J D Potter

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
    Carolyn M Hutter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
    BMC Cancer 10:670. 2010
  2. pmc Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats
    Stuart G Baker
    Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, USA
    BMC Cancer 9:89. 2009
  3. pmc Comparative evaluation of gene-set analysis methods
    Qi Liu
    School of Public Health, University of Alberta, Edmonton, Alberta, T6G2G3, Canada
    BMC Bioinformatics 8:431. 2007
  4. pmc Improving gene set analysis of microarray data by SAM-GS
    Irina Dinu
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    BMC Bioinformatics 8:242. 2007
  5. ncbi request reprint Colorectal cancer: molecules and populations
    J D Potter
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 91:916-32. 1999
  6. ncbi request reprint Methyl supply, methyl metabolizing enzymes and colorectal neoplasia
    John D Potter
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Nutr 132:2410S-2412S. 2002
  7. ncbi request reprint Epidemiology, cancer genetics and microarrays: making correct inferences, using appropriate designs
    John D Potter
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, MP 900, Seattle, WA 98109 1024, USA
    Trends Genet 19:690-5. 2003
  8. ncbi request reprint COX-2 and gastric cancer: More on inflammation and neoplasia
    John D Potter
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Gastroenterology 130:2198-200. 2006
  9. ncbi request reprint Vegetables, fruit, and cancer
    John D Potter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Lancet 366:527-30. 2005
  10. ncbi request reprint Epidemiology informing clinical practice: from bills of mortality to population laboratories
    John D Potter
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98109 1024, USA
    Nat Clin Pract Oncol 2:625-34. 2005

Detail Information

Publications120 found, 100 shown here

  1. pmc Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
    Carolyn M Hutter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
    BMC Cancer 10:670. 2010
    ..Genome-wide association studies and subsequent replication studies have shown that single nucleotide polymorphisms (SNPs) in the chromosomal region 8q24 are associated with colorectal cancer susceptibility...
  2. pmc Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats
    Stuart G Baker
    Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, USA
    BMC Cancer 9:89. 2009
    ..These disrupted interactions are hypothesized to be mediated by molecules, termed morphostats, which diffuse through the tissue to determine cell phenotype and maintain tissue architecture...
  3. pmc Comparative evaluation of gene-set analysis methods
    Qi Liu
    School of Public Health, University of Alberta, Edmonton, Alberta, T6G2G3, Canada
    BMC Bioinformatics 8:431. 2007
    ..subject sampling. The three methods were compared based on a simulation experiment and analyses of three real-world microarray datasets...
  4. pmc Improving gene set analysis of microarray data by SAM-GS
    Irina Dinu
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    BMC Bioinformatics 8:242. 2007
    ..We describe here some critical problems with GSEA and propose an alternative method by extending the individual-gene analysis method, Significance Analysis of Microarray (SAM), to gene-set analyses (SAM-GS)...
  5. ncbi request reprint Colorectal cancer: molecules and populations
    J D Potter
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 91:916-32. 1999
    ..Understanding the roles of environmental exposures and host susceptibilities in molecular pathways has implications for screening, treatment, surveillance, and prevention...
  6. ncbi request reprint Methyl supply, methyl metabolizing enzymes and colorectal neoplasia
    John D Potter
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Nutr 132:2410S-2412S. 2002
    ....
  7. ncbi request reprint Epidemiology, cancer genetics and microarrays: making correct inferences, using appropriate designs
    John D Potter
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, MP 900, Seattle, WA 98109 1024, USA
    Trends Genet 19:690-5. 2003
  8. ncbi request reprint COX-2 and gastric cancer: More on inflammation and neoplasia
    John D Potter
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Gastroenterology 130:2198-200. 2006
  9. ncbi request reprint Vegetables, fruit, and cancer
    John D Potter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Lancet 366:527-30. 2005
  10. ncbi request reprint Epidemiology informing clinical practice: from bills of mortality to population laboratories
    John D Potter
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98109 1024, USA
    Nat Clin Pract Oncol 2:625-34. 2005
    ..Improved molecular classification of disease will allow smaller, focused clinical trials to be undertaken and, ultimately, the tailoring of treatment to the biological profile of patient and disease...
  11. ncbi request reprint At the interfaces of epidemiology, genetics and genomics
    J D Potter
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nat Rev Genet 2:142-7. 2001
    ..The only recourse is to teach each other the rules of your own game and then decide whether you can collectively invent a new sport. Welcome to the dialogue at the intersections of epidemiology with genetics and genomics...
