Susan Searles Nielsen

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. doi request reprint Family cancer history and risk of brain tumors in children: results of the SEARCH international brain tumor study
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Causes Control 19:641-8. 2008
  2. ncbi request reprint Accuracy of prenatal smoking data from Washington State birth certificates in a population-based sample with cotinine measurements
    Susan Searles Nielsen
    Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA Electronic address
    Ann Epidemiol 24:236-9. 2014
  3. ncbi request reprint An evaluation of semi-quantitative test strips for the measurement of nitrate in drinking water in epidemiologic studies
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Expo Sci Environ Epidemiol 18:142-8. 2008
  4. pmc Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1)
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Environ Health Perspect 113:909-13. 2005
  5. pmc Water quality monitoring records for estimating tap water arsenic and nitrate: a validation study
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, M4 C308, Seattle, Washington, USA
    Environ Health 9:4. 2010
  6. pmc Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Environ Health Perspect 118:144-9. 2010
  7. pmc Childhood brain tumors and maternal cured meat consumption in pregnancy: differential effect by glutathione S-transferases
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, PO Box 19024, 1100 Fairview Avenue North, MS M4 C308, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 20:2413-9. 2011
  8. pmc Newborn screening archives as a specimen source for epidemiologic studies: feasibility and potential for bias
    Susan Searles Nielsen
    Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109 1024, USA
    Ann Epidemiol 18:58-64. 2008
  9. ncbi request reprint Lung cancer risk among female textile workers exposed to endotoxin
    George Astrakianakis
    Departments of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    J Natl Cancer Inst 99:357-64. 2007
  10. ncbi request reprint Household water source and the risk of childhood brain tumours: results of the SEARCH International Brain Tumor Study
    Beth A Mueller
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M4 C308, Seattle, WA 98109 1024, USA
    Int J Epidemiol 33:1209-16. 2004

Detail Information

Publications48

  1. doi request reprint Family cancer history and risk of brain tumors in children: results of the SEARCH international brain tumor study
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Causes Control 19:641-8. 2008
    ..To examine whether childhood brain tumors (CBTs) are associated with a family history of brain tumors or other cancers in an international case-control study...
  2. ncbi request reprint Accuracy of prenatal smoking data from Washington State birth certificates in a population-based sample with cotinine measurements
    Susan Searles Nielsen
    Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA Electronic address
    Ann Epidemiol 24:236-9. 2014
    ..To assess the accuracy of smoking data in contemporary U.S. birth certificates...
  3. ncbi request reprint An evaluation of semi-quantitative test strips for the measurement of nitrate in drinking water in epidemiologic studies
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Expo Sci Environ Epidemiol 18:142-8. 2008
    ..Nitrate/nitrite test strips may be useful in some epidemiologic studies, but should be used with caution, preferably as a screening tool or when laboratory assays are not feasible...
  4. pmc Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1)
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Environ Health Perspect 113:909-13. 2005
    ..Larger studies that measure plasma PON1 levels and incorporate more accurate estimates of pesticide exposure will be required to confirm these observations...
  5. pmc Water quality monitoring records for estimating tap water arsenic and nitrate: a validation study
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, M4 C308, Seattle, Washington, USA
    Environ Health 9:4. 2010
    ..As an alternative, studies might estimate contaminant levels in individual homes by using publicly available water quality monitoring records, either alone or in combination with geographic information systems (GIS)...
  6. pmc Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Environ Health Perspect 118:144-9. 2010
    ..Insecticides that target the nervous system may play a role in the development of childhood brain tumors (CBTs). Constitutive genetic variation affects metabolism of these chemicals...
  7. pmc Childhood brain tumors and maternal cured meat consumption in pregnancy: differential effect by glutathione S-transferases
    Susan Searles Nielsen
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, PO Box 19024, 1100 Fairview Avenue North, MS M4 C308, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 20:2413-9. 2011
    ..We explored whether this possible association was modified by fetal genetic polymorphisms in genes coding for glutathione S-transferases (GSTs) that may inactivate nitroso compounds...
  8. pmc Newborn screening archives as a specimen source for epidemiologic studies: feasibility and potential for bias
    Susan Searles Nielsen
    Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109 1024, USA
    Ann Epidemiol 18:58-64. 2008
    ..To evaluate the feasibility of obtaining dried blood spots (DBS) from newborn screening archives for subjects in epidemiologic studies and using these specimens for genotyping, and to evaluate the potential for bias in their use...
