Research Topics
Species | P A NewcombSummaryAffiliation: Fred Hutchinson Cancer Research Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The association between NSAID use and colorectal cancer mortality: results from the women's health initiativeAnna E Coghill
Corresponding Author Polly A Newcomb, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109
Cancer Epidemiol Biomarkers Prev 21:1966-73. 2012..Recent data also suggests an inverse association between NSAID use and death due to colorectal cancer (CRC)...- Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer developmentAbra G Brisbin
Department of Health Sciences Research, Mayo Clinic, Rochester, USA
BMC Med Genet 12:156. 2011..However, the abundance of associations around 128 Mb on chromosome 8 could mask the appearance of a weaker, but important, association elsewhere on 8q24... - Impact of colon cancer screening on family history phenotypePolly A Newcomb
Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Epidemiology 23:308-10. 2012..If effective cancer screening is more common in people with a family history of cancer, the relationship between family history and cancer incidence may become distorted... 
Dairy food and ovarian cancer riskPolly A Newcomb
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Lancet 367:797-9. 2006- Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancerPolly A Newcomb
Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 16:2331-43. 2007..Family studies have served as a cornerstone of genetic research on colorectal cancer... - Prediagnostic use of hormone therapy and mortality after breast cancerPolly A Newcomb
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 17:864-71. 2008..Due to the high prevalence of past and current hormone use, it is important to investigate whether these preparations are related to breast cancer mortality... - Long-term efficacy of sigmoidoscopy in the reduction of colorectal cancer incidencePolly A Newcomb
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle 98109 1024, USA
J Natl Cancer Inst 95:622-5. 2003..Current recommendations regarding the frequency of sigmoidoscopy screening may be unnecessarily aggressive... - Patterns of postmenopausal progestin use with estrogen in relation to endometrial cancer (United States)Polly A Newcomb
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Causes Control 14:195-201. 2003..To investigate the risk of endometrial cancer associated with various regimens of postmenopausal hormone therapy... - Bisphosphonates for osteoporosis treatment are associated with reduced breast cancer riskP A Newcomb
Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, 610 Walnut Street, Madison, WI 53726, USA
Br J Cancer 102:799-802. 2010..In addition to their bone resorption properties, the most commonly used nitrogen-containing bisphosphonate compounds also inhibit protein prenylation, and thus may exert anti-tumour properties... - Hormone therapy in relation to survival from large bowel cancerPolly A Newcomb
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Mailstop M4 B402, Seattle, WA 98109, USA
Cancer Causes Control 20:409-16. 2009..Because we detected no differences in survival among users of HT compared to non-users, the results suggest that HT use may affect only the incidence of some colorectal tumors... - Late age at first full term birth is strongly associated with lobular breast cancerPolly A Newcomb
University of Wisconsin Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA
Cancer 117:1946-56. 2011..Late age at first full-term birth and nulliparity are known to increase breast cancer risk. The frequency of these risk factors has increased in recent decades... - Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in womenPolly A Newcomb
Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, Washington 98109, USA
Cancer Res 67:7534-9. 2007..Progestin may enhance the estrogenic effect of conjugated estrogen so the combination may be more biologically active in the colon than E alone... - Tamoxifen and risk of large bowel cancer in women with breast cancerP A Newcomb
Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, WA 98109 1024, USA
Breast Cancer Res Treat 53:271-7. 1999..The increasingly consistent association between estrogen replacement therapy and colorectal cancer suggests that the anti-estrogen tamoxifen may also be associated with large bowel cancer incidence... - Fracture history and risk of breast and endometrial cancerP A Newcomb
University of Wisconsin Comprehensive Cancer Center, Madison, WI 53706, USA
Am J Epidemiol 153:1071-8. 2001..15, 95% CI: 0.05, 0.43). These data suggest that the endogenous hormonal factors associated with increased fracture risk are also related to decreased breast cancer risk and, more strongly, to endometrial cancer risk... - Electric blanket or mattress cover use and breast cancer incidence in women 50-79 years of ageJ A McElroy
University of Wisconsin Comprehensive Cancer Center, Madison 53705, USA
