Ulrike Peters

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Serum lycopene, other carotenoids, and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:962-8. 2007
  2. pmc Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants
    Yumie Takata
    Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e38612. 2012
  3. pmc Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
    Megan D Fesinmeyer
    Department of Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Obesity (Silver Spring) 21:835-46. 2013
  4. pmc Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
    Ulrike Peters
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gastroenterology 144:799-807.e24. 2013
  5. pmc A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
    Ulrike Peters
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003171. 2013
  6. pmc A pooled analysis of smoking and colorectal cancer: timing of exposure and interactions with environmental factors
    Jian Gong
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 21:1974-85. 2012
  7. pmc Polymorphism analysis of six selenoprotein genes: support for a selective sweep at the glutathione peroxidase 1 locus (3p21) in Asian populations
    Charles B Foster
    Section of Pediatric Infectious Diseases, Division of Pediatrics, Desk A120, The Children s Hospital, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    BMC Genet 7:56. 2006
  8. ncbi request reprint Association of genetic variants in the calcium-sensing receptor with risk of colorectal adenoma
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Cancer Epidemiol Biomarkers Prev 13:2181-6. 2004
  9. pmc Meta-analysis of new genome-wide association studies of colorectal cancer risk
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA
    Hum Genet 131:217-34. 2012
  10. ncbi request reprint High serum selenium and reduced risk of advanced colorectal adenoma in a colorectal cancer early detection program
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:315-20. 2006

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Serum lycopene, other carotenoids, and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:962-8. 2007
    ..This has stimulated extensive laboratory and clinical research, as well as much commercial and public enthusiasm. However, the epidemiologic evidence remains inconclusive...
  2. pmc Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants
    Yumie Takata
    Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e38612. 2012
    ..Our study is the first to report positive associations of plasma SEPP1 concentrations with the risk of EA and aneuploidy, which warrants further investigation...
  3. pmc Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
    Megan D Fesinmeyer
    Department of Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Obesity (Silver Spring) 21:835-46. 2013
    ..However, studies of this complex trait have focused on ancestrally European populations, despite the high prevalence of obesity in some minority groups...
  4. pmc Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
    Ulrike Peters
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gastroenterology 144:799-807.e24. 2013
    ..Heritable factors contribute to the development of colorectal cancer. Identifying the genetic loci associated with colorectal tumor formation could elucidate the mechanisms of pathogenesis...
  5. pmc A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
    Ulrike Peters
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003171. 2013
    ..Importantly our study demonstrated that comprehensive fine-mapping in AA provides a powerful approach to narrow in on the functional candidate(s) underlying the initial GWAS findings in European populations...
  6. pmc A pooled analysis of smoking and colorectal cancer: timing of exposure and interactions with environmental factors
    Jian Gong
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 21:1974-85. 2012
    ..What is unclear, however, is the impact of quitting smoking on risk attenuation and whether other risk factors for CRC modify this association...
  7. pmc Polymorphism analysis of six selenoprotein genes: support for a selective sweep at the glutathione peroxidase 1 locus (3p21) in Asian populations
    Charles B Foster
    Section of Pediatric Infectious Diseases, Division of Pediatrics, Desk A120, The Children s Hospital, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    BMC Genet 7:56. 2006
    ....
  8. ncbi request reprint Association of genetic variants in the calcium-sensing receptor with risk of colorectal adenoma
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Cancer Epidemiol Biomarkers Prev 13:2181-6. 2004
    ..We assessed the associations between CASR gene variants and risk for colorectal adenoma, a cancer precursor. We further investigated gene-diet interactions between the CASR variants and calcium intake on adenoma risk...
  9. pmc Meta-analysis of new genome-wide association studies of colorectal cancer risk
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA
    Hum Genet 131:217-34. 2012
    ..03; combined p value 1.9 × 10(-4)). Our study suggests a complex nature of the contribution of common genetic variants to risk for colorectal cancer...
