P A Newcomb

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Pre-diagnostic NSAID use but not hormone therapy is associated with improved colorectal cancer survival in women
    A E Coghill
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109, USA
    Br J Cancer 104:763-8. 2011
  2. pmc Alcohol consumption before and after breast cancer diagnosis: associations with survival from breast cancer, cardiovascular disease, and other causes
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Clin Oncol 31:1939-46. 2013
  3. pmc The association between NSAID use and colorectal cancer mortality: results from the women's health initiative
    Anna E Coghill
    Corresponding Author Polly A Newcomb, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109
    Cancer Epidemiol Biomarkers Prev 21:1966-73. 2012
  4. pmc Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development
    Abra G Brisbin
    Department of Health Sciences Research, Mayo Clinic, Rochester, USA
    BMC Med Genet 12:156. 2011
  5. pmc Impact of colon cancer screening on family history phenotype
    Polly A Newcomb
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Epidemiology 23:308-10. 2012
  6. ncbi request reprint Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:2331-43. 2007
  7. pmc Late age at first full term birth is strongly associated with lobular breast cancer
    Polly A Newcomb
    University of Wisconsin Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA
    Cancer 117:1946-56. 2011
  8. pmc Bisphosphonates for osteoporosis treatment are associated with reduced breast cancer risk
    P A Newcomb
    Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, 610 Walnut Street, Madison, WI 53726, USA
    Br J Cancer 102:799-802. 2010
  9. ncbi request reprint Patterns of postmenopausal progestin use with estrogen in relation to endometrial cancer (United States)
    Polly A Newcomb
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Causes Control 14:195-201. 2003
  10. pmc Hormone therapy in relation to survival from large bowel cancer
    Polly A Newcomb
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Mailstop M4 B402, Seattle, WA 98109, USA
    Cancer Causes Control 20:409-16. 2009

Detail Information

Publications100

  1. pmc Pre-diagnostic NSAID use but not hormone therapy is associated with improved colorectal cancer survival in women
    A E Coghill
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109, USA
    Br J Cancer 104:763-8. 2011
    ..Non-steroidal anti-inflammatory drugs (NSAIDs) and hormone therapy (HT) independently decrease the risk of colorectal cancer. However, their role in altering survival after a colorectal cancer diagnosis is not well established...
  2. pmc Alcohol consumption before and after breast cancer diagnosis: associations with survival from breast cancer, cardiovascular disease, and other causes
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Clin Oncol 31:1939-46. 2013
    ..Alcohol intake is associated with increased risk of breast cancer. In contrast, the relation between alcohol consumption and breast cancer survival is less clear...
  3. pmc The association between NSAID use and colorectal cancer mortality: results from the women's health initiative
    Anna E Coghill
    Corresponding Author Polly A Newcomb, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109
    Cancer Epidemiol Biomarkers Prev 21:1966-73. 2012
    ..Recent data also suggests an inverse association between NSAID use and death due to colorectal cancer (CRC)...
  4. pmc Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development
    Abra G Brisbin
    Department of Health Sciences Research, Mayo Clinic, Rochester, USA
    BMC Med Genet 12:156. 2011
    ..However, the abundance of associations around 128 Mb on chromosome 8 could mask the appearance of a weaker, but important, association elsewhere on 8q24...
  5. pmc Impact of colon cancer screening on family history phenotype
    Polly A Newcomb
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Epidemiology 23:308-10. 2012
    ..If effective cancer screening is more common in people with a family history of cancer, the relationship between family history and cancer incidence may become distorted...
  6. ncbi request reprint Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:2331-43. 2007
    ..Family studies have served as a cornerstone of genetic research on colorectal cancer...
  7. pmc Late age at first full term birth is strongly associated with lobular breast cancer
    Polly A Newcomb
    University of Wisconsin Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA
    Cancer 117:1946-56. 2011
    ..Late age at first full-term birth and nulliparity are known to increase breast cancer risk. The frequency of these risk factors has increased in recent decades...
  8. pmc Bisphosphonates for osteoporosis treatment are associated with reduced breast cancer risk
    P A Newcomb
    Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, 610 Walnut Street, Madison, WI 53726, USA
    Br J Cancer 102:799-802. 2010
    ..In addition to their bone resorption properties, the most commonly used nitrogen-containing bisphosphonate compounds also inhibit protein prenylation, and thus may exert anti-tumour properties...
  9. ncbi request reprint Patterns of postmenopausal progestin use with estrogen in relation to endometrial cancer (United States)
    Polly A Newcomb
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Causes Control 14:195-201. 2003
    ..To investigate the risk of endometrial cancer associated with various regimens of postmenopausal hormone therapy...
