Rachel Sparks

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R488-98. 2004
  2. ncbi Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:889-93. 2004
  3. ncbi PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:616-9. 2005
  4. ncbi Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, University of Washington, Seattle, Washington 98109 1024, USA
    Hum Mutat 26:394-5. 2005
  5. ncbi TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Int J Epidemiol 33:955-61. 2004
  6. ncbi Pharmacogenetics and folate metabolism -- a promising direction
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 900, Seattle, WA 98109 1024, USA
    Pharmacogenomics 3:299-313. 2002
  7. ncbi Cyclooxygenase 1 (COX1) polymorphisms in African-American and Caucasian populations
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, University of Washington, Seattle, WA 98109 1024, USA
    Hum Mutat 20:409-10. 2002
  8. ncbi Prostaglandin H synthases: members of a class of quasi-linear threshold switches
    William D Hazelton
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2 B500 Seattle, WA 98109 1024, USA
    Biochem Pharmacol 68:423-32. 2004
  9. ncbi Community-onset methicillin-resistant Staphylococcus aureus associated with antibiotic use and the cytotoxin Panton-Valentine leukocidin during a furunculosis outbreak in rural Alaska
    Henry C Baggett
    Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska 99508, USA
    J Infect Dis 189:1565-73. 2004
  10. ncbi Expression, genomic structure and mapping of the thymus specific protease prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility
    Saijai Cheunsuk
    Division of Gastroenterology, Department of Internal Medicine, University of California Davis, Davis, CA 95817, USA
    J Autoimmun 18:311-6. 2002

Collaborators

Detail Information

Publications11

  1. ncbi UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R488-98. 2004
    ....
  2. ncbi Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:889-93. 2004
    ..These preliminary findings require confirmation in larger studies of colorectal neoplasia...
  3. ncbi PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:616-9. 2005
    ....
  4. ncbi Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, University of Washington, Seattle, Washington 98109 1024, USA
    Hum Mutat 26:394-5. 2005
    ..Given the evolutionary evidence, these variants may be functional and therefore of relevance for disease endpoints related to inflammation and angiogenesis, as well as for the pharmacogenetics of non-steroidal anti-inflammatory drugs...
  5. ncbi TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Int J Epidemiol 33:955-61. 2004
    ..A polymorphism in the signal peptide sequence of the TGFbeta1 gene (L10P) has been associated with increased levels of plasma TGFbeta1 in individuals with the P allele...
  6. ncbi Pharmacogenetics and folate metabolism -- a promising direction
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, MP 900, Seattle, WA 98109 1024, USA
    Pharmacogenomics 3:299-313. 2002
    ..Findings to date illustrate the potential for targeting therapy based on patients' genotypes with improved outcomes and reduced toxicity...
  7. ncbi Cyclooxygenase 1 (COX1) polymorphisms in African-American and Caucasian populations
    Cornelia M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, University of Washington, Seattle, WA 98109 1024, USA
    Hum Mutat 20:409-10. 2002
    ..More detailed phenotypic characterizations of these COX1 polymorphisms remain to be undertaken...
  8. ncbi Prostaglandin H synthases: members of a class of quasi-linear threshold switches
    William D Hazelton
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2 B500 Seattle, WA 98109 1024, USA
    Biochem Pharmacol 68:423-32. 2004
    ..Mathematical modeling helps explain how these adaptations enable the PTGS1 and PTGS2 enzymes to maintain their physiological roles while avoiding potentially damaging consequences...
  9. ncbi Community-onset methicillin-resistant Staphylococcus aureus associated with antibiotic use and the cytotoxin Panton-Valentine leukocidin during a furunculosis outbreak in rural Alaska
    Henry C Baggett
    Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska 99508, USA
    J Infect Dis 189:1565-73. 2004
    ..001). The majority of MRSA isolates were closely related by PFGE. CONCLUSION: Selective antibiotic pressure for drug-resistant strains carrying PVL may have led to the emergence and spread of CO-MRSA in rural Alaska...
  10. ncbi Expression, genomic structure and mapping of the thymus specific protease prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility
    Saijai Cheunsuk
    Division of Gastroenterology, Department of Internal Medicine, University of California Davis, Davis, CA 95817, USA
    J Autoimmun 18:311-6. 2002
    ..These findings support the role of Prss16 in T-cell development and susceptibility to autoimmunity in the mouse...
  11. ncbi A Michaelis-Menten-style model for the autocatalytic enzyme prostaglandin H synthase
    Joseph H Tien
    Center for Applied Mathematics, Cornell University, 657 Frank H T Rhodes Hall, Ithaca, NY 14853, USA
    Bull Math Biol 67:683-700. 2005
    ..Applying the QSSA for this model can be useful in computationally intensive modeling endeavors involving PGHS...