  10. ncbi request reprint High serum selenium and reduced risk of advanced colorectal adenoma in a colorectal cancer early detection program
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:315-20. 2006
    ..Although substantial evidence suggests that smoking is a strong effect modifier for other antioxidative nutrients, little is known about smoking-selenium interactions in colorectal tumors...
  11. doi request reprint Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma
    Ulrike Peters
    Public Health Science, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1144-54. 2008
    ..We therefore investigated whether genetic variants in selenoenzymes abundantly expressed in the colon are associated with advanced colorectal adenoma, a cancer precursor...
  12. ncbi request reprint Calcium intake and colorectal adenoma in a US colorectal cancer early detection program
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Clin Nutr 80:1358-65. 2004
    ..Calcium can reduce the risk of colorectal tumors by binding secondary bile and fatty acids, which leads to antiproliferative effects in the bowel, or by acting directly on the colonic epithelium, which affects differentiation and apoptosis...
  13. pmc Selenium and the prevention of prostate and colorectal cancer
    Ulrike Peters
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98109 1024, USA
    Mol Nutr Food Res 52:1261-72. 2008
    ..Furthermore, characterization of functional effects of polymorphisms in selenoenzymes is needed...
  14. pmc Serum selenium and risk of prostate cancer-a nested case-control study
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Clin Nutr 85:209-17. 2007
    ..Interrelations with other antioxidative agents and oxidative stressors, such as smoking, are poorly understood...
  15. ncbi request reprint Vitamin E and selenium supplementation and risk of prostate cancer in the Vitamins and lifestyle (VITAL) study cohort
    Ulrike Peters
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Causes Control 19:75-87. 2008
    ..We aimed to investigate the association of vitamin E and selenium supplementation with prostate cancer in the VITamins And Lifestyle (VITAL) study, a cohort study specifically designed to examine supplement use and future cancer risk...
  16. pmc Genetic variation in calcium-sensing receptor and risk for colon cancer
    Linda M Dong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:2755-65. 2008
    ..We also examined interactions among CASR, calcium, and vitamin D intake and previously genotyped vitamin D-related genes...
  17. pmc Vitamin D pathway gene variants and prostate cancer prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 70:1448-60. 2010
    ..Increased understanding of relevant germline genetic variation with disease outcome could aid in the development of vitamin-D-based therapies...
  18. pmc Variation in the FGFR2 gene and the effects of postmenopausal hormone therapy on invasive breast cancer
    Ross L Prentice
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 18:3079-85. 2009
    ..Single nucleotide polymorphisms (SNP) in the fibroblast growth factor receptor 2 (FGFR2) gene are substantially associated with postmenopausal breast cancer risk and could influence hormone therapy effects...
  19. ncbi request reprint Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer risk
    Victoria A Kirsh
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:245-54. 2006
    ....
  20. pmc Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
  21. pmc Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
    Carolyn M Hutter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
    BMC Cancer 10:670. 2010
    ..Genome-wide association studies and subsequent replication studies have shown that single nucleotide polymorphisms (SNPs) in the chromosomal region 8q24 are associated with colorectal cancer susceptibility...
  22. pmc Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk
    Linda M Dong
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:2540-8. 2009
    ..As this is the first study to evaluate these genes in relation to colon cancer, additional studies are needed to confirm these results...
  23. pmc Adipokine genes and prostate cancer risk
    Steven C Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Cancer 124:869-76. 2009
    ..05). Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis...
  24. pmc Genome-wide association study of serum selenium concentrations
    Jian Gong
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nutrients 5:1706-18. 2013
    ..Additional studies are needed to replicate these findings. Identification of genetic variation that impacts selenium concentrations may contribute to a better understanding of which genes regulate circulating selenium concentrations...
  25. pmc Vitamin D pathway gene variants and prostate cancer risk
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:1929-33. 2009
    ....
  26. pmc Serum retinol and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial
    Jeannette M Schenk
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 18:1227-31. 2009
    ..Further research is needed to better understand the significance of elevations in serum retinol concentrations and the possible biological mechanisms through which retinol affects prostate cancer...