  10. pmc Hormone therapy in relation to survival from large bowel cancer
    Polly A Newcomb
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Mailstop M4 B402, Seattle, WA 98109, USA
    Cancer Causes Control 20:409-16. 2009
    ..Because we detected no differences in survival among users of HT compared to non-users, the results suggest that HT use may affect only the incidence of some colorectal tumors...
  11. ncbi request reprint Dairy food and ovarian cancer risk
    Polly A Newcomb
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 367:797-9. 2006
  12. pmc Prediagnostic use of hormone therapy and mortality after breast cancer
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:864-71. 2008
    ..Due to the high prevalence of past and current hormone use, it is important to investigate whether these preparations are related to breast cancer mortality...
  13. ncbi request reprint Fracture history and risk of breast and endometrial cancer
    P A Newcomb
    University of Wisconsin Comprehensive Cancer Center, Madison, WI 53706, USA
    Am J Epidemiol 153:1071-8. 2001
    ..15, 95% CI: 0.05, 0.43). These data suggest that the endogenous hormonal factors associated with increased fracture risk are also related to decreased breast cancer risk and, more strongly, to endometrial cancer risk...
  14. ncbi request reprint Tamoxifen and risk of large bowel cancer in women with breast cancer
    P A Newcomb
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 53:271-7. 1999
    ..The increasingly consistent association between estrogen replacement therapy and colorectal cancer suggests that the anti-estrogen tamoxifen may also be associated with large bowel cancer incidence...
  15. ncbi request reprint Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, Washington 98109, USA
    Cancer Res 67:7534-9. 2007
    ..Progestin may enhance the estrogenic effect of conjugated estrogen so the combination may be more biologically active in the colon than E alone...
  16. ncbi request reprint Long-term efficacy of sigmoidoscopy in the reduction of colorectal cancer incidence
    Polly A Newcomb
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle 98109 1024, USA
    J Natl Cancer Inst 95:622-5. 2003
    ..Current recommendations regarding the frequency of sigmoidoscopy screening may be unnecessarily aggressive...
  17. ncbi request reprint Electric blanket or mattress cover use and breast cancer incidence in women 50-79 years of age
    J A McElroy
    University of Wisconsin Comprehensive Cancer Center, Madison 53705, USA
    Epidemiology 12:613-7. 2001
    ..This study provides evidence against a positive association between electric blanket or mattress cover use and breast cancer...
  18. ncbi request reprint Postmenopausal estrogen and progestin use in relation to breast cancer risk
    Polly A Newcomb
    University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53706, USA
    Cancer Epidemiol Biomarkers Prev 11:593-600. 2002
    ..09; 95% CI, 1.07-4.07 for ever use versus nonuse). Estrogen-progestin use, both sequential and continuous, appears to be more strongly associated with risk of breast cancer than use of estrogen alone...
  19. pmc Proportion of invasive breast cancer attributable to risk factors modifiable after menopause
    Brian L Sprague
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726, USA
    Am J Epidemiol 168:404-11. 2008
    ..3%. These findings suggest that a substantial fraction of postmenopausal breast cancer may be avoided by purposeful changes in lifestyle later in life...
  20. ncbi request reprint Cholecystectomy and endometrial cancer: a marker of long-term elevated estrogen exposure?
    L M Morimoto
    Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Int J Gynecol Cancer 16:1348-53. 2006
    ....
  21. ncbi request reprint Nonsteroidal anti-inflammatory drug use and protection against colorectal cancer in women
    M J Reeves
    Section of Chronic Disease and Health Promotion, Bureau of Public Health, Wisconsin Division of Health, Madison, 53703, USA
    Cancer Epidemiol Biomarkers Prev 5:955-60. 1996
    ..79; 95% CI, 0.46-1.36). These data add support to the hypothesis that regular NSAID use is associated with lower colorectal cancer risk in women and suggest that the type of NSAID used may be important...
  22. ncbi request reprint Hormonal risk factors for endometrial cancer: modification by cigarette smoking (United States)
    L M Newcomer
    Cancer Prevention Research Program, Fred Hutchinson Research Center, Seattle, WA 98109-1024, USA
    Cancer Causes Control 12:829-35. 2001
    ..CONCLUSION: These results suggest that smoking moderates the risk associated with endometrial cancer among women at greatest risk, specifically women who are obese or who use postmenopausal hormones...
  23. ncbi request reprint Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: genetic factors
    Libby M Morimoto
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 14:1394-401. 2005
    ..This analysis provides evidence that common variation in IGF genes may contribute to the variation in circulating levels observed between individuals...