  12. ncbi request reprint Epidemiologic research in the face of an obesity epidemic
    John D Potter
    Public Health Sciences Division of the Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Epidemiology 17:124-7. 2006
  13. ncbi request reprint Morphogens, morphostats, microarchitecture and malignancy
    John D Potter
    Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B814, Seattle, Washington 98109 1024, USA
    Nat Rev Cancer 7:464-74. 2007
    ..This Review will describe what we know about morphostats and morphostasis, discuss the evidence for the role of disruption of morphostasis in malignancy, and address some testable hypotheses...
  14. ncbi request reprint Pancreas cancer--we know about smoking, but do we know anything else?
    John D Potter
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 155:793-5; discussion 796-7. 2002
  15. ncbi request reprint Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: personal and lifestyle factors (United States)
    Libby M Morimoto
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Causes Control 16:917-27. 2005
    ..Only age was significantly related to circulating IGFBP-3. Although the sources of inter-individual variation of IGF-1 and IGFB-3 are not yet fully understood, this analysis provides some insights into factors that may contribute...
  16. ncbi request reprint Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps
    Elizabeth M Poole
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:502-8. 2006
    ..A more comprehensive investigation of genetic variability in prostaglandin synthesis in relation to risk of colorectal neoplasia and NSAID pharmacogenetics is warranted...
  17. ncbi request reprint Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets
    J W Lampe
    Cancer Prevention Research Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Carcinogenesis 21:1157-62. 2000
    ..This points to a complex association between consumption of a typical diet of various vegetables and biotransformation enzyme activities in humans, an association that may be difficult to interpret in observational studies...
  18. pmc Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors
    P T Campbell
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
    Gut 58:661-7. 2009
    ..Less understood is the risk of colon cancer associated with common polymorphisms in MMR genes and the potential interacting role of lifestyle factors known to damage DNA...
  19. ncbi request reprint Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy...
  20. ncbi request reprint Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk
    Ellen L Goode
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:157-62. 2004
    ..These findings add to what is known about the complexities of genetic variations in one-carbon-metabolizing enzymes in relation to colorectal carcinogenesis...
  21. ncbi request reprint UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Pharmacogenetics 9:341-9. 1999
    ..These highly prevalent polymorphisms, which result in modified expression and activity of UGTs, may influence susceptibility to cancers associated with altered metabolism of endogenous and xenobiotic compounds...
  22. ncbi request reprint MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors
    C M Ulrich
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Nutr 135:2462-7. 2005
    ..These results suggest a novel mechanism by which MTHFR polymorphisms can affect the risk of colon cancer...
  23. ncbi request reprint Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium
    H S Kim
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 10:869-74. 2001
    ....
  24. ncbi request reprint TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Int J Epidemiol 33:955-61. 2004
    ..A polymorphism in the signal peptide sequence of the TGFbeta1 gene (L10P) has been associated with increased levels of plasma TGFbeta1 in individuals with the P allele...
  25. ncbi request reprint Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential?
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:1012-8. 2002
    ..Overall, the similarity of the risk profiles of colorectal hyperplastic polyps, adenoma, and cancer provides additional support for the growing body of evidence that some hyperplastic polyps may have neoplastic potential...
  26. pmc Dietary and demographic correlates of serum beta-glucuronidase activity
    Sonia S Maruti
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nutr Cancer 62:208-19. 2010
    ..In conclusion, several dietary and nondietary factors were associated with beta -glucuronidase activity; however, confirmation of these associations are needed...
  27. ncbi request reprint Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: genetic factors
    Libby M Morimoto
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 14:1394-401. 2005
    ..This analysis provides evidence that common variation in IGF genes may contribute to the variation in circulating levels observed between individuals...
  28. pmc Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer
    Brenda Diergaarde
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 17:1751-9. 2008
    ..Our results support the hypothesis that specific polymorphisms in genes involved in sex hormone metabolism may modify the effect of E+P use on breast cancer risk...
  29. ncbi request reprint Epoxide hydrolase Tyr113His polymorphism is associated with elevated risk of colorectal polyps in the presence of smoking and high meat intake
    C M Ulrich
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 10:875-82. 2001
    ....
  30. ncbi request reprint Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y)
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 9:329-33. 2000
    ..This warrants evaluation both in larger, multiethnic cohorts and in relation to known ecological differences in risk of sex hormone-dependent cancers...
