Julie M Overbaugh

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses
    Dawnnica Eastman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Virol J 5:90. 2008
  2. pmc Medication diaries do not improve outcomes with highly active antiretroviral therapy in Kenyan children: a randomized clinical trial
    Dalton C Wamalwa
    Department of Paediatrics University of Nairobi, Nairobi, Kenya
    J Int AIDS Soc 12:8. 2009
  3. pmc Evaluation of a single round polymerase chain reaction assay using dried blood spots for diagnosis of HIV-1 infection in infants in an African setting
    Bhavna H Chohan
    Department of Medical Microbiology, University of Nairobi College of Health Sciences, off Ngong Road, Nairobi, Box 19767 00202, Kenya
    BMC Pediatr 11:18. 2011
  4. pmc A prospective study of vaginal trichomoniasis and HIV-1 shedding in women on antiretroviral therapy
    Linnet N Masese
    Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
    BMC Infect Dis 11:307. 2011
  5. pmc Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women
    Paul K Drain
    Department of Medicine, University of Washington, 1959 NE Pacific, A 300 Health Sciences, Box 356340, Seattle, WA 98105, USA
    BMC Infect Dis 6:85. 2006
  6. pmc Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective study
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    BMC Infect Dis 7:63. 2007
  7. pmc Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease
    Christine M Rousseau
    Department of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109 1024, USA
    J Infect Dis 187:741-7. 2003
  8. ncbi request reprint Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya
    J Overbaugh
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Infect Dis 179:S401-4. 1999
  9. pmc Receptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins
    J Overbaugh
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA 98109 1024, USA
    Microbiol Mol Biol Rev 65:371-89, table of contents. 2001
  10. ncbi request reprint Selection forces and constraints on retroviral sequence variation
    J Overbaugh
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 292:1106-9. 2001

Research Grants

Collaborators

Detail Information

Publications74

  1. pmc Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses
    Dawnnica Eastman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Virol J 5:90. 2008
    ..To begin to address this, we analyzed the envelope sequence variation of viruses that evolved in animals infected with variants of SIVMne that had been cloned from an index animal at different stages of infection...
  2. pmc Medication diaries do not improve outcomes with highly active antiretroviral therapy in Kenyan children: a randomized clinical trial
    Dalton C Wamalwa
    Department of Paediatrics University of Nairobi, Nairobi, Kenya
    J Int AIDS Soc 12:8. 2009
    ..abstract:..
  3. pmc Evaluation of a single round polymerase chain reaction assay using dried blood spots for diagnosis of HIV-1 infection in infants in an African setting
    Bhavna H Chohan
    Department of Medical Microbiology, University of Nairobi College of Health Sciences, off Ngong Road, Nairobi, Box 19767 00202, Kenya
    BMC Pediatr 11:18. 2011
    ....
  4. pmc A prospective study of vaginal trichomoniasis and HIV-1 shedding in women on antiretroviral therapy
    Linnet N Masese
    Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
    BMC Infect Dis 11:307. 2011
    ..We tested the hypothesis that T. vaginalis infection would increase vaginal HIV-1 RNA shedding in women on ART, and that successful treatment would reduce vaginal HIV-1 RNA levels...
  5. pmc Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women
    Paul K Drain
    Department of Medicine, University of Washington, 1959 NE Pacific, A 300 Health Sciences, Box 356340, Seattle, WA 98105, USA
    BMC Infect Dis 6:85. 2006
    ..Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response...
  6. pmc Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective study
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    BMC Infect Dis 7:63. 2007
    ..However, vitamin E supplementation has also been reported to increase CCR5 expression, which could increase HIV-1 replication. We hypothesized that vitamin E levels at HIV-1 acquisition may influence disease progression...
  7. pmc Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease
    Christine M Rousseau
    Department of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109 1024, USA
    J Infect Dis 187:741-7. 2003
    ..3-3.0; P<.001). These results indicate that the risk of infant infection from breast-feeding is influenced by breast-milk virus load, which is highest early after delivery...