  24. pmc Inverse association of NSAID use and ovarian cancer in relation to oral contraceptive use and parity
    K J Wernli
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109, USA
    Br J Cancer 98:1781-3. 2008
    ..47, 95% CI 0.27-0.82) but not among parous women (OR=0.81, 95% CI 0.64-1.04) (P-interaction=0.05). These results suggest that use of NSAIDs were beneficial to women at greatest risk for ovarian cancer...
  25. ncbi request reprint Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosis
    V M Chia
    Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Int J Gynecol Cancer 17:441-6. 2007
    ..The results suggest that history of obesity and diabetes may increase risk of mortality after endometrial cancer diagnosis; modification of these characteristics may improve survival after endometrial cancer diagnosis...
  26. ncbi request reprint Weight change and risk of endometrial cancer
    A Trentham-Dietz
    University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
    Int J Epidemiol 35:151-8. 2006
    ..Obesity is an established risk factor for endometrial cancer. Less well understood is the role of weight gain and weight change in determining risk...
  27. ncbi request reprint Risk of recurrence after ductal carcinoma in situ of the breast
    L A Habel
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 7:689-96. 1998
    ..However, larger studies are needed to more clearly document predictors of disease recurrence after DCIS...
  28. ncbi request reprint From menarche to menopause: trends among US Women born from 1912 to 1969
    Hazel B Nichols
    University of Wisconsin Comprehensive Cancer Center, Madison, WI 53726, USA
    Am J Epidemiol 164:1003-11. 2006
    ..1 years among women born between 1915 and 1919 to 37.7 years among the 1935-1939 cohort (p = 0.0001). These findings have implications for women's lifetime exposure to circulating endogenous hormones...
  29. ncbi request reprint Cigarette smoking and risk of breast carcinoma in situ
    Amy Trentham-Dietz
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
    Epidemiology 18:629-38. 2007
    ..Although the associations with cigarette smoking have been explored extensively for invasive breast cancer, the relation to in situ cancer has not previously been examined in depth...
  30. ncbi request reprint Vitamin D receptor polymorphism and breast cancer risk
    Polly A Newcomb
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:1503-4. 2002
  31. ncbi request reprint Oral contraceptive use, reproductive factors, and colorectal cancer risk: findings from Wisconsin
    Hazel B Nichols
    UW Comprehensive Cancer Center, University of Wisconsin Comprehensive Cancer Center, WARF Building Room 305, 610 Walnut Street, Madison, WI 53726, USA
    Cancer Epidemiol Biomarkers Prev 14:1212-8. 2005
    ..No significant associations were observed between colorectal cancer risk and age at menarche or age at menopause. These findings suggest differential roles of reproductive factors in colon and rectal cancer etiology...
  32. doi request reprint Reproductive factors and histologic subtype in relation to mortality after a breast cancer diagnosis
    S Warren Andersen
    University of Wisconsin Carbone Cancer Center, 610 Walnut St, WARF Room 307, Madison, WI 53726, USA
    Breast Cancer Res Treat 130:975-80. 2011
    ..We found increasing parity reduced mortality in ductal and lobular breast cancer. The number of full-term births, rather than age at first birth, has an effect on both breast cancer-specific and overall mortality...
  33. ncbi request reprint Health-related quality of life in female long-term colorectal cancer survivors
    A Trentham-Dietz
    University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
    Oncologist 8:342-9. 2003
    ....
  34. ncbi request reprint Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: personal and lifestyle factors (United States)
    Libby M Morimoto
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Causes Control 16:917-27. 2005
    ..Only age was significantly related to circulating IGFBP-3. Although the sources of inter-individual variation of IGF-1 and IGFB-3 are not yet fully understood, this analysis provides some insights into factors that may contribute...
  35. ncbi request reprint Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancer
    Brian L Sprague
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin 53726, USA
    Cancer Epidemiol Biomarkers Prev 16:236-43. 2007
    ..Lifetime strenuous occupational activity was not associated with invasive breast cancer risk. These results provide further evidence that, for most women, physical activity may reduce the risk of invasive breast cancer...
  36. ncbi request reprint Postmenopausal hormone therapy and risk of breast cancer by histologic type (United States)
    Laura M Newcomer
    Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 14:225-33. 2003
    ..Postmenopausal hormone use and risk of breast cancer by histopathology was examined in a large multi-centered population-based case-control study...
  37. ncbi request reprint Hormone replacement therapy in relation to survival in women diagnosed with colon cancer
    Margaret T Mandelson
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Cancer Causes Control 14:979-84. 2003
    ....