Epidemiology 12:613-7. 2001..This study provides evidence against a positive association between electric blanket or mattress cover use and breast cancer... - Postmenopausal estrogen and progestin use in relation to breast cancer riskPolly A Newcomb
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53706, USA
Cancer Epidemiol Biomarkers Prev 11:593-600. 2002..09; 95% CI, 1.07-4.07 for ever use versus nonuse). Estrogen-progestin use, both sequential and continuous, appears to be more strongly associated with risk of breast cancer than use of estrogen alone... - Proportion of invasive breast cancer attributable to risk factors modifiable after menopauseBrian L Sprague
Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726, USA
Am J Epidemiol 168:404-11. 2008..3%. These findings suggest that a substantial fraction of postmenopausal breast cancer may be avoided by purposeful changes in lifestyle later in life... - Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure?L M Morimoto
Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Int J Gynecol Cancer 16:1348-53. 2006.... - Nonsteroidal anti-inflammatory drug use and protection against colorectal cancer in womenM J Reeves
Section of Chronic Disease and Health Promotion, Bureau of Public Health, Wisconsin Division of Health, Madison, 53703, USA
Cancer Epidemiol Biomarkers Prev 5:955-60. 1996..79; 95% CI, 0.46-1.36). These data add support to the hypothesis that regular NSAID use is associated with lower colorectal cancer risk in women and suggest that the type of NSAID used may be important... - Hormonal risk factors for endometrial cancer: modification by cigarette smoking (United States)L M Newcomer
Cancer Prevention Research Program, Fred Hutchinson Research Center, Seattle, WA 98109-1024, USA
Cancer Causes Control 12:829-35. 2001..CONCLUSION: These results suggest that smoking moderates the risk associated with endometrial cancer among women at greatest risk, specifically women who are obese or who use postmenopausal hormones... - Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: genetic factorsLibby M Morimoto
Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Cancer Epidemiol Biomarkers Prev 14:1394-401. 2005..This analysis provides evidence that common variation in IGF genes may contribute to the variation in circulating levels observed between individuals... - Weight change and risk of endometrial cancerA Trentham-Dietz
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
Int J Epidemiol 35:151-8. 2006..Obesity is an established risk factor for endometrial cancer. Less well understood is the role of weight gain and weight change in determining risk... - Inverse association of NSAID use and ovarian cancer in relation to oral contraceptive use and parityK J Wernli
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109, USA
Br J Cancer 98:1781-3. 2008..47, 95% CI 0.27-0.82) but not among parous women (OR=0.81, 95% CI 0.64-1.04) (P-interaction=0.05). These results suggest that use of NSAIDs were beneficial to women at greatest risk for ovarian cancer... - Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosisV M Chia
Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Int J Gynecol Cancer 17:441-6. 2007..The results suggest that history of obesity and diabetes may increase risk of mortality after endometrial cancer diagnosis; modification of these characteristics may improve survival after endometrial cancer diagnosis... - Risk of recurrence after ductal carcinoma in situ of the breastL A Habel
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 7:689-96. 1998..However, larger studies are needed to more clearly document predictors of disease recurrence after DCIS... - Vitamin D receptor polymorphism and breast cancer riskPolly A Newcomb
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 11:1503-4. 2002 - Oral contraceptive use, reproductive factors, and colorectal cancer risk: findings from WisconsinHazel B Nichols
UW Comprehensive Cancer Center, University of Wisconsin Comprehensive Cancer Center, WARF Building Room 305, 610 Walnut Street, Madison, WI 53726, USA
Cancer Epidemiol Biomarkers Prev 14:1212-8. 2005..No significant associations were observed between colorectal cancer risk and age at menarche or age at menopause. These findings suggest differential roles of reproductive factors in colon and rectal cancer etiology... - Cigarette smoking and risk of breast carcinoma in situAmy Trentham-Dietz
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
Epidemiology 18:629-38. 2007..Although the associations with cigarette smoking have been explored extensively for invasive breast cancer, the relation to in situ cancer has not previously been examined in depth... - From menarche to menopause: trends among US Women born from 1912 to 1969Hazel B Nichols
University of Wisconsin Comprehensive Cancer Center, Madison, WI 53726, USA
Am J Epidemiol 164:1003-11. 2006..1 years among women born between 1915 and 1919 to 37.7 years among the 1935-1939 cohort (p = 0.0001). These findings have implications for women's lifetime exposure to circulating endogenous hormones... 