  27. pmc Specialty supplements and prostate cancer risk in the VITamins and Lifestyle (VITAL) cohort
    Theodore M Brasky
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nutr Cancer 63:573-82. 2011
    ..Grapeseed may be a potential chemopreventive agent; however, as current evidence is limited, it should not yet be promoted for prevention of prostate cancer...
  28. ncbi request reprint A prospective study of lycopene and tomato product intake and risk of prostate cancer
    Victoria A Kirsh
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:92-8. 2006
    ..Dietary lycopene and tomato products may reduce risk of prostate cancer; however, uncertainty remains about this possible association...
  29. pmc Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers
    Yumie Takata
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
    Cancer Causes Control 20:497-504. 2009
    ..To examine the association between breast cancer risk and the fatty acid composition of phospholipids in prediagnostic serum samples...
  30. pmc Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study
    Christopher S Carlson
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Biol 11:e1001661. 2013
    ..Models based directly on functional variation may generalize more robustly, but the identification of functional variants remains challenging. ..
  31. pmc Serum vitamin D concentration and prostate cancer risk: a nested case-control study
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 100:796-804. 2008
    ....
  32. doi request reprint Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
    Ju Hyun Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland, USA
    Nat Genet 42:570-5. 2010
    ..However, for BPC cancers, which have modest familial aggregation, our analysis suggests that risk models based on common variants alone will have modest discriminatory power (63.5% area under curve), even with new discoveries...
  33. ncbi request reprint Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:2623-30. 2007
    ..Furthermore, we found no relationship between calcium intake and circulating vitamin D...
  34. pmc Fine Mapping and Identification of BMI Loci in African Americans
    Jian Gong
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA Electronic address
    Am J Hum Genet 93:661-71. 2013
    ..These results demonstrate that fine mapping in AAs is a powerful approach for both narrowing in on the underlying causal variants in known loci and discovering BMI-related loci. ..
  35. pmc Non-steroidal anti-inflammatory drugs and cancer incidence by sex in the VITamins And Lifestyle (VITAL) cohort
    Theodore M Brasky
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Unit, Seattle, WA 98109 1024, USA
    Cancer Causes Control 23:431-44. 2012
    ..A recent meta-analysis of randomized trials of aspirin reported a reduction in cancer mortality; however, few studies have investigated whether aspirin or other NSAIDs reduce overall cancer risk...
  36. ncbi request reprint A prospective study of meat and meat mutagens and prostate cancer risk
    Amanda J Cross
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Res 65:11779-84. 2005
    ..01-1.61). In conclusion, very well done meat was positively associated with prostate cancer risk. In addition, this study lends epidemiologic support to the animal studies, which have implicated PhIP as a prostate carcinogen...
  37. pmc Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
    Megan D Fesinmeyer
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    BMC Med Genet 14:6. 2013
    ..Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored...
  38. pmc SBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases
    Shuo Jiao
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genet Epidemiol 37:452-64. 2013
    ....
  39. pmc Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions
    Nilanjan Chatterjee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Am J Hum Genet 79:1002-16. 2006
    ....
  40. pmc Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Am J Epidemiol 172:578-90. 2010
    ..These results contribute further evidence that aspirin may have chemopreventive activity against prostate cancer and highlight the need for additional research...
  41. pmc Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival
    Xabier Garcia-Albeniz
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 34:292-8. 2013
    ..These findings suggest that individuals with this SMAD7 variant that develop CRC are more probably to have tumors with greater invasiveness and methylation of RUNX3, which potentially contributes to their poorer observed survival...
  42. ncbi request reprint Meat, meat cooking methods and preservation, and risk for colorectal adenoma
    Rashmi Sinha
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 65:8034-41. 2005
    ..04; 95% CI, 0.90-1.19). Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma...
