Brian Reid

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. doi request reprint Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus
    Xiaohong Li
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024
    Cancer Prev Res (Phila) 7:114-27. 2014
  2. doi request reprint Early events during neoplastic progression in Barrett's esophagus
    Brian J Reid
    Fred Hutchinson Cancer Research Center, Divisions of Human Biology and Public Health Sciences, Department of Genome Sciences, University of Washington, Seattle, WA, USA
    Cancer Biomark 9:307-24. 2010
  3. pmc New strategies in Barrett's esophagus: integrating clonal evolutionary theory with clinical management
    Brian J Reid
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, P O Box 19024, Seattle, WA 98109, USA
    Clin Cancer Res 17:3512-9. 2011
  4. pmc Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis
    Brian J Reid
    Divisions of Public Health Sciences and Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 98109 Seattle, USA
    Nat Rev Cancer 10:87-101. 2010
  5. ncbi request reprint Biomarkers in Barrett's esophagus
    Brian J Reid
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 100 Fairview Avenue North, Seattle, WA 98109, USA
    Gastrointest Endosc Clin N Am 13:369-97. 2003
  6. ncbi request reprint The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Res 64:7629-33. 2004
  7. ncbi request reprint Genetic mechanisms of TP53 loss of heterozygosity in Barrett's esophagus: implications for biomarker validation
    V Jon Wongsurawat
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 15:509-16. 2006
  8. ncbi request reprint Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH
    Lisa A Lai
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Genes Chromosomes Cancer 46:532-42. 2007
  9. pmc Deletion at fragile sites is a common and early event in Barrett's esophagus
    Lisa A Lai
    Department of Pathology, University of Washington, Seattle, WA, USA
    Mol Cancer Res 8:1084-94. 2010
  10. ncbi request reprint Leukocyte telomere length predicts cancer risk in Barrett's esophagus
    Rosa Ana Risques
    Department of Pathology, University of Washington, Seattle, WA 98195 7705, USA
    Cancer Epidemiol Biomarkers Prev 16:2649-55. 2007

