Amanda I Phipps

..We evaluated changes in colorectal cancer (CRC) incidence and mortality by anatomic site to assess the possible impact of CRC screening...

..Similarly, current NSAID use was not associated with endometrial cancer risk (HR = 1.01, 95% CI = 0.88-1.16), regardless of BMI. Migraine history and NSAID use do not appear to be associated with risk of endometrial cancer...

..The independent association between BRAF mutation status and CRC survival, however, remains unclear...

..However, relationships between these factors and risk of molecularly-defined subtypes of breast cancer have not been established...

..Smoking and alcohol consumption are associated with an increased risk of developing colorectal cancer. However, it is unclear whether these exposures are associated with survival after colorectal cancer diagnosis...

..Focusing on potentially modifiable breast cancer risk factors, we examined the relationship between body size, physical activity, and triple-negative disease risk...

..Hormonally mediated risk factors may be differentially related to risk of triple-negative and ER+ breast cancers...

..31-2.56). Neither parity nor age at first birth was associated with triple-negative breast cancer. In contrast to ER+ and ER-/PR-/HER2+ subtypes, reproductive history does not appear to be a risk factor for triple-negative breast cancer...

..Having a first-degree family history of breast cancer was associated with an increased risk of triple-negative breast cancer with a magnitude of association similar to that for the predominant ER+ subtype and ER-/PR-/HER2+ breast cancer...

..We compared associations between several factors and risk of ductal, lobular, and mixed ductal-lobular breast cancers...

..Reproductive factors may plausibly be differentially correlated with the risk of different breast cancer subtypes because these factors are presumed to impact exposure to endogenous sex hormones...

..Given the expanding obesity epidemic, the widespread cessation of hormone therapy use, and the poor prognosis of triple-negative tumors, this novel finding merits confirmation...

..19, 95% CI: 0.05-0.68). Associations did not differ according to recency of use. These results suggest that long duration of use of continuous-combined estrogen-progestin therapy is associated with a reduced risk of endometrial cancer...

..79; CI, 0.64-0.98 in replication]. No associations were noted for SNPs of AR, ESR1, or PGR. SNPs in the promoter of ESR2 may be important to pathways related to the association between ERβ and tumor progression and metastasis...

..Our results suggest that SSPs and other large, right-sided serrated lesions have a unique molecular profile that is similar to CIMP-high, BRAF-mutated colorectal cancers. Cancer Res; 73(9); 2863-72. ©2013 AACR...

..This study assesses distinctions between menopausal status definitions using commonly collected epidemiologic data, and explores their impact on study outcomes using breast cancer rates as an example...

....

..If effective cancer screening is more common in people with a family history of cancer, the relationship between family history and cancer incidence may become distorted...

..05-1.30; P = .005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC...

..Recent data also suggests an inverse association between NSAID use and death due to colorectal cancer (CRC)...

..What is unclear, however, is the impact of quitting smoking on risk attenuation and whether other risk factors for CRC modify this association...

..We examined the influence of migration history and acculturation on breast cancer risk in Hispanic women ages 35 to 79 years...

..Given the widespread and increasing use of medical diagnostic radiation, continued surveillance of breast cancer risk is warranted, particularly in women at specific genetic risk, such as those carrying mutations in BRCA1 or BRCA2...

..Information on the prevalence of pathogenic BRCA1 mutation carriers in racial/ethnic minority populations is limited...

..This analysis examines the extent to which these and other breast cancer incidence trends could have been impacted by bias in intercensal population projections...