  9. ncbi request reprint Lung cancer risk among female textile workers exposed to endotoxin
    George Astrakianakis
    Departments of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    J Natl Cancer Inst 99:357-64. 2007
    ..We examine the association between endotoxin exposure and lung cancer risk in a cohort of female textile workers...
  10. ncbi request reprint Household water source and the risk of childhood brain tumours: results of the SEARCH International Brain Tumor Study
    Beth A Mueller
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M4 C308, Seattle, WA 98109 1024, USA
    Int J Epidemiol 33:1209-16. 2004
    ..We examined whether household water source and the presence of nitrates or nitrites in residential water were associated with increased risks of childhood brain tumours (CBT)...
  11. ncbi request reprint Development of a cancer research study in the Shanghai textile industry
    Janice E Camp
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
    Int J Occup Environ Health 9:347-56. 2003
    ..This project is an example of the unique research opportunities to be found in China, and illustrates how these data sources may be lost due to ongoing changes in the Chinese economy...
  12. pmc LINE-1 DNA methylation, smoking and risk of Parkinson's disease
    Susan Searles Nielsen
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    J Parkinsons Dis 2:303-8. 2012
    ..LINE-1 promoter methylation is associated with decreased LINE-1 propagation...
  13. ncbi request reprint Risks of biliary tract cancer and occupational exposures among Shanghai women textile workers: a case-cohort study
    Chin Kuo Chang
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Am J Ind Med 49:690-8. 2006
    ..Biliary tract cancer (BTC) is a relatively rare malignancy worldwide. Little is known about potential etiologic contributions of occupational exposures...
  14. ncbi request reprint Cotton dust and endotoxin levels in three Shanghai textile factories: a comparison of samplers
    George Astrakianakis
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    J Occup Environ Hyg 3:418-27. 2006
    ....
  15. ncbi request reprint Occupational exposures and risks of liver cancer among Shanghai female textile workers--a case-cohort study
    Chin Kuo Chang
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Int J Epidemiol 35:361-9. 2006
    ..We investigated associations of occupational exposures to dusts and chemicals in a cohort of female textile workers...
  16. ncbi request reprint Brain tumors and occupational exposures in a cohort of female textile workers in Shanghai, China
    Laura S Gold
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N PO Box 19024 Seattle, WA 98109, USA
    Scand J Work Environ Health 32:178-84. 2006
    ..This study assessed the associations between brain tumors and specific processes and exposures among female textile workers in Shanghai, China...
  17. ncbi request reprint Modeling, estimation and validation of cotton dust and endotoxin exposures in Chinese textile operations
    George Astrakianakis
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Ann Occup Hyg 50:573-82. 2006
    ....
  18. pmc Occupational factors and risk of Parkinson's disease: A population-based case-control study
    Jordan A Firestone
    Department of Neurology, University of Washington, Seattle, USA
    Am J Ind Med 53:217-23. 2010
    ..Parkinson's disease (PD) has been associated with various workplace factors, but the evidence is inconsistent...
  19. ncbi request reprint Cancer among women textile workers in Shanghai, China: overall incidence patterns, 1989-1998
    Karen J Wernli
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Am J Ind Med 44:595-9. 2003
    ..Cancer incidence in women textile workers has not been adequately studied. The aim of this study was to examine site-specific cancer incidence patterns in a cohort of 267,400 women textile workers in Shanghai, China...
  20. pmc Environmental tobacco smoke and Parkinson's disease
    Susan Searles Nielsen
    University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, Washington 98195 7234, USA
    Mov Disord 27:293-6. 2012
    ..Parkinson's disease is inversely associated with cigarette smoking, but its relation with passive smoking or environmental tobacco smoke exposure is rarely examined...
  21. ncbi request reprint Occupational exposures and breast cancer among women textile workers in Shanghai
    Roberta M Ray
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Epidemiology 18:383-92. 2007
    ..Breast cancer incidence rates have been increasing in China over the past 2 decades. Most studies have focused on reproductive, dietary, and genetic risk factors. Little is known about the contribution of occupational exposures...
  22. pmc Occupational risk factors for endometrial cancer among textile workers in Shanghai, China
    Karen J Wernli
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington 9810, USA
    Am J Ind Med 51:673-9. 2008
    ..A case-cohort study was conducted to investigate associations between occupational exposures and endometrial cancer nested within a large cohort of textile workers in Shanghai, China...
