Research Topics
Genomes and Genes
| Ulrike PetersSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
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Publications
Serum lycopene, other carotenoids, and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trialUlrike Peters
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 16:962-8. 2007..This has stimulated extensive laboratory and clinical research, as well as much commercial and public enthusiasm. However, the epidemiologic evidence remains inconclusive...
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysisUlrike Peters
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington School of Public Health, University of Washington, Seattle, Washington Electronic address
Gastroenterology 144:799-807.e24. 2013..Heritable factors contribute to the development of colorectal cancer. Identifying the genetic loci associated with colorectal tumor formation could elucidate the mechanisms of pathogenesis...- A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) studyUlrike Peters
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Genet 9:e1003171. 2013..Importantly our study demonstrated that comprehensive fine-mapping in AA provides a powerful approach to narrow in on the functional candidate(s) underlying the initial GWAS findings in European populations... - Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology studyMegan D Fesinmeyer
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
BMC Med Genet 14:6. 2013..Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored... - A pooled analysis of smoking and colorectal cancer: timing of exposure and interactions with environmental factorsJian Gong
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 21:1974-85. 2012..What is unclear, however, is the impact of quitting smoking on risk attenuation and whether other risk factors for CRC modify this association... - Polymorphism analysis of six selenoprotein genes: support for a selective sweep at the glutathione peroxidase 1 locus (3p21) in Asian populationsCharles B Foster
Section of Pediatric Infectious Diseases, Division of Pediatrics, Desk A120, The Children s Hospital, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
BMC Genet 7:56. 2006.... - High serum selenium and reduced risk of advanced colorectal adenoma in a colorectal cancer early detection programUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
Cancer Epidemiol Biomarkers Prev 15:315-20. 2006..Although substantial evidence suggests that smoking is a strong effect modifier for other antioxidative nutrients, little is known about smoking-selenium interactions in colorectal tumors... - Selenium and the prevention of prostate and colorectal cancerUlrike Peters
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98109 1024, USA
Mol Nutr Food Res 52:1261-72. 2008..Furthermore, characterization of functional effects of polymorphisms in selenoenzymes is needed... 
Variation in the selenoenzyme genes and risk of advanced distal colorectal adenomaUlrike Peters
Public Health Science, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 17:1144-54. 2008..We therefore investigated whether genetic variants in selenoenzymes abundantly expressed in the colon are associated with advanced colorectal adenoma, a cancer precursor...- Vitamin E and selenium supplementation and risk of prostate cancer in the Vitamins and lifestyle (VITAL) study cohortUlrike Peters
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
Cancer Causes Control 19:75-87. 2008..We aimed to investigate the association of vitamin E and selenium supplementation with prostate cancer in the VITamins And Lifestyle (VITAL) study, a cohort study specifically designed to examine supplement use and future cancer risk... - Serum selenium and risk of prostate cancer-a nested case-control studyUlrike Peters
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Clin Nutr 85:209-17. 2007..Interrelations with other antioxidative agents and oxidative stressors, such as smoking, are poorly understood... - Association of genetic variants in the calcium-sensing receptor with risk of colorectal adenomaUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
Cancer Epidemiol Biomarkers Prev 13:2181-6. 2004..We assessed the associations between CASR gene variants and risk for colorectal adenoma, a cancer precursor. We further investigated gene-diet interactions between the CASR variants and calcium intake on adenoma risk... - Calcium intake and colorectal adenoma in a US colorectal cancer early detection programUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Clin Nutr 80:1358-65. 2004..Calcium can reduce the risk of colorectal tumors by binding secondary bile and fatty acids, which leads to antiproliferative effects in the bowel, or by acting directly on the colonic epithelium, which affects differentiation and apoptosis... - Meta-analysis of new genome-wide association studies of colorectal cancer riskUlrike Peters
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA
Hum Genet 131:217-34. 2012..03; combined p value 1.9 × 10(-4)). Our study suggests a complex nature of the contribution of common genetic variants to risk for colorectal cancer... - Genetic variation in calcium-sensing receptor and risk for colon cancerLinda M Dong
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 17:2755-65. 2008..We also examined interactions among CASR, calcium, and vitamin D intake and previously genotyped vitamin D-related genes... - Variation in the FGFR2 gene and the effects of postmenopausal hormone therapy on invasive breast cancerRoss L Prentice