Reproductive factors and histologic subtype in relation to mortality after a breast cancer diagnosisS Warren Andersen
University of Wisconsin Carbone Cancer Center, 610 Walnut St, WARF Room 307, Madison, WI 53726, USA
Breast Cancer Res Treat 130:975-80. 2011..We found increasing parity reduced mortality in ductal and lobular breast cancer. The number of full-term births, rather than age at first birth, has an effect on both breast cancer-specific and overall mortality...- Health-related quality of life in female long-term colorectal cancer survivorsA Trentham-Dietz
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
Oncologist 8:342-9. 2003.... - Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancerBrian L Sprague
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin 53726, USA
Cancer Epidemiol Biomarkers Prev 16:236-43. 2007..Lifetime strenuous occupational activity was not associated with invasive breast cancer risk. These results provide further evidence that, for most women, physical activity may reduce the risk of invasive breast cancer... - Hormone replacement therapy in relation to survival in women diagnosed with colon cancerMargaret T Mandelson
Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
Cancer Causes Control 14:979-84. 2003.... - Postmenopausal hormone therapy and risk of breast cancer by histologic type (United States)Laura M Newcomer
Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA
Cancer Causes Control 14:225-33. 2003..Of particular interest is the association between combined hormone therapy and increased risk of lobular carcinoma. This lesion is increasingly common but, nonetheless, comprises fewer than 10% of invasive breast cancers... - Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: personal and lifestyle factors (United States)Libby M Morimoto
Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Causes Control 16:917-27. 2005..Only age was significantly related to circulating IGFBP-3. Although the sources of inter-individual variation of IGF-1 and IGFB-3 are not yet fully understood, this analysis provides some insights into factors that may contribute... - Pre-diagnostic NSAID use but not hormone therapy is associated with improved colorectal cancer survival in womenA E Coghill
Fred Hutchinson Cancer Research Center, Cancer Prevention Program, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109, USA
Br J Cancer 104:763-8. 2011..Non-steroidal anti-inflammatory drugs (NSAIDs) and hormone therapy (HT) independently decrease the risk of colorectal cancer. However, their role in altering survival after a colorectal cancer diagnosis is not well established... - Breast cancer risk factors and second primary malignancies among women with breast cancerAmy Trentham-Dietz
Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
Breast Cancer Res Treat 105:195-207. 2007..To examine the association between breast cancer risk factors and second primary cancers (independent diagnoses occurring at least 12 months after the initial breast cancer diagnosis) among breast cancer survivors... - Effects of birth order and maternal age on breast cancer risk: modification by whether women had been breast-fedHazel B Nichols
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
Epidemiology 19:417-23. 2008..Recent studies have also considered potential health effects associated with exposure to environmental contaminants in breastmilk... - The relationship between gravidity and parity and colorectal cancer riskKaren J Wernli
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Womens Health (Larchmt) 18:995-1001. 2009.... - Hormone therapy and ovarian cancer: incidence and survivalKaren J Wernli
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Cancer Causes Control 19:605-13. 2008.... - Antidepressant medication use and breast cancer riskKaren J Wernli
Program in Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Pharmacoepidemiol Drug Saf 18:284-90. 2009..Despite the uniform conclusion, there is a continuous rise in the proportion of women using antidepressants, lending support to further monitoring of disease effects... - Body mass index and the risk of death following the diagnosis of colorectal cancer in postmenopausal women (United States)V Paul Doria-Rose
Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, P O Box 19024, Seattle, Washington 98109 1024, USA
Cancer Causes Control 17:63-70. 2006..We examined survival in a group of postmenopausal women according to BMI... - Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polypsKaren J Wernli