  31. ncbi request reprint Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women
    Charlotte Atkinson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:868-74. 2004
    ..Thus, this 12-month moderate intensity exercise intervention did not significantly alter urinary excretion of 2-OH E(1), 16alpha-OH E(1), or their ratio in this population of women...
  32. doi request reprint DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps
    Audrey Y Jung
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:330-8. 2008
    ..01). These gene-diet interactions suggest that polymorphisms relevant to DNA methylation or alcohol metabolism may play a role in colorectal carcinogenesis in conjunction with a high-risk diet...
  33. ncbi request reprint Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia
    Kim Robien
    Cancer Prevention Program, Public Health Division, University of Washington Cancer Center, Seattle, Washington, USA
    Biol Blood Marrow Transplant 12:973-80. 2006
    ..A direct trade-off between drug toxicity and drug efficacy may play a role. Alternatively, the systemic folate environment, regulated by host tissues, might influence donor T-cell growth and activity...
  34. pmc Genetic variation in calcium-sensing receptor and risk for colon cancer
    Linda M Dong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:2755-65. 2008
    ..We also examined interactions among CASR, calcium, and vitamin D intake and previously genotyped vitamin D-related genes...
  35. ncbi request reprint Mismatch repair polymorphisms and colorectal polyps: hMLH1-93G>A variant modifies risk associated with smoking
    Joon Ho Yu
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109 1024, USA
    Am J Gastroenterol 101:1313-9. 2006
    ..The aim of our study was to determine if polymorphisms in the DNA MMR genes hMLH1 and hMSH6 are associated with an increased risk of colorectal polyps, and to evaluate interactions with exposures known to cause DNA damage...
  36. ncbi request reprint Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk
    Victoria M Chia
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:2697-703. 2007
    ..There were no associations of leptin receptor genotypes or haplotypes and adenoma risk. The results of this study suggest that, in men, leptin may be associated with risk of colorectal adenomas...
  37. ncbi request reprint Polymorphisms in DNA repair genes and associations with cancer risk
    Ellen L Goode
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:1513-30. 2002
    ..Such studies may benefit from analysis of multiple genes or polymorphisms and from the consideration of relevant exposures that may influence the likelihood of cancer in the presence of reduced DNA repair capacity...
  38. pmc Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma
    Elizabeth M Poole
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 19:547-57. 2010
    ..Prostaglandins are metabolites of omega-6 and omega-3 polyunsaturated fatty acids; their biosynthesis is the primary target of nonsteroidal anti-inflammatory drugs (NSAID), which reduce colorectal neoplasia risk...
  39. ncbi request reprint Folic acid supplementation during methotrexate immunosuppression is not associated with early toxicity, risk of acute graft-versus-host disease or relapse following hematopoietic transplantation
    K Robien
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Bone Marrow Transplant 37:687-92. 2006
    ..Our results suggest that concurrent folic acid supplementation does not change MTX effectiveness or toxicity in this patient population...
  40. ncbi request reprint Modulation of human glutathione S-transferases by botanically defined vegetable diets
    J W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 9:787-93. 2000
    ..GST responses were more pronounced in women than men, but it is not clear from this study whether this is a dose-per-body-weight or a sex-specific effect...
  41. ncbi request reprint Soy isoflavones do not modulate circulating insulin-like growth factor concentrations in an older population in an intervention trial
    Kenneth F Adams
    Fred Hutchinson Cancer Research Center, University of Washington, Center for Health Studies, Group Health Cooperative, Seattle, WA, USA
    J Nutr 133:1316-9. 2003
    ..A 12 mo, 83 mg/d soy isoflavone intervention did not modulate serum IGF in an older, mostly male population...
  42. pmc Citrus fruit intake is associated with lower serum bilirubin concentration among women with the UGT1A1*28 polymorphism
    Misty R Saracino
    Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
    J Nutr 139:555-60. 2009
    ..006 and 0.03, respectively). These results suggest that citrus consumption may increase UGT1A1 activity among women with the 7/7 genotype...
  43. pmc Serum beta-glucuronidase activity in response to fruit and vegetable supplementation: a controlled feeding study
    Sonia S Maruti
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1808-12. 2008
    ..One hypothesized, but understudied, chemopreventive mechanism is that plant food constituents inhibit beta-glucuronidase, an acid hydrolase that deconjugates glucuronides...