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 18:3079-85. 2009..Single nucleotide polymorphisms (SNP) in the fibroblast growth factor receptor 2 (FGFR2) gene are substantially associated with postmenopausal breast cancer risk and could influence hormone therapy effects... - Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer riskVictoria A Kirsh
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
J Natl Cancer Inst 98:245-54. 2006..However, vitamin E supplementation in male smokers and beta-carotene supplementation in men with low dietary beta-carotene intakes were associated with reduced risk of this disease... - Vitamin D pathway gene variants and prostate cancer prognosisSarah K Holt
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Prostate 70:1448-60. 2010..Increased understanding of relevant germline genetic variation with disease outcome could aid in the development of vitamin-D-based therapies... - Vitamin D-related genes, serum vitamin D concentrations and prostate cancer riskJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Carcinogenesis 30:769-76. 2009..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status... - Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysisCarolyn M Hutter
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
BMC Cancer 10:670. 2010..Genome-wide association studies and subsequent replication studies have shown that single nucleotide polymorphisms (SNPs) in the chromosomal region 8q24 are associated with colorectal cancer susceptibility... - Serum vitamin D concentration and prostate cancer risk: a nested case-control studyJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bethesda, MD 20892, USA
J Natl Cancer Inst 100:796-804. 2008.... - Vitamin D pathway gene variants and prostate cancer riskSarah K Holt
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 18:1929-33. 2009.... - Specialty supplements and prostate cancer risk in the VITamins and Lifestyle (VITAL) cohortTheodore M Brasky
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Nutr Cancer 63:573-82. 2011..Grapeseed may be a potential chemopreventive agent; however, as current evidence is limited, it should not yet be promoted for prevention of prostate cancer... - Adipokine genes and prostate cancer riskSteven C Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Int J Cancer 124:869-76. 2009..05). Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis... - Serum retinol and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trialJeannette M Schenk
Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 18:1227-31. 2009..Further research is needed to better understand the significance of elevations in serum retinol concentrations and the possible biological mechanisms through which retinol affects prostate cancer... - Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer riskLinda M Dong
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 18:2540-8. 2009..As this is the first study to evaluate these genes in relation to colon cancer, additional studies are needed to confirm these results... - A prospective study of lycopene and tomato product intake and risk of prostate cancerVictoria A Kirsh
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 15:92-8. 2006..Evidence for protective associations in subjects with a family history of prostate cancer requires further corroboration... - Estimation of effect size distribution from genome-wide association studies and implications for future discoveriesJu Hyun Park
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland, USA
Nat Genet 42:570-5. 2010..However, for BPC cancers, which have modest familial aggregation, our analysis suggests that risk models based on common variants alone will have modest discriminatory power (63.5% area under curve), even with new discoveries... - Non-steroidal anti-inflammatory drugs and cancer incidence by sex in the VITamins And Lifestyle (VITAL) cohortTheodore M Brasky
The Fred Hutchinson Cancer Research Center, Cancer Prevention Unit, Seattle, WA 98109 1024, USA
Cancer Causes Control 23:431-44. 2012..A recent meta-analysis of randomized trials of aspirin reported a reduction in cancer mortality; however, few studies have investigated whether aspirin or other NSAIDs reduce overall cancer risk... - Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokersYumie Takata
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
Cancer Causes Control 20:497-504. 2009..To examine the association between breast cancer risk and the fatty acid composition of phospholipids in prediagnostic serum samples... - A prospective study of meat and meat mutagens and prostate cancer riskAmanda J Cross
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Res 65:11779-84. 2005..01-1.61). In conclusion, very well done meat was positively associated with prostate cancer risk. In addition, this study lends epidemiologic support to the animal studies, which have implicated PhIP as a prostate carcinogen... - Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survivalXabier Garcia-Albeniz
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Carcinogenesis 34:292-8. 2013..These findings suggest that individuals with this SMAD7 variant that develop CRC are more probably to have tumors with greater invasiveness and methylation of RUNX3, which potentially contributes to their poorer observed survival... - Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trialJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 16:2623-30. 2007..Furthermore, we found no relationship between calcium intake and circulating vitamin D... - Meat, meat cooking methods and preservation, and risk for colorectal adenomaRashmi Sinha
