E Petersdorf

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Genetics of allogeneic hematopoietic cell transplantation. Role of HLA matching, functional variation in immune response genes
    John A Hansen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Ave N, D2 100, P O Box 19024, Seattle, WA 98109 1024, USA
    Immunol Res 41:56-78. 2008
  2. pmc Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study
    Alexa J Resler
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    BMC Cancer 13:219. 2013
  3. pmc Mapping MHC haplotype effects in unrelated donor hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA
    Blood 121:1896-905. 2013
  4. pmc Genetics of graft-versus-host disease: the major histocompatibility complex
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States
    Blood Rev 27:1-12. 2013
  5. pmc MHC-resident variation affects risks after unrelated donor hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Sci Transl Med 4:144ra101. 2012
  6. ncbi request reprint Tissue typing in support of unrelated hematopoietic cell transplantation
    E W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Ctr, Division of Clinical Research, and Department of Medicine, University of Washington, Seattle 98109 1024, USA
    Tissue Antigens 61:1-11. 2003
  7. pmc Risk assessment in haematopoietic stem cell transplantation: histocompatibility
    Effie W Petersdorf
    Department of Medicine, University of Washington, 1959 Northeast Pacific, Seattle, WA 98195, USA
    Best Pract Res Clin Haematol 20:155-70. 2007
  8. ncbi request reprint Limits of HLA mismatching in unrelated hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, D4 100 Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Blood 104:2976-80. 2004
  9. pmc MHC haplotype matching for unrelated hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e8. 2007
  10. ncbi request reprint Immunogenomics of unrelated hematopoietic cell transplantation
    Effie W Petersdorf
    University of Washington, Fred Hutchinson Cancer Research Center, D4 100, Seattle, WA 98109, USA
    Curr Opin Immunol 18:559-64. 2006