  38. pmc KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers
    A I Phipps
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Br J Cancer 108:1757-64. 2013
    ..We evaluated the relationship between KRAS-mutation status and CRC survival, considering heterogeneity in this association by tumour and patient characteristics...
  39. ncbi request reprint Insulin-like growth factor polymorphisms and colorectal cancer risk
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Cancer Prevention, 1100 Fairview Avenue North, M4 B402, Seattle WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:1204-11. 2005
    ..01). The current study provides some support for a role of IGFs in colorectal cancer etiology, particularly in mediating the relationship of common risk factors (physical activity, BMI, and postmenopausal hormone use)...
  40. pmc Antidepressant medication use and breast cancer risk
    Karen J Wernli
    Program in Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Pharmacoepidemiol Drug Saf 18:284-90. 2009
    ..Despite the uniform conclusion, there is a continuous rise in the proportion of women using antidepressants, lending support to further monitoring of disease effects...
  41. ncbi request reprint No evidence of an association of JC virus and colon neoplasia
    Polly A Newcomb
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, DE 320, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:662-6. 2004
    ..Among the colon tissues, one normal tissue (<0.5%) and none of the matched tumors tested positive for JCV. There is no evidence in these data to indicate that JCV is the cause of genetic instability in colorectal cancer...
  42. ncbi request reprint Breast cancer risk factors and second primary malignancies among women with breast cancer
    Amy Trentham-Dietz
    Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
    Breast Cancer Res Treat 105:195-207. 2007
    ..To examine the association between breast cancer risk factors and second primary cancers (independent diagnoses occurring at least 12 months after the initial breast cancer diagnosis) among breast cancer survivors...
  43. pmc Potential exposure to PCBs, DDT, and PBDEs from sport-caught fish consumption in relation to breast cancer risk in Wisconsin
    Jane A McElroy
    University of Wisconsin Comprehensive Cancer Center, Madison, 53726, USA
    Environ Health Perspect 112:156-62. 2004
    ..16-2.50). In this study we found no overall association between recent consumption of sport-caught fish and breast cancer, although there may be an increased breast cancer risk for subgroups of women who are young and/or premenopausal...
  44. pmc Colorectal cancer cases and relatives of cases indicate similar willingness to receive and disclose genetic information
    Rachel M Ceballos
    School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Genet Test 12:415-20. 2008
    ....
  45. pmc Effects of birth order and maternal age on breast cancer risk: modification by whether women had been breast-fed
    Hazel B Nichols
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
    Epidemiology 19:417-23. 2008
    ..Recent studies have also considered potential health effects associated with exposure to environmental contaminants in breastmilk...
  46. doi request reprint Family history and colorectal cancer survival in women
    Anne C Kirchhoff
    Department of Health Services, University of Washington, School of Public Health and Community Medicine, P O Box 357230, Seattle, WA 98195, USA
    Fam Cancer 7:287-92. 2008
    ..We examined the relationship between self-reported first-degree family history of colorectal cancer and survival...
  47. pmc Hormone therapy and ovarian cancer: incidence and survival
    Karen J Wernli
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Cancer Causes Control 19:605-13. 2008
    ....
  48. ncbi request reprint Oral contraceptive use and risk of breast cancer by histologic type
    Laura M Newcomer
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Int J Cancer 106:961-4. 2003
    ..Oral contraceptive use was not clearly associated with ductal carcinoma (OR = 1.2, 95%CI = 0.8-1.9). These results suggest that the association between oral contraceptive use and risk of breast cancer may vary by histologic type...
  49. pmc The relationship between gravidity and parity and colorectal cancer risk
    Karen J Wernli
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Womens Health (Larchmt) 18:995-1001. 2009
    ....
  50. ncbi request reprint Body mass index and the risk of death following the diagnosis of colorectal cancer in postmenopausal women (United States)
    V Paul Doria-Rose
    Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, P O Box 19024, Seattle, Washington 98109 1024, USA
    Cancer Causes Control 17:63-70. 2006
    ..We examined survival in a group of postmenopausal women according to BMI...
  51. ncbi request reprint The incidence of colorectal cancer following a negative screening sigmoidoscopy: implications for screening interval
    V Paul Doria-Rose
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Gastroenterology 127:714-22. 2004
    ..We estimated the annual incidence of distal and proximal CRC in the first 5 years following a negative sigmoidoscopy examination to gauge the potential benefit of rescreening in <5 years...
  52. pmc Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps
    Karen J Wernli
    Program in Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Growth Horm IGF Res 20:305-9. 2010
    ....
