Research Topics
Genomes and GenesSpecies | PHILIPPE M SORIANOSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somitesP Soriano
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Development 124:2691-700. 1997..These results indicate that PDGFs may exert their functions during early embryogenesis by affecting cell survival and patterning...- Neuronal position in the developing brain is regulated by mouse disabled-1B W Howell
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Nature 389:733-7. 1997..Because mDab1 is expressed in wild-type cortical neurons, and Reelin expression is normal in mdab1 mutants, mDab1 may be part of a Reelin-regulated or parallel pathway that controls the final positioning of neurons... - Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in miceJ D Hildebrand
Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Cell 99:485-97. 1999..Finally, cytoskeletal polarity within the neuroepithelium is perturbed in mutant embryos. In concert, these observations suggest that Shrm is a critical determinant of the cellular architecture required for proper neurulation... 
Src family kinases are required for integrin but not PDGFR signal transductionR A Klinghoffer
Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North Mailstop C3 168, PO Box 19204, Seattle, WA 98109 1024, USA
EMBO J 18:2459-71. 1999..These results demonstrate that SFK activity is essential during embryogenesis and suggest that defects observed in SYF triple mutant embryos may be linked to deficiencies in signaling by extracellular matrix-coupled receptors...- Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant miceP Soriano
Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Genes Dev 8:1888-96. 1994..These results indicate that whereas the beta receptor is essential in certain cell types during embryonic development, its broader role may be masked because of compensation by the alpha-subunit... - Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant miceP L Stein
Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Genes Dev 8:1999-2007. 1994..Taken together, these data are consistent with the hypothesis that, at least in some cells, these kinases are able to compensate for the loss of the other related kinases... - Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesisM Komada
Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genes Dev 13:1475-85. 1999..The vesicular localization of Hrs was disrupted in cells treated with wortmannin, implicating Hrs in the phosphatidylinositol 3-kinase pathway of membrane trafficking... - Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cellsG R MacGregor
Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
Development 121:1487-96. 1995..In homozygous mutants, primordial germ cells appear unaffected indicating that TNAP is not essential for their development or migration... - E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesisM Komada
Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 USA
Genes Dev 14:1332-42. 2000.... - Early myotome specification regulates PDGFA expression and axial skeleton developmentM D Tallquist
Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Development 127:5059-70. 2000..These results underscore the importance of growth factor signaling within the developing somite and suggest an important role for myogenic determination factors in orchestrating normal development of the axial skeleton... - Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathwaysM D Tallquist
Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genes Dev 14:3179-90. 2000..Our observations indicate that although loss of these pathways can lead to attenuated PDGF-dependent cellular function, certain PDGFR-beta-induced signal cascades are not essential for survival in mice... - The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functionsR A Klinghoffer
Program in Developmental Biology and Division, Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Mol Cell 7:343-54. 2001..This observation provides a framework for discussing the evolution of receptor tyrosine kinase functional specificity... - Mice deficient in Six5 develop cataracts: implications for myotonic dystrophyT R Klesert
Program in Developmental Biology and Divisions of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Nat Genet 25:105-9. 2000..Our results suggest that SIX5 deficiency contributes to the cataract phenotype in myotonic dystrophy, and that myotonic dystrophy represents a multigenic disorder... - Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene functionM D Tallquist
Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Genesis 26:113-5. 2000 - Specific and redundant roles of Src and Fyn in organizing the cytoskeletonS M Thomas
Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Nature 376:267-71. 1995..Thus, Src family kinases have both specific and overlapping functions in regulation of the cytoskeleton. The disturbance of these functions may be a molecular basis for the phenotype exhibited by csk- mutants... - The secretory protein Sec8 is required for paraxial mesoderm formation in the mouseG A Friedrich
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Dev Biol 192:364-74. 1997..A description of the mutant phenotype and the cloning of the gene is presented here and the results are considered in light of the possibility that the Sec8 protein is involved in secretion... - The helix-loop-helix gene E2A is required for B cell formationY Zhuang
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
Cell 79:875-84. 1994..Surprisingly, heterozygous embryos contain, on average, about half as many B cells as wild-type embryos, suggesting the existence of a counting mechanism that translates levels of E2A into numbers of B cells... - Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in miceZ Chen
Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Genes Dev 8:2293-301. 1994..Although transcription of a number of muscle-specific genes believed to be TEF-1 targets appears normal, the defect in cardiogenesis is likely attributable to diminished transcription of one or several cardiac-specific genes... - Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cellsB P Zambrowicz
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 94:3789-94. 1997..This third transcript potentially encodes a novel protein of at least 505 amino acids that is conserved in humans and in Caenorhabditis elegans... - Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiationK P Foley
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North Mailstop A2 025, P O Box 19024, Seattle, WA 98109 1024, USA
EMBO J 17:774-85. 1998....
Research Grants
- SIGNAL TRANSDUCTION AND MOUSE DEVELOPMENTPhilippe Soriano; Fiscal Year: 2007..These studies should help us understand growth factor regulatory mechanisms, and provide information on the specificity and interplay of growth factor signaling pathways in physiological processes. ..