    Section of Urology, VA Puget Sound Health Care System and the Department of Urology, University of Washington, Seattle, WA 98108, USA
    J Clin Oncol 21:1147-54. 2003
    ..The goal of this study was to determine the relationship between primary treatment, urinary dysfunction, sexual dysfunction, and general health-related quality of life (HRQOL) in prostate cancer...
  76. pmc Prostate cancer specific mortality and Gleason 7 disease differences in prostate cancer outcomes between cases with Gleason 4 + 3 and Gleason 3 + 4 tumors in a population based cohort
    Jonathan L Wright
    Department of Urology, University of Washington School of Public Health, Seattle, Washington 98195, USA
    J Urol 182:2702-7. 2009
    ..In this population based cohort we determined prostate cancer outcomes at different Gleason scores, particularly the different Gleason 7 patterns...
  77. ncbi request reprint Cigarette smoking and prostate cancer-specific mortality following diagnosis in middle-aged men
    Zhihong Gong
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109 1024, USA
    Cancer Causes Control 19:25-31. 2008
    ..The aim of this study was to examine associations of smoking at the time of diagnosis with the risk of prostate cancer death in a population-based cohort of men with prostate cancer...
  78. ncbi request reprint Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types
    Amanda Ewart-Toland
    UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Carcinogenesis 26:1368-73. 2005
    ..The data also underline the advantages of comparative association studies involving study populations from different ethnic groups for determination of disease risk...
  79. ncbi request reprint A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk
    Goutham Narla
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 65:1213-22. 2005
    ....
  80. ncbi request reprint Racial/Ethnic differences in functional outcomes in the 5 years after diagnosis of localized prostate cancer
    Terri Kang Johnson
    University of Southern California Keck School of Medicine, Dept of Preventive Medicine, 1441 Eastlake Ave, Rm 3427A, MC9175, Los Angeles, CA 90089 9175, USA
    J Clin Oncol 22:4193-201. 2004
    ..We investigated racial/ethnic differences in functional outcomes up to 5 years after diagnosis among men with aggressively treated localized prostate cancer...
  81. pmc Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics
    Nicola J Camp
    University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108, USA
    Hum Mol Genet 16:1271-8. 2007
    ..This collaborative study by the ICPCG illustrates the value of consortium efforts and the continued utility of linkage analysis using informative pedigrees to localize genes for complex diseases...
  82. ncbi request reprint Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q
    Daniel J Schaid
    Division of Biostatistics, Mayo Clinic, Rochester, MN, USA
    Hum Genet 121:729-35. 2007
    ..001) was found on chromosomes 19q and 5q, with P-values <or= 0.01 observed on chromosomes 3q, 7q, and 16q. Our results confirm reports of Gleason score linkage to chromosome 19q and suggest new loci for further investigation...
  83. ncbi request reprint Cruciferous vegetables and prostate cancer risk: confounding by PSA screening
    Alan R Kristal
    Cancer Epidemiol Biomarkers Prev 13:1265. 2004
  84. ncbi request reprint Population attributable risks of esophageal and gastric cancers
    Lawrence S Engel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 95:1404-13. 2003
    ..Herein, we estimate the population attributable risks (PARs) for various risk factors observed in a multicenter population-based case-control study...
  85. ncbi request reprint Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
    Gastroenterology 124:1193-201. 2003
    ..The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite...
  86. pmc Natural experiment examining impact of aggressive screening and treatment on prostate cancer mortality in two fixed cohorts from Seattle area and Connecticut
    Grace Lu-Yao
    HealthStat, Princeton, NJ 08543, USA
    BMJ 325:740. 2002
    ..To determine whether the more intensive screening and treatment for prostate cancer in the Seattle-Puget Sound area in 1987-90 led to lower mortality from prostate cancer than in Connecticut...
  87. pmc A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Hum Genet 77:219-29. 2005
    ....
  88. ncbi request reprint Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24
    Miia Suuriniemi
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:809-14. 2007
    ..S. samples. Although the data were provocative, the U.S. samples were not population based, which precludes assessment of the potential contribution of this locus to prostate cancer incidence in the United States...
  89. ncbi request reprint Affected relative pairs and simultaneous search for two-locus linkage in the presence of epistasis
    Daniel J Schaid
    Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Genet Epidemiol 31:431-49. 2007
    ..These novel score statistics should prove useful for linkage studies of other complex human diseases...
  90. ncbi request reprint Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb
    Bo Johanneson
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Hum Genet 123:65-75. 2008
    ..Combining these results with data from the earlier ICPCG study reduces the three-recombination interval at 22q12.3 to approximately 1.36 Mb...
  91. ncbi request reprint Suggestive genetic linkage to chromosome 11p11.2-q12.2 in hereditary prostate cancer families with primary kidney cancer
    Bo Johanneson
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA
    Prostate 67:732-42. 2007
    ..Towards that end, we analyzed a genome-wide scan of HPC families with primary kidney cancer...