  8. ncbi request reprint Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya
    J Overbaugh
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Infect Dis 179:S401-4. 1999
    ..Of interest, our data suggest that the complexity of the virus that is transmitted may be different in female and male sexual exposures...
  9. pmc Receptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins
    J Overbaugh
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA 98109 1024, USA
    Microbiol Mol Biol Rev 65:371-89, table of contents. 2001
    ..In this review, we will focus on the various strategies used by mammalian retroviruses to gain entry into the cell. The choice of receptors will also be discussed in light of pressures that drive viral evolution and persistence...
  10. ncbi request reprint Selection forces and constraints on retroviral sequence variation
    J Overbaugh
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 292:1106-9. 2001
    ....
  11. pmc Independent effects of nevirapine prophylaxis and HIV-1 RNA suppression in breast milk on early perinatal HIV-1 transmission
    Michael H Chung
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 46:472-8. 2007
    ..The mechanism of action of single-dose nevirapine on reducing mother-to-child transmission of HIV-1 may involve reduction of maternal HIV-1 or prophylaxis of infants...
  12. pmc HIV-1 persists in breast milk cells despite antiretroviral treatment to prevent mother-to-child transmission
    Dara A Lehman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    AIDS 22:1475-85. 2008
    ..The effects of short-course antiretrovirals given to reduce mother-to-child transmission (MTCT) on temporal patterns of cell-associated HIV-1 RNA and DNA in breast milk are not well defined...
  13. pmc Highly active antiretroviral therapy versus zidovudine/nevirapine effects on early breast milk HIV type-1 Rna: a phase II randomized clinical trial
    Michael H Chung
    Department of Medicine, University of Washington, Seattle, WA, USA
    Antivir Ther 13:799-807. 2008
    ..Defining the effect of antiretroviral regimens on breast milk HIV type-1 (HIV-1) levels is useful to inform the rational design of strategies to decrease perinatal HIV-1 transmission...
  14. pmc Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET 012 nevirapine versus short-course zidovudine
    Michael H Chung
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS 19:1415-22. 2005
    ....
  15. pmc Lower risk of resistance after short-course HAART compared with zidovudine/single-dose nevirapine used for prevention of HIV-1 mother-to-child transmission
    Dara A Lehman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Acquir Immune Defic Syndr 51:522-9. 2009
    ....
  16. ncbi request reprint Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding
    Stephanie M J Rainwater
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 0124, USA
    Curr HIV Res 5:189-97. 2007
    ....
  17. pmc Antiretroviral adherence and development of drug resistance are the strongest predictors of genital HIV-1 shedding among women initiating treatment
    Susan M Graham
    University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 202:1538-42. 2010
    ..04). These results emphasize the importance of adherence to optimize the potential benefits of ART for reducing HIV-1 transmission risk...
  18. pmc Comparison of human immunodeficiency virus type 1 viral loads in Kenyan women, men, and infants during primary and early infection
    Barbra A Richardson
    Department of Biostatistics, University of Washington and Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, 98104, USA
    J Virol 77:7120-3. 2003
    ....
  19. pmc Breast-milk infectivity in human immunodeficiency virus type 1-infected mothers
    Barbra A Richardson
    Department of Biostatistics, University of Washington, Harborview Medical Center, Box 359909, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    J Infect Dis 187:736-40. 2003
    ..The probability of HIV-1 infection per liter of breast milk ingested by an infant is similar in magnitude to the probability of heterosexual transmission of HIV-1 per unprotected sex act in adults...
  20. pmc Association of levels of HIV-1-infected breast milk cells and risk of mother-to-child transmission
    Christine M Rousseau
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Infect Dis 190:1880-8. 2004
    ..09; P=.03) and breast milk (HR, 1.01; P=1.00). This suggests that infected BMCs may play a more important role in transmission of HIV via breast-feeding than does cell-free virus...