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Res 65:8034-41. 2005..04; 95% CI, 0.90-1.19). Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma... - Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal womenMichael N Passarelli
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Res 73:767-75. 2013..79; CI, 0.64-0.98 in replication]. No associations were noted for SNPs of AR, ESR1, or PGR. SNPs in the promoter of ESR2 may be important to pathways related to the association between ERβ and tumor progression and metastasis... - Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia riskSonja I Berndt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Hum Mol Genet 17:2665-72. 2008..008. This study confirms the association between colorectal neoplasia and the 8q24 polymorphisms located between 128.47 and 128.54 Mb and suggests a role for these variants in the formation of multiple adenomas... - Characterization of 9p24 risk locus and colorectal adenoma and cancer: gene-environment interaction and meta-analysisJonathan D Kocarnik
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 19:3131-9. 2010..A potential susceptibility locus for colorectal cancer on chromosome 9p24 (rs719725) was initially identified through a genome-wide association study, though replication attempts have been inconclusive... - Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysisYumie Takata
Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 20:1822-30. 2011..Furthermore, genetic variants in selenoenzymes may be associated with colorectal cancer risk... - Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactionsNilanjan Chatterjee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Am J Hum Genet 79:1002-16. 2006.... - Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma riskUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, EPS 3024, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 13:546-52. 2004..We investigated the association of circulating vitamin D metabolites and a genetic variant of the VDR gene with advanced colorectal adenoma, a precursor lesion of colorectal cancer... - Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer riskClaudia A Salinas
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Am J Epidemiol 172:578-90. 2010..These results contribute further evidence that aspirin may have chemopreventive activity against prostate cancer and highlight the need for additional research... - Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortalityGaia Pocobelli
Department of Epidemiology, University of Washington, Seattle, USA
Am J Epidemiol 170:472-83. 2009..Multivitamin and vitamin E use were not associated with cancer mortality. Some of the associations we observed were small and may have been due to unmeasured healthy behaviors that were more common in supplement users... - Zinc intake from supplements and diet and prostate cancerAlejandro Gonzalez
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Nutritional Sciences Interdisciplinary Degree Program, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
Nutr Cancer 61:206-15. 2009..Because few other epidemiologic studies have investigated the association between zinc and prostate cancer, and these have not yielded consistent findings, further research is needed... - Serum α-tocopherol and γ-tocopherol concentrations and prostate cancer risk in the PLCO Screening Trial: a nested case-control studyStephanie J Weinstein
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Servies, Bethesda, Maryland, United States of America
PLoS ONE 7:e40204. 2012..Many studies suggest protective effects among smokers and for aggressive prostate cancer, however... - Association between use of specialty dietary supplements and C-reactive protein concentrationsElizabeth D Kantor
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Am J Epidemiol 176:1002-13. 2012.... - Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenomaHans Christian Erichsen
Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4605, USA
Nutr Cancer 60:652-9. 2008..49, 95% confidence interval = 0.25-0.95 for haplotype G-C vs. haplotype C-C). The findings should be confirmed in follow-up studies, and further investigation is required to probe the functional basis of this finding... - Polymorphisms in the adenomatous polyposis coli (APC) gene and advanced colorectal adenoma riskHui Lee Wong
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
Eur J Cancer 46:2457-66. 2010..Fat intake modified the APC D1822V-adenoma association, but further studies are warranted... - Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancerCrystal N Holick
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, USA
Cancer Epidemiol Biomarkers Prev 16:1990-9. 2007..Our findings suggest that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer... - Dietary fibre and colorectal adenoma in a colorectal cancer early detection programmeUlrike Peters
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, DHHS, MD 20892 7273, USA
Lancet 361:1491-5. 2003..Although dietary fibre has been reported to have no association with colorectal adenoma and cancer, in some studies this topic remains controversial... - Urinary mutagenesis and fried red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding studyUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892 7273, USA
