Research Topics
Species | Brian ReidSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
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Publications
New strategies in Barrett's esophagus: integrating clonal evolutionary theory with clinical managementBrian J Reid
Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, P O Box 19024, Seattle, WA 98109, USA
Clin Cancer Res 17:3512-9. 2011..The challenge for investigators of Barrett's esophagus lies in integrating knowledge about genomic instability and clonal evolution into clinical management to increase the lifespan and quality of life of individuals with this condition...
Early events during neoplastic progression in Barrett's esophagusBrian J Reid
Fred Hutchinson Cancer Research Center, Divisions of Human Biology and Public Health Sciences, Department of Genome Sciences, University of Washington, Seattle, WA, USA
Cancer Biomark 9:307-24. 2010..Recent advances in SNP array technology provide a uniform platform to assess chromosome instability...- Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesisBrian J Reid
Divisions of Public Health Sciences and Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 98109 Seattle, USA
Nat Rev Cancer 10:87-101. 2010..Given that 95% of oesophageal adenocarcinomas arise in individuals without a prior diagnosis of Barrett's oesophagus, what strategies can be used to reduce late diagnosis of oesophageal adenocarcinoma?.. 
Biomarkers in Barrett's esophagusBrian J Reid
Division of Human Biology, Fred Hutchinson Cancer Research Center, 100 Fairview Avenue North, Seattle, WA 98109, USA
Gastrointest Endosc Clin N Am 13:369-97. 2003..These studies are likely to be of clinical interest because they may becoming the basis for randomized clinical trials to prevent cancer in BE...- The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinomaCarlo C Maley
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Cancer Res 64:7629-33. 2004..This implies that interventions that limit expansion of genetically unstable clones may reduce risk of progression to cancer... - Genetic mechanisms of TP53 loss of heterozygosity in Barrett's esophagus: implications for biomarker validationV Jon Wongsurawat
Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 15:509-16. 2006..FISH will require validation in adequately powered longitudinal studies before implementation as a clinical diagnostic for esophageal adenocarcinoma risk prediction... - Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGHLisa A Lai
Department of Pathology, University of Washington, Seattle, WA 98195, USA
Genes Chromosomes Cancer 46:532-42. 2007.... - Dietary supplement use and risk of neoplastic progression in esophageal adenocarcinoma: a prospective studyLinda M Dong
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
Nutr Cancer 60:39-48. 2008..10-0.60). In this cohort study, use of multivitamins and single antioxidant supplements was associated with a significantly reduced risk of EA and markers of neoplastic progression among individuals with Barrett's esophagus... - Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagusCarlo C Maley
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Res 64:3414-27. 2004..Virtually all of the other lesion expansions, including microsatellite shifts, could be explained as hitchhikers on p16 lesion clonal expansions. These techniques can be applied to any neoplasm... - Chromosomal instability in Barrett's esophagus is related to telomere shorteningJennifer C Finley
Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195-7705, USA
Cancer Epidemiol Biomarkers Prev 15:1451-7. 2006.... - Deletion at fragile sites is a common and early event in Barrett's esophagusLisa A Lai
Department of Pathology, University of Washington, Seattle, WA, USA
Mol Cancer Res 8:1084-94. 2010..Deletion and genomic instability at FRA3B and other fragile sites could thus be a biomarker of genetic damage in BE patients and a potential biomarker of cancer risk... - Leukocyte telomere length predicts cancer risk in Barrett's esophagusRosa Ana Risques
Department of Pathology, University of Washington, Seattle, WA 98195 7705, USA
Cancer Epidemiol Biomarkers Prev 16:2649-55. 2007..Patients and.. - Longitudinal study of insulin-like growth factor, insulin-like growth factor binding protein-3, and their polymorphisms: risk of neoplastic progression in Barrett's esophagusSid H Siahpush
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 16:2387-95. 2007..IGF-I and its main binding protein, IGF binding protein-3 (IGFBP-3), and their polymorphisms have been investigated in relation to risk of many cancers, but not esophageal adenocarcinoma... - Nonsteroidal anti-inflammatory drug use, body mass index, and anthropometry in relation to genetic and flow cytometric abnormalities in Barrett's esophagusThomas L Vaughan
Program in Epidemiology T L V, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 11:745-52. 2002..We also conclude that NSAID use may reduce the risk of progression to cancer in this population. Prospective studies are needed to confirm these results... - The case for early detectionRuth Etzioni
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