  21. pmc Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant
    Xueling Wu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    J Virol 80:835-44. 2006
    ....
  22. ncbi request reprint CC and CXC chemokines in breastmilk are associated with mother-to-child HIV-1 transmission
    Carey Farquhar
    Department of Medicine, University of Washington, Seattle, 98104, USA
    Curr HIV Res 3:361-9. 2005
    ..CC and CXC chemokines may play a role in mother-to-child HIV-1 transmission by blocking HIV-1 binding to chemokine receptors and impeding viral entry into cells...
  23. pmc Subtype C Is associated with increased vaginal shedding of HIV-1
    Grace C John-Stewart
    Department of Medicine, University of Washington, Seattle, 98104, USA
    J Infect Dis 192:492-6. 2005
    ..4-8.8]; P = .006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [95% CI, 1.1-8.6]; P = .03). These observations suggest that HIV-1 subtype influences mucosal shedding of HIV-1...
  24. ncbi request reprint Association between cervical shedding of herpes simplex virus and HIV-1
    R Scott McClelland
    International AIDS Research and Training Program, Department of Medicine, University of Washington, Box 359909, 325 9th Avenue, Seattle, WA 98104, USA
    AIDS 16:2425-30. 2002
    ..To investigate the association between the cervical shedding of herpes simplex virus (HSV) and HIV-1...
  25. ncbi request reprint A comparison of genital HIV-1 shedding and sexual risk behavior among Kenyan women based on eligibility for initiation of HAART according to WHO guidelines
    R Scott McClelland
    Departments of Medicine, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 41:611-5. 2006
    ..Guidelines for initiating antiretrovirals are based on markers of advanced disease and are not directly linked to markers of HIV-1 transmission such as viral shedding...
  26. ncbi request reprint Initiation of antiretroviral therapy leads to a rapid decline in cervical and vaginal HIV-1 shedding
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington, USA
    AIDS 21:501-7. 2007
    ..Antiretroviral therapy (ART) may decrease HIV-1 infectivity in women by reducing genital HIV-1 shedding...
  27. pmc Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 5:e9. 2008
    ..Using a naturally occurring HIV-1 Envelope (Env) variant as a template, we sought to identify features of Env that would enhance exposure of conserved HIV-1 epitopes...
  28. pmc Cross-subtype neutralization sensitivity despite monoclonal antibody resistance among early subtype A, C, and D envelope variants of human immunodeficiency virus type 1
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109 1024, USA
    J Virol 83:7783-8. 2009
    ..However, significant cross-subtype neutralization by plasma was observed, indicating that there may be other epitopes, not yet defined by the limited available MAbs, which could be recognized more broadly...
  29. ncbi request reprint HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    AIDS 21:693-702. 2007
    ..An effective HIV-1 vaccine or microbicide must block the transmitted virus variants that initially establish a new infection; consequently, it is critical that such viruses be isolated and characterized...
  30. pmc Genetic drift of HIV populations in culture
    Yegor Voronin
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    PLoS Genet 5:e1000431. 2009
    ..We propose that appreciation of these effects will allow better understanding of the evolutionary forces acting on HIV in infected patients...
  31. pmc Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progression
    Anne Piantadosi
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Virol 83:10269-74. 2009
    ..Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection...
  32. ncbi request reprint Transmission of HIV-1 in the face of neutralizing antibodies
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Curr HIV Res 5:578-87. 2007
    ....
  33. pmc Antiretroviral strategies to prevent mother-to-child transmission of HIV: striking a balance between efficacy, feasibility, and resistance
    Dara A Lehman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 6:e1000169. 2009
    ..Dara Lehman and colleagues discuss a randomized trial that found that adding up to a week of twice-daily zidovudine+lamivudine to single-dose nevirapine reduces the risk of resistance in mothers and infants...
  34. pmc Comparative immunogenicity of subtype a Human Immunodeficiency Virus type 1 envelope exhibiting differential exposure of conserved neutralization epitopes
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Virol 84:2573-84. 2010
    ....