  43. pmc Genetic variation in GPX1 is associated with GPX1 activity in a comprehensive analysis of genetic variations in selenoenzyme genes and their activity and oxidative stress in humans
    Yumie Takata
    Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Nutr 142:419-26. 2012
    ..03 and 0.02, respectively). Overall, our study supports the hypothesis that common genetic variants in selenoenzymes affect their activity...
  44. pmc The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study
    Mariaelisa Graff
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 62:1763-7. 2013
    ..Future research should compare and contrast our findings with results using longitudinal data...
  45. ncbi request reprint Urinary mutagenesis and fried red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding study
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892 7273, USA
    Environ Mol Mutagen 43:53-74. 2004
    ..The data from this study indicate that urinary mutagenicity correlates with mutagenic exposure from cooked meat and can potentially be used as a marker in etiological studies on cancer...
  46. pmc Genome-wide search for gene-gene interactions in colorectal cancer
    Shuo Jiao
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e52535. 2012
    ..1) (nominal combined p = 2.51×10(-6); Bonferroni adjusted p = 0.03). Our study represents the first comprehensive search for GxG in CRC, and our results may provide new insight into the genetic etiology of CRC...
  47. pmc Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysis
    Yumie Takata
    Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 20:1822-30. 2011
    ..Furthermore, genetic variants in selenoenzymes may be associated with colorectal cancer risk...
  48. ncbi request reprint Insulin resistance-related genes and advanced left-sided colorectal adenoma
    Marc J Gunter
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 16:703-8. 2007
    ....
  49. ncbi request reprint Choice of exposure scores for categorical regression in meta-analysis: a case study of a common problem
    Dora Il'yasova
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Cancer Causes Control 16:383-8. 2005
    ..This method requires the assignment of a single score to each exposure category. We examined how closely meta-analytical categorical regression approximates the results of analysis based on the individual-level continuous exposure...
  50. pmc Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women
    Michael N Passarelli
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 73:767-75. 2013
    ..79; CI, 0.64-0.98 in replication]. No associations were noted for SNPs of AR, ESR1, or PGR. SNPs in the promoter of ESR2 may be important to pathways related to the association between ERβ and tumor progression and metastasis...
  51. pmc Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 17:2665-72. 2008
    ..008. This study confirms the association between colorectal neoplasia and the 8q24 polymorphisms located between 128.47 and 128.54 Mb and suggests a role for these variants in the formation of multiple adenomas...
  52. pmc Characterization of 9p24 risk locus and colorectal adenoma and cancer: gene-environment interaction and meta-analysis
    Jonathan D Kocarnik
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 19:3131-9. 2010
    ..A potential susceptibility locus for colorectal cancer on chromosome 9p24 (rs719725) was initially identified through a genome-wide association study, though replication attempts have been inconclusive...
  53. pmc Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality
    Gaia Pocobelli
    Department of Epidemiology, University of Washington, Seattle, USA
    Am J Epidemiol 170:472-83. 2009
    ..Multivitamin and vitamin E use were not associated with cancer mortality. Some of the associations we observed were small and may have been due to unmeasured healthy behaviors that were more common in supplement users...
  54. pmc Zinc intake from supplements and diet and prostate cancer
    Alejandro Gonzalez
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Nutritional Sciences Interdisciplinary Degree Program, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Nutr Cancer 61:206-15. 2009
    ..Because few other epidemiologic studies have investigated the association between zinc and prostate cancer, and these have not yielded consistent findings, further research is needed...
  55. ncbi request reprint Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, EPS 3024, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:546-52. 2004
    ..We investigated the association of circulating vitamin D metabolites and a genetic variant of the VDR gene with advanced colorectal adenoma, a precursor lesion of colorectal cancer...
  56. pmc Dietary supplement use and risk of neoplastic progression in esophageal adenocarcinoma: a prospective study
    Linda M Dong
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
    Nutr Cancer 60:39-48. 2008
    ..10-0.60). In this cohort study, use of multivitamins and single antioxidant supplements was associated with a significantly reduced risk of EA and markers of neoplastic progression among individuals with Barrett's esophagus...
