Genomes and Genes
Leslie J Saucedo
Affiliation: Fred Hutchinson Cancer Research Center
- Why size matters: altering cell sizeLeslie J Saucedo
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
Curr Opin Genet Dev 12:565-71. 2002..Several physiological repercussions of altering cell size have been identified...
- Chewing the fat; regulating autophagy in DrosophilaSavraj S Grewal
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 USA
Dev Cell 7:148-50. 2004..Two reports in this issue of Developmental Cell describe how both PI3 kinase and TOR signaling in Drosophila are critical for controlling autophagy in response to developmental and environmental cues...
- EndoGI modulates Notch signaling and axon guidance in DrosophilaDavid D O'Keefe
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Av, N Seattle, WA 98109, USA
Mech Dev 128:59-70. 2011..Our data is therefore consistent with EndoGI functioning as a positive regulator of the Notch signaling pathway, playing a critical role during axon guidance of motor neurons...
- Rheb promotes cell growth as a component of the insulin/TOR signalling networkLeslie J Saucedo
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Nat Cell Biol 5:566-71. 2003..Levels of rheb mRNA are rapidly induced in response to protein starvation, and overexpressed Rheb can drive cell growth in starved animals, suggesting a role for Rheb in the nutritional control of cell growth...
- Rheb is a direct target of the tuberous sclerosis tumour suppressor proteinsYong Zhang
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
Nat Cell Biol 5:578-81. 2003..Point mutations in the GAP domain of Tsc2 disrupted its ability to regulate Rheb without affecting the ability of Tsc2 to form a complex with Tsc1. Our studies identify Rheb as a molecular target of the TSC tumour suppressors...
- Filling out the Hippo pathwayLeslie J Saucedo
Department of Biology, University of Puget Sound, 1500 North Warner Street, Tacoma, Washington 98416, USA
Nat Rev Mol Cell Biol 8:613-21. 2007..Although poorly characterized in mammals, several components of the Hippo pathway seem to be tumour suppressors in humans...