MARY ROSSING

..However, few studies have evaluated variations in the risks of breast cancer-specific mortality across ER/PR status by either demographic or clinical characteristics...

..9). Our results suggest that use of cimetidine does not influence risk of female breast cancer. Further, these data provide little evidence to support the previously hypothesized preventive effect of cimetidine on risk of prostate cancer...

..We assessed the sensitivity, specificity, and positive predictive value of a proposed symptom index and of symptoms included in the consensus recommendation...

..In a population-based case-control study of epithelial ovarian cancer, we assessed risk associated with recreational physical activity with a focus on characterizing risk within histologic subtypes...

..We assessed the risk associated with a prior diagnosis of, and ovarian surgery following, ovarian cysts and endometriosis, with a focus on characterizing risk among tumor subgroups...

..These findings, if replicated, may have implications both for public health and development of chemoprevention strategies...

..The association of smoking with other histologic types of ovarian cancer is less clear, but potentially holds greater importance for prevention of disease incidence and mortality...

..In particular, we sought to characterize the independent relation of body weight at particular ages with risk...

..While the results of this study support the hypothesis that a subset of nulliparous women who experience infertility may be at increased risk of ovarian cancer, the reasons for this increase in risk remain unclear...

..No association of ovarian cancer risk was observed with any of the other polymorphisms examined, either alone or in combination...

..An increased risk of ovarian cancer among users of antidepressants and benzodiazepines has been observed in some but not all prior studies. We examined these associations in a population-based case-control study...

..However, they add to the weight of evidence that, in the aggregate, provides little support for the use of analgesic drugs as chemoprevention for this disease...

..This analysis shows the importance of consortia, like the OCAC, in either confirming or refuting the validity of putative findings in studies with smaller sample sizes. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3567-72)...

..5-18.4) increased risk of ovarian cancer. Together, these two studies provide some support for the hypothesis that late age at primary infection with a common agent (conceivably, EBV) may play a role in the etiology of ovarian cancer...

..Green tea, which is commonly consumed in countries with low ovarian cancer incidence, should be further investigated for its cancer prevention properties...

..In a population-based study of 812 women ages 35-74 years with epithelial ovarian cancer diagnosed in Washington State from 2002 to 2005 and 1313 controls, we assessed the relation of such factors to disease risk...

..These data provide suggestive evidence that the rs2295190 T allele, or another allele in linkage disequilibrium with it, may be associated with increased risk of invasive ovarian cancer...

..Our results fail to support prior evidence of an association of the CCK C-45T polymorphism with the ability to quit smoking...

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..Our results provide only limited support for the hypothesis that use of aspirin may reduce the risk of this disease, and no indication of protection from other NSAIDs...

..73, 1.53). NSAID use was unrelated to risk of endometrial cancer in both obese and nonobese women. Results from this study suggest that the use of aspirin or other NSAIDs has little or no influence on the risk of endometrial cancer...

..The weakness of these associations and the absence of additional influence of dose or duration of use argue against any causal interpretation...

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..Few longitudinal studies have examined physical activity (PA) levels in breast cancer survivors and how those levels change following cancer diagnosis and treatment...

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..The proposed study, by expanding our knowledge of the role of progestogens, estrogens, and androgens in the development of ovarian cancer, will inform efforts to develop effective strategies to prevent this disease. ..

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..g., SSRIs or tricyclics), and individual drugs such as fluoxetine and paroxetine. Use of the pharmacy database will provide unbiased and complete exposure data relative to previous studies based on self-reported drug use. ..

..In the future, such knowledge may allow the identification of subgroups of individuals who are most likely to benefit from particular pharmacologic interventions. ..

..The proposed study, by expanding our knowledge of the role of progestogens, estrogens, and androgens in the development of ovarian cancer, will inform efforts to develop effective strategies to prevent this disease. ..