  57. pmc Serum α-tocopherol and γ-tocopherol concentrations and prostate cancer risk in the PLCO Screening Trial: a nested case-control study
    Stephanie J Weinstein
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Servies, Bethesda, Maryland, United States of America
    PLoS ONE 7:e40204. 2012
    ..Many studies suggest protective effects among smokers and for aggressive prostate cancer, however...
  58. pmc Association between use of specialty dietary supplements and C-reactive protein concentrations
    Elizabeth D Kantor
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Am J Epidemiol 176:1002-13. 2012
    ....
  59. pmc Polymorphisms in the adenomatous polyposis coli (APC) gene and advanced colorectal adenoma risk
    Hui Lee Wong
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Eur J Cancer 46:2457-66. 2010
    ..Fat intake modified the APC D1822V-adenoma association, but further studies are warranted...
  60. ncbi request reprint Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer
    Crystal N Holick
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, USA
    Cancer Epidemiol Biomarkers Prev 16:1990-9. 2007
    ..Our findings suggest that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer...
  61. pmc Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma
    Hans Christian Erichsen
    Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4605, USA
    Nutr Cancer 60:652-9. 2008
    ..49, 95% confidence interval = 0.25-0.95 for haplotype G-C vs. haplotype C-C). The findings should be confirmed in follow-up studies, and further investigation is required to probe the functional basis of this finding...
  62. ncbi request reprint Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme
    Ulrike Peters
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, DHHS, MD 20892 7273, USA
    Lancet 361:1491-5. 2003
    ..Although dietary fibre has been reported to have no association with colorectal adenoma and cancer, in some studies this topic remains controversial...
  63. ncbi request reprint Insulin resistance-related gene polymorphisms and risk of prostate cancer
    Steven C Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:1315-7. 2007
  64. pmc Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data
    Lin S Chen
    Biostatistics and Biomathematics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Hum Genet 86:860-71. 2010
    ..Elucidating the role of variation in these pathways may enhance our understanding of colon cancer etiology...
  65. pmc Variation in the FGFR2 gene and the effect of a low-fat dietary pattern on invasive breast cancer
    Ross L Prentice
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:74-9. 2010
    ..Single nucleotide polymorphisms (SNP) in the FGFR2 gene relate strongly to breast cancer risk and could influence intervention effects...
  66. pmc Genetic variation on 9p22 is associated with abnormal ovarian ultrasound results in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 6:e21731. 2011
    ..The single nucleotide polymorphism (SNP) markers localize to the BNC2 gene, which has been associated with ovarian development...
  67. ncbi request reprint Fat, fiber, fruits, vegetables, and risk of colorectal adenomas
    Aleyamma Mathew
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Cancer 108:287-92. 2004
    ..This is likely to be an indicator of "unhealthy" food (meat, dairy, margarine, mayonnaise, sweet baked food) consumption in this population. Increased intake of dietary fiber was associated with a moderately decreased risk of adenomas...
  68. pmc Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer
    Amanda I Phipps
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Gastroenterology 143:51-4.e4. 2012
    ..05-1.30; P = .005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC...
  69. pmc Fine-mapping and initial characterization of QT interval loci in African Americans
    Christy L Avery
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Genet 8:e1002870. 2012
    ....
  70. pmc Association between adult height, genetic susceptibility and risk of glioma
    Cari M Kitahara
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Epidemiol 41:1075-85. 2012
    ..In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease...
  71. pmc Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe Study
    Carolyn M Hutter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:1950-9. 2011
    ..These studies have primarily been conducted in populations of European descent. To fully understand the impact of these loci, it is important to study groups with other genetic ancestries, including African American women...