Program in Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Growth Horm IGF Res 20:305-9. 2010.... - Potential exposure to PCBs, DDT, and PBDEs from sport-caught fish consumption in relation to breast cancer risk in WisconsinJane A McElroy
University of Wisconsin Comprehensive Cancer Center, Madison, 53726, USA
Environ Health Perspect 112:156-62. 2004..16-2.50). In this study we found no overall association between recent consumption of sport-caught fish and breast cancer, although there may be an increased breast cancer risk for subgroups of women who are young and/or premenopausal... - No evidence of an association of JC virus and colon neoplasiaPolly A Newcomb
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, DE-320, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 13:662-6. 2004..Among the colon tissues, one normal tissue (<0.5%) and none of the matched tumors tested positive for JCV. There is no evidence in these data to indicate that JCV is the cause of genetic instability in colorectal cancer... - Oral contraceptive use and risk of breast cancer by histologic typeLaura M Newcomer
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Int J Cancer 106:961-4. 2003..Oral contraceptive use was not clearly associated with ductal carcinoma (OR = 1.2, 95%CI = 0.8-1.9). These results suggest that the association between oral contraceptive use and risk of breast cancer may vary by histologic type... - Colorectal cancer cases and relatives of cases indicate similar willingness to receive and disclose genetic informationRachel M Ceballos
School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
Genet Test 12:415-20. 2008.... - The incidence of colorectal cancer following a negative screening sigmoidoscopy: implications for screening intervalV Paul Doria-Rose
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Gastroenterology 127:714-22. 2004..We estimated the annual incidence of distal and proximal CRC in the first 5 years following a negative sigmoidoscopy examination to gauge the potential benefit of rescreening in <5 years... - Family history and colorectal cancer survival in womenAnne C Kirchhoff
Department of Health Services, University of Washington, School of Public Health and Community Medicine, P O Box 357230, Seattle, WA 98195, USA
Fam Cancer 7:287-92. 2008..We examined the relationship between self-reported first-degree family history of colorectal cancer and survival... - Insulin-like growth factor polymorphisms and colorectal cancer riskLibby M Morimoto
Fred Hutchinson Cancer Research Center, Cancer Prevention, 1100 Fairview Avenue North, M4 B402, Seattle WA 98109, USA
Cancer Epidemiol Biomarkers Prev 14:1204-11. 2005..01). The current study provides some support for a role of IGFs in colorectal cancer etiology, particularly in mediating the relationship of common risk factors (physical activity, BMI, and postmenopausal hormone use)... - Sources of cadmium exposure among healthy premenopausal womenScott V Adams
Fred Hutchinson Cancer Research Center, PO Box 19024, M4 B402, Seattle, WA 98109, USA
Sci Total Environ 409:1632-7. 2011..Cigarettes are the dominant source of cadmium exposure among smokers; the primary source of cadmium in non-smokers is food. We investigated sources of cadmium exposure in a sample of healthy women... - On combining family-based and population-based case-control data in association studiesYingye Zheng
Biostatistics and Biomathematics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Biometrics 66:1024-33. 2010..Efficiencies of different designs are contrasted in the simulation. We applied the methods to data from the Colorectal Cancer Family Registry... - Incomplete screening flexible sigmoidoscopy associated with female sex, age, and increased risk of colorectal cancerV P Doria-Rose
Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, M4 B402, PO Box 19024, Seattle, Washington 98109 1024, USA
Gut 54:1273-8. 2005..However, no prior study has reported the subsequent risk of colorectal cancer (CRC) following incomplete sigmoidoscopy... - Urinary cadmium levels and tobacco smoke exposure in women age 20-69 years in the United StatesJ A McElroy
University of Wisconsin, Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
J Toxicol Environ Health A 70:1779-82. 2007.... - Physical activity and survival after diagnosis of invasive breast cancerCrystal N Holick