Research Grants

Collaborators

Detail Information

Publications46

  1. doi request reprint Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus
    Xiaohong Li
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024
    Cancer Prev Res (Phila) 7:114-27. 2014
    ..Cancer Prev Res; 7(1); 114-27. ©2013 AACR. ..
  2. doi request reprint Early events during neoplastic progression in Barrett's esophagus
    Brian J Reid
    Fred Hutchinson Cancer Research Center, Divisions of Human Biology and Public Health Sciences, Department of Genome Sciences, University of Washington, Seattle, WA, USA
    Cancer Biomark 9:307-24. 2010
    ..Recent advances in SNP array technology provide a uniform platform to assess chromosome instability...
  3. pmc New strategies in Barrett's esophagus: integrating clonal evolutionary theory with clinical management
    Brian J Reid
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, P O Box 19024, Seattle, WA 98109, USA
    Clin Cancer Res 17:3512-9. 2011
    ..The challenge for investigators of Barrett's esophagus lies in integrating knowledge about genomic instability and clonal evolution into clinical management to increase the lifespan and quality of life of individuals with this condition...
  4. pmc Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis
    Brian J Reid
    Divisions of Public Health Sciences and Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 98109 Seattle, USA
    Nat Rev Cancer 10:87-101. 2010
    ..Given that 95% of oesophageal adenocarcinomas arise in individuals without a prior diagnosis of Barrett's oesophagus, what strategies can be used to reduce late diagnosis of oesophageal adenocarcinoma?..
  5. ncbi request reprint Biomarkers in Barrett's esophagus
    Brian J Reid
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 100 Fairview Avenue North, Seattle, WA 98109, USA
    Gastrointest Endosc Clin N Am 13:369-97. 2003
    ..These studies are likely to be of clinical interest because they may becoming the basis for randomized clinical trials to prevent cancer in BE...
  6. ncbi request reprint The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Res 64:7629-33. 2004
    ..This implies that interventions that limit expansion of genetically unstable clones may reduce risk of progression to cancer...
  7. ncbi request reprint Genetic mechanisms of TP53 loss of heterozygosity in Barrett's esophagus: implications for biomarker validation
    V Jon Wongsurawat
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 15:509-16. 2006
    ..If an alternative biomarker assay, such as fluorescence in situ hybridization (FISH), provided equivalent results, then translation to the clinic might be accelerated, because LOH genotyping is presently limited to research centers...
  8. ncbi request reprint Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH
    Lisa A Lai
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Genes Chromosomes Cancer 46:532-42. 2007
    ....
  9. pmc Deletion at fragile sites is a common and early event in Barrett's esophagus
    Lisa A Lai
    Department of Pathology, University of Washington, Seattle, WA, USA
    Mol Cancer Res 8:1084-94. 2010
    ..Deletion and genomic instability at FRA3B and other fragile sites could thus be a biomarker of genetic damage in BE patients and a potential biomarker of cancer risk...
  10. ncbi request reprint Leukocyte telomere length predicts cancer risk in Barrett's esophagus
    Rosa Ana Risques
    Department of Pathology, University of Washington, Seattle, WA 98195 7705, USA
    Cancer Epidemiol Biomarkers Prev 16:2649-55. 2007
    ..Patients and..
  11. pmc Dietary supplement use and risk of neoplastic progression in esophageal adenocarcinoma: a prospective study
    Linda M Dong
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
    Nutr Cancer 60:39-48. 2008
    ..10-0.60). In this cohort study, use of multivitamins and single antioxidant supplements was associated with a significantly reduced risk of EA and markers of neoplastic progression among individuals with Barrett's esophagus...
  12. ncbi request reprint Chromosomal instability in Barrett's esophagus is related to telomere shortening
    Jennifer C Finley
    Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195 7705, USA
    Cancer Epidemiol Biomarkers Prev 15:1451-7. 2006
    ....
  13. ncbi request reprint Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:3414-27. 2004
    ..Virtually all of the other lesion expansions, including microsatellite shifts, could be explained as hitchhikers on p16 lesion clonal expansions. These techniques can be applied to any neoplasm...
  14. ncbi request reprint Longitudinal study of insulin-like growth factor, insulin-like growth factor binding protein-3, and their polymorphisms: risk of neoplastic progression in Barrett's esophagus
    Sid H Siahpush
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 16:2387-95. 2007
    ..IGF-I and its main binding protein, IGF binding protein-3 (IGFBP-3), and their polymorphisms have been investigated in relation to risk of many cancers, but not esophageal adenocarcinoma...
  15. ncbi request reprint Nonsteroidal anti-inflammatory drug use, body mass index, and anthropometry in relation to genetic and flow cytometric abnormalities in Barrett's esophagus
    Thomas L Vaughan
    Program in Epidemiology T L V, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:745-52. 2002
    ..We also conclude that NSAID use may reduce the risk of progression to cancer in this population. Prospective studies are needed to confirm these results...
  16. ncbi request reprint The case for early detection
    Ruth Etzioni
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Rev Cancer 3:243-52. 2003