Environ Mol Mutagen 43:53-74. 2004..The data from this study indicate that urinary mutagenicity correlates with mutagenic exposure from cooked meat and can potentially be used as a marker in etiological studies on cancer... - Insulin resistance-related genes and advanced left-sided colorectal adenomaMarc J Gunter
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 16:703-8. 2007.... - Insulin resistance-related gene polymorphisms and risk of prostate cancerSteven C Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 16:1315-7. 2007 - Genome-wide search for gene-gene interactions in colorectal cancerShuo Jiao
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 7:e52535. 2012..1) (nominal combined p = 2.51×10(-6); Bonferroni adjusted p = 0.03). Our study represents the first comprehensive search for GxG in CRC, and our results may provide new insight into the genetic etiology of CRC... - Variation in the FGFR2 gene and the effect of a low-fat dietary pattern on invasive breast cancerRoss L Prentice
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 19:74-9. 2010..Single nucleotide polymorphisms (SNP) in the FGFR2 gene relate strongly to breast cancer risk and could influence intervention effects... - Genetic variation in GPX1 is associated with GPX1 activity in a comprehensive analysis of genetic variations in selenoenzyme genes and their activity and oxidative stress in humansYumie Takata
Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
J Nutr 142:419-26. 2012..03 and 0.02, respectively). Overall, our study supports the hypothesis that common genetic variants in selenoenzymes affect their activity... - Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variantsYumie Takata
Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 7:e38612. 2012..Our study is the first to report positive associations of plasma SEPP1 concentrations with the risk of EA and aneuploidy, which warrants further investigation... - Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS dataLin S Chen
Biostatistics and Biomathematics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Hum Genet 86:860-71. 2010..Elucidating the role of variation in these pathways may enhance our understanding of colon cancer etiology... - Fat, fiber, fruits, vegetables, and risk of colorectal adenomasAleyamma Mathew
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Int J Cancer 108:287-92. 2004..Increased intake of dietary fiber was associated with a moderately decreased risk of adenomas... - Genetic variation on 9p22 is associated with abnormal ovarian ultrasound results in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
PLoS ONE 6:e21731. 2011..The single nucleotide polymorphism (SNP) markers localize to the BNC2 gene, which has been associated with ovarian development... - Choice of exposure scores for categorical regression in meta-analysis: a case study of a common problemDora Il'yasova
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Cancer Causes Control 16:383-8. 2005..This method requires the assignment of a single score to each exposure category. We examined how closely meta-analytical categorical regression approximates the results of analysis based on the individual-level continuous exposure... - Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancerAmanda I Phipps
Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Gastroenterology 143:51-4.e4. 2012..05-1.30; P = .005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC... - Fine-mapping and initial characterization of QT interval loci in African AmericansChristy L Avery
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS Genet 8:e1002870. 2012.... - Association between adult height, genetic susceptibility and risk of gliomaCari M Kitahara
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Int J Epidemiol 41:1075-85. 2012..In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease... - Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe StudyCarolyn M Hutter
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 20:1950-9. 2011..These studies have primarily been conducted in populations of European descent. To fully understand the impact of these loci, it is important to study groups with other genetic ancestries, including African American women... - A haplotype-based test of association using data from cohort and nested case-control epidemiologic studiesJinbo Chen
Biostatistics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Hum Hered 58:18-29. 2004..Utilizing simulated data in the context of two genomic regions GPX1 and GPX3, we evaluate the validity of the proposed test for small sample sizes and study its power in the presence and absence of missing genotype data... - Genetic variants in the MRPS30 region and postmenopausal breast cancer riskYing Huang
Fred Hutchinson Cancer Research Center, Divisions of Public Health Sciences, and Vaccine and Infectious Diseases, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
Genome Med 3:42. 2011..Genotype by environment interactions may contribute further to such explanation, and may help to refine the genomic regions of interest... - Dietary supplement use and risk of neoplastic progression in esophageal adenocarcinoma: a prospective studyLinda M Dong
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
Nutr Cancer 60:39-48. 2008..10-0.60). In this cohort study, use of multivitamins and single antioxidant supplements was associated with a significantly reduced risk of EA and markers of neoplastic progression among individuals with Barrett's esophagus... - Correlation between selenium concentrations and glutathione peroxidase activity in serum and human prostate tissueYumie Takata