  35. pmc Increased levels of HIV-1-infected cells in endocervical secretions after the luteinizing hormone surge
    Sarah Benki
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Acquir Immune Defic Syndr 47:529-34. 2008
    ..001) in endocervical specimens. These data suggest that sampling of cell-associated endocervical HIV-1 increases after the periovulatory period, which could result in increased exposure to HIV-1-infected cells during sexual contact...
  36. ncbi request reprint HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Infect Dis 195:1177-80. 2007
    ..There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads...
  37. pmc Validation of performance of the gen-probe human immunodeficiency virus type 1 viral load assay with genital swabs and breast milk samples
    Dana DeVange Panteleeff
    Divisions of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Clin Microbiol 40:3929-37. 2002
    ....
  38. ncbi request reprint High levels of cervical HIV-1 RNA during early HIV-1 infection
    Ludo Lavreys
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    AIDS 20:2389-90. 2006
    ..43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006)...
  39. pmc HIV-1 evolution in gag and env is highly correlated but exhibits different relationships with viral load and the immune response
    Anne Piantadosi
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    AIDS 23:579-87. 2009
    ..To evaluate relationships between HIV-1 evolution, including immune evasion, and markers of disease progression during chronic infection...
  40. pmc Characterization of neutralizing antibody responses elicited by clade A envelope immunogens derived from early transmitted viruses
    Zane Kraft
    Seattle Biomedical Research Institute, 307 Westlake Avenue North, Seattle, WA 98109, USA
    J Virol 82:5912-21. 2008
    ..Our data also indicate that the development of cross-reactive NAbs against clade A viruses faces similar hurdles to the development of cross-reactive anti-clade B NAbs...
  41. pmc Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels
    Bhavna Chohan
    Division of Human Biology, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, C3 168 Seattle, WA 98109 1024, USA
    J Virol 79:6528-31. 2005
    ..Thus, our study also suggests that the extent of glycosylation in the infecting virus could impact disease progression...
  42. ncbi request reprint Micronutrient supplementation increases genital tract shedding of HIV-1 in women: results of a randomized trial
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 37:1657-63. 2004
    ..The potential benefit of micronutrient supplementation in HIV-1-seropositive women should be considered in relation to the potential for increased infectivity...
  43. pmc Comparison of CD4 cell count, viral load, and other markers for the prediction of mortality among HIV-1-infected Kenyan pregnant women
    Elizabeth R Brown
    Department of Biostatistics, University of Washington, Seattle, WA, USA
    J Infect Dis 199:1292-300. 2009
    ..There are limited data regarding the relative merits of biomarkers as predictors of mortality or time to initiation of antiretroviral therapy (ART)...
  44. pmc Examination of a second region of the HIV type 1 genome reveals additional cases of superinfection
    Anne Piantadosi
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    AIDS Res Hum Retroviruses 24:1221. 2008
    ..Our results suggest that studies that examine only small genome regions may lead to underestimates of the risk of superinfection, highlighting the need for more extensive studies examining multiple regions of the HIV-1 genome...
  45. pmc Analysis of the percentage of human immunodeficiency virus type 1 sequences that are hypermutated and markers of disease progression in a longitudinal cohort, including one individual with a partially defective Vif
    Anne Piantadosi
    Fred Hutchinson Cancer Center, Seattle, WA 98109 1024, USA
    J Virol 83:7805-14. 2009
    ....
  46. ncbi request reprint Cyclic shedding of HIV-1 RNA in cervical secretions during the menstrual cycle
    Sarah Benki
    Division of Human Biology, Fred Hutchinson Cancer Research Center, and Department of Microbiology, University of Washington, Seattle, Washington 98109, USA
    J Infect Dis 189:2192-201. 2004
    ..4). These data support the hypothesis that the level of HIV-1 RNA in cervical secretions is influenced by the menstrual cycle, and they suggest that the risk of heterosexual transmission of HIV-1 may increase as menses is approached...