  44. ncbi request reprint Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial
    Laura Lewis Frank
    Fred Hutchinson Cancer Research Center, Cancer Prevention, Seattle, WA 98109 1024, USA
    Obes Res 13:615-25. 2005
    ..This study examined the effects of exercise on metabolic risk variables insulin, leptin, glucose, and triglycerides in overweight/obese postmenopausal women...
  45. ncbi request reprint Microsomal epoxide hydrolase polymorphisms are not associated with colon cancer risk
    Kim Robien
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1350-2. 2005
  46. ncbi request reprint Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene
    C M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 9:1381-5. 2000
    ..The potential functional relevance of the common 6-bp deletion in the TS gene needs to be investigated, because this enzyme is plausibly of major importance not only in cancer treatment but also in cancer prevention...
  47. ncbi request reprint The shape of age-incidence curves of female breast cancer by hormone-receptor status
    Y Yasui
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, USA
    Cancer Causes Control 10:431-7. 1999
    ..We therefore hypothesized and examined whether the age-specific risk of breast cancer, especially its change at menopause, differs by estrogen and progesterone receptor (ER/PR) status...
  48. ncbi request reprint Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled trial
    Kenneth F Adams
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Clin Nutr 82:620-6. 2005
    ..Colorectal epithelial cell proliferation has been used extensively as an intermediate endpoint biomarker for colorectal neoplasia...
  49. ncbi request reprint Hormone replacement therapy in relation to survival in women diagnosed with colon cancer
    Margaret T Mandelson
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Cancer Causes Control 14:979-84. 2003
    ....
  50. ncbi request reprint Polymorphisms predicted to alter function in prostaglandin E2 synthase and prostaglandin E2 receptors
    Jeannette Bigler
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Pharmacogenet Genomics 17:221-7. 2007
    ..Several lines of evidence implicate prostaglandin E2 in carcinogenesis; this study aimed to identify genetic variants in genes related to prostaglandin E2 synthesis and signaling...
  51. doi request reprint Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women
    Julie A Meyers
    Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
    J Endocrinol 199:51-60. 2008
    ..Our study does not support a link between leptin and other immune parameters among overweight or obese, but otherwise healthy postmenopausal women, perhaps because such effects are only present at low or deficient leptin concentrations...
  52. ncbi request reprint Telomere length in the colon declines with age: a relation to colorectal cancer?
    Jacintha O'Sullivan
    Department of Pathology, University of Washington, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 15:573-7. 2006
    ..We suggest that the positive association between telomere length and age in the oldest patients is a consequence of selective survival of elderly patients with long colonocyte telomeres...
  53. ncbi request reprint Not the time to abandon the food frequency questionnaire: counterpoint
    Alan R Kristal
    Cancer Prevention Program, Fred Hutchinson Canser Research Center, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 15:1759-60. 2006
  54. ncbi request reprint Risk of microsatellite-unstable colorectal cancer is associated jointly with smoking and nonsteroidal anti-inflammatory drug use
    Victoria M Chia
    Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Res 66:6877-83. 2006
    ....
  55. pmc C-reactive protein genotypes and haplotypes, polymorphisms in NSAID-metabolizing enzymes, and risk of colorectal polyps
    Elizabeth M Poole
    Fred Hutchinson Cancer Research Center, Seattle, University of Washington, Seattle, Washington, USA
    Pharmacogenet Genomics 19:113-20. 2009
    ..Polymorphisms in CRP have been associated with differential CRP concentrations among healthy adults, with some evidence for functional effects on CRP expression...
  56. ncbi request reprint Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402 Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:2509-16. 2005
    ..A pathway-based approach to data analysis is needed to help discern the independent and combined effects of dietary intakes and genetic variability in folate metabolism...
  57. ncbi request reprint Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:1588-97. 2006
    ..A hypothesized mechanism for exercise-induced colon cancer risk reduction might be through alterations in colon crypt cell architecture and proliferation...
  58. pmc Nonsteroidal anti-inflammatory drugs and prostate cancer risk in the VITamins And Lifestyle (VITAL) cohort
    Theodore M Brasky
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:3185-8. 2010
    ..Several epidemiologic studies have reported inverse associations between nonsteroidal anti-inflammatory drugs (NSAIDs) and prostate cancer risk, although many studies are limited by assessment of short-term use only...