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Prostate 69:1635-42. 2009..Hence, we investigated the correlation between serum and prostate tissue selenium concentrations and prostate tissue activity of glutathione peroxidase (GPX), a major selenoenzyme with antioxidant properties... - Diet and risk of endometriosis in a population-based case-control studyBritton Trabert
Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
Br J Nutr 105:459-67. 2011..1: OR 0·6, >2 servings/d v. ≤ 1: OR 0·7), but this association was not statistically significant for the highest tertile. The present study suggests that specific dietary components may be associated with endometriosis risk... - A prospective study of dietary alpha-linolenic acid and the risk of prostate cancer (United States)Daniel O Koralek
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Cancer Causes Control 17:783-91. 2006..Alpha-linolenic acid (ALA) is the most common omega-3 fatty acid in the Western diet. The relation of dietary intake of ALA to prostate cancer risk remains unresolved... - Correlates of toenail zinc in a free-living U.S. populationAlejandro Gonzalez
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Nutritional Sciences Program, University of Washington, Seattle, WA 98109 1024, USA
Ann Epidemiol 18:74-7. 2008..The study aim was to identify dietary and other factors that influence toenail zinc in a healthy population, in order to understand the usefulness of this biomarker in public health studies... - Genetic susceptibility to cancer: the role of polymorphisms in candidate genesLinda M Dong
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
JAMA 299:2423-36. 2008..Continuing advances in genotyping technologies and the inclusion of DNA collection in observational studies have resulted in an increasing number of genetic association studies... - Methods for etiologic and early marker investigations in the PLCO trialRichard B Hayes
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, Bethesda, MD 20892, USA
Mutat Res 592:147-54. 2005..g., diet), biochemical, and genetic factors. Early detection studies focus on blood-based biologic markers of early disease. Clinical epidemiology is also an important component of the PLCO trial... - Urinary mutagenicity and colorectal adenoma riskUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7273, USA
Cancer Epidemiol Biomarkers Prev 12:1253-6. 2003..2-13.9, comparing the highest with the lowest quintile). In our study population, diet may have contributed to mutagenic exposure, which was positively associated with colorectal adenoma risk... - Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genesBritton Trabert
University of Washington, Seattle, Washington, USA
Fertil Steril 96:1401-1406.e3. 2011..To evaluate the relationship between common genetic variation in genes involved in the biosynthesis and signaling of estrogen and progesterone and endometriosis risk... - Nonsteroidal anti-inflammatory drugs and prostate cancer risk in the VITamins And Lifestyle (VITAL) cohortTheodore M Brasky
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 19:3185-8. 2010..Several epidemiologic studies have reported inverse associations between nonsteroidal anti-inflammatory drugs (NSAIDs) and prostate cancer risk, although many studies are limited by assessment of short-term use only... - Boron intake and prostate cancer riskAlejandro Gonzalez
Cancer Prevention Pragram, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Causes Control 18:1131-40. 2007..Only one small epidemiological study has been conducted of boron, which found that those in the highest quartile of boron intake had less than half the risk of prostate cancer versus those in the lowest quartile... - Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification TrialCara L Carty
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Am J Clin Nutr 93:516-24. 2011..The Women's Health Initiative Dietary Modification (DM) Trial was a randomized controlled trial that compared the effects of a low-fat (≤20% of total energy) or a usual diet in relation to chronic disease risk in postmenopausal women... - Dietary fibre and risk of colorectal cancer in the Breast Cancer Detection Demonstration Project (BCDDP) follow-up cohortVolker Mai
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
Int J Epidemiol 32:234-9. 2003..We investigated the association between dietary fibre intake and risk of CRC in a cohort of women that prospectively answered a food frequency questionnaire (FFQ)... - The use of imputed values in the meta-analysis of genome-wide association studiesShuo Jiao
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Genet Epidemiol 35:597-605. 2011..Our results show that the performance of the inverse variance weight is always indistinguishable from the optimal weight and similar to or better than the other two methods... - Causes of death in patients with celiac disease in a population-based Swedish cohortUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7273, USA
Arch Intern Med 163:1566-72. 2003..Patients with celiac disease have an increased risk of death from gastrointestinal malignancies and lymphomas, but little is known about mortality from other causes and few studies have assessed long-term outcomes... - Carbohydrate, glycemic index, and glycemic load and colorectal adenomas in the Prostate, Lung, Colorectal, and Ovarian Screening StudyAndrew Flood