  72. ncbi request reprint A haplotype-based test of association using data from cohort and nested case-control epidemiologic studies
    Jinbo Chen
    Biostatistics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Hum Hered 58:18-29. 2004
    ..Utilizing simulated data in the context of two genomic regions GPX1 and GPX3, we evaluate the validity of the proposed test for small sample sizes and study its power in the presence and absence of missing genotype data...
  73. pmc Genetic variants in the MRPS30 region and postmenopausal breast cancer risk
    Ying Huang
    Fred Hutchinson Cancer Research Center, Divisions of Public Health Sciences, and Vaccine and Infectious Diseases, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Genome Med 3:42. 2011
    ..Genotype by environment interactions may contribute further to such explanation, and may help to refine the genomic regions of interest...
  74. pmc Correlation between selenium concentrations and glutathione peroxidase activity in serum and human prostate tissue
    Yumie Takata
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 69:1635-42. 2009
    ..Hence, we investigated the correlation between serum and prostate tissue selenium concentrations and prostate tissue activity of glutathione peroxidase (GPX), a major selenoenzyme with antioxidant properties...
  75. ncbi request reprint Methods for etiologic and early marker investigations in the PLCO trial
    Richard B Hayes
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, Bethesda, MD 20892, USA
    Mutat Res 592:147-54. 2005
    ..g., diet), biochemical, and genetic factors. Early detection studies focus on blood-based biologic markers of early disease. Clinical epidemiology is also an important component of the PLCO trial...
  76. pmc Correlates of toenail zinc in a free-living U.S. population
    Alejandro Gonzalez
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Nutritional Sciences Program, University of Washington, Seattle, WA 98109 1024, USA
    Ann Epidemiol 18:74-7. 2008
    ..The study aim was to identify dietary and other factors that influence toenail zinc in a healthy population, in order to understand the usefulness of this biomarker in public health studies...
  77. ncbi request reprint Urinary mutagenicity and colorectal adenoma risk
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7273, USA
    Cancer Epidemiol Biomarkers Prev 12:1253-6. 2003
    ..2-13.9, comparing the highest with the lowest quintile). In our study population, diet may have contributed to mutagenic exposure, which was positively associated with colorectal adenoma risk...
  78. ncbi request reprint A prospective study of dietary alpha-linolenic acid and the risk of prostate cancer (United States)
    Daniel O Koralek
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Cancer Causes Control 17:783-91. 2006
    ..Alpha-linolenic acid (ALA) is the most common omega-3 fatty acid in the Western diet. The relation of dietary intake of ALA to prostate cancer risk remains unresolved...
  79. pmc Genetic susceptibility to cancer: the role of polymorphisms in candidate genes
    Linda M Dong
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    JAMA 299:2423-36. 2008
    ..Continuing advances in genotyping technologies and the inclusion of DNA collection in observational studies have resulted in an increasing number of genetic association studies...
  80. pmc Diet and risk of endometriosis in a population-based case-control study
    Britton Trabert
    Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    Br J Nutr 105:459-67. 2011
    ..1: OR 0·6, >2 servings/d v. ≤ 1: OR 0·7), but this association was not statistically significant for the highest tertile. The present study suggests that specific dietary components may be associated with endometriosis risk...
  81. pmc Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes
    Britton Trabert
    University of Washington, Seattle, Washington, USA
    Fertil Steril 96:1401-1406.e3. 2011
    ..To evaluate the relationship between common genetic variation in genes involved in the biosynthesis and signaling of estrogen and progesterone and endometriosis risk...
  82. pmc Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification Trial
    Cara L Carty
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Clin Nutr 93:516-24. 2011
    ..The Women's Health Initiative Dietary Modification (DM) Trial was a randomized controlled trial that compared the effects of a low-fat (≤20% of total energy) or a usual diet in relation to chronic disease risk in postmenopausal women...
  83. ncbi request reprint Boron intake and prostate cancer risk
    Alejandro Gonzalez
    Cancer Prevention Pragram, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 18:1131-40. 2007
    ..Only one small epidemiological study has been conducted of boron, which found that those in the highest quartile of boron intake had less than half the risk of prostate cancer versus those in the lowest quartile...