  53. pmc Sources of cadmium exposure among healthy premenopausal women
    Scott V Adams
    Fred Hutchinson Cancer Research Center, PO Box 19024, M4 B402, Seattle, WA 98109, USA
    Sci Total Environ 409:1632-7. 2011
    ..Cigarettes are the dominant source of cadmium exposure among smokers; the primary source of cadmium in non-smokers is food. We investigated sources of cadmium exposure in a sample of healthy women...
  54. pmc On combining family-based and population-based case-control data in association studies
    Yingye Zheng
    Biostatistics and Biomathematics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Biometrics 66:1024-33. 2010
    ..Efficiencies of different designs are contrasted in the simulation. We applied the methods to data from the Colorectal Cancer Family Registry...
  55. ncbi request reprint Urinary cadmium levels and tobacco smoke exposure in women age 20-69 years in the United States
    J A McElroy
    University of Wisconsin, Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
    J Toxicol Environ Health A 70:1779-82. 2007
    ....
  56. pmc Incomplete screening flexible sigmoidoscopy associated with female sex, age, and increased risk of colorectal cancer
    V P Doria-Rose
    Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, M4 B402, PO Box 19024, Seattle, Washington 98109 1024, USA
    Gut 54:1273-8. 2005
    ..However, no prior study has reported the subsequent risk of colorectal cancer (CRC) following incomplete sigmoidoscopy...
  57. doi request reprint Physical activity and survival after diagnosis of invasive breast cancer
    Crystal N Holick
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 17:379-86. 2008
    ..This study provides support for reduced overall mortality and mortality from breast cancer among women who engage in physical activity after breast cancer diagnosis...
  58. ncbi request reprint Differences in breast cancer risk factors by tumor marker subtypes among premenopausal Vietnamese and Chinese women
    Hazel B Nichols
    University of Wisconsin Comprehensive Cancer Center, Madison, WI, USA
    Cancer Epidemiol Biomarkers Prev 14:41-7. 2005
    ..Our findings support the hypothesis that some breast cancer risk factors differ by ER and HER-2/neu tumor marker subtypes...
  59. ncbi request reprint Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk
    Victoria M Chia
    Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:2697-703. 2007
    ..There were no associations of leptin receptor genotypes or haplotypes and adenoma risk. The results of this study suggest that, in men, leptin may be associated with risk of colorectal adenomas...
  60. ncbi request reprint Endometrial cancer incidence in relation to electric blanket use
    Jane A McElroy
    University of Wisconsin Comprehensive Cancer Center, Madison, WI 53726, USA
    Am J Epidemiol 156:262-7. 2002
    ..49, 1.54) as compared with never users. Despite its small size and potential misclassification of exposure, this study provides evidence against an association between electric blanket or mattress cover use and endometrial cancer...
  61. ncbi request reprint Occupational exposure to electromagnetic field and breast cancer risk in a large, population-based, case-control study in the United States
    Jane A McElroy
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, WI 53726, USA
    J Occup Environ Med 49:266-74. 2007
    ..Our objective was to evaluate women who were occupationally exposed to electromagnetic fields (EMF) and breast cancer risk...
  62. ncbi request reprint Nitrogen-nitrate exposure from drinking water and colorectal cancer risk for rural women in Wisconsin, USA
    Jane A McElroy
    University of Wisconsin, Paul P Carbone Comprehensive Cancer Center, Madison, WI 53726, USA
    J Water Health 6:399-409. 2008
    ..These results suggest that if an association exists with nitrate-nitrogen exposure from residential drinking water consumption, it may be limited to proximal colon cancer...
  63. ncbi request reprint Cadmium exposure and breast cancer risk
    Jane A McElroy
    University of Wisconsin Comprehensive Cancer Center, Room 307 WARF, 610 Walnut St, Madison, WI 53726, USA
    J Natl Cancer Inst 98:869-73. 2006
    ..Whether increased cadmium is a causal factor for breast cancer or reflects the effects of treatment or disease remains to be determined...
  64. ncbi request reprint Risk of microsatellite-unstable colorectal cancer is associated jointly with smoking and nonsteroidal anti-inflammatory drug use
    Victoria M Chia
    Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cancer Res 66:6877-83. 2006
    ....
  65. ncbi request reprint Detection method and breast carcinoma histology
    Laura M Newcomer
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer 95:470-7. 2002
    ..The association between method of detection and breast carcinoma histopathology has not been assessed adequately in a population-based setting...
  66. ncbi request reprint Statin use and risk of breast cancer
    Gaia Pocobelli
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Cancer 112:27-33. 2008
    ..We analyzed data from a population-based case-control study to evaluate the association between the use of statins and breast cancer risk...