Nat Rev Cancer 3:243-52. 2003..been revitalized by the advent of novel molecular technologies that can identify cellular changes at the level of the genome or proteome, but how can we harness these new technologies to develop effective and practical screening tests?.. - NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinomaPatricia C Galipeau
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Med 4:e67. 2007..We aimed to evaluate somatic genetic abnormalities with NSAIDs as predictors of EA in a prospective cohort study of patients with BE... - Direct inference of SNP heterozygosity rates and resolution of LOH detectionXiaohong Li
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Comput Biol 3:e244. 2007..New experimental designs for LOH studies would also benefit from considering the power of detection and sample sizes required to accomplish the proposed aims... - Cell proliferation, cell cycle abnormalities, and cancer outcome in patients with Barrett's esophagus: a long-term prospective studyDennis L Chao
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Clin Cancer Res 14:6988-95. 2008.... - p16 mutation spectrum in the premalignant condition Barrett's esophagusThomas G Paulson
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 3:e3809. 2008.... - Single nucleotide polymorphism-based genome-wide chromosome copy change, loss of heterozygosity, and aneuploidy in Barrett's esophagus neoplastic progressionXiaohong Li
Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Prev Res (Phila) 1:413-23. 2008..Measures of chromosomal instability can be quantified in whole biopsies using SNP-based genotyping and have potential to be an integrated platform for cancer risk stratification in BE... - Translation of an STR-based biomarker into a clinically compatible SNP-based platform for loss of heterozygosityHeather D Kissel
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Biomark 5:143-58. 2009.... - Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysisDennis L Chao
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C1 157, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 15:1935-40. 2006.... - Chromosomal instability and copy number alterations in Barrett's esophagus and esophageal adenocarcinomaThomas G Paulson
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Clin Cancer Res 15:3305-14. 2009.... - Low-fat, high fruit and vegetable diets and weight loss do not affect biomarkers of cellular proliferation in Barrett esophagusAlan R Kristal
Fred Hutchinson Cancer Research Center, Cancer Prevention Program, M4 B402, P O Box 19024, Seattle, WA, USA
Cancer Epidemiol Biomarkers Prev 14:2377-83. 2005..We conclude that substantial dietary change has no short-term effects on biomarkers of cellular proliferation in Barrett esophagus or on clinical observations of the Barrrett segment... - Focus on Barrett's esophagus and esophageal adenocarcinomaThomas G Paulson
Divisions of Human Biology and Public Health Sciences, University of Washington, Seattle 98109, USA
Cancer Cell 6:11-6. 2004 - Transcriptional analyses of Barrett's metaplasia and normal upper GI mucosaeMichael T Barrett
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
Neoplasia 4:121-8. 2002..Furthermore, we identified clusters of genes that are specific to each of the tissues, to the Barrett's metaplastic epithelia, and a cluster of genes that was distinct between squamous and non-squamous epithelia... - Serum selenium levels in relation to markers of neoplastic progression among persons with Barrett's esophagusRebecca E Rudolph
Cancer Prevention and Trials Program, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle 98109 1024, USA
J Natl Cancer Inst 95:750-7. 2003..We used a cross-sectional study to investigate the relationship between serum selenium levels and markers of neoplastic progression among persons with Barrett's esophagus... - Neosquamous epithelium does not typically arise from Barrett's epitheliumThomas G Paulson
Division of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Clin Cancer Res 12:1701-6. 2006.... - Application of biomarkers in cancer risk management: evaluation from stochastic clonal evolutionary and dynamic system optimization points of viewXiaohong Li
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America
PLoS Comput Biol 7:e1001087. 2011..This approach will allow optimization of available resources for cancer control and intervention timing based on molecular biomarkers in predicting cancer among various risk subsets that dynamically evolve over time... - Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective studyThomas L Vaughan
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, Seattle, WA 98109, USA
Lancet Oncol 6:945-52. 2005..We aimed to assess the role of NSAID in the development of oesophageal adenocarcinoma and precursor lesions in people with Barrett's oesophagus--a metaplastic disorder that confers a high risk of oesophageal adenocarcinoma... - Extended lifespan of Barrett's esophagus epithelium transduced with the human telomerase catalytic subunit: a useful in vitro modelM Corinna A Palanca-Wessels
Department of Pathology, University of Washington, Seattle, Washington, USA
Carcinogenesis 24:1183-90. 2003..Long-lived Barrett's esophagus epithelial cultures should provide a useful in vitro model for studies of neoplastic evolution and chemopreventive therapies... - Molecular phenotype of spontaneously arising 4N (G2-tetraploid) intermediates of neoplastic progression in Barrett's esophagusMichael T Barrett