Research Grants

Detail Information

Publications45

  1. ncbi request reprint Genetics of allogeneic hematopoietic cell transplantation. Role of HLA matching, functional variation in immune response genes
    John A Hansen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Ave N, D2 100, P O Box 19024, Seattle, WA 98109 1024, USA
    Immunol Res 41:56-78. 2008
    ....
  2. pmc Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study
    Alexa J Resler
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    BMC Cancer 13:219. 2013
    ..Toll-like receptors (TLRs) and the transcription factor nuclear factor-κB (NFκB) are important in inflammation and cancer...
  3. pmc Mapping MHC haplotype effects in unrelated donor hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA
    Blood 121:1896-905. 2013
    ..Knowledge of the SNP content of HLA haplotypes provides a means to estimate risks prior to transplantation and to lower complications through judicious selection of donors with favorable MHC genetics...
  4. pmc Genetics of graft-versus-host disease: the major histocompatibility complex
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States
    Blood Rev 27:1-12. 2013
    ..This review highlights the state-of-the art in the field of histocompatibility and immunogenetics of the MHC with respect to genetic risk factors for GVHD...
  5. pmc MHC-resident variation affects risks after unrelated donor hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Sci Transl Med 4:144ra101. 2012
    ..In conclusion, the success of HLA-matched unrelated donor hematopoietic cell transplantation depends on non-HLA MHC region genetic variation. Prospective SNP screening and matching provides an approach for lowering risks to patients...
  6. ncbi request reprint Tissue typing in support of unrelated hematopoietic cell transplantation
    E W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Ctr, Division of Clinical Research, and Department of Medicine, University of Washington, Seattle 98109 1024, USA
    Tissue Antigens 61:1-11. 2003
    ....
  7. pmc Risk assessment in haematopoietic stem cell transplantation: histocompatibility
    Effie W Petersdorf
    Department of Medicine, University of Washington, 1959 Northeast Pacific, Seattle, WA 98195, USA
    Best Pract Res Clin Haematol 20:155-70. 2007
    ..Increased availability of HCT through the use of HLA-mismatched related and unrelated donors is feasible with a more complete understanding of permissible HLA mismatches and the role of NK-KIR genes in transplantation...
  8. ncbi request reprint Limits of HLA mismatching in unrelated hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, D4 100 Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Blood 104:2976-80. 2004
    ..Whenever possible, HLA-C mismatches should be avoided for patients with early stage CML, and HLA-DQB1 mismatches should be avoided for patients with multiple mismatches...
  9. pmc MHC haplotype matching for unrelated hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e8. 2007
    ..Genes that influence transplantation outcome could be identified by using linkage disequilibrium (LD)-mapping approaches, if the extended MHC haplotypes of the unrelated donor and recipient could be defined...
  10. ncbi request reprint Immunogenomics of unrelated hematopoietic cell transplantation
    Effie W Petersdorf
    University of Washington, Fred Hutchinson Cancer Research Center, D4 100, Seattle, WA 98109, USA
    Curr Opin Immunol 18:559-64. 2006
    ..These data show that clinical outcome following transplantation is shaped by the combined effects of many genes within the MHC and their sequence polymorphisms...
  11. ncbi request reprint Genetics of risk factors for graft-versus-host disease
    Effie W Petersdorf
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Semin Hematol 43:11-23. 2006
    ..The contribution of donor and host genetic differences in cytokine genes in modulating risks of GVHD has recently been recognized...
  12. ncbi request reprint HLA matching in allogeneic stem cell transplantation
    Effie W Petersdorf
    University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Division of Clinical Research, Seattle, Washington 98109, USA
    Curr Opin Hematol 11:386-91. 2004
    ..The goal of this review is to summarize new findings in the field of immunogenetics and HCT from unrelated donors using myeloablative conditioning regimens...
  13. pmc Definition of HLA-DQ as a transplantation antigen
    E W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 93:15358-63. 1996
    ..6 (1.2, 2.2; P = 0.003). These results provide evidence that HLA-DQ is a transplant antigen and suggest that evaluation of both HLA-DQB1 and HLA-DRB1 is necessary in selecting potential donors...
  14. pmc Optimal HLA matching in hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, United States
    Curr Opin Immunol 20:588-93. 2008
    ..Optimizing the overall outcome of hematopoietic cell transplantation requires an appreciation for the relative importance of HLA factors with respect to other non-genetic factors that also influence transplant outcome...
  15. pmc New advances in hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Huchinson Cancer Research Center, Seattle, Washington 98109, USA
    Curr Opin Hematol 15:549-54. 2008
    ..The present review highlights sentinel work published since 2006 on the definition of the transplantation barrier and the elucidation of cytokine and immune response gene variation in defining posttransplant risks...
  16. ncbi request reprint Population study of allelic diversity in the human MHC class I-related MIC-A gene