  47. ncbi request reprint The effect of hormonal contraception on genital tract shedding of HIV-1
    Chia C Wang
    Department of Medicine, University of Washington, Seattle, Washington 98104 2499, USA
    AIDS 18:205-9. 2004
    ..We conducted a prospective study to determine if cervical shedding of HIV-1 increased after initiating hormonal contraception...
  48. ncbi request reprint Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:1466-71. 2004
    ..Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity...
  49. pmc Hormonal contraception and HIV-1 disease progression among postpartum Kenyan women
    Barbra A Richardson
    Department of Biostatistics, University of Washington, Seattle, WA 98194 2499, USA
    AIDS 21:749-53. 2007
    ..To assess the immediate and longer-term effects of the use of hormonal contraception on the progression of HIV-1 disease in postpartum women...
  50. pmc Quantification of genital human immunodeficiency virus type 1 (HIV-1) DNA in specimens from women with low plasma HIV-1 RNA levels typical of HIV-1 nontransmitters
    Sarah Benki
    Department of Microbiology, University of Washington, Seattle, WA 98109, USA, and Coast Provincial General Hospital, Mombasa, Kenya
    J Clin Microbiol 44:4357-62. 2006
    ..The assay described here can be utilized in future efforts to examine the role of cell-associated HIV-1 in transmission...
  51. ncbi request reprint Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue, Seattle, WA 98109, USA
    AIDS 18:615-9. 2004
    ..Infection with multiple viral variants was associated with higher plasma HIV-1 RNA levels and faster CD4 T-cell decline...
  52. ncbi request reprint Sequence variability of the integrase protein from a diverse collection of HIV type 1 isolates representing several subtypes
    Cara Carthel Burns
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    AIDS Res Hum Retroviruses 18:1031-41. 2002
    ..The high degree of genetic homogeneity among the virus isolates representing several subtypes indicates that a single drug targeted against IN might be effective for all HIV-1 infections...
  53. pmc Temporal analysis of HIV envelope sequence evolution and antibody escape in a subtype A-infected individual with a broad neutralizing antibody response
    Katherine A Bosch
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Virology 398:115-24. 2010
    ..These studies suggest a complex pattern of virus evolution in this individual with a broad NAb response, including persistence of neutralization-sensitive viruses...
  54. pmc Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression
    Manish Sagar
    Divisions of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
    J Virol 77:12921-6. 2003
    ..01) 4 to 24 months after infection compared to women who were infected with a single viral genotype. These studies suggest that early HIV-1 genetic diversity is linked to faster disease progression...
  55. pmc Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission
    Carey Farquhar
    Department of Medicine, University of Washington, 325 Ninth Avenue, Box 359909, Seattle, WA 98104, USA
    AIDS 24:153-5. 2010
    ..0-7.0) after adjusting for maternal HIV-1 viral load. Interventions targeting these novel risk factors could lead to more effective prevention of transmission during pregnancy...
  56. ncbi request reprint Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in women
    Ludo Lavreys
    Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:303-11. 2004
    ..These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection...
  57. pmc A TRIM5alpha-independent post-entry restriction to HIV-1 infection of macaque cells that is dependent on the path of entry
    Mario Javier Pineda
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Virology 363:310-8. 2007
    ..Thus, these findings suggest that post-entry events are dependent upon the mechanism by which HIV-1 enters the cell...
  58. ncbi request reprint Virus load during primary Human Immunodeficiency Virus (HIV) type 1 infection is related to the severity of acute HIV illness in Kenyan women
    Ludo Lavreys
    University of Washington, Seattle, WA, 98104, USA
    Clin Infect Dis 35:77-81. 2002
    ..4 log(10) copies/mL...
