Elaine Ostrander

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. ncbi request reprint Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24
    Miia Suuriniemi
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:809-14. 2007
  2. pmc Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women
    Danielle M Friedrichsen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R629-35. 2004
  3. pmc An integrated 4249 marker FISH/RH map of the canine genome
    Matthew Breen
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    BMC Genomics 5:65. 2004
  4. ncbi request reprint The domestic dog genome
    Elaine A Ostrander
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Curr Biol 14:R98-9. 2004
  5. ncbi request reprint Finding prostate cancer susceptibility genes
    Elaine A Ostrander
    Division of Clinical Research1, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Annu Rev Genomics Hum Genet 5:151-75. 2004
  6. ncbi request reprint Canine genetics comes of age
    E A Ostrander
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D4 100, Seattle, WA 98109 1024, USA
    Trends Genet 16:117-24. 2000
  7. ncbi request reprint Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer
    Brandon L Pierce
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 67:410-5. 2007
  8. pmc Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics
    Nicola J Camp
    University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108, USA
    Hum Mol Genet 16:1271-8. 2007
  9. pmc Molecular genetics: DNA analysis of a putative dog clone
    Heidi G Parker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 440:E1-2. 2006
  10. ncbi request reprint Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years
    Kathleen E Malone
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 66:8297-308. 2006

Research Grants

  1. GENETICS OF PROSTATE CANCER SUSCEPTIBILITY
    Elaine Ostrander; Fiscal Year: 2001
  2. GENETICS OF PROSTATE CANCER SUSCEPTIBILITY
    Elaine Ostrander; Fiscal Year: 2003
  3. A High Density Gene Map of the Canine Genome
    Elaine Ostrander; Fiscal Year: 2003
  4. Genetics of Cancer Susceptibility--Multisystem Approach
    Elaine Ostrander; Fiscal Year: 2004

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24
    Miia Suuriniemi
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:809-14. 2007
    ..S. samples. Although the data were provocative, the U.S. samples were not population based, which precludes assessment of the potential contribution of this locus to prostate cancer incidence in the United States...
  2. pmc Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women
    Danielle M Friedrichsen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R629-35. 2004
    ..However, the 1100delC mutation has only been investigated in a few population-based studies and none from North America...
  3. pmc An integrated 4249 marker FISH/RH map of the canine genome
    Matthew Breen
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    BMC Genomics 5:65. 2004
    ..Understanding the genetic basis of both phenotypic variation and disease susceptibility in the dog provides new ways in which to dissect the genetics of human health and biology...
  4. ncbi request reprint The domestic dog genome
    Elaine A Ostrander
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Curr Biol 14:R98-9. 2004
  5. ncbi request reprint Finding prostate cancer susceptibility genes
    Elaine A Ostrander
    Division of Clinical Research1, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Annu Rev Genomics Hum Genet 5:151-75. 2004
    ..To increase the ability to find disease-associated loci, much denser genome-wide scans must be undertaken in multiple ethnic groups. In addition, new ways of defining homogenous subsets of families need to be developed...
  6. ncbi request reprint Canine genetics comes of age
    E A Ostrander
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D4 100, Seattle, WA 98109 1024, USA
    Trends Genet 16:117-24. 2000
    ..We will review the current state of the map and discuss the particular disease states in which canines stand to make the greatest contribution to medical genetics...
  7. ncbi request reprint Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer
    Brandon L Pierce
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 67:410-5. 2007
    ....
  8. pmc Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics
    Nicola J Camp
    University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108, USA
    Hum Mol Genet 16:1271-8. 2007
    ..This collaborative study by the ICPCG illustrates the value of consortium efforts and the continued utility of linkage analysis using informative pedigrees to localize genes for complex diseases...
  9. pmc Molecular genetics: DNA analysis of a putative dog clone
    Heidi G Parker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 440:E1-2. 2006
    ..In light of recent concerns regarding the creation of cloned human cell lines from the same institution, we have undertaken an independent test to determine the validity of the claims made by Lee et al....