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Cancer Epidemiol Biomarkers Prev 17:379-86. 2008..This study provides support for reduced overall mortality and mortality from breast cancer among women who engage in physical activity after breast cancer diagnosis... - Nitrogen-nitrate exposure from drinking water and colorectal cancer risk for rural women in Wisconsin, USAJane A McElroy
University of Wisconsin, Paul P Carbone Comprehensive Cancer Center, Madison, WI 53726, USA
J Water Health 6:399-409. 2008..These results suggest that if an association exists with nitrate-nitrogen exposure from residential drinking water consumption, it may be limited to proximal colon cancer... - Statin use and risk of breast cancerGaia Pocobelli
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Cancer 112:27-33. 2008..We analyzed data from a population-based case-control study to evaluate the association between the use of statins and breast cancer risk... - Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma riskVictoria M Chia
Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 16:2697-703. 2007..There were no associations of leptin receptor genotypes or haplotypes and adenoma risk. The results of this study suggest that, in men, leptin may be associated with risk of colorectal adenomas... - Occupational exposure to electromagnetic field and breast cancer risk in a large, population-based, case-control study in the United StatesJane A McElroy
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, WI 53726, USA
J Occup Environ Med 49:266-74. 2007..Our objective was to evaluate women who were occupationally exposed to electromagnetic fields (EMF) and breast cancer risk... - Endometrial cancer incidence in relation to electric blanket useJane A McElroy
University of Wisconsin Comprehensive Cancer Center, Madison, WI 53726, USA
Am J Epidemiol 156:262-7. 2002..49, 1.54) as compared with never users. Despite its small size and potential misclassification of exposure, this study provides evidence against an association between electric blanket or mattress cover use and endometrial cancer... - Differences in breast cancer risk factors by tumor marker subtypes among premenopausal Vietnamese and Chinese womenHazel B Nichols
University of Wisconsin Comprehensive Cancer Center, Madison, WI, USA
Cancer Epidemiol Biomarkers Prev 14:41-7. 2005..Our findings support the hypothesis that some breast cancer risk factors differ by ER and HER-2/neu tumor marker subtypes... - Cadmium exposure and breast cancer riskJane A McElroy
University of Wisconsin Comprehensive Cancer Center, Room 307 WARF, 610 Walnut St, Madison, WI 53726, USA
J Natl Cancer Inst 98:869-73. 2006..Whether increased cadmium is a causal factor for breast cancer or reflects the effects of treatment or disease remains to be determined... - Detection method and breast carcinoma histologyLaura M Newcomer
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Cancer 95:470-7. 2002..CONCLUSIONS: Among women age > or = 50 years, breast cancer detection by mammography, self detection, and CBE varied according to tumor histopathology... - Risk of microsatellite-unstable colorectal cancer is associated jointly with smoking and nonsteroidal anti-inflammatory drug useVictoria M Chia
Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Cancer Res 66:6877-83. 2006.... - KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markersA I Phipps
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Br J Cancer 108:1757-64. 2013..Patterns were similar for overall survival.Conclusion:Kirsten Ras (KRAS)-mutated CRC was associated with statistically significantly poorer survival after diagnosis than KRAS-wild-type CRC... - Genetic variation in TP53 and risk of breast cancer in a population-based case control studyBrian L Sprague
Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726, USA
Carcinogenesis 28:1680-6. 2007..03). These results indicate that common variation in the TP53 gene could modify the risk of invasive breast cancer... - Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential?Libby M Morimoto
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 11:1012-8. 2002..Overall, the similarity of the risk profiles of colorectal hyperplastic polyps, adenoma, and cancer provides additional support for the growing body of evidence that some hyperplastic polyps may have neoplastic potential... - Prevalence and treatment of menopausal symptoms among breast cancer survivorsPatricia F Harris
Department of Medicine, University of Wisconsin, Madison, WI, USA