  23. ncbi request reprint Development of a job exposure matrix (JEM) for the textile industry in Shanghai, China
    Karen J Wernli
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Occup Environ Hyg 3:521-9. 2006
    ..This JEM could be applicable for epidemiologic research in other textile industries...
  24. ncbi request reprint Menstrual and reproductive factors in relation to risk of endometrial cancer in Chinese women
    Karen J Wernli
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Causes Control 17:949-55. 2006
    ..50, 95% CI 0.23-1.07). This prospective study confirms findings from previous case-control studies relating menstrual, reproductive, and contraceptive factors and endometrial carcinoma...
  25. doi request reprint Occupational exposures and ovarian cancer in textile workers
    Karen J Wernli
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Epidemiology 19:244-50. 2008
    ..Occupational risk factors for ovarian cancer have been investigated only to a limited extent. We conducted a case-cohort study to examine associations between occupational exposures and ovarian cancer in the textile industry...
  26. ncbi request reprint Occupational risk factors for esophageal and stomach cancers among female textile workers in Shanghai, China
    Karen J Wernli
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 163:717-25. 2006
    ..01) and stomach cancer (p-trend < 0.001) when exposures were lagged 20 years. Endotoxin has not been previously reported to be a protective factor for either stomach cancer or esophageal cancer and therefore warrants further study...
  27. pmc Physical activity, physical exertion, and miscarriage risk in women textile workers in Shanghai, China
    Eva Y Wong
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Am J Ind Med 53:497-505. 2010
    ..Strenuous occupational physical activity and physical demands may be risk factors for adverse reproductive outcomes...
  28. pmc Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers
    Jonathan N Hofmann
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Environ Health Perspect 117:1402-8. 2009
    ..However, few human studies have investigated associations between PON1 status and intermediate end points, such as serum cholinesterase [butyrylcholinesterase (BuChE)] inhibition, among OP-exposed individuals...
  29. ncbi request reprint Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men
    Paola Costa-Mallen
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, 100, Seattle, WA 98105, USA
    Neurosci Lett 385:158-62. 2005
    ..These results demonstrate that particular combinations of genotypes for MAO-B and DRD2 genes are associated with significantly higher risk for smoking behavior in men, but not in women...
  30. ncbi request reprint The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease
    Paola Costa-Mallen
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98104, USA
    Am J Med Genet B Neuropsychiatr Genet 147:216-22. 2008
    ..To our knowledge, this is the first study that investigates the association of Hp genotypes with the risk of PD...
  31. ncbi request reprint Dopamine transporter (SLC6A3) 5' region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson's disease
    Samir N Kelada
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Pharmacogenet Genomics 15:659-68. 2005
    ..In addition, our findings provide further evidence supporting an association of PD with the VNTR polymorphism...
  32. pmc Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State
    Jonathan N Hofmann
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Occup Environ Med 67:375-86. 2010
    ..To identify potential risk factors for serum cholinesterase (BuChE) inhibition among agricultural pesticide handlers exposed to organophosphate (OP) and N-methyl-carbamate (CB) insecticides...
  33. ncbi request reprint No associations between Parkinson's disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes
    Starlyn Okada
    Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195 7234, USA
    Neurosci Lett 375:178-80. 2005
    ..No associations were detected for either gene variant or for any allele combinations...
  34. ncbi request reprint Glycophorin A is a potential biomarker for the mutagenic effects of pesticides
    Tim K Takaro
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Int J Occup Environ Health 10:256-61. 2004
    ..Despite the small sample size due to the alleleotype restriction, these findings support the hypothesis that some pesticides are mutagenic to hematopoietic stem cells...
  35. ncbi request reprint Diabetes, smoking, and other medical conditions in relation to Parkinson's disease risk
    Karen M Powers
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, 98195 7234, USA
    Parkinsonism Relat Disord 12:185-9. 2006
    ..However, among diabetics, the PD risk was especially reduced in non-smoking men (OR = 0.09, 95% CI = 0.02, 0.44). Other medical conditions showed no strong relations with PD...
  36. ncbi request reprint 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study
    Samir N P Kelada
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Hum Mol Genet 15:3055-62. 2006
    ..66 (95% CI: 1.73-18.53). Thus, allelic variants in SLC6A3, which affect gene expression, are associated with PD in this population and may interact with occupational pesticide exposure to increase PD risk...