  84. pmc Nonsteroidal anti-inflammatory drugs and prostate cancer risk in the VITamins And Lifestyle (VITAL) cohort
    Theodore M Brasky
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:3185-8. 2010
    ..Several epidemiologic studies have reported inverse associations between nonsteroidal anti-inflammatory drugs (NSAIDs) and prostate cancer risk, although many studies are limited by assessment of short-term use only...
  85. ncbi request reprint Dietary fibre and risk of colorectal cancer in the Breast Cancer Detection Demonstration Project (BCDDP) follow-up cohort
    Volker Mai
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
    Int J Epidemiol 32:234-9. 2003
    ..We investigated the association between dietary fibre intake and risk of CRC in a cohort of women that prospectively answered a food frequency questionnaire (FFQ)...
  86. pmc The use of imputed values in the meta-analysis of genome-wide association studies
    Shuo Jiao
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Genet Epidemiol 35:597-605. 2011
    ..Our results show that the performance of the inverse variance weight is always indistinguishable from the optimal weight and similar to or better than the other two methods...
  87. ncbi request reprint Causes of death in patients with celiac disease in a population-based Swedish cohort
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7273, USA
    Arch Intern Med 163:1566-72. 2003
    ..Patients with celiac disease have an increased risk of death from gastrointestinal malignancies and lymphomas, but little is known about mortality from other causes and few studies have assessed long-term outcomes...
  88. ncbi request reprint Advancing the calcium-colorectal cancer hypothesis
    Arthur Schatzkin
    J Natl Cancer Inst 96:893-4. 2004
  89. ncbi request reprint Adherence to the USDA Food Guide, DASH Eating Plan, and Mediterranean dietary pattern reduces risk of colorectal adenoma
    L Beth Dixon
    Department of Nutrition, Food Studies, and Public Health, New York University, New York City, NY 10012, USA
    J Nutr 137:2443-50. 2007
    ..lt;or=2 = 0.74, 95% CI = 0.55-0.99; P-trend = 0.08). Following the current U.S. dietary recommendations or a Mediterranean dietary pattern is associated with reduced risk of colorectal adenoma, especially in men...
  90. ncbi request reprint Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trial
    Amy E Millen
    University at Buffalo, School of Public Health and Health Professions, Department of Social and Preventive Medicine, Buffalo, NY 14214 8001, USA
    Am J Clin Nutr 86:1754-64. 2007
    ..Research on the association between fruit and vegetable intake and risk of colorectal adenoma is inconclusive...
  91. ncbi request reprint Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 16:1581-6. 2007
    ..These results suggest that the Ala variant of SOD2 is associated with moderately increased risk of prostate cancer, particularly among men with lower intakes of dietary and supplemental vitamin E...
  92. ncbi request reprint Development and application of a simple routine method for the determination of selenium in serum by octopole reaction system ICPMS
    Stefan Sturup
    Dartmouth Trace Element Analysis Core Facility, Departments of Earth Sciences and Chemistry, Dartmouth College, 6105 Sherman Fairchild Hall, Hanover, NH, 03755, USA
    Anal Bioanal Chem 381:686-94. 2005
    ..For the Seronorm certified reference material a value of 911+/-75 microg L-1 (n=31) for zinc was obtained, which corresponds well to the certified zinc value of 920+/-60 microg L-1...
  93. ncbi request reprint Carbohydrate, glycemic index, and glycemic load and colorectal adenomas in the Prostate, Lung, Colorectal, and Ovarian Screening Study
    Andrew Flood
    University of Minnesota, Minneapolis, MN, Henry Ford Hospital, Detroit, MI, USA
    Am J Clin Nutr 84:1184-92. 2006
    ..It is possible that high-glycemic-load diets, through their hyperinsulinemic effects, can increase the risk of colorectal cancer...