J Pain Symptom Manage 23:501-9. 2002..Instead, cases treat menopausal symptoms with vitamin E and soy products, even though the safety and efficacy of these therapies are unproven. The increased use of soy products in this population has not been previously documented... - Risk of breast cancer for women living in rural areas from adult exposure to atrazine from well water in WisconsinJane A McElroy
University of Wisconsin Comprehensive Cancer Center, Madison, WI 53726, USA
J Expo Sci Environ Epidemiol 17:207-14. 2007..The possible risk for women exposed to levels of atrazine at or above statutory action levels of >or=3 ppb (OR 1.3, 95% CI 0.3-6.5) could not be ruled out due to small numbers in this category... - Selection bias in the assessment of gene-environment interaction in case-control studiesLibby M Morimoto
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Am J Epidemiol 158:259-63. 2003..The authors present an example to illustrate this concept... - Oral contraceptive use and risk of breast carcinoma in situHazel B Nichols
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
Cancer Epidemiol Biomarkers Prev 16:2262-8. 2007..16; 95% CI, 1.01-1.32 for ever versus never use). Consistent with invasive breast cancer, these results suggest that oral contraceptive use is at most a minor contributor to BCIS risk... - Duration of sleep and breast cancer risk in a large population-based case-control studyJane A McElroy
University of Wisconsin Comprehensive Cancer Center, Madison, 53726, USA
J Sleep Res 15:241-9. 2006..In contrast, short duration of sleep (<7 h/night) is not substantially associated with increased risk. Further research in this area is warranted... - Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calciumH S Kim
Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 10:869-74. 2001.... - Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer riskMazyar Shadman
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
World J Gastroenterol 15:2336-9. 2009..To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs (NSAIDs) or statins and colorectal cancer risk... - Correlates of age at menarche among sixth grade students in WisconsinAmy Trentham-Dietz
University of Wisconsin Comprehensive Cancer Center, Madison, USA
WMJ 104:65-9. 2005..03) and participated in fewer hours of sporting activity (P=0.08) than students who had not yet reached menarche. These preliminary data suggest that further investigation of the determinants of menarche is both feasible and warranted... - Why hormones protect against large bowel cancer: old ideas, new evidencePolly A Newcomb
Cancer Prevention Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Adv Exp Med Biol 617:259-69. 2008 - Geocoding addresses from a large population-based study: lessons learnedJane A McElroy
Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
Epidemiology 14:399-407. 2003..The goal of this project was to develop an iterative geocoding process that would achieve a high match rate in a large population-based health study... - Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancerAnna E Coghill
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Gut 60:491-8. 2011..The role of prediagnostic NSAID use was therefore examined in relation to colorectal cancer-specific survival among cases from the Seattle Colon Cancer Family Registry (Seattle Colon CFR)... - Social networks and quality of life among female long-term colorectal cancer survivorsAmy L Sapp
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
Cancer 98:1749-58. 2003..The results of this study should be of interest to those seeking to understand or improve HRQoL among this growing population... - Predictors of urinary cadmium levels in adult femalesJane A McElroy
University of Wisconsin Paul P Carbone Comprehensive Cancer Center, 610 Walnut Street, 370 WARF, Madison, WI 53726, USA
Sci Total Environ 382:214-23. 2007..Similar to other studies, age and smoking were the strongest determinants of creatinine-adjusted urinary cadmium concentration... - Reproducibility of serum leptin, insulin-like growth factor-I, and insulin-like growth factor-binding protein-3 measurementsVictoria M Chia
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
Horm Res 69:295-300. 2008.... - Calcium and colorectal cancer: some questions remainVictoria Chia
Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
Nutr Rev 62:115-20. 2004..Because colon cancer is a common disease, even a modest decrease in risk has the potential for preventing a substantial number of cases... - What causes cancer? Reports from sixth-grade girlsHazel B Nichols