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Cancer Res 63:4211-7. 2003..These results describe the molecular phenotype of dysregulated G(2)-M functions and cell cycle checkpoints in a key intermediate of human neoplastic progression... - Single nucleotide polymorphism array analysis of flow-sorted epithelial cells from frozen versus fixed tissues for whole genome analysis of allelic loss in breast cancerElizabeth L Schubert
Division of Human Biology, Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Am J Pathol 160:73-9. 2002.... - Reproducible two-dimensional capillary electrophoresis analysis of Barrett's esophagus tissuesJames R Kraly
Department of Chemistry, University of Washington, Seattle, WA 98195-1700, USA
Anal Chem 78:5977-86. 2006..These results suggest that two-dimensional capillary electrophoresis may be of value for the rapid characterization of endoscopic and surgical biopsies... - Flow cytometric enrichment for respiratory epithelial cells in sputumPetra S Kraemer
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA
Cytometry A 60:1-7. 2004..With further development, this methodology may be useful as part of a molecular screening approach of populations at high risk for lung cancer... - Cancer prevention strategies that address the evolutionary dynamics of neoplastic cells: simulating benign cell boosters and selection for chemosensitivityCarlo C Maley
Division of Human Biology, Fred Hutchinson Cancer Research Center, P O Box 19024, Mailstop C1 157, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 13:1375-84. 2004..Effective therapeutic and prevention strategies will have to alter the competitive dynamics of a neoplasm to counter progression toward invasion, metastasis, and death... - Biologic properties of columnar epithelium underneath reepithelialized squamous mucosa in Barrett's esophagusJason L Hornick
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 29:372-80. 2005..Prospective studies of large numbers of patients with BUSI will be required to determine the magnitude of its risk of progression to cancer... - Natural selection in neoplastic progression of Barrett's esophagusCarlo C Maley
Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
Semin Cancer Biol 15:474-83. 2005..Evolutionary analyses provide insights for clinical management, including rates of progression to cancer and emergence of resistance to interventions... - Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagusAmitabh Srivastava
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Gastroenterol 102:483-93; quiz 694. 2007..The aim of this discovery study was to evaluate the hypothesis that extent of LGD and HGD are risk factors for progression to EA... - Genetic clonal diversity predicts progression to esophageal adenocarcinomaCarlo C Maley
The Wistar Institute, 3601 Spruce St, Philadelphia, Pennsylvania 19104, USA
Nat Genet 38:468-73. 2006..6) and ploidy abnormalities. Progression to cancer through accumulation of clonal diversity, on which natural selection acts, may be a fundamental principle of neoplasia with important clinical implications... - Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohortLeslie C Lomo
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Surg Pathol 30:423-35. 2006..Based on these findings, BCDA warrants further investigation as a possible subtype of true dysplasia despite the morphologic appearance of surface maturation... - Mucin core polypeptide expression in the progression of neoplasia in Barrett's esophagusJonathan N Glickman
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hum Pathol 37:1304-15. 2006..Alterations in MUC expression occur in the progression of dysplasia in BE. However, none of these markers helps identify a subgroup of patients at increased risk for neoplasia... - Cancer as an evolutionary and ecological processLauren M F Merlo
Cellular and Molecular Oncology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Nat Rev Cancer 6:924-35. 2006..The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer... - Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forwardGary J Kelloff
National Cancer Institute, Bethesda, Maryland 20852, USA
Clin Cancer Res 12:3661-97. 2006.... - Translational Research Working Group developmental pathway for biospecimen-based assessment modalitiesSudhir Srivastava
Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA
Clin Cancer Res 14:5672-7. 2008..This paper introduces the pathway in the context of prior work and discusses key challenges associated with the biomarker development process in light of the pathway...
Research Grants
- PREDICTORS OF PROGRESSION IN BARRETTS ESOPHAGUSBrian Reid; Fiscal Year: 1999..Statistical analyses, which vary by specific aim, will include logistic regression (adjusting for length of follow-up) and construction of ROC curves. ..
- Predictors of Progression in Barret's EsophagusBrian Reid; Fiscal Year: 2001..Successful completion of these aims will provide a scientific basis for i) prevention trials using candidate interventions and validated intermediate endpoints, and ii) a more rational surveillance strategy for BE. ..
- Barrett's Esophagus: Predictors of ProgressionBrian Reid; Fiscal Year: 2007..Core A (Leadership) provides a vehicle for inter project and core communications. ..