  59. ncbi request reprint Exercise effect on weight and body fat in men and women
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Obesity (Silver Spring) 15:1496-512. 2007
    ..The effect of national exercise recommendations on adiposity is unknown and may differ by sex. We examined long-term effects of aerobic exercise on adiposity in women and men...
  60. ncbi request reprint Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, Washington 98109, USA
    Cancer Res 67:7534-9. 2007
    ..Progestin may enhance the estrogenic effect of conjugated estrogen so the combination may be more biologically active in the colon than E alone...
  61. pmc A prospective study of bowel motility and related factors on breast cancer risk
    Sonia S Maruti
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1746-50. 2008
    ..However, only one other epidemiologic study thus far, to our knowledge, has examined the relation between bowel motility and breast cancer risk...
  62. ncbi request reprint The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women
    Shelley S Tworoger
    Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Obes Res 12:972-81. 2004
    ..These genes metabolize estrogens and androgens, which are important in body fat regulation...
  63. ncbi request reprint Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:889-93. 2004
    ..These preliminary findings require confirmation in larger studies of colorectal neoplasia...
  64. ncbi request reprint Nutrition and physical activity and chronic disease prevention: research strategies and recommendations
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 96:1276-87. 2004
    ....
  65. ncbi request reprint Serum beta-glucuronidase activity is inversely associated with plant-food intakes in humans
    Johanna W Lampe
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Nutr 132:1341-4. 2002
    ..Although these associations are modest, the data suggest that plant foods, particularly constituents of fruits and fiber-containing foods, may influence human beta-glucuronidase activity in a potentially favorable direction...
  66. ncbi request reprint No evidence of an association of JC virus and colon neoplasia
    Polly A Newcomb
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, DE 320, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:662-6. 2004
    ..Among the colon tissues, one normal tissue (<0.5%) and none of the matched tumors tested positive for JCV. There is no evidence in these data to indicate that JCV is the cause of genetic instability in colorectal cancer...
  67. ncbi request reprint UGT1A1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial
    Jyh Lurn Chang
    Interdisciplinary Graduate Program in Nutritional Sciences, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    J Nutr 137:890-7. 2007
    ..002). These results suggest that serum bilirubin glucuronidation is modulated by dietary intervention, but factors such as UGT1A1 genotype and sex may affect the response to diet...
  68. ncbi request reprint Assessment of a one-page questionnaire on long-term recreational physical activity
    Alyson J Littman
    Fred Hutchinson Cancer Research Center, Public Health Sciences, Seattle, Washington 98109 1024, USA
    Epidemiology 15:105-13. 2004
    ..Although there is considerable published research on methods to assess current or recent recreational physical activity, there are few short, self-administered questionnaires designed to assess long-term physical activity...
  69. ncbi request reprint FDR-controlling testing procedures and sample size determination for microarrays
    Shuying S Li
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Stat Med 24:2267-80. 2005
    ..Thus, these existing procedures can overestimate the power and underestimate the sample size. Accordingly, we developed a simulation-based method to provide more accurate estimates for power and sample size...
  70. pmc Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer
    Anna E Coghill
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Gut 60:491-8. 2011
    ..The role of prediagnostic NSAID use was therefore examined in relation to colorectal cancer-specific survival among cases from the Seattle Colon Cancer Family Registry (Seattle Colon CFR)...
  71. ncbi request reprint A practical method for collecting 3-day food records in a large cohort
    Ann Shattuck Kolar
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Epidemiology 16:579-83. 2005
    ..However, food records are considered unsuitable for large studies due to the need to train participants and to review and correct completed records...
  72. ncbi request reprint Dietary determinants of plasma enterolactone
    Neilann K Horner
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:121-6. 2002
    ....
  73. ncbi request reprint Folate supplementation: too much of a good thing?
    Cornelia M Ulrich
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:189-93. 2006
  74. ncbi request reprint Postmenopausal hormone therapy and risk of breast cancer by histologic type (United States)
    Laura M Newcomer
    Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 14:225-33. 2003
    ..Postmenopausal hormone use and risk of breast cancer by histopathology was examined in a large multi-centered population-based case-control study...
  75. ncbi request reprint Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:2331-43. 2007
    ..Family studies have served as a cornerstone of genetic research on colorectal cancer...
  76. ncbi request reprint Insulin-like growth factor polymorphisms and colorectal cancer risk
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Cancer Prevention, 1100 Fairview Avenue North, M4 B402, Seattle WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:1204-11. 2005
    ..01). The current study provides some support for a role of IGFs in colorectal cancer etiology, particularly in mediating the relationship of common risk factors (physical activity, BMI, and postmenopausal hormone use)...