    E W Petersdorf
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109 1024, USA
    Immunogenetics 49:605-12. 1999
    ..These results confirm and extend previous knowledge on the polymorphism of MIC-A. The strong positive linkage of certain MIC-A and HLA-B alleles may have implications for studies related to MHC-associated diseases and transplantation...
  17. ncbi request reprint Effect of HLA mismatches on the outcome of hematopoietic transplants
    E W Petersdorf
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Curr Opin Immunol 11:521-6. 1999
    ..These findings demonstrate that HLA allelic differences are biologically relevant in human transplantation...
  18. pmc The World Marrow Donor Association: 20 years of international collaboration for the support of unrelated donor and cord blood hematopoietic cell transplantation
    E W Petersdorf
    Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98109, USA
    Bone Marrow Transplant 45:807-10. 2010
    ..In this special issue of Bone Marrow Transplantation, the activities of the WMDA and a vision for future directions in the field are presented...
  19. ncbi request reprint The biological significance of HLA-DP gene variation in haematopoietic cell transplantation
    E W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D4 100, Seattle, WA 98109 1024, USA
    Br J Haematol 112:988-94. 2001
    ..1; P = 0.01). HLA-DP plays an important role in the alloimmune response. A threshold effect of multiple HLA-DP disparities is evident in determining the risk of acute GVHD after haematopoietic cell transplantation from unrelated donors...
  20. ncbi request reprint Genomics of unrelated-donor hematopoietic cell transplantation
    E Petersdorf
    University of Washington, School of Medicine, 1959 NE Pacific Street, Seattle, Washington 98105, USA
    Curr Opin Immunol 13:582-9. 2001
    ..Delineation of the function of these markers as transplantation determinants may provide alternative means for optimizing the results of hematopoietic cell transplantation...
  21. ncbi request reprint Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation
    E W Petersdorf
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    N Engl J Med 345:1794-800. 2001
    ..that allele mismatches that are detectable only at the DNA level are less immunogenic than those that are serologically detectable and thereby are associated with a lower risk of graft failure after hematopoietic-cell transplantation..
  22. ncbi request reprint MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studies
    M Malkki
    The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Tissue Antigens 66:114-24. 2005
    ..Markers with high HSH values will be most informative in studies investigating MHC region disease-susceptibility genes where HLA haplotypic effects are known to exist...
  23. ncbi request reprint HLA matching in hematopoietic cell transplantation
    E M Mickelson
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Hum Immunol 61:92-100. 2000
    ..The use of these methods to optimize donor selection will improve both donor identification and the success of unrelated donor transplants...
  24. ncbi request reprint 14thInternational HLA and Immunogenetics Workshop: report on hematopoietic cell transplantation
    E Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Tissue Antigens 69:17-24. 2007
    ....
  25. ncbi request reprint The role of HLA matching in hematopoietic cell transplantation
    J A Hansen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Rev Immunogenet 1:359-73. 1999
    ..There remain, however, important unanswered questions about the relative importance of different HLA loci in matching strategies, as well as incomplete information about permissible limits of mismatching in different patient populations...
  26. ncbi request reprint Hematopoietic stem cell transplants from unrelated donors
    J A Hansen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Immunol Rev 157:141-51. 1997
    ..In order to provide transplants for all patients, improved methods for GVHD prophylaxis are needed that will make it possible to safely perform transplants even across limited degrees of HLA disparity...
  27. pmc Mapping MHC-resident transplantation determinants
    Mari Malkki
    The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biol Blood Marrow Transplant 13:986-95. 2007
    ..67; 95% confidence interval, 0.45-0.98; P=.04). These results suggest that Msats may be informative for mapping MHC-resident genetic variation of clinical importance in HCT...
  28. pmc An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens
    Wendy M Leisenring
    Clinical Research Division, Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, 98109, USA
    Blood 108:749-55. 2006
    ..These results demonstrate that clinical manifestations of GVHD severity can be used to accurately predict the risk of NRM in real time...
  29. pmc Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster
    Lisa G Johnson
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, PO Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:199-207. 2011
    ....
  30. ncbi request reprint Allogeneic hematopoietic stem cell transplantation for myelofibrosis
    H Joachim Deeg
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 102:3912-8. 2003
    ..Results with unrelated donors were comparable with those with HLA-identical sibling transplants. Thus, allogeneic hematopoietic cell transplantation offers long-term relapse-free survival for patients with myelofibrosis...