  67. ncbi request reprint Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium
    H S Kim
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 10:869-74. 2001
    ....
  68. ncbi request reprint Prevalence and treatment of menopausal symptoms among breast cancer survivors
    Patricia F Harris
    Department of Medicine, University of Wisconsin, Madison, WI, USA
    J Pain Symptom Manage 23:501-9. 2002
    ..Instead, cases treat menopausal symptoms with vitamin E and soy products, even though the safety and efficacy of these therapies are unproven. The increased use of soy products in this population has not been previously documented...
  69. ncbi request reprint Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential?
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:1012-8. 2002
    ..Overall, the similarity of the risk profiles of colorectal hyperplastic polyps, adenoma, and cancer provides additional support for the growing body of evidence that some hyperplastic polyps may have neoplastic potential...
  70. ncbi request reprint Oral contraceptive use and risk of breast carcinoma in situ
    Hazel B Nichols
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
    Cancer Epidemiol Biomarkers Prev 16:2262-8. 2007
    ..16; 95% CI, 1.01-1.32 for ever versus never use). Consistent with invasive breast cancer, these results suggest that oral contraceptive use is at most a minor contributor to BCIS risk...
  71. ncbi request reprint Selection bias in the assessment of gene-environment interaction in case-control studies
    Libby M Morimoto
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Epidemiol 158:259-63. 2003
    ..The authors present an example to illustrate this concept...
  72. ncbi request reprint Genetic variation in TP53 and risk of breast cancer in a population-based case control study
    Brian L Sprague
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726, USA
    Carcinogenesis 28:1680-6. 2007
    ..03). These results indicate that common variation in the TP53 gene could modify the risk of invasive breast cancer...
  73. ncbi request reprint Duration of sleep and breast cancer risk in a large population-based case-control study
    Jane A McElroy
    University of Wisconsin Comprehensive Cancer Center, Madison, 53726, USA
    J Sleep Res 15:241-9. 2006
    ..In contrast, short duration of sleep (<7 h/night) is not substantially associated with increased risk. Further research in this area is warranted...
  74. ncbi request reprint Risk of breast cancer for women living in rural areas from adult exposure to atrazine from well water in Wisconsin
    Jane A McElroy
    University of Wisconsin Comprehensive Cancer Center, Madison, WI 53726, USA
    J Expo Sci Environ Epidemiol 17:207-14. 2007
    ..The possible risk for women exposed to levels of atrazine at or above statutory action levels of >or=3 ppb (OR 1.3, 95% CI 0.3-6.5) could not be ruled out due to small numbers in this category...
  75. ncbi request reprint Correlates of age at menarche among sixth grade students in Wisconsin
    Amy Trentham-Dietz
    University of Wisconsin Comprehensive Cancer Center, Madison, USA
    WMJ 104:65-9. 2005
    ..03) and participated in fewer hours of sporting activity (P=0.08) than students who had not yet reached menarche. These preliminary data suggest that further investigation of the determinants of menarche is both feasible and warranted...
  76. pmc Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk
    Mazyar Shadman
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    World J Gastroenterol 15:2336-9. 2009
    ..To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs (NSAIDs) or statins and colorectal cancer risk...
  77. doi request reprint Why hormones protect against large bowel cancer: old ideas, new evidence
    Polly A Newcomb
    Cancer Prevention Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Adv Exp Med Biol 617:259-69. 2008
  78. ncbi request reprint Geocoding addresses from a large population-based study: lessons learned
    Jane A McElroy
    Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
    Epidemiology 14:399-407. 2003
    ..The goal of this project was to develop an iterative geocoding process that would achieve a high match rate in a large population-based health study...
  79. pmc Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer
    Anna E Coghill
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Gut 60:491-8. 2011
    ..The role of prediagnostic NSAID use was therefore examined in relation to colorectal cancer-specific survival among cases from the Seattle Colon Cancer Family Registry (Seattle Colon CFR)...
  80. ncbi request reprint What causes cancer? Reports from sixth-grade girls
    Hazel B Nichols
    The University of Wisconsin Comprehensive Cancer Center, Madison, USA
    J Cancer Educ 21:142-6. 2006
    ..We evaluated students' perception of cancer causation among sixth-grade girls living in Wisconsin...
  81. ncbi request reprint Social networks and quality of life among female long-term colorectal cancer survivors
    Amy L Sapp
    University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
    Cancer 98:1749-58. 2003
    ..The current study examines female long-term colorectal cancer survivors' health-related quality of life (HRQoL) in relation to social networks...