The University of Wisconsin Comprehensive Cancer Center, Madison, USA
J Cancer Educ 21:142-6. 2006..We evaluated students' perception of cancer causation among sixth-grade girls living in Wisconsin... - Infectious agents and colorectal cancer: a review of Helicobacter pylori, Streptococcus bovis, JC virus, and human papillomavirusAndrea N Burnett-Hartman
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 17:2970-9. 2008..For each of these agents, a review of possible mechanisms for carcinogenesis and epidemiologic evidence is discussed, and future directions for research are proposed... - Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancerYawei Zhang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
Cancer Epidemiol Biomarkers Prev 15:353-8. 2006..6; 95% CI, 1.1-2.4; P = 0.02). In conclusion, our results do not support that the polymorphisms evaluated in six BER pathway genes play a major role in breast carcinogenesis, particularly in Caucasian populations... - Association of NAT2 and smoking in relation to breast cancer incidence in a population-based case-control study (United States)Kathleen M Egan
Division of General Internal Medicine and the Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, 37232, USA
Cancer Causes Control 14:43-51. 2003..To evaluate the potential interaction between N-acetyltransferase 2 (NAT2) and smoking in breast cancer incidence... - Early life risk factors in cancer: the relation of birth weight to adult obesityNicole M Leong
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Int J Cancer 103:789-91. 2003..76). These data suggest that both low and high birth weights are associated with higher adult BMI and support the hypothesis that fetal experience may influence adult obesity with potential consequences for risk of several major cancers... - Recreational physical activity and ovarian cancer in a population-based case-control studyElizabeth R Bertone
Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003 9304, USA
Int J Cancer 99:431-6. 2002..70; 95% CI = 0.36-1.35; p for trend = 0.41). Overall, our results provide only limited support for an inverse association between recreational physical activity and risk of ovarian cancer... - Early life factors in relation to breast cancer risk in postmenopausal womenLinda Titus-Ernstoff
Norris Cotton Cancer Center and the Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Cancer Epidemiol Biomarkers Prev 11:207-10. 2002..Overall, our results are consistent with previous studies and suggest that these early life factors have a modest influence on breast cancer risk in postmenopausal women... - Alcohol consumption and ovarian cancer risk in a population-based case-control studyNeeraja B Peterson
Center for Health Services Research, Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
Int J Cancer 119:2423-7. 2006..30), though results for other subtypes were based on sparse data and results were imprecise. In this study, neither total alcohol consumption as a young adult nor recently was associated with an increase in the risk of ovarian cancer... - Whole-genome amplification of oral rinse self-collected DNA in a population-based case-control study of breast cancerXueying Liang
Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Cancer Epidemiol Biomarkers Prev 16:1610-4. 2007..Whole-genome amplification may introduce substantial allele amplification bias in gDNA collected using a common protocol in population-based epidemiologic studies... - Familial relative risk estimates for use in epidemiologic analysesYutaka Yasui
Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
Am J Epidemiol 164:697-705. 2006.... - Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer riskMia M Gaudet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Hum Genet 121:483-90. 2007..Additional studies are required to replicate these findings and to determine whether rs361525 is a causative SNP or is a marker of a causative SNP... - Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United States)Neeraja B Peterson
Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University School of Medicine, Medical Center East, Suite 6000, Nashville, TN 37232 8300, USA
Cancer Causes Control 17:459-67. 2006..To examine the relationship between anthropometric measures and ovarian cancer by menopausal status... - Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analysesMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 7076, Rockville, MD 20952 7234, USA