  10. ncbi request reprint Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years
    Kathleen E Malone
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 66:8297-308. 2006
    ....
  11. ncbi request reprint Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics
    Daniel J Schaid
    Harwick 7, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hum Genet 120:471-85. 2006
    ..This provides a basis for attempts to identify these genes, with potential clinical utility for men with aggressive prostate cancer and their relatives...
  12. pmc A single IGF1 allele is a major determinant of small size in dogs
    Nathan B Sutter
    National Human Genome Research Institute, Building 50, Room 5349, 50 South Drive MSC 8000, Bethesda, MD 20892 8000, USA
    Science 316:112-5. 2007
    ..A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs...
  13. ncbi request reprint Affected relative pairs and simultaneous search for two-locus linkage in the presence of epistasis
    Daniel J Schaid
    Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Genet Epidemiol 31:431-49. 2007
    ..These novel score statistics should prove useful for linkage studies of other complex human diseases...
  14. ncbi request reprint Genetic susceptibility to aggressive prostate cancer
    Elaine A Ostrander
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, 50 South Drive, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:1761-4. 2006
  15. ncbi request reprint Germline mutations in the BRCA2 gene and susceptibility to hereditary prostate cancer
    Ilir Agalliu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, USA
    Clin Cancer Res 13:839-43. 2007
    ..However, studies of the contribution of BRCA2 mutations to the etiology of hereditary prostate cancer (HPC) have been inconsistent...
  16. ncbi request reprint Human Genome Variation 2006: emerging views on structural variation and large-scale SNP analysis
    Goncalo Abecasis
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 39:153-5. 2007
    ..The meeting highlighted recent advances in characterization of genetic variation, including genome-wide association studies and structural variation...
  17. ncbi request reprint Suggestive genetic linkage to chromosome 11p11.2-q12.2 in hereditary prostate cancer families with primary kidney cancer
    Bo Johanneson
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA
    Prostate 67:732-42. 2007
    ..Towards that end, we analyzed a genome-wide scan of HPC families with primary kidney cancer...
  18. ncbi request reprint Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q
    Daniel J Schaid
    Division of Biostatistics, Mayo Clinic, Rochester, MN, USA
    Hum Genet 121:729-35. 2007
    ..001) was found on chromosomes 19q and 5q, with P-values <or= 0.01 observed on chromosomes 3q, 7q, and 16q. Our results confirm reports of Gleason score linkage to chromosome 19q and suggest new loci for further investigation...
  19. pmc Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer
    Liesel M FitzGerald
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    BMC Cancer 8:230. 2008
    ..These associations suggest the hypothesis that the gene fusion may be used as a prognostic indicator for prostate cancer...
  20. pmc Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer
    Marc D Tischkowitz
    Department of Oncology and Medical Genetics, Cancer Prevention Centre, E740, Sir MB Davis Jewish General Hospital, McGill University, Montreal, QC, Canada
    Cancer Lett 270:173-80. 2008
    ..Although we cannot rule out a subtle influence of the CHEK2 variants on PRCA risk, these results suggest that germline CHEK2 mutations have a minor role in, if any, PRCA susceptibility in AJ men...
  21. pmc Association of megalin genetic polymorphisms with prostate cancer risk and prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
    Clin Cancer Res 14:3823-31. 2008
    ..Genetic variation within megalin could potentially influence levels of steroid hormone uptake...
  22. pmc Statin use and risk of prostate cancer: results from a population-based epidemiologic study
    Ilir Agalliu
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 168:250-60. 2008
    ..Although statin use was not associated with overall prostate cancer risk, the finding of an increased risk associated with statin use among obese men, particularly use for extended durations, warrants further investigation...
  23. pmc Single-nucleotide-polymorphism-based association mapping of dog stereotypes
    Paul Jones
    The WALTHAM Centre for Pet Nutrition, Waltham on the Wolds, Leicsestershire LE14 4RT, United Kingdom
    Genetics 179:1033-44. 2008
    ..The strengths and limitations of the approach are discussed as well as its potential to identify loci regulating the within-breed incidence of specific polygenic diseases...