  82. ncbi request reprint Calcium and colorectal cancer: some questions remain
    Victoria Chia
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Nutr Rev 62:115-20. 2004
    ..Because colon cancer is a common disease, even a modest decrease in risk has the potential for preventing a substantial number of cases...
  83. doi request reprint Reproducibility of serum leptin, insulin-like growth factor-I, and insulin-like growth factor-binding protein-3 measurements
    Victoria M Chia
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
    Horm Res 69:295-300. 2008
    ....
  84. ncbi request reprint Predictors of urinary cadmium levels in adult females
    Jane A McElroy
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, 610 Walnut Street, 370 WARF, Madison, WI 53726, USA
    Sci Total Environ 382:214-23. 2007
    ..Similar to other studies, age and smoking were the strongest determinants of creatinine-adjusted urinary cadmium concentration...
  85. pmc Infectious agents and colorectal cancer: a review of Helicobacter pylori, Streptococcus bovis, JC virus, and human papillomavirus
    Andrea N Burnett-Hartman
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:2970-9. 2008
    ..For each of these agents, a review of possible mechanisms for carcinogenesis and epidemiologic evidence is discussed, and future directions for research are proposed...
  86. ncbi request reprint Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 7076, Rockville, MD 20952 7234, USA
    Hum Genet 119:376-88. 2006
    ..Evaluation of potential underlying gene-gene interactions or associations in population subgroups will require even larger sample sizes...
  87. ncbi request reprint STK15 polymorphism and breast cancer risk in a population-based study
    Kathleen M Egan
    Vanderbilt University Medical Center, Suite 6000, MCE, Nashville, TN 37232 8300, USA
    Carcinogenesis 25:2149-53. 2004
    ..79). No interaction was detected between STK15 variants and estrogenic risk factors, although the power of these analyses was limited. These results suggest that STK15 may represent a low penetrance type breast cancer susceptibility gene...
  88. ncbi request reprint Early life factors in relation to breast cancer risk in postmenopausal women
    Linda Titus-Ernstoff
    Norris Cotton Cancer Center and the Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Cancer Epidemiol Biomarkers Prev 11:207-10. 2002
    ..Overall, our results are consistent with previous studies and suggest that these early life factors have a modest influence on breast cancer risk in postmenopausal women...
  89. ncbi request reprint Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United States)
    Neeraja B Peterson
    Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University School of Medicine, Medical Center East, Suite 6000, Nashville, TN 37232 8300, USA
    Cancer Causes Control 17:459-67. 2006
    ..To examine the relationship between anthropometric measures and ovarian cancer by menopausal status...
  90. ncbi request reprint Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer
    Yawei Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:353-8. 2006
    ..6; 95% CI, 1.1-2.4; P = 0.02). In conclusion, our results do not support that the polymorphisms evaluated in six BER pathway genes play a major role in breast carcinogenesis, particularly in Caucasian populations...
  91. ncbi request reprint Recreational physical activity and ovarian cancer in a population-based case-control study
    Elizabeth R Bertone
    Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003 9304, USA
    Int J Cancer 99:431-6. 2002
    ..70; 95% CI = 0.36-1.35; p for trend = 0.41). Overall, our results provide only limited support for an inverse association between recreational physical activity and risk of ovarian cancer...
  92. ncbi request reprint Socioeconomic risk factors for breast cancer: distinguishing individual- and community-level effects
    Stephanie A Robert
    School of Social Work, Center for Demography of Health and Aging, Institute for Research on Poverty, University of Wisconsin Madison, 53706, USA
    Epidemiology 15:442-50. 2004
    ..We examined whether women living in such communities remained at greater risk of breast cancer after controlling for individual education and other known individual-level risk factors...
  93. ncbi request reprint Alcohol consumption and ovarian cancer risk in a population-based case-control study
    Neeraja B Peterson
    Center for Health Services Research, Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Int J Cancer 119:2423-7. 2006
    ..30), though results for other subtypes were based on sparse data and results were imprecise. In this study, neither total alcohol consumption as a young adult nor recently was associated with an increase in the risk of ovarian cancer...
  94. ncbi request reprint Familial relative risk estimates for use in epidemiologic analyses
    Yutaka Yasui
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    Am J Epidemiol 164:697-705. 2006
    ....
  95. ncbi request reprint Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Hum Genet 121:483-90. 2007
    ..Additional studies are required to replicate these findings and to determine whether rs361525 is a causative SNP or is a marker of a causative SNP...
  96. ncbi request reprint Association of NAT2 and smoking in relation to breast cancer incidence in a population-based case-control study (United States)
    Kathleen M Egan
    Division of General Internal Medicine and the Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, 37232, USA
    Cancer Causes Control 14:43-51. 2003
    ..To evaluate the potential interaction between N-acetyltransferase 2 (NAT2) and smoking in breast cancer incidence...