  59. ncbi request reprint A decrease in albumin in early HIV type 1 infection predicts subsequent disease progression
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS Res Hum Retroviruses 23:1197-200. 2007
    ..0, p = 0.008). Trends for an increased risk of mortality were also seen. A greater decrease in albumin levels accompanying HIV-1 acquisition may be a marker for changes in early infection associated with more rapid disease progression...
  60. pmc Acute HIV infection among Kenyan infants
    Barbra A Richardson
    Department of Biostatistics, University of Washington, Seattle, Washington, USA
    Clin Infect Dis 46:289-95. 2008
    ..Clinical signs and symptoms of acute human immunodeficiency virus (HIV) infection in infants are not well characterized...
  61. ncbi request reprint Risk factors for human immunodeficiency virus type-1 acquisition in women in Africa
    Sarah Benki
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Neurovirol 11:58-65. 2005
    ..In addition, they are a potential source of transmission to their infants. A better understanding of the factors that influence HIV-1 susceptibility is key to developing interventions to control the epidemic...
  62. ncbi request reprint Immunogenicity and protective efficacy of Gag/Pol/Env vaccines derived from temporal isolates of SIVmne against cognate virus challenge
    Patricia Polacino
    Washington National Primate Research Center, University of Washington, Seattle, WA, USA
    J Med Primatol 36:254-65. 2007
    ..SIVmne170 is a molecular clone isolated from a pig-tailed macaque 170 weeks after inoculation with SIVmneCL8...
  63. ncbi request reprint Effect of contraceptive methods on natural history of HIV: studies from the Mombasa cohort
    Jared M Baeten
    University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 38:S18-21. 2005
  64. ncbi request reprint A real-time PCR-based method to independently sample single simian immunodeficiency virus genomes from macaques with a range of viral loads
    Dawnnica Williams
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA
    J Med Primatol 33:227-35. 2004
    ..Using this method, we have estimated the intra-animal viral diversity for a cohort of five pig-tailed macaques (Macaca nemestrina) infected with SIVMne variants, which displayed a broad range of viral loads at setpoint...
  65. pmc Human immunodeficiency virus type 1 superinfection occurs despite relatively robust neutralizing antibody responses
    Catherine A Blish
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Virol 82:12094-103. 2008
    ..These data indicate that preventing infection by vaccination will likely require broader and more potent NAb responses than those found in HIV-1-infected individuals...
  66. pmc Chronic HIV-1 infection frequently fails to protect against superinfection
    Anne Piantadosi
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Pathog 3:e177. 2007
    ..Implications from HIV-1 superinfection cases, in which natural re-exposure leads to re-infection, will need to be considered in developing strategies for eliciting protective immunity to HIV-1...
  67. ncbi request reprint Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan women
    Jared M Baeten
    Seattle HIV Prevention Trials Unit, Department of Medicine, University of Washington, 9012 Boren Avenue, Seattle, WA 98104, USA
    AIDS 21:1771-7. 2007
    ..A recent study from Uganda and Zimbabwe found that women using hormonal contraception were at increased risk for HIV-1 if they were seronegative for herpes simplex virus type 2 (HSV-2), but not if they were HSV-2 seropositive...
  68. ncbi request reprint Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    AIDS Res Hum Retroviruses 22:430-7. 2006
    ..Analysis of HIV-1 sequences from about 3 years after infection revealed that the level of diversity and diversification was similar between the women in the two groups...
  69. pmc Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle, USA
    J Virol 78:7279-83. 2004
    ..S. women, one U.S. man, and one Kenyan man near the time of seroconversion. These findings suggest that early HIV-1 genetic diversity is not exclusive to women from Africa or to infection with any particular HIV-1 subtype...
  70. ncbi request reprint No evidence for rapid subtype C spread within an epidemic in which multiple subtypes and intersubtype recombinants circulate
    Stephanie Rainwater
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    AIDS Res Hum Retroviruses 21:1060-5. 2005
    ..This latter finding suggests that reinfection may have occurred in high-risk groups early in the epidemic, leading to intersubtype recombinant viruses that underwent secondary spread...