  24. doi request reprint Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1203-13. 2008
    ....
  25. doi request reprint Diabetes mellitus and prostate cancer risk
    Brandon L Pierce
    Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 68:1126-32. 2008
    ..The objective of this study was to examine the association between PCa risk and several characteristics of DM (duration, age at diagnosis, treatment) in data from two population-based, case-control studies of PCa...
  26. pmc Evaluation of a variant in the transcription factor 7-like 2 (TCF7L2) gene and prostate cancer risk in a population-based study
    Ilir Agalliu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 68:740-7. 2008
    ..Specifically, the same risk allele of single nucleotide polymorphism (SNP) rs12255372 that is associated with diabetes (T allele) has recently been associated with an increased risk of breast cancer...
  27. pmc Canine population structure: assessment and impact of intra-breed stratification on SNP-based association studies
    Pascale Quignon
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 2:e1324. 2007
    ..Little is known, however, about genetic variation among dogs of the same breed collected from different geographic regions...
  28. pmc Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case-control study of Caucasian and African-American women
    Britton Trabert
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Fairview Ave N, Seattle, Washington 98109 1024, USA
    Breast Cancer Res 9:R84. 2007
    ..The involvement of vitamin D receptor (VDR), which is a key mediator in the vitamin D pathway, in breast cancer etiology has long been of interest...
  29. ncbi request reprint Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb
    Bo Johanneson
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Hum Genet 123:65-75. 2008
    ..Combining these results with data from the earlier ICPCG study reduces the three-recombination interval at 22q12.3 to approximately 1.36 Mb...
  30. ncbi request reprint Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer
    Crystal N Holick
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, USA
    Cancer Epidemiol Biomarkers Prev 16:1990-9. 2007
    ..Our findings suggest that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer...
  31. pmc Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds
    Heidi G Parker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 17:1562-71. 2007
    ..This work both establishes that the primary cea mutation arose as a single disease allele in a common ancestor of herding breeds as well as highlights the value of comparative population analysis for refining regions of linkage...
  32. pmc Validity of models for predicting BRCA1 and BRCA2 mutations
    Giovanni Parmigiani
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21205 2011, USA
    Ann Intern Med 147:441-50. 2007
    ..At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the merits and limitations of these models are not fully understood...
  33. ncbi request reprint Genome sequence, comparative analysis and haplotype structure of the domestic dog
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 438:803-19. 2005
    ..The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health...
  34. ncbi request reprint The canine genome
    Elaine A Ostrander
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 15:1706-16. 2005
    ..We suggest that given these resources and the unique characteristics of breeds, that the dog is a uniquely valuable resource for studying the genetic basis of complex traits...
  35. pmc Canine genomics and genetics: running with the pack
    Heidi G Parker
    PLoS Genet 1:e58. 2005
    ..We then highlight findings of interest related to disease gene mapping and population structure. Finally, we summarize novel results on the genetics of morphologic variation...
  36. ncbi request reprint Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study
    Joanna M Lubieniecka
    Division of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 59:357-9. 2004
    ..The transmembrane serine protease 2 (TMPRSS2) gene encodes a type II transmembrane protein which, due to its cell surface localization, could be a potentially useful predictive marker for PCa...
  37. ncbi request reprint BRCA1 and BRCA2 mutations in women from Shanghai China
    Nicola M Suter
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:181-9. 2004
    ..Most alterations observed appear unique to the Chinese population, suggesting a resource that will be useful for assessing risk among both Chinese women and United States women of Chinese descent...
  38. pmc Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families
    Danielle M Friedrichsen
    Divisions of Clinical Research and Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 101:1939-44. 2004
    ..12 (P = 0.00007). These studies highlight the utility of analyzing defined sets of families with a common origin for reducing locus heterogeneity problems associated with studying complex traits...
  39. ncbi request reprint Genomic scan of 254 hereditary prostate cancer families
    Marta Janer
    Institute for Systems Biology, Seattle, Washington, USA
    Prostate 57:309-19. 2003
    ..These analyses support the existence of multiple HPC loci, whose presence may be best identified by analyses of large, including pooled, datasets which consider locus heterogeneity...