  94. ncbi request reprint Prospective study of fruit and vegetable intake and risk of prostate cancer
    Victoria A Kirsh
    Research Unit, Division of Preventive Oncology, Cancer Care Ontario, Toronto, ON, Canada
    J Natl Cancer Inst 99:1200-9. 2007
    ..Several epidemiologic studies have reported associations between fruit and vegetable intake and reduced risk of prostate cancer, but the findings are inconsistent and data on clinically relevant advanced prostate cancer are limited...
  95. ncbi request reprint Calcium from diet and supplements is associated with reduced risk of colorectal cancer in a prospective cohort of women
    Andrew Flood
    Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Cancer Epidemiol Biomarkers Prev 14:126-32. 2005
    ..e., diet or supplements)...
  96. ncbi request reprint Characterization of two SNPs (single nucleotide polymorphisms) in the porcine INSL3 gene and their exclusion as a common genetic basis of hernia inguinalis in pigs
    Christoph Knorr
    Institute of Veterinary Medicine, Georg August University of Goettingen, Goettingen, Germany
    Biochem Genet 42:11-9. 2004
    ..Screening of the two SNPs in a population of hernia inguinalis affected full and half sib piglets (n = 223) revealed that the SNPs can be excluded as a common genetic basis for this congenital disorder in this pedigree...
  97. ncbi request reprint Prevalence of Porphyromonas gingivalis fimA genotypes in Caucasians
    Thomas Beikler
    Department of Periodontology, University of Munster, Munster, Germany
    Eur J Oral Sci 111:390-4. 2003
    ..The results indicate that predominant fimA genotypes in Caucasian periodontitis patients are types I, II, and IV. However, there was no difference in the association of the various fimA genotypes with disease severity...
  98. ncbi request reprint Sequence variations of mitochondrial DNA and individual sensitivity to the ototoxic effect of cisplatin
    Ulrike Peters
    Institute for Human Genetics, University of Muenster, Muenster, Germany
    Anticancer Res 23:1249-55. 2003
    ..Since mutations in the mitochondrial genome are associated with hearing loss, we analyzed whether sequence variations of mtDNA are associated with individual sensitivity to cisplatin-induced ototoxicity...

Research Grants11

  1. Prospective Study on Selenium, Genectics of Selenoenzymes, and Colorectal Cancer
    Ulrike Peters; Fiscal Year: 2010
    ..Given the public health importance of colorectal cancer and the increasing use of selenium supplements in the United States, there is a need for the type of investigation that we are proposing. ..
  2. Genome-Wide Association Study of Nonsynonymous SNPs in Colon Cancer
    Ulrike Peters; Fiscal Year: 2009
    ....
  3. Prospective Study on Selenium, Genectics of Selenoenzymes, and Colorectal Cancer
    Ulrike Peters; Fiscal Year: 2006
    ..Given the public health importance of colorectal cancer and the increasing use of selenium supplements in the United States, there is a need for the type of investigation that we are proposing. ..
  4. Genome-Wide Association Study of Nonsynonymous SNPs in Colon Cancer
    Ulrike Peters; Fiscal Year: 2010
    ....
  5. Prospective Study on Selenium, Genectics of Selenoenzymes, and Colorectal Cancer
    Ulrike Peters; Fiscal Year: 2007
    ..Given the public health importance of colorectal cancer and the increasing use of selenium supplements in the United States, there is a need for the type of investigation that we are proposing. ..
  6. Selenium genetic variation in selenoenzymes and prostate cancer
    Ulrike Peters; Fiscal Year: 2007
    ....
  7. Genome-Wide Association Study of Nonsynonymous SNPs in Colon Cancer
    Ulrike Peters; Fiscal Year: 2009
    ..We expect our findings to enhance our understanding of the mechanisms underlying colorectal carcinogenesis. In turn, this will lead to improved prevention and treatment strategies. ..
  8. Genetic variations in calcium and vitamin D related gen*
    Ulrike Peters; Fiscal Year: 2006
    ....