    ..been revitalized by the advent of novel molecular technologies that can identify cellular changes at the level of the genome or proteome, but how can we harness these new technologies to develop effective and practical screening tests?..
  17. pmc NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma
    Patricia C Galipeau
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e67. 2007
    ..We aimed to evaluate somatic genetic abnormalities with NSAIDs as predictors of EA in a prospective cohort study of patients with BE...
  18. pmc Direct inference of SNP heterozygosity rates and resolution of LOH detection
    Xiaohong Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Comput Biol 3:e244. 2007
    ..New experimental designs for LOH studies would also benefit from considering the power of detection and sample sizes required to accomplish the proposed aims...
  19. pmc p16 mutation spectrum in the premalignant condition Barrett's esophagus
    Thomas G Paulson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 3:e3809. 2008
    ....
  20. pmc Cell proliferation, cell cycle abnormalities, and cancer outcome in patients with Barrett's esophagus: a long-term prospective study
    Dennis L Chao
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Clin Cancer Res 14:6988-95. 2008
    ....
  21. pmc Single nucleotide polymorphism-based genome-wide chromosome copy change, loss of heterozygosity, and aneuploidy in Barrett's esophagus neoplastic progression
    Xiaohong Li
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Prev Res (Phila) 1:413-23. 2008
    ..Measures of chromosomal instability can be quantified in whole biopsies using SNP-based genotyping and have potential to be an integrated platform for cancer risk stratification in BE...
  22. pmc Translation of an STR-based biomarker into a clinically compatible SNP-based platform for loss of heterozygosity
    Heather D Kissel
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Biomark 5:143-58. 2009
    ....
  23. pmc Chromosomal instability and copy number alterations in Barrett's esophagus and esophageal adenocarcinoma
    Thomas G Paulson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Cancer Res 15:3305-14. 2009
    ....
  24. ncbi request reprint Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis
    Dennis L Chao
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C1 157, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 15:1935-40. 2006
    ....
  25. ncbi request reprint Focus on Barrett's esophagus and esophageal adenocarcinoma
    Thomas G Paulson
    Divisions of Human Biology and Public Health Sciences, University of Washington, Seattle 98109, USA
    Cancer Cell 6:11-6. 2004
  26. ncbi request reprint Neosquamous epithelium does not typically arise from Barrett's epithelium
    Thomas G Paulson
    Division of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Clin Cancer Res 12:1701-6. 2006
    ....
  27. pmc Transcriptional analyses of Barrett's metaplasia and normal upper GI mucosae
    Michael T Barrett
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Neoplasia 4:121-8. 2002
    ..Furthermore, we identified clusters of genes that are specific to each of the tissues, to the Barrett's metaplastic epithelia, and a cluster of genes that was distinct between squamous and non-squamous epithelia...
  28. pmc Serum selenium levels in relation to markers of neoplastic progression among persons with Barrett's esophagus
    Rebecca E Rudolph
    Cancer Prevention and Trials Program, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle 98109 1024, USA
    J Natl Cancer Inst 95:750-7. 2003
    ..We used a cross-sectional study to investigate the relationship between serum selenium levels and markers of neoplastic progression among persons with Barrett's esophagus...
  29. ncbi request reprint Low-fat, high fruit and vegetable diets and weight loss do not affect biomarkers of cellular proliferation in Barrett esophagus
    Alan R Kristal
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, M4 B402, P O Box 19024, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 14:2377-83. 2005
    ..We conclude that substantial dietary change has no short-term effects on biomarkers of cellular proliferation in Barrett esophagus or on clinical observations of the Barrrett segment...
  30. pmc Application of biomarkers in cancer risk management: evaluation from stochastic clonal evolutionary and dynamic system optimization points of view
    Xiaohong Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America
    PLoS Comput Biol 7:e1001087. 2011
    ..This approach will allow optimization of available resources for cancer control and intervention timing based on molecular biomarkers in predicting cancer among various risk subsets that dynamically evolve over time...
  31. ncbi request reprint Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study
    Thomas L Vaughan
    Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, Seattle, WA 98109, USA
    Lancet Oncol 6:945-52. 2005
    ..We aimed to assess the role of NSAID in the development of oesophageal adenocarcinoma and precursor lesions in people with Barrett's oesophagus--a metaplastic disorder that confers a high risk of oesophageal adenocarcinoma...
  32. pmc Extended lifespan of Barrett's esophagus epithelium transduced with the human telomerase catalytic subunit: a useful in vitro model
    M Corinna A Palanca-Wessels
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Carcinogenesis 24:1183-90. 2003
    ..Long-lived Barrett's esophagus epithelial cultures should provide a useful in vitro model for studies of neoplastic evolution and chemopreventive therapies...
  33. ncbi request reprint Molecular phenotype of spontaneously arising 4N (G2-tetraploid) intermediates of neoplastic progression in Barrett's esophagus