  77. ncbi request reprint Vitamin E and selenium supplementation and risk of prostate cancer in the Vitamins and lifestyle (VITAL) study cohort
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Causes Control 19:75-87. 2008
    ..We aimed to investigate the association of vitamin E and selenium supplementation with prostate cancer in the VITamins And Lifestyle (VITAL) study, a cohort study specifically designed to examine supplement use and future cancer risk...
  78. pmc Specialty supplements and breast cancer risk in the VITamins And Lifestyle (VITAL) Cohort
    Theodore M Brasky
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:1696-708. 2010
    ..However, there have been no prospective studies of the association between the long-term use of these supplements and breast cancer risk...
  79. ncbi request reprint Moderate-intensity exercise reduces the incidence of colds among postmenopausal women
    Jessica Chubak
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, Wash 98109 1024, USA
    Am J Med 119:937-42. 2006
    ..Our aim was to assess the effect of a moderate-intensity, year-long exercise program on the risk of colds and other upper respiratory tract infections in postmenopausal women...
  80. pmc KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers
    A I Phipps
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Br J Cancer 108:1757-64. 2013
    ..We evaluated the relationship between KRAS-mutation status and CRC survival, considering heterogeneity in this association by tumour and patient characteristics...
  81. pmc Pre-diagnostic NSAID use but not hormone therapy is associated with improved colorectal cancer survival in women
    A E Coghill
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109, USA
    Br J Cancer 104:763-8. 2011
    ..Non-steroidal anti-inflammatory drugs (NSAIDs) and hormone therapy (HT) independently decrease the risk of colorectal cancer. However, their role in altering survival after a colorectal cancer diagnosis is not well established...
  82. ncbi request reprint Breast cancer risk and "delayed" primary Epstein-Barr virus infection
    Y Yasui
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 10:9-16. 2001
    ..018). Adjusting for additional potential confounders did not modify the associations appreciably. The implications of the findings and a potential biological mechanism are presented...
  83. ncbi request reprint Sleep, ghrelin, leptin and changes in body weight during a 1-year moderate-intensity physical activity intervention
    A J Littman
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Int J Obes (Lond) 31:466-75. 2007
    ..To investigate cross-sectional and longitudinal relationships among exercise, sleep, ghrelin and leptin...
  84. ncbi request reprint Morphostats: a missing concept in cancer biology
    J D Potter
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 10:161-70. 2001
    ..Disruption of the functions of morphostats may result in a variety of abnormalities. Such disruption may be a key event in carcinogenesis...
  85. ncbi request reprint Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism
    C M Ulrich
    Public Health Sciences Division and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Blood 98:231-4. 2001
    ..23; 34% slower to 20 000/microL, P =.08). Patients with decreased MTHFR activity appear at risk of higher MTX toxicity. Because of the high prevalence of the TT genotype, these results may have implications for MTX dosage...
  86. ncbi request reprint Soy protein and bone mineral density in older men and women: a randomized trial
    K M Newton
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Maturitas 55:270-7. 2006
    ..Test the hypothesis that soy isoflavone supplementation preserves bone mineral density (BMD) in men and women...
  87. ncbi request reprint CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk
    J Bigler
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 61:3566-9. 2001
    ..73). The variants of these enzymes did not influence the association between nonaspirin NSAIDs and adenoma risk. These data indicate that the effectiveness of chemopreventive drugs can be modulated by the genotype of metabolizing enzymes...
  88. ncbi request reprint PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States)
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, 84108, USA
    Cancer Causes Control 17:239-49. 2006
    ..These data suggest that PPARgamma may be associated with many aspects of colorectal cancer including insulin- and inflammation-related mechanisms...
  89. ncbi request reprint MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer
    Karen Curtin
    University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Cancer Epidemiol Biomarkers Prev 13:285-92. 2004
    ..The possible interaction with hormone-replacement therapy warrants additional investigation...
  90. ncbi request reprint Dairy foods, calcium, and colorectal cancer: a pooled analysis of 10 cohort studies
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 96:1015-22. 2004
    ..Studies in animals have suggested that calcium may reduce the risk of colorectal cancer. However, results from epidemiologic studies of intake of calcium or dairy foods and colorectal cancer risk have been inconclusive...