Hum Genet 119:376-88. 2006..Evaluation of potential underlying gene-gene interactions or associations in population subgroups will require even larger sample sizes... - STK15 polymorphism and breast cancer risk in a population-based studyKathleen M Egan
Vanderbilt University Medical Center, Suite 6000, MCE, Nashville, TN 37232 8300, USA
Carcinogenesis 25:2149-53. 2004..79). No interaction was detected between STK15 variants and estrogenic risk factors, although the power of these analyses was limited. These results suggest that STK15 may represent a low penetrance type breast cancer susceptibility gene... - Urinary lead exposure and breast cancer risk in a population-based case-control studyJane A McElroy
Family and Community Medicine, University of Missouri, Columbia, MO 53212, USA
Cancer Epidemiol Biomarkers Prev 17:2311-7. 2008..Lead may be a facilitative or permissive carcinogen, which means that lead may permit or augment the genotoxic effects of other exposures... - Socioeconomic risk factors for breast cancer: distinguishing individual- and community-level effectsStephanie A Robert
School of Social Work, Center for Demography of Health and Aging, Institute for Research on Poverty, University of Wisconsin Madison, 53706, USA
Epidemiology 15:442-50. 2004..We examined whether women living in such communities remained at greater risk of breast cancer after controlling for individual education and other known individual-level risk factors... - Evidence for an association between JC virus and colorectal neoplasiaC Richard Boland
Cancer Epidemiol Biomarkers Prev 13:2285-6; author reply 2286. 2004
Research Grants
- HORMONE REPLACEMENT THERAPY AND LARGE BOWEL CANCER RISKPolly Newcomb; Fiscal Year: 2002..The proposed study and its extensions should provide clear evidence for the degree to which HRT is protective against colorectal cancer and permit the determination of some of the relevant pathways for that protection. ..
- Colon Cancer Risk: IGF Polymorphisms/Lifestyle FactorsPolly Newcomb; Fiscal Year: 2003..As an adjunct to an existing study, this is an efficient, valid cost-effective approach to the investigation of the association between polymorphisms and cancer risk. ..
- LEPTIN, IGFS AND COLORECTAL ADENOMA CANCER RISKPolly Newcomb; Fiscal Year: 2005..This study may provide insights into the biologic mechanisms whereby obesity is associated with colorectal cancer risk, as well as have practical implications for cancer prevention. ..
- Seattle Colorectal Cancer Family Registry (CFR)Polly Newcomb; Fiscal Year: 2006..The Seattle CFR provides an important population-based perspective within our consortium studies of colorectal cancer. ..
- Medications, Genetic Variability & Breast CancerPolly Newcomb; Fiscal Year: 2007..abstract_text> ..
- Hormones and Colon Cancer: Epigenetic Subtypes, Risk, and SurvivalPolly Newcomb; Fiscal Year: 2007....
- Colon Cancer Pathways: Hyperplastic Polyps and AdenomasPolly Newcomb; Fiscal Year: 2009..The results of this study will have implications for understanding the biology and prevention of colorectal cancer. ..
- Breast Cancer in situ: Recurrence and Quality of LifePolly Newcomb; Fiscal Year: 2002..The proposed population-based cohort offers a powerful opportunity to inform women and physicians as they consider the trade-offs currently inherent in BCIS treatment. ..
- RISK FACTORS AND BIOMARKERS FOR IN SITU BREAST CANCERPolly Newcomb; Fiscal Year: 1999..The findings of this study may have important implications for breast cancer prevention and intervention. In addition, this study will establish the foundation for follow-up studies. ..
- PHYSICAL ACTIVITY, LIFESTYLE AND BREAST CANCER RISKPolly Newcomb; Fiscal Year: 1999....
- ALCOHOL CONSUMPTION, LACTATION, AND BREAST CANCER RISKPolly Newcomb; Fiscal Year: 1991..The Harvard School of Public Health and the University of Wisconsin Clinical Cancer Center will both serve as coordinating centers and have submitted separate applications with identical research plans...
- HORMONES, ALCOHOL CONSUMPTION AND BREAST CANCER RISKPolly Newcomb; Fiscal Year: 1993..The University of Wisconsin Clinical Cancer Center and the Harvard School of Public Health will continue to coordinate the study and have submitted separate applications with identical research plans...
- Hormones and Colon Cancer: Epigenetic Subtypes, Risk, and SurvivalPolly Newcomb; Fiscal Year: 2009....