  37. ncbi request reprint Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake
    Harvey Checkoway
    University of Washington, School of Public Health and Community Medicine, Department of Environmental Health, Seattle, WA 98195, USA
    Am J Epidemiol 155:732-8. 2002
    ..4, 95% CI: 0.2, 0.9) and two or more cola drinks/day (OR = 0.6, 95% CI: 0.3, 1.4). The associations for tea and cola drinks were not confounded by smoking or coffee consumption...
  38. ncbi request reprint DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson's disease cases and unrelated controls
    Paola Costa-Mallen
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195 6099, USA
    Mov Disord 19:76-83. 2004
    ..No commonly occurring (>10%) polymorphisms were found in the exons or the intronic sequences flanking the exons, although several rare variants were detected in the coding and promoter regions...
  39. ncbi request reprint Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease
    Thanh G Ton
    Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
    Mov Disord 21:964-9. 2006
    ..Our results provide only limited support for the hypothesis that use of aspirin may reduce the risk of this disease, and no indication of protection from other NSAIDs...
  40. ncbi request reprint Later life disability status following incarceration as a prisoner of war
    Stephen C Hunt
    VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Mil Med 173:613-8. 2008
    ..The objective of this project was to identify aspects of POW incarceration which are associated with later life disability status...
  41. pmc Selecting appropriate study designs to address specific research questions in occupational epidemiology
    Harvey Checkoway
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
    Occup Environ Med 64:633-8. 2007
    ..limitations of conventional study designs including cohort studies, cross-sectional studies, repeated measures studies, case-control (industry- and community-based) studies, and more recently developed variants of the nested case-control..
  42. ncbi request reprint Silica, silicosis, and lung cancer
    Alon Peretz
    Department of Environmental and Occupational Health Sciences, University of Washington, School of Public Health, Seattle, Washington 98105, USA
    Isr Med Assoc J 8:114-8. 2006
    ..The decision raised a debate in the scientific arena, and a few scientists have questioned the basis upon which causality was determined. We review the literature regarding the level of evidence of crystalline silica carcinogenicity...
  43. ncbi request reprint Characterization of the in vitro transcriptional activity of polymorphic alleles of the human monoamine oxidase-B gene
    Paola Costa-Mallen
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, 98105, USA
    Neurosci Lett 383:171-5. 2005
    ..Allele G of intron 13 had significantly higher activity than allele A in both cell lines. These results indicate transcriptional activity differences between MAO-B variant alleles that are naturally occurring in the population...
  44. pmc Calcium channel blockers and beta-blockers in relation to Parkinson's disease
    Thanh G N Ton
    Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195 7326, USA
    Parkinsonism Relat Disord 13:165-9. 2007
    ..The weakness of these associations and the absence of additional influence of dose or duration of use argue against any causal interpretation...
  45. ncbi request reprint Pesticides and risk of Parkinson disease: a population-based case-control study
    Jordan A Firestone
    Department of Neurology, University of Washington, PO Box 359739, Seattle, WA 98104, USA
    Arch Neurol 62:91-5. 2005
    ..Pesticide exposures are suspected risk factors for Parkinson disease (PD), but epidemiological observations have been inconsistent...
  46. pmc Dietary fats, cholesterol and iron as risk factors for Parkinson's disease
    Karen M Powers
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195 7234, USA
    Parkinsonism Relat Disord 15:47-52. 2009
    ..Epidemiologic findings suggest that dietary components may contribute to the etiology of Parkinson's disease (PD). This population-based case-control study evaluated PD risk and dietary intake of fats, cholesterol and iron...
  47. ncbi request reprint Risk of malformations associated with residential proximity to hazardous waste sites in Washington State
    Carrie M Kuehn
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Environ Res 103:405-12. 2007
    ..Hazardous waste sites are often located within populated areas. Thus, the possibility of increased malformation occurrence among those in close proximity deserves closer scrutiny...
  48. pmc A method to model season of birth as a surrogate environmental risk factor for disease
    Jimmy Thomas Efird
    Cancer Research Center of Hawaii, John A Burns School of Medicine, 651 Ilalo Street, Biosciences Bldg 320 B, Honolulu, HI 96813, USA
    Int J Environ Res Public Health 5:49-53. 2008
    ..Advantages of this derivative-free method include ease of use, increased statistical power to detect associations, and the ability to avoid potentially arbitrary, subjective demarcation of seasons...