NINA REDA SALAMA

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc The Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components
    Olivier Humbert
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA
    Nucleic Acids Res 36:6893-906. 2008
  2. pmc DNA damage triggers genetic exchange in Helicobacter pylori
    Marion S Dorer
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Pathog 6:e1001026. 2010
  3. pmc Helicobacter pylori's unconventional role in health and disease
    Marion S Dorer
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Pathog 5:e1000544. 2009
  4. pmc Multiple peptidoglycan modification networks modulate Helicobacter pylori's cell shape, motility, and colonization potential
    Laura K Sycuro
    Molecular and Cellular Biology Graduate Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Pathog 8:e1002603. 2012
  5. pmc Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori
    Nina R Salama
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3 168, Seattle, Washington 981091024, USA
    Nat Rev Microbiol 11:385-99. 2013
  6. pmc Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection
    Nina R Salama
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Bacteriol 189:3834-45. 2007
  7. pmc Recombination and DNA repair in Helicobacter pylori
    Marion S Dorer
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Annu Rev Microbiol 65:329-48. 2011
  8. pmc Global transposon mutagenesis and essential gene analysis of Helicobacter pylori
    Nina R Salama
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Bacteriol 186:7926-35. 2004
  9. pmc Identification of Helicobacter pylori genes that contribute to stomach colonization
    David N Baldwin
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Infect Immun 75:1005-16. 2007
  10. pmc Pediatric Helicobacter pylori isolates display distinct gene coding capacities and virulence gene marker profiles
    Sarah Talarico
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Clin Microbiol 47:1680-8. 2009

Collaborators

  • Waldemar Vollmer
  • David Y Graham
  • Javier Torres
  • Anne Muller
  • Jeannette Guarner
  • Benjamin D Gold
  • J C Atherton
  • S Falkow
  • JAY SOLNICK
  • Marion S Dorer
  • Laura K Sycuro
  • Jutta Fero
  • Susan K Amundsen
  • David N Baldwin
  • Sarah Talarico
  • Delia M Pinto-Santini
  • Jacob Biboy
  • Zachary Pincus
  • Petra S Kraemer
  • Gerald R Smith
  • Olivier Humbert
  • Delia Pinto-Santini
  • Jill M Moore
  • Petra Born
  • Timna J Wyckoff
  • Tate H Sessler
  • Chelsea A Stern
  • Kimberley D Gutierrez
  • Larry A Gallagher
  • Steven Czinn
  • Mark R Pelletier
  • Dexter T Thompson
  • Allison Mitchell
  • Laurence Rohmer
  • Shawn J Skerett
  • Mitchell J Brittnacher
  • Colin Manoil
  • Mike Wasnick
  • Gareth A Cromie
  • Lori M Hansen
  • Petra Kraemer
  • Michael K Hall
  • Benjamin Shepherd