University of Minnesota, Minneapolis, MN, Henry Ford Hospital, Detroit, MI, USA
Am J Clin Nutr 84:1184-92. 2006..It is possible that high-glycemic-load diets, through their hyperinsulinemic effects, can increase the risk of colorectal cancer... - Calcium from diet and supplements is associated with reduced risk of colorectal cancer in a prospective cohort of womenAndrew Flood
Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
Cancer Epidemiol Biomarkers Prev 14:126-32. 2005..e., diet or supplements)... - Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer studyDaehee Kang
Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
Cancer Epidemiol Biomarkers Prev 16:1581-6. 2007..These results suggest that the Ala variant of SOD2 is associated with moderately increased risk of prostate cancer, particularly among men with lower intakes of dietary and supplemental vitamin E... - Prospective study of fruit and vegetable intake and risk of prostate cancerVictoria A Kirsh
Research Unit, Division of Preventive Oncology, Cancer Care Ontario, Toronto, ON, Canada
J Natl Cancer Inst 99:1200-9. 2007..Several epidemiologic studies have reported associations between fruit and vegetable intake and reduced risk of prostate cancer, but the findings are inconsistent and data on clinically relevant advanced prostate cancer are limited... - Advancing the calcium-colorectal cancer hypothesisArthur Schatzkin
J Natl Cancer Inst 96:893-4. 2004 - Development and application of a simple routine method for the determination of selenium in serum by octopole reaction system ICPMSStefan Sturup
Dartmouth Trace Element Analysis Core Facility, Departments of Earth Sciences and Chemistry, Dartmouth College, 6105 Sherman Fairchild Hall, Hanover, NH, 03755, USA
Anal Bioanal Chem 381:686-94. 2005..For the Seronorm certified reference material a value of 911+/-75 microg L-1 (n=31) for zinc was obtained, which corresponds well to the certified zinc value of 920+/-60 microg L-1... - Adherence to the USDA Food Guide, DASH Eating Plan, and Mediterranean dietary pattern reduces risk of colorectal adenomaL Beth Dixon
Department of Nutrition, Food Studies, and Public Health, New York University, New York City, NY 10012, USA
J Nutr 137:2443-50. 2007..lt;or=2 = 0.74, 95% CI = 0.55-0.99; P-trend = 0.08). Following the current U.S. dietary recommendations or a Mediterranean dietary pattern is associated with reduced risk of colorectal adenoma, especially in men... - Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trialAmy E Millen
University at Buffalo, School of Public Health and Health Professions, Department of Social and Preventive Medicine, Buffalo, NY 14214 8001, USA
Am J Clin Nutr 86:1754-64. 2007..Research on the association between fruit and vegetable intake and risk of colorectal adenoma is inconclusive... - Characterization of two SNPs (single nucleotide polymorphisms) in the porcine INSL3 gene and their exclusion as a common genetic basis of hernia inguinalis in pigsChristoph Knorr
Institute of Veterinary Medicine, Georg August University of Goettingen, Goettingen, Germany
Biochem Genet 42:11-9. 2004..Screening of the two SNPs in a population of hernia inguinalis affected full and half sib piglets (n = 223) revealed that the SNPs can be excluded as a common genetic basis for this congenital disorder in this pedigree... - Sequence variations of mitochondrial DNA and individual sensitivity to the ototoxic effect of cisplatinUlrike Peters
Institute for Human Genetics, University of Muenster, Muenster, Germany
Anticancer Res 23:1249-55. 2003..Since mutations in the mitochondrial genome are associated with hearing loss, we analyzed whether sequence variations of mtDNA are associated with individual sensitivity to cisplatin-induced ototoxicity... - Prevalence of Porphyromonas gingivalis fimA genotypes in CaucasiansThomas Beikler
Department of Periodontology, University of Munster, Munster, Germany
Eur J Oral Sci 111:390-4. 2003..The results indicate that predominant fimA genotypes in Caucasian periodontitis patients are types I, II, and IV. However, there was no difference in the association of the various fimA genotypes with disease severity...
Research Grants
- Genome-Wide Association Study of Nonsynonymous SNPs in Colon CancerUlrike Peters; Fiscal Year: 2009....
- Prospective Study on Selenium, Genectics of Selenoenzymes, and Colorectal CancerUlrike Peters; Fiscal Year: 2010..Given the public health importance of colorectal cancer and the increasing use of selenium supplements in the United States, there is a need for the type of investigation that we are proposing. ..
- Genome-Wide Association Study of Nonsynonymous SNPs in Colon CancerUlrike Peters; Fiscal Year: 2010....
- Genome-Wide Association Study of Nonsynonymous SNPs in Colon CancerUlrike Peters; Fiscal Year: 2009..We expect our findings to enhance our understanding of the mechanisms underlying colorectal carcinogenesis. In turn, this will lead to improved prevention and treatment strategies. ..
- Prospective Study on Selenium, Genectics of Selenoenzymes, and Colorectal CancerUlrike Peters; Fiscal Year: 2007..Given the public health importance of colorectal cancer and the increasing use of selenium supplements in the United States, there is a need for the type of investigation that we are proposing. ..
- Selenium genetic variation in selenoenzymes and prostate cancerUlrike Peters; Fiscal Year: 2007....
- Genetic variations in calcium and vitamin D related gen*Ulrike Peters; Fiscal Year: 2006....