  92. ncbi request reprint Genetic susceptibility to aggressive prostate cancer
    Elaine A Ostrander
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, 50 South Drive, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:1761-4. 2006
  93. ncbi request reprint Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics
    Daniel J Schaid
    Harwick 7, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hum Genet 120:471-85. 2006
    ..This provides a basis for attempts to identify these genes, with potential clinical utility for men with aggressive prostate cancer and their relatives...
  94. ncbi request reprint Health outcomes in older men with localized prostate cancer: results from the Prostate Cancer Outcomes Study
    Richard M Hoffman
    Medicine Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA
    Am J Med 119:418-25. 2006
    ..We compared health-related quality-of-life (HRQOL) outcomes and survival of men with localized prostate cancer who received aggressive treatment with those receiving conservative management...
  95. pmc Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer
    Marc D Tischkowitz
    Department of Oncology and Medical Genetics, Cancer Prevention Centre, E740, Sir MB Davis Jewish General Hospital, McGill University, Montreal, QC, Canada
    Cancer Lett 270:173-80. 2008
    ..Although we cannot rule out a subtle influence of the CHEK2 variants on PRCA risk, these results suggest that germline CHEK2 mutations have a minor role in, if any, PRCA susceptibility in AJ men...
  96. pmc GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas
    Louise Wideroff
    Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, EPN 4005, 6130 Executive Boulevard, MSC 7344, Bethesda, MD 20892 7344, USA
    Cancer Detect Prev 31:233-6. 2007
    ..In a population-based case-control study, we examined risks in relation to polymorphisms of the following genes: GSTP1; GSTM1; GSTT1; NAT1; and CYP1A1...
  97. ncbi request reprint Carbonated soft drink consumption and risk of esophageal adenocarcinoma
    Susan T Mayne
    Department of Epidemiology and Public Health, Yale University School of Medicine and Cancer Center, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 98:72-5. 2006
    ..These findings indicate that CSD consumption (especially diet CSD) is inversely associated with risk of esophageal adenocarcinoma, and thus it is not likely to have contributed to the rising incidence rates...
  98. ncbi request reprint Risk of breast cancer classified by joint estrogen receptor and progesterone receptor status among women 20-44 years of age
    Julie A Britton
    Division of Environmental Health Science, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Epidemiol 156:507-16. 2002
    ..These findings only modestly support the hypothesis that hormonally related risk factors have differing relations with ER+PR+ versus ER-PR- tumors among younger women...
  99. ncbi request reprint Self-report of prostatitis and its risk factors in a random sample of middle-aged men
    Ivan Rothman
    Department of Urology, University of Washington School of Medicine Seattle, Washington 98195 6510, USA
    Urology 64:876-9; discussion 879-80. 2004
    ..To determine the risk factors for the self-reported history of prostatitis and to determine whether a self-reported history of prostatitis is related to the diagnosis of prostate cancer...
  100. ncbi request reprint Dietary intake and risk of postmenopausal breast cancer (United States)
    Jackilen Shannon
    Portland VA Medical Center, 3710 SW US Veterans Hospital Rd P3 HSRD, Portland, Oregon 97201, USA
    Cancer Causes Control 14:19-27. 2003
    ..In this case-control study, we evaluate the associations between red meat, fish, dairy products, and fruits and vegetables, and risk of breast cancer in postmenopausal women...
  101. ncbi request reprint Five-year outcomes after prostatectomy or radiotherapy for prostate cancer: the prostate cancer outcomes study
    Arnold L Potosky
    Division of Cancer Control and Population Sciences, National Cancer Institute, EPN Rm 4005, 6130 Executive Blvd, MSC 7344, Bethesda, MD 20892 7344, USA
    J Natl Cancer Inst 96:1358-67. 2004
    ..We present treatment-specific quality-of-life outcomes for prostate cancer patients 5 years after initial diagnosis...

Research Grants25

  1. NSAIDS and Other Medications in Prostate Cancer Etiology
    Janet Stanford; Fiscal Year: 2005
    ..Results of the study may provide unique insights on the pathogenesis of this complex disease and lead to innovative strategies for prostate cancer prevention. ..
  2. GENETIC EPIDEMIOLOGY OF PROSTATE CANCER
    Janet Stanford; Fiscal Year: 2007
    ..abstract_text> ..
  3. Inflammatory Pathway Gene Polymorphisms and Risk of Prostate Cancer
    Janet Stanford; Fiscal Year: 2007
    ....
  4. GENETIC EPIDEMIOLOGY OF PROSTATE CANCER
    Janet Stanford; Fiscal Year: 2003
    ..abstract_text> ..
  5. Oncogenic Human Papillomaviruses & Prostate Cancer Risk
    Janet Stanford; Fiscal Year: 2002
    ..If there is an association, the results will have important public health implications since both the exposure and the disease are common. ..
  6. GENETIC POLYMORPHISMS IN THE GSTPI LOCUS AND PROSTATE CA
    Janet Stanford; Fiscal Year: 2001
    ....
  7. GENETIC POLYMORPHISMS AND PROSTATE CANCER RISK
    Janet Stanford; Fiscal Year: 2001
    ..abstract_text> ..