Rachel Sparks

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R488-98. 2004
  2. ncbi request reprint Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:889-93. 2004
  3. ncbi request reprint PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:616-9. 2005
  4. ncbi request reprint Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, University of Washington, Seattle, Washington 98109 1024, USA
    Hum Mutat 26:394-5. 2005
  5. ncbi request reprint TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Int J Epidemiol 33:955-61. 2004
  6. ncbi request reprint Pharmacogenetics and folate metabolism -- a promising direction
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 900, Seattle, WA 98109 1024, USA
    Pharmacogenomics 3:299-313. 2002
  7. ncbi request reprint Cyclooxygenase 1 (COX1) polymorphisms in African-American and Caucasian populations
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, University of Washington, Seattle, WA 98109 1024, USA
    Hum Mutat 20:409-10. 2002
  8. ncbi request reprint Prostaglandin H synthases: members of a class of quasi-linear threshold switches
    William D Hazelton
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2 B500 Seattle, WA 98109 1024, USA
    Biochem Pharmacol 68:423-32. 2004
  9. ncbi request reprint Community-onset methicillin-resistant Staphylococcus aureus associated with antibiotic use and the cytotoxin Panton-Valentine leukocidin during a furunculosis outbreak in rural Alaska
    Henry C Baggett
    Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska 99508, USA
    J Infect Dis 189:1565-73. 2004
  10. ncbi request reprint Expression, genomic structure and mapping of the thymus specific protease prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility
    Saijai Cheunsuk
    Division of Gastroenterology, Department of Internal Medicine, University of California Davis, Davis, CA 95817, USA
    J Autoimmun 18:311-6. 2002

Collaborators

Detail Information

Publications11

  1. pmc UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R488-98. 2004
    ....
  2. ncbi request reprint Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:889-93. 2004
    ..These preliminary findings require confirmation in larger studies of colorectal neoplasia...
  3. ncbi request reprint PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:616-9. 2005
    ....
  4. ncbi request reprint Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, University of Washington, Seattle, Washington 98109 1024, USA
    Hum Mutat 26:394-5. 2005
    ..Given the evolutionary evidence, these variants may be functional and therefore of relevance for disease endpoints related to inflammation and angiogenesis, as well as for the pharmacogenetics of non-steroidal anti-inflammatory drugs...
  5. ncbi request reprint TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Int J Epidemiol 33:955-61. 2004
    ..A polymorphism in the signal peptide sequence of the TGFbeta1 gene (L10P) has been associated with increased levels of plasma TGFbeta1 in individuals with the P allele...
  6. ncbi request reprint Pharmacogenetics and folate metabolism -- a promising direction
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 900, Seattle, WA 98109 1024, USA
    Pharmacogenomics 3:299-313. 2002
    ..Findings to date illustrate the potential for targeting therapy based on patients' genotypes with improved outcomes and reduced toxicity...
  7. ncbi request reprint Cyclooxygenase 1 (COX1) polymorphisms in African-American and Caucasian populations
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, University of Washington, Seattle, WA 98109 1024, USA
    Hum Mutat 20:409-10. 2002
    ..More detailed phenotypic characterizations of these COX1 polymorphisms remain to be undertaken...
  8. ncbi request reprint Prostaglandin H synthases: members of a class of quasi-linear threshold switches
    William D Hazelton
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2 B500 Seattle, WA 98109 1024, USA
    Biochem Pharmacol 68:423-32. 2004
    ..Mathematical modeling helps explain how these adaptations enable the PTGS1 and PTGS2 enzymes to maintain their physiological roles while avoiding potentially damaging consequences...
  9. ncbi request reprint Community-onset methicillin-resistant Staphylococcus aureus associated with antibiotic use and the cytotoxin Panton-Valentine leukocidin during a furunculosis outbreak in rural Alaska
    Henry C Baggett
    Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska 99508, USA
    J Infect Dis 189:1565-73. 2004
    ..During a CO-MRSA skin infection outbreak in Alaska, we assessed risk factors for disease and whether a virulence factor, Panton-Valentine leukocidin (PVL), could account for the high rates of MRSA skin infection in this region...
  10. ncbi request reprint Expression, genomic structure and mapping of the thymus specific protease prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility
    Saijai Cheunsuk
    Division of Gastroenterology, Department of Internal Medicine, University of California Davis, Davis, CA 95817, USA
    J Autoimmun 18:311-6. 2002
    ..These findings support the role of Prss16 in T-cell development and susceptibility to autoimmunity in the mouse...
  11. ncbi request reprint A Michaelis-Menten-style model for the autocatalytic enzyme prostaglandin H synthase
    Joseph H Tien
    Center for Applied Mathematics, Cornell University, 657 Frank H T Rhodes Hall, Ithaca, NY 14853, USA
    Bull Math Biol 67:683-700. 2005
    ..Applying the QSSA for this model can be useful in computationally intensive modeling endeavors involving PGHS...