  91. ncbi request reprint Waist-to-hip ratio and breast cancer mortality
    Marilyn J Borugian
    Cancer Control Research Program, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Am J Epidemiol 158:963-8. 2003
    ..Elevated WHR was confirmed as a predictor of breast cancer mortality, with menopausal status and ER status at diagnosis found to be important modifiers of that relation...
  92. ncbi request reprint Adherence to the AICR cancer prevention recommendations and subsequent morbidity and mortality in the Iowa Women's Health Study cohort
    James R Cerhan
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 13:1114-20. 2004
    ....
  93. ncbi request reprint Associations of total energy and macronutrients with colon cancer risk in African Americans and Whites: results from the North Carolina colon cancer study
    Jessie Satia-Abouta
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Epidemiol 158:951-62. 2003
    ..These findings may provide an explanation for some of the racial differences in colon cancer incidence...
  94. ncbi request reprint Associations of micronutrients with colon cancer risk in African Americans and whites: results from the North Carolina Colon Cancer Study
    Jessie Satia-Abouta
    Department of Nutrition, School of Public Health, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 12:747-54. 2003
    ....
  95. ncbi request reprint Eating frequency and the risk of colon cancer
    Ashley O Coates
    Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94612 2304, USA
    Nutr Cancer 43:121-6. 2002
    ..The increased risk of colon cancer limited to men eating less than three times per day may be due to uncontrolled confounding...
  96. ncbi request reprint Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn, USA
    JAMA 289:323-30. 2003
    ..The increasing prevalence of obesity is a major public health concern. Physical activity may promote weight and body fat loss...
  97. ncbi request reprint Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma subtypes and B-cell chronic lymphocytic leukemia: a prospective study
    James R Cerhan
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Am J Epidemiol 156:527-35. 2002
    ..The opposite associations of body mass index with small lymphocytic lymphoma versus B-CLL may be a chance finding but, if confirmed, would suggest different etiologies for these malignancies...
  98. ncbi request reprint Reliability in the classification of advanced colorectal adenomas
    Mary Beth Terry
    Department of Epidemiology, Joseph L Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 11:660-3. 2002
    ....
  99. ncbi request reprint Risk factors for advanced colorectal adenomas: a pooled analysis
    Mary Beth Terry
    Department of Epidemiology, Joseph L Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 11:622-9. 2002
    ....
  100. ncbi request reprint Physical activity and colon cancer: confounding or interaction?
    Martha L Slattery
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City 84108, USA
    Med Sci Sports Exerc 34:913-9. 2002
    ..Confounding and effect modification are examined to better understand the physical activity and colon cancer association...
  101. ncbi request reprint Fruits, vegetables, and adenomatous polyps: the Minnesota Cancer Prevention Research Unit case-control study
    Stephanie A Smith-Warner
    Division of Epidemiology, University of Minnesota, Minneapolis, MN, USA
    Am J Epidemiol 155:1104-13. 2002
    ....

Research Grants23

  1. Genome-Wide Association Study of Nonsynonymous SNPs in Colon Cancer
    John Potter; Fiscal Year: 2007
    ....
  2. Aspirin, UGT1A6 Genotype, and Colon Gene Expression
    Johanna Lampe; Fiscal Year: 2006
    ..By targeting relevant pathways, side effects caused by the use of NSAIDs or specific Cox-2 inhibitors may be avoided. ..
  3. NSAID and COX/PG Metabolism and Colorectal Cancer
    John Potter; Fiscal Year: 2006
    ..Ultimately, such information on the metabolic variation will be useful in optimizing NSAIDs and NSAID regimens and will allow individual tailoring of chemoprevention. ..
  4. GENETIC LINKAGE IN COLORECTAL CANCER FAMILES
    John Potter; Fiscal Year: 2006
    ..A key future aim is to combine these families with those of other CRC linkage studies in the US and UK to amass an extensive resource with further increased power to understand CRC genetic susceptibility. ..
  5. Multi-Center Study of Pancreatic Cancer Etiology
    John Potter; Fiscal Year: 2007
    ..abstract_text> ..
  6. GENETIC EPIDEMIOLOGIC STUDIES OF POLYPS AND CANCER
    John Potter; Fiscal Year: 2003
    ....
  7. Seattle Colorectal Cancer Family Registry (CFR)
    Polly Newcomb; Fiscal Year: 2007
    ..The CCFR - S provides an important\par population-based perspective within our consortium studies of colorectal cancer.\fs20\par \par } ..