Thomas G Paulson

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Res 64:7629-33. 2004
  2. pmc p16 mutation spectrum in the premalignant condition Barrett's esophagus
    Thomas G Paulson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 3:e3809. 2008
  3. pmc Chromosomal instability and copy number alterations in Barrett's esophagus and esophageal adenocarcinoma
    Thomas G Paulson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Cancer Res 15:3305-14. 2009
  4. ncbi request reprint Neosquamous epithelium does not typically arise from Barrett's epithelium
    Thomas G Paulson
    Division of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Clin Cancer Res 12:1701-6. 2006
  5. pmc Cell proliferation, cell cycle abnormalities, and cancer outcome in patients with Barrett's esophagus: a long-term prospective study
    Dennis L Chao
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Clin Cancer Res 14:6988-95. 2008
  6. ncbi request reprint Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis
    Dennis L Chao
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C1 157, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 15:1935-40. 2006
  7. ncbi request reprint Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:3414-27. 2004
  8. ncbi request reprint Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH
    Lisa A Lai
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Genes Chromosomes Cancer 46:532-42. 2007
  9. pmc Warburg and Crabtree effects in premalignant Barrett's esophagus cell lines with active mitochondria
    Martin T Suchorolski
    Molecular and Cellular Biology Department, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e56884. 2013
  10. pmc Direct inference of SNP heterozygosity rates and resolution of LOH detection
    Xiaohong Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Comput Biol 3:e244. 2007

Research Grants

  1. CHROMOSOME ALTERATIONS IN BARRETT'S ESOPHAGUS
    THOMAS PAULSON; Fiscal Year: 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Res 64:7629-33. 2004
    ..This implies that interventions that limit expansion of genetically unstable clones may reduce risk of progression to cancer...
  2. pmc p16 mutation spectrum in the premalignant condition Barrett's esophagus
    Thomas G Paulson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 3:e3809. 2008
    ....
  3. pmc Chromosomal instability and copy number alterations in Barrett's esophagus and esophageal adenocarcinoma
    Thomas G Paulson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Cancer Res 15:3305-14. 2009
    ....
  4. ncbi request reprint Neosquamous epithelium does not typically arise from Barrett's epithelium
    Thomas G Paulson
    Division of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Clin Cancer Res 12:1701-6. 2006
    ....
  5. pmc Cell proliferation, cell cycle abnormalities, and cancer outcome in patients with Barrett's esophagus: a long-term prospective study
    Dennis L Chao
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Clin Cancer Res 14:6988-95. 2008
    ....
  6. ncbi request reprint Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis
    Dennis L Chao
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C1 157, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 15:1935-40. 2006
    ....
  7. ncbi request reprint Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:3414-27. 2004
    ..Virtually all of the other lesion expansions, including microsatellite shifts, could be explained as hitchhikers on p16 lesion clonal expansions. These techniques can be applied to any neoplasm...
  8. ncbi request reprint Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH
    Lisa A Lai
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Genes Chromosomes Cancer 46:532-42. 2007
    ....
  9. pmc Warburg and Crabtree effects in premalignant Barrett's esophagus cell lines with active mitochondria
    Martin T Suchorolski
    Molecular and Cellular Biology Department, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e56884. 2013
    ..Periodic ischemia occurs in the premalignant condition Barrett's esophagus (BE) due to tissue damage from chronic acid-bile reflux and may select for early adaptations to hypoxia, including upregulation of glycolysis...
  10. pmc Direct inference of SNP heterozygosity rates and resolution of LOH detection
    Xiaohong Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Comput Biol 3:e244. 2007
    ..New experimental designs for LOH studies would also benefit from considering the power of detection and sample sizes required to accomplish the proposed aims...
  11. doi request reprint Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus
    Xiaohong Li
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024
    Cancer Prev Res (Phila) 7:114-27. 2014
    ..Cancer Prev Res; 7(1); 114-27. ©2013 AACR. ..
  12. pmc Reproducible two-dimensional capillary electrophoresis analysis of Barrett's esophagus tissues
    James R Kraly
    Department of Chemistry, University of Washington, Seattle, WA 98195 1700, USA
    Anal Chem 78:5977-86. 2006
    ..These results suggest that two-dimensional capillary electrophoresis may be of value for the rapid characterization of endoscopic and surgical biopsies...
  13. pmc Extended lifespan of Barrett's esophagus epithelium transduced with the human telomerase catalytic subunit: a useful in vitro model
    M Corinna A Palanca-Wessels
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Carcinogenesis 24:1183-90. 2003
    ..Long-lived Barrett's esophagus epithelial cultures should provide a useful in vitro model for studies of neoplastic evolution and chemopreventive therapies...
  14. ncbi request reprint Genetic clonal diversity predicts progression to esophageal adenocarcinoma
    Carlo C Maley
    The Wistar Institute, 3601 Spruce St, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 38:468-73. 2006
    ..6) and ploidy abnormalities. Progression to cancer through accumulation of clonal diversity, on which natural selection acts, may be a fundamental principle of neoplasia with important clinical implications...
  15. ncbi request reprint Focus on Barrett's esophagus and esophageal adenocarcinoma
    Thomas G Paulson
    Divisions of Human Biology and Public Health Sciences, University of Washington, Seattle 98109, USA
    Cancer Cell 6:11-6. 2004

Research Grants1

  1. CHROMOSOME ALTERATIONS IN BARRETT'S ESOPHAGUS
    THOMAS PAULSON; Fiscal Year: 2005
    ..The results from these analyses will be of interest to both clinical and basic researchers in studying EA and other cancers. ..