Alanna Ruddell

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Dynamic contrast-enhanced magnetic resonance imaging of tumor-induced lymph flow
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Neoplasia 10:706-13, 1 p following 713. 2008
  2. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
  3. pmc B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Neoplasia 13:748-57. 2011
  4. ncbi request reprint Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation
    Pau Mezquita
    Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Oncogene 24:889-901. 2005
  5. pmc Lymph node mapping in the mouse
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol Methods 332:170-4. 2008
  6. pmc Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1
    Momoko Furuya
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 185:5769-77. 2010
  7. pmc B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, the Department of Biological Structure, and the Department of Comparative Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Am J Pathol 163:2233-45. 2003
  8. ncbi request reprint Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis
    Sean S Parghi
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, PO Box 19024, MS C2 023, Seattle, WA 98109, USA
    Oncogene 23:4413-21. 2004
  9. pmc Evaluation of reference genes for quantitative PCR analysis of mouse lymphocytes
    Tina C Albershardt
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Immunol Methods 384:196-9. 2012

Research Grants

  1. c-Myc Expression during Lymphomagenesis
    M Ruddell; Fiscal Year: 2009
  2. C MYC EXPRESSION DURING ALV LYMPHOMAGENESIS
    M Ruddell; Fiscal Year: 2004
  3. Lymph Node Alterations in Cancer
    M ALANNA RUDDELL; Fiscal Year: 2010

Collaborators

  • Kenneth R Maravilla
  • Paul E Neiman
  • Jonathan S Alexander
  • M Ruddell
  • M ALANNA RUDDELL
  • Maria I Harrell
  • Brian M Iritani
  • Tina C Albershardt
  • Sean S Parghi
  • Momoko Furuya
  • Pau Mezquita
  • Kimberly A Brandvold
  • Andrew G Farr
  • Bendicht U Pauli
  • Amanda Paulovich
  • Sara B Kirschbaum
  • Heidi Zhang
  • Sandra J Bowers

Detail Information

Publications9

  1. pmc Dynamic contrast-enhanced magnetic resonance imaging of tumor-induced lymph flow
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Neoplasia 10:706-13, 1 p following 713. 2008
    ..Low-molecular weight gadolinium contrast is already used for 1.5-T MRI scanning in humans, which should facilitate translation of this imaging assay...
  2. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
    ..Lymph node lymphangiogenesis and increased lymph flow through tumor-draining lymph nodes may actively promote metastasis via the lymphatics...
  3. pmc B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Neoplasia 13:748-57. 2011
    ....
  4. ncbi request reprint Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation
    Pau Mezquita
    Division of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Oncogene 24:889-901. 2005
    ..Myc stimulates VEGF production by a rapamycin- and LY294002-sensitive pathway, which does not involve alteration of eIF4E activity...
  5. pmc Lymph node mapping in the mouse
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol Methods 332:170-4. 2008
    ..These techniques allow accurate and rapid identification of lymph nodes and lymphatic drainage in normal as well as diseased mice...
  6. pmc Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1
    Momoko Furuya
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 185:5769-77. 2010
    ....
  7. pmc B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, the Department of Biological Structure, and the Department of Comparative Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Am J Pathol 163:2233-45. 2003
    ..These results indicate that constitutive c-Myc expression stimulates angiogenesis and lymphangiogenesis, which may promote the rapid growth and metastasis of c-Myc-expressing cancer cells, respectively...
  8. ncbi request reprint Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis
    Sean S Parghi
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, PO Box 19024, MS C2 023, Seattle, WA 98109, USA
    Oncogene 23:4413-21. 2004
    ....
  9. pmc Evaluation of reference genes for quantitative PCR analysis of mouse lymphocytes
    Tina C Albershardt
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Immunol Methods 384:196-9. 2012
    ..We provide a shortlist of reference genes to use for normalization and recommend freely available software programs as a rapid approach to validate potential reference genes...

Research Grants12

  1. c-Myc Expression during Lymphomagenesis
    M Ruddell; Fiscal Year: 2009
    ..Identification of the factors directing lymph node alterations and tumor dissemination will be useful in the development of diagnostic assays and therapies for metastasis via the lymph nodes. ..
  2. C MYC EXPRESSION DURING ALV LYMPHOMAGENESIS
    M Ruddell; Fiscal Year: 2004
    ....
  3. Lymph Node Alterations in Cancer
    M ALANNA RUDDELL; Fiscal Year: 2010
    ..Our experiments will investigate the contribution of this lymph node response to tumor spread to draining lymph nodes and other locations in the body. ..