  31. ncbi request reprint Increasingly frequent diagnosis of acute gastrointestinal graft-versus-host disease after allogeneic hematopoietic cell transplantation
    Paul J Martin
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 10:320-7. 2004
    ..A high diagnostic sensitivity and increased awareness that gut GVHD can occur without skin involvement account for the increased incidence of acute GVHD at our center...
  32. ncbi request reprint Evaluation of a CD25-specific immunotoxin for prevention of graft-versus-host disease after unrelated marrow transplantation
    Paul J Martin
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 10:552-60. 2004
    ....
  33. ncbi request reprint Hematologic responses of patients with MDS to antithymocyte globulin plus etanercept correlate with improved flow scores of marrow cells
    H Joachim Deeg
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Leuk Res 28:1177-80. 2004
    ..These data show that a combination of ATG plus etanercept offers effective palliative therapy for unselected patients with MDS. Further trials incorporating these two agents are warranted...
  34. ncbi request reprint Human leukocyte antigen matching in unrelated donor hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Semin Hematol 42:76-84. 2005
    ..The influence of nongenetic factors on the tolerability of HLA mismatching has recently become evident, demonstrating a need for the integration of both genetic and nongenetic variables in donor selection...
  35. pmc Cervical and vulvar cancer risk in relation to the joint effects of cigarette smoking and genetic variation in interleukin 2
    Shehnaz K Hussain
    Program in Epidemiology, Division of Public Health Sciences, University of Washington, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 17:1790-9. 2008
    ..87; 95% CI, 1.00-3.48), and for carriership of the TTCC/TTCC diplotype (IOR, 2.08; 95% CI, 1.01-4.30). These results suggest that cervical and vulvar SCC risk among cigarette smokers is modified by genetic variation in IL2...
  36. pmc Long-range multilocus haplotype phasing of the MHC
    Zhen Guo
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 103:6964-9. 2006
    ..Availability of an efficient method for MHC haplotype phase determination will facilitate the mapping of causative MHC-resident genes in many human diseases and has the potential to be broadened to other polymorphic gene complexes...
  37. pmc Oligonucleotide arrays for high-throughput SNPs detection in the MHC class I genes: HLA-B as a model system
    Zhen Guo
    Institute for Systems Biology, Seattle, WA 98105, USA
    Genome Res 12:447-57. 2002
    ..The oligonucleotide array method described in this paper provides unambiguous detection of complex heterozygous SNP combinations. This methodological approach may be applied to other highly polymorphic gene systems...
  38. ncbi request reprint Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles
    David M Koelle
    Department of Medicine, University of Washington, Seattle, USA
    Blood 99:3844-7. 2002
    ..Given the prevalence of this viral infection and the HLA alleles involved, it is possible that this cross-reactivity may be involved in clinically significant events...
  39. ncbi request reprint Duration of immunosuppressive treatment for chronic graft-versus-host disease
    Betty L Stewart
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109, USA
    Blood 104:3501-6. 2004
    ..After the dose of prednisone was taken into account, progressive onset was not associated with an increased risk of nonrelapse mortality...
  40. ncbi request reprint Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D
    Margaret A Holmes
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 169:1395-400. 2002
    ....
  41. ncbi request reprint The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation
    Bronwen E Shaw
    Anthony Nolan Research Institute, London, UK
    Blood 110:4560-6. 2007
    ..Knowledge of the DPB1 matching status prior to transplantation will aid in more precise risk stratification for the individual patient...
  42. ncbi request reprint Nomenclature for factors of the HLA system, 2002
    Steven G E Marsh
    Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, United Kingdom
    Hum Immunol 63:1213-68. 2002
  43. ncbi request reprint Genomic polymorphism and allogeneic hematopoietic transplantation outcome
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biol Blood Marrow Transplant 12:19-27. 2006
    ....
  44. ncbi request reprint Nomenclature for factors of the HLA system, 2002
    Steven G E Marsh
    Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, London, UK
    Eur J Immunogenet 29:463-515. 2002
  45. ncbi request reprint Nomenclature for Factors of the HLA System, 2004
    Steven G E Marsh
    Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, United Kingdom
    Hum Immunol 66:571-636. 2005

Research Grants12

  1. Hematopopietic Stem Cell Transplantation
    Effie Petersdorf; Fiscal Year: 2007
    ..Successin achieving these goals will broaden the applicability of unrelated HCT to the treatment of blood disorders. ..
  2. Clinical Significance of MHC Haplotypes in Hematopoietic Cell Transplantation
    Effie Petersdorf; Fiscal Year: 2007
    ..abstract_text> ..
  3. SNPs in Lung Cancer Risk and Therapeutic Response
    Effie Petersdorf; Fiscal Year: 2004
    ..abstract_text> ..
  4. OPTIMIZING BMT FOR CANCER BY GENETIC MATCHING OF DONORS
    Effie Petersdorf; Fiscal Year: 2003
    ....
  5. Clinical Significance of MHC Haplotypes in HCT
    Effie W Petersdorf; Fiscal Year: 2010
    ..We will use the tool to find the genes that are important to transplant success. ..