  97. doi request reprint Urinary lead exposure and breast cancer risk in a population-based case-control study
    Jane A McElroy
    Family and Community Medicine, University of Missouri, Columbia, MO 53212, USA
    Cancer Epidemiol Biomarkers Prev 17:2311-7. 2008
    ..Lead may be a facilitative or permissive carcinogen, which means that lead may permit or augment the genotoxic effects of other exposures...
  98. ncbi request reprint Whole-genome amplification of oral rinse self-collected DNA in a population-based case-control study of breast cancer
    Xueying Liang
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Epidemiol Biomarkers Prev 16:1610-4. 2007
    ..Whole-genome amplification may introduce substantial allele amplification bias in gDNA collected using a common protocol in population-based epidemiologic studies...
  99. ncbi request reprint Early life risk factors in cancer: the relation of birth weight to adult obesity
    Nicole M Leong
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 103:789-91. 2003
    ..76). These data suggest that both low and high birth weights are associated with higher adult BMI and support the hypothesis that fetal experience may influence adult obesity with potential consequences for risk of several major cancers...
  100. ncbi request reprint Evidence for an association between JC virus and colorectal neoplasia
    C Richard Boland
    Cancer Epidemiol Biomarkers Prev 13:2285-6; author reply 2286. 2004

Research Grants38

  1. HORMONES, ALCOHOL CONSUMPTION AND BREAST CANCER RISK
    Polly Newcomb; Fiscal Year: 1993
    ..The University of Wisconsin Clinical Cancer Center and the Harvard School of Public Health will continue to coordinate the study and have submitted separate applications with identical research plans...
  2. HORMONE REPLACEMENT THERAPY AND LARGE BOWEL CANCER RISK
    Polly Newcomb; Fiscal Year: 2002
    ..The proposed study and its extensions should provide clear evidence for the degree to which HRT is protective against colorectal cancer and permit the determination of some of the relevant pathways for that protection. ..
  3. PHYSICAL ACTIVITY, LIFESTYLE AND BREAST CANCER RISK
    Polly Newcomb; Fiscal Year: 1999
    ....
  4. LEPTIN, IGFS AND COLORECTAL ADENOMA CANCER RISK
    Polly Newcomb; Fiscal Year: 2005
    ..This study may provide insights into the biologic mechanisms whereby obesity is associated with colorectal cancer risk, as well as have practical implications for cancer prevention. ..
  5. Hormones and Colon Cancer: Epigenetic Subtypes, Risk, and Survival
    Polly Newcomb; Fiscal Year: 2009
    ....
  6. RISK FACTORS AND BIOMARKERS FOR IN SITU BREAST CANCER
    Polly Newcomb; Fiscal Year: 1999
    ..The findings of this study may have important implications for breast cancer prevention and intervention. In addition, this study will establish the foundation for follow-up studies. ..
  7. ALCOHOL CONSUMPTION, LACTATION, AND BREAST CANCER RISK
    Polly Newcomb; Fiscal Year: 1991
    ..The Harvard School of Public Health and the University of Wisconsin Clinical Cancer Center will both serve as coordinating centers and have submitted separate applications with identical research plans...
  8. Hormones and Colon Cancer: Epigenetic Subtypes, Risk, and Survival
    Polly Newcomb; Fiscal Year: 2007
    ....
  9. Seattle Colorectal Cancer Family Registry (CFR)
    Polly Newcomb; Fiscal Year: 2006
    ..The Seattle CFR provides an important population-based perspective within our consortium studies of colorectal cancer. ..
  10. Colon Cancer Risk: IGF Polymorphisms/Lifestyle Factors
    Polly Newcomb; Fiscal Year: 2003
    ..As an adjunct to an existing study, this is an efficient, valid cost-effective approach to the investigation of the association between polymorphisms and cancer risk. ..
  11. Colon Cancer Pathways: Hyperplastic Polyps and Adenomas
    Polly Newcomb; Fiscal Year: 2009
    ..The results of this study will have implications for understanding the biology and prevention of colorectal cancer. ..
  12. Medications, Genetic Variability & Breast Cancer
    Polly Newcomb; Fiscal Year: 2007
    ..abstract_text> ..
  13. Breast Cancer in situ: Recurrence and Quality of Life
    Polly Newcomb; Fiscal Year: 2002
    ..The proposed population-based cohort offers a powerful opportunity to inform women and physicians as they consider the trade-offs currently inherent in BCIS treatment. ..