    Michael T Barrett
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cancer Res 63:4211-7. 2003
    ..These results describe the molecular phenotype of dysregulated G(2)-M functions and cell cycle checkpoints in a key intermediate of human neoplastic progression...
  34. pmc Reproducible two-dimensional capillary electrophoresis analysis of Barrett's esophagus tissues
    James R Kraly
    Department of Chemistry, University of Washington, Seattle, WA 98195 1700, USA
    Anal Chem 78:5977-86. 2006
    ..These results suggest that two-dimensional capillary electrophoresis may be of value for the rapid characterization of endoscopic and surgical biopsies...
  35. pmc Single nucleotide polymorphism array analysis of flow-sorted epithelial cells from frozen versus fixed tissues for whole genome analysis of allelic loss in breast cancer
    Elizabeth L Schubert
    Division of Human Biology, Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Pathol 160:73-9. 2002
    ....
  36. ncbi request reprint Flow cytometric enrichment for respiratory epithelial cells in sputum
    Petra S Kraemer
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cytometry A 60:1-7. 2004
    ..However, obtaining abnormal exfoliated cells for detailed molecular studies is limited because respiratory epithelial cells comprise only about 1% of sputum cell populations...
  37. ncbi request reprint Cancer prevention strategies that address the evolutionary dynamics of neoplastic cells: simulating benign cell boosters and selection for chemosensitivity
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, P O Box 19024, Mailstop C1 157, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:1375-84. 2004
    ..Effective therapeutic and prevention strategies will have to alter the competitive dynamics of a neoplasm to counter progression toward invasion, metastasis, and death...
  38. ncbi request reprint Biologic properties of columnar epithelium underneath reepithelialized squamous mucosa in Barrett's esophagus
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:372-80. 2005
    ..Prospective studies of large numbers of patients with BUSI will be required to determine the magnitude of its risk of progression to cancer...
  39. ncbi request reprint Natural selection in neoplastic progression of Barrett's esophagus
    Carlo C Maley
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
    Semin Cancer Biol 15:474-83. 2005
    ..Evolutionary analyses provide insights for clinical management, including rates of progression to cancer and emergence of resistance to interventions...
  40. ncbi request reprint Genetic clonal diversity predicts progression to esophageal adenocarcinoma
    Carlo C Maley
    The Wistar Institute, 3601 Spruce St, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 38:468-73. 2006
    ..6) and ploidy abnormalities. Progression to cancer through accumulation of clonal diversity, on which natural selection acts, may be a fundamental principle of neoplasia with important clinical implications...
  41. ncbi request reprint Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort
    Leslie C Lomo
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 30:423-35. 2006
    ..Based on these findings, BCDA warrants further investigation as a possible subtype of true dysplasia despite the morphologic appearance of surface maturation...
  42. ncbi request reprint Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus
    Amitabh Srivastava
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 102:483-93; quiz 694. 2007
    ..The aim of this discovery study was to evaluate the hypothesis that extent of LGD and HGD are risk factors for progression to EA...
  43. ncbi request reprint Mucin core polypeptide expression in the progression of neoplasia in Barrett's esophagus
    Jonathan N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 37:1304-15. 2006
    ..Alterations in MUC expression occur in the progression of dysplasia in BE. However, none of these markers helps identify a subgroup of patients at increased risk for neoplasia...
  44. pmc Translational Research Working Group developmental pathway for biospecimen-based assessment modalities
    Sudhir Srivastava
    Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 14:5672-7. 2008
    ..This paper introduces the pathway in the context of prior work and discusses key challenges associated with the biomarker development process in light of the pathway...
  45. ncbi request reprint Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward
    Gary J Kelloff
    National Cancer Institute, Bethesda, Maryland 20852, USA
    Clin Cancer Res 12:3661-97. 2006
    ....
  46. ncbi request reprint Cancer as an evolutionary and ecological process
    Lauren M F Merlo
    Cellular and Molecular Oncology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 6:924-35. 2006
    ..The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer...

Research Grants7

  1. PREDICTORS OF PROGRESSION IN BARRETTS ESOPHAGUS
    Brian Reid; Fiscal Year: 1999
    ..Statistical analyses, which vary by specific aim, will include logistic regression (adjusting for length of follow-up) and construction of ROC curves. ..
  2. Predictors of Progression in Barret's Esophagus
    Brian Reid; Fiscal Year: 2001
    ..Successful completion of these aims will provide a scientific basis for i) prevention trials using candidate interventions and validated intermediate endpoints, and ii) a more rational surveillance strategy for BE. ..
  3. Barrett's Esophagus: Predictors of Progression
    Brian Reid; Fiscal Year: 2007
    ..Core A (Leadership) provides a vehicle for inter project and core communications. ..