  40. ncbi request reprint Association of HPC2/ELAC2 polymorphisms with risk of prostate cancer in a population-based study
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:876-81. 2003
    ..We estimate that the Ser217Leu genotype may account for approximately 14% of less aggressive prostate cancer cases and 9% of all sporadic cases in the general United States population of white men <age 65 years...
  41. ncbi request reprint Linkage mapping of the primary disease locus for collie eye anomaly
    Jennifer K Lowe
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, USA
    Genomics 82:86-95. 2003
    ..076), in a region corresponding to human chromosome 2q35. These results suggest the presence of a developmental regulatory gene important in ocular embryogenesis, with potential implications for other disorders of ocular vascularization...
  42. pmc A 1-Mb resolution radiation hybrid map of the canine genome
    Richard Guyon
    Unité Mixte de Recherche 6061, Centre National de la Recherche Scientifique, Genetique et Developpement, Faculte de Medecine, 35043 Rennes Cedex, France
    Proc Natl Acad Sci U S A 100:5296-301. 2003
    ..This work continues to define the canine system as the method of choice in the pursuit of the genes causing mammalian variation and disease...
  43. ncbi request reprint Androgen receptor (CAG)n and (GGC)n polymorphisms and breast cancer risk in a population-based case-control study of young women
    Nicola M Suter
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:127-35. 2003
    ..In addition, these data suggest that AR repeat length may be partly responsible for the increased risk for early-onset breast cancer in women who use OCs, although these findings need replication in other populations...
  44. pmc Understanding missense mutations in the BRCA1 gene: an evolutionary approach
    Melissa A Fleming
    Divisions of Clinical Research and Human Biology, and Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 100:1151-6. 2003
    ..Investigation of the functional role of missense changes in breast-cancer susceptibility should focus on 38 missense changes in conserved and 3 in rapidly evolving regions of exon 11...
  45. ncbi request reprint BRCA1 and BRCA2 sequence variants in Chinese breast cancer families
    Xiangcheng Zhi
    Breast Department Tianjin Cancer Hospital of Tianjin Medical University, Tianjin, P R China
    Hum Mutat 20:474. 2002
    ..Larger, more detailed, studies will be necessary to determine which factors underlie this difference...
  46. ncbi request reprint Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3
    Duska J Sidjanin
    Center for Canine Genetics and Reproduction, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Hum Mol Genet 11:1823-33. 2002
    ....
  47. ncbi request reprint Vitamin D receptor gene polymorphisms and prostate cancer risk
    Mahesh B Keitheri Cheteri
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 59:409-18. 2004
    ..To further evaluate this relationship, we conducted a population-based case-control study of the VDR BsmI, FokI, and Poly-A polymorphisms, and prostate cancer...
  48. ncbi request reprint Genetic structure of the purebred domestic dog
    Heidi G Parker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Post Office Box 19024, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, USA
    Science 304:1160-4. 2004
    ..These results provide a genetic classification of dog breeds and will aid studies of the genetics of phenotypic breed differences...
  49. ncbi request reprint A high-resolution comparative map of canine Chromosome 5q14.3-q33 constructed utilizing the 1.5x canine genome sequence
    Kenine E Comstock
    Clinical and Human Biology Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, D4 100, P O Box 19024, Seattle, Washington 98109 1024, USA
    Mamm Genome 15:544-51. 2004
    ..Moreover, this study demonstrates the utility of genomic survey sequences when combined with accurate genome maps for rapid mapping of disease susceptibility loci...
  50. ncbi request reprint Prostate cancer and genetic susceptibility: a genome scan incorporating disease aggressiveness
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Prostate 66:317-25. 2006
    ..Linkage studies attempting to map genes for hereditary prostate cancer (HPC) have proved challenging, and one potential problem contributing to this challenge is the variability in disease phenotypes...
  51. ncbi request reprint Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Science 309:613-7. 2005
    ..We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement...