  71. pmc The infectious molecular clone and pseudotyped virus models of human immunodeficiency virus type 1 exhibit significant differences in virion composition with only moderate differences in infectivity and inhibition sensitivity
    Nicholas M Provine
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    J Virol 83:9002-7. 2009
    ..Differences in Env incorporation and cleavage translated into moderate differences in assays infectivity and sensitivity to neutralizing antibodies and entry inhibitors...
  72. ncbi request reprint HIV-1 superinfection and its implications for vaccine design
    Bhavna H Chohan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, C3 168, Seattle, WA 98104 1024, USA
    Curr HIV Res 8:596-601. 2010
    ..To address these questions, larger population-based studies that define the incidence and timing of superinfection and include collection of samples for immunological studies are needed...
  73. pmc The breadth and potency of passively acquired human immunodeficiency virus type 1-specific neutralizing antibodies do not correlate with the risk of infant infection
    John B Lynch
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Virol 85:5252-61. 2011
    ....
  74. pmc Adaptation of subtype a human immunodeficiency virus type 1 envelope to pig-tailed macaque cells
    Daryl Humes
    Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington, USA
    J Virol 85:4409-20. 2011
    ..These findings identify the inefficient use of Ptm CD4 as an unappreciated restriction to subtype A HIV-1 replication in Ptm cells and reveal amino acid changes to gp120 that can overcome this barrier...

Research Grants25

  1. REGULATION OF FELV REPLICATION AND PATHOGENESIS
    Julie Overbaugh; Fiscal Year: 1999
    ....
  2. LENTIVIRAL VARIATION AND AIDS
    Julie Overbaugh; Fiscal Year: 2007
    ..Collectively these studies will define the interplay between the properties of the infecting virus, the immune response and replication fitness in SIV/HIV pathogenesis. ..
  3. EARLY INFECTION IN WOMEN EXPOSED MUCOSALLY TO HIV-1
    Julie Overbaugh; Fiscal Year: 2007
    ..abstract_text> ..
  4. Characterization of HIV-1 Antibody Responses in Chronically Infected Women
    Julie Overbaugh; Fiscal Year: 2007
    ....
  5. THE ROLE OF ANTIBODIES IN MOTHER TO CHILD HIV TRANSMISSION
    Julie Overbaugh; Fiscal Year: 2009
    ..Here, we propose to test the hypothesis that broad and potent neutralizing antibodies protect infants of HIV- 1 positive mothers from infection. ..
  6. Characterization of HIV-1 Antibody Responses in Chronically Infected Women
    Julie Overbaugh; Fiscal Year: 2009
    ....
  7. THE ROLE OF ANTIBODIES IN MOTHER TO CHILD HIV TRANSMISSION
    Julie M Overbaugh; Fiscal Year: 2010
    ..Here, we propose to test the hypothesis that broad and potent neutralizing antibodies protect infants of HIV- 1 positive mothers from infection. ..
  8. REGULATION OF FELV REPLICATION AND PATHOGENESIS
    Julie Overbaugh; Fiscal Year: 2004
    ..In this regard, it is striking that in both FeLV and HIV infection, there is selection for T-cell tropic, cytopathic variants in the host, despite the many differences between these viruses. ..
  9. LENTIVIRAL VARIATION AND AIDS
    Julie Overbaugh; Fiscal Year: 2002
    ..The expectation is that knowledge gained will provide insight into the mechanisms underlying progression to AIDS. ..
  10. PREVENTION OF HIV SHEDDING IN WOMEN--TRIAL OF VITAMIN A
    Julie Overbaugh; Fiscal Year: 2003
    ..If this preliminary result is confirmed in a full-scale clinical trial, vitamin A supplementation may offer a simple inexpensive intervention to decrease heterosexual and vertical transmission of HIV-1 in the developing world. ..
  11. Characterization of HIV-1 Antibody Responses in Chronically Infected Women
    Julie M Overbaugh; Fiscal Year: 2010
    ....