Detail Information

Publications19

  1. pmc The Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components
    Olivier Humbert
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA
    Nucleic Acids Res 36:6893-906. 2008
    ..HpyAXII was highly conserved (92%, n = 50), suggesting that GTAC methylation confers a selective advantage to H. pylori. However, M.HpyAXII activity did not enhance H. pylori fitness during stomach colonization of a mouse infection model...
  2. pmc DNA damage triggers genetic exchange in Helicobacter pylori
    Marion S Dorer
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Pathog 6:e1001026. 2010
    ..pylori, DNA damage induced genetic exchange may facilitate spread of antibiotic resistance and selection of fitter variants through re-assortment of preexisting alleles in this important human pathogen...
  3. pmc Helicobacter pylori's unconventional role in health and disease
    Marion S Dorer
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Pathog 5:e1000544. 2009
    ..The story of H. pylori teaches us to look more deeply at our resident microbiome and the complexity of its interactions, both in this complex population and within our own tissues, to gain a better understanding of health and disease...
  4. pmc Multiple peptidoglycan modification networks modulate Helicobacter pylori's cell shape, motility, and colonization potential
    Laura K Sycuro
    Molecular and Cellular Biology Graduate Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Pathog 8:e1002603. 2012
    ..As gastric mucus displays viscoelastic gel-like properties, our results suggest enhanced penetration of the mucus barrier underlies the fitness advantage conferred by H. pylori's characteristic shape...
  5. pmc Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori
    Nina R Salama
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3 168, Seattle, Washington 981091024, USA
    Nat Rev Microbiol 11:385-99. 2013
    ..We also describe the immunobiology of H. pylori infection and highlight how this bacterium manipulates the innate and adaptive immune systems of the host to promote its own persistence...
  6. pmc Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection
    Nina R Salama
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Bacteriol 189:3834-45. 2007
    ....
  7. pmc Recombination and DNA repair in Helicobacter pylori
    Marion S Dorer
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Annu Rev Microbiol 65:329-48. 2011
    ..Elucidation of DNA recombination, repair, and diversification programs in this pathogen will reveal connections between these pathways and their importance to infection...
  8. pmc Global transposon mutagenesis and essential gene analysis of Helicobacter pylori
    Nina R Salama
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Bacteriol 186:7926-35. 2004
    ..A limited screen for motility mutants allowed us to estimate that 4.5% of the genome is dedicated to this virulence-associated phenotype...
  9. pmc Identification of Helicobacter pylori genes that contribute to stomach colonization
    David N Baldwin
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Infect Immun 75:1005-16. 2007
    ..pylori strain variation on the pathogenic potential of this organism...
  10. pmc Pediatric Helicobacter pylori isolates display distinct gene coding capacities and virulence gene marker profiles
    Sarah Talarico
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Clin Microbiol 47:1680-8. 2009
    ..Most children were infected with H. pylori strains lacking the cag PAI, but the presence of a complete cag PAI, in contrast to other virulence markers, was associated with more severe gastroduodenal disease...
  11. ncbi request reprint The biology of Helicobacter pylori infection, a major risk factor for gastric adenocarcinoma
    Delia Pinto-Santini
    Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3 168, PO Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1853-8. 2005
    ..The exact mechanisms that lead to cancer induction are not clear, but study of the bacterial factors important for colonization and the host responses to the infection are starting to yield important clues...
  12. pmc Cag3 is a novel essential component of the Helicobacter pylori Cag type IV secretion system outer membrane subcomplex
    Delia M Pinto-Santini
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Bacteriol 191:7343-52. 2009
    ..Finally, lack of Cag3 lowers HpVirB7 steady-state levels, further indicating Cag3 makes a subcomplex with this protein...
  13. ncbi request reprint Using genomic microarrays to study insertional/transposon mutant libraries
    David N Baldwin
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Methods Enzymol 421:90-110. 2007
    ..The combination of these methods facilitates tracking large numbers of mutants for phenotypic studies. This improves both the efficiency of genome-saturating library screens and contributes to the functional annotation of unknown genes...
  14. pmc Helicobacter pylori AddAB helicase-nuclease and RecA promote recombination-related DNA repair and survival during stomach colonization
    Susan K Amundsen
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Microbiol 69:994-1007. 2008
    ..Our results reveal requirements for double-strand break repair and recombination during both acute and chronic phases of H. pylori stomach infection...
  15. pmc Peptidoglycan crosslinking relaxation promotes Helicobacter pylori's helical shape and stomach colonization
    Laura K Sycuro
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Cell 141:822-33. 2010
    ..Our findings suggest that the coordinated action of multiple proteins relaxes peptidoglycan crosslinking, enabling helical cell curvature and twist...
  16. ncbi request reprint Seeking completeness in bacterial mutant hunts
    Nina R Salama
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, PO Box 19024, Seattle, WA 98109 1024, USA
    Curr Opin Microbiol 9:307-11. 2006
    ..Such libraries also serve as a source of individual mutants for examining the biological relevance of gene associations revealed by transcriptional profiling or homology...
  17. pmc Genome-wide screen in Francisella novicida for genes required for pulmonary and systemic infection in mice
    Petra S Kraemer
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Infect Immun 77:232-44. 2009
    ..These included two genes, those for ATP synthase C (FTN_1645) and thioredoxin (FTN_1415), that when mutated allowed increased host survival and conferred protection in vaccination experiments...
  18. pmc Dual nuclease and helicase activities of Helicobacter pylori AddAB are required for DNA repair, recombination, and mouse infectivity
    Susan K Amundsen
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Biol Chem 284:16759-66. 2009
    ..pylori AddAB participates in both DNA repair and recombination. These results support a role for both the AddAB nuclease and helicase in DNA repair and promoting infectivity...
  19. pmc Mutational analysis of metronidazole resistance in Helicobacter pylori
    Jill M Moore
    Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle WA 98109 1024, USA
    Antimicrob Agents Chemother 49:1236-7. 2005
    ..Several chromosomal loci have been implicated in resistance to this drug. Saturation transposon mutagenesis of the H. pylori genome revealed inactivation of the rdxA gene as uniquely able to confer metronidazole resistance...

Research Grants7

  1. Genetic requirements of Helicobacter pylori infection
    Nina Salama; Fiscal Year: 2004
    ..These processes likely contribute to the various diseases associated with Hp and may highlight potential therapeutic targets. ..
  2. Genetic requirements of Helicobacter pylori infection
    Nina Salama; Fiscal Year: 2005
    ..These processes likely contribute to the various diseases associated with Hp and may highlight potential therapeutic targets. ..
  3. Genetic requirements of Helicobacter pylori infection
    Nina Salama; Fiscal Year: 2006
    ..These processes likely contribute to the various diseases associated with Hp and may highlight potential therapeutic targets. ..
  4. Genetic requirements of Helicobacter pylori infection
    Nina Salama; Fiscal Year: 2007
    ..These processes likely contribute to the various diseases associated with Hp and may highlight potential therapeutic targets. ..
  5. Genetic requirements of Helicobacter pylori infection
    Nina Salama; Fiscal Year: 2009
    ..Our work will identify targets for developing antimicrobial therapies and, through the study of genetic exchange, bring new knowledge on the mechanisms by which antimicrobial resistance is spread through bacterial populations. ..
  6. Genetic requirements of Helicobacter pylori infection
    NINA REDA SALAMA; Fiscal Year: 2010
    ..Our work will identify targets for developing antimicrobial therapies and, through the study of genetic exchange, bring new knowledge on the mechanisms by which antimicrobial resistance is spread through bacterial populations. ..