  52. pmc A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Hum Genet 77:219-29. 2005
    ....
  53. ncbi request reprint Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types
    Amanda Ewart-Toland
    UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Carcinogenesis 26:1368-73. 2005
    ..The data also underline the advantages of comparative association studies involving study populations from different ethnic groups for determination of disease risk...
  54. ncbi request reprint IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer
    Danielle M Friedrichsen
    Division of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 65:44-51. 2005
    ..Several polymorphisms within the IGF-I and IGFBP-3 coding regions have been associated with increased serum protein levels...
  55. ncbi request reprint A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk
    Goutham Narla
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 65:1213-22. 2005
    ....
  56. ncbi request reprint The keeshond defect in cardiac conotruncal development is oligogenic
    Petra Werner
    Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancy Street, Philadelphia, PA 19104 6010, USA
    Hum Genet 116:368-77. 2005
    ..We excluded from the linked regions in the dog, a number of genes known to have a role in the etiology of CTDs and predict that continuing studies will identify CTD-predisposing genes not previously recognized...
  57. ncbi request reprint Expanded repeat in canine epilepsy
    Hannes Lohi
    The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Science 307:81. 2005
    ..Clinicopathologic characterization establishes affected animals as a model for Lafora disease, the most severe teenage-onset human epilepsy...
  58. ncbi request reprint Dog star rising: the canine genetic system
    Nathan B Sutter
    National Human Genome Research Institute, National Institutes of Health, 50 South Drive, MSC8002, Building 50, Room 5222, Bethesda, Maryland 20892, USA
    Nat Rev Genet 5:900-10. 2004
    ....
  59. pmc Extensive and breed-specific linkage disequilibrium in Canis familiaris
    Nathan B Sutter
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Genome Res 14:2388-96. 2004
    ..We also report low haplotype diversity within regions of high LD, with 80% of chromosomes in a breed carrying two to four haplotypes, as well as a high degree of haplotype sharing among breeds...
  60. ncbi request reprint Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers
    Kimberly A Zuhlke
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0946, USA
    Clin Cancer Res 10:5975-80. 2004
    ..To examine the possibility that germ-line BRCA1 mutations were associated with hereditary prostate cancer, individuals from 93 families with evidence of linkage to chromosome 17q were screened for germ-line BRCA1 mutations...
  61. ncbi request reprint A polymorphism in the CYP17 gene and risk of prostate cancer
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:243-7. 2002
    ..It is also possible that CYP17 interacts with other genes that influence risk of familial prostate cancer...
  62. ncbi request reprint A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog
    Frode Lingaas
    Norwegian School of Veterinary Science, Oslo
    Hum Mol Genet 12:3043-53. 2003
    ..Strong evidence is provided that the RCND mutation may have a homozygous lethal effect (P<0.01)...
  63. pmc Survey sequencing and radiation hybrid mapping to construct comparative maps
    Christophe Hitte
    CNRS, Université de Rennesl, Rennes Cedex, France
    Methods Mol Biol 422:65-77. 2008
    ....

Research Grants8

  1. GENETICS OF PROSTATE CANCER SUSCEPTIBILITY
    Elaine Ostrander; Fiscal Year: 2001
    ..These experiments will provide a foundation for subsequent physical mapping efforts and candidate cDNA analysis. ..
  2. GENETICS OF PROSTATE CANCER SUSCEPTIBILITY
    Elaine Ostrander; Fiscal Year: 2003
    ..The resulting data will provide information about the type and distribution of mutations in high-risk families as well as provide useful information for understanding genetic heterogeneity of prostate cancer. ..
  3. A High Density Gene Map of the Canine Genome
    Elaine Ostrander; Fiscal Year: 2003
    ..abstract_text> ..
  4. Genetics of Cancer Susceptibility--Multisystem Approach
    Elaine Ostrander; Fiscal Year: 2004
    ..This K05 will provide the resources, and particularly the time, necessary to provide guidance and mentoring to students and postdocs in my lab as they pursue the new avenues of research that will achieve the integration of our efforts. ..