J Lee Nelson

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism
    J Lee Nelson
    Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 104:1637-42. 2007
  2. ncbi request reprint Maternal HLA class II compatibility in men with systemic lupus erythematosus
    Anne M Stevens
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
    Arthritis Rheum 52:2768-73. 2005
  3. ncbi request reprint Maternal microchimerism in healthy adults in lymphocytes, monocyte/macrophages and NK cells
    Laurence S Loubiere
    Human Immunogenetics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Lab Invest 86:1185-92. 2006
  4. ncbi request reprint Quantification of maternal microchimerism by HLA-specific real-time polymerase chain reaction: studies of healthy women and women with scleroderma
    Nathalie C Lambert
    Immunogenetics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Arthritis Rheum 50:906-14. 2004
  5. ncbi request reprint HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women
    Melissa A Schiff
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98104, USA
    Hum Immunol 66:1050-6. 2005
  6. ncbi request reprint Male microchimerism in women without sons: quantitative assessment and correlation with pregnancy history
    Zhen Yan
    Program in Human Immunogenetics, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
    Am J Med 118:899-906. 2005
  7. ncbi request reprint Prospective study of fetal DNA in serum and disease activity during pregnancy in women with inflammatory arthritis
    Zhen Yan
    Immunogenetics D2 100, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
    Arthritis Rheum 54:2069-73. 2006
  8. pmc High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study
    Richard A Nash
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 110:1388-96. 2007
  9. doi request reprint Soluble donor DNA and islet injury after transplantation
    Vijayakrishna K Gadi
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Transplantation 92:607-11. 2011
  10. pmc Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host?
    Hilary S Gammill
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Blood 116:2706-12. 2010

Detail Information

Publications43

  1. pmc Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism
    J Lee Nelson
    Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 104:1637-42. 2007
    ..Thus, T1D patients have higher levels of MMc in their circulation than unaffected siblings and healthy individuals, and MMc contributes to islet beta cells in a mother's progeny...
  2. ncbi request reprint Maternal HLA class II compatibility in men with systemic lupus erythematosus
    Anne M Stevens
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
    Arthritis Rheum 52:2768-73. 2005
    ..Male subjects were selected in order to avoid confounding due to fetal microchimerism, which may occur in women...
  3. ncbi request reprint Maternal microchimerism in healthy adults in lymphocytes, monocyte/macrophages and NK cells
    Laurence S Loubiere
    Human Immunogenetics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Lab Invest 86:1185-92. 2006
    ..Studies are needed to investigate the immunological effects and function of maternal Mc and to explore whether maternal Mc in cellular subsets has biological effects on her progeny...
  4. ncbi request reprint Quantification of maternal microchimerism by HLA-specific real-time polymerase chain reaction: studies of healthy women and women with scleroderma
    Nathalie C Lambert
    Immunogenetics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Arthritis Rheum 50:906-14. 2004
    ..This study was undertaken to investigate the frequency and quantitative levels of maternal Mc (MMc) in healthy women and women with SSc...
  5. ncbi request reprint HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women
    Melissa A Schiff
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98104, USA
    Hum Immunol 66:1050-6. 2005
    ..7, 95% CI 0.9-7.3). Additionally, DQA1*0102 was associated with increased risk (OR 4.5, 95% CI 1.3-5.3) and HLA-A*02 with decreased risk (OR 0.4, CI 0.2-0.9). Our findings are discussed along with studies in other populations...
  6. ncbi request reprint Male microchimerism in women without sons: quantitative assessment and correlation with pregnancy history
    Zhen Yan
    Program in Human Immunogenetics, Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
    Am J Med 118:899-906. 2005
    ..We investigated male microchimerism in women without sons and examined correlation with prior pregnancy history. Immunologic consequences of microchimerism are unknown. We studied healthy women and women with rheumatoid arthritis (RA)...
  7. ncbi request reprint Prospective study of fetal DNA in serum and disease activity during pregnancy in women with inflammatory arthritis
    Zhen Yan
    Immunogenetics D2 100, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
    Arthritis Rheum 54:2069-73. 2006
    ....
  8. pmc High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study
    Richard A Nash
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 110:1388-96. 2007
    ..Sustained responses including a decrease in dermal fibrosis were observed exceeding those previously reported with other therapies. HDIT and autologous HCT for SSc should be evaluated in a randomized clinical trial...
  9. doi request reprint Soluble donor DNA and islet injury after transplantation
    Vijayakrishna K Gadi
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Transplantation 92:607-11. 2011
    ..We hypothesized that immediate allograft injury is a key constraint on independence from exogenous insulin use...
  10. pmc Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host?
    Hilary S Gammill
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Blood 116:2706-12. 2010
    ....
  11. pmc Chimeric maternal cells with tissue-specific antigen expression and morphology are common in infant tissues
    Anne M Stevens
    Center for Immunity and Immunotherapy, Children s Hospital Research Institute, Seattle, WA 98101, USA
    Pediatr Dev Pathol 12:337-46. 2009
    ..Loss of tolerance to maternal parenchymal cells could lead to organ-specific "auto" inflammatory disease and elimination of maternal cells in areas of inflammation...
  12. ncbi request reprint Microchimerism: an investigative frontier in autoimmunity and transplantation
    Kristina M Adams
    Program in Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    JAMA 291:1127-31. 2004
    ..Advances in this new frontier of research with varied and numerous implications for human health are summarized...
  13. pmc Does pregnancy provide vaccine-like protection against rheumatoid arthritis?
    Katherine A Guthrie
    Clinical Statistics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Arthritis Rheum 62:1842-8. 2010
    ..Fetal cells acquired during pregnancy provide a potential explanation for modulation of RA risk by pregnancy. The present study was undertaken to examine the effect of parity on RA risk...
  14. pmc Pregnancy, microchimerism, and the maternal grandmother
    Hilary S Gammill
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 6:e24101. 2011
    ..An intriguing question is whether the population of cells from her own mother can influence either maternal health during pregnancy and/or the next generation (grandchildren)...
  15. pmc Case-control study of fetal microchimerism and breast cancer
    Vijayakrishna K Gadi
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS ONE 3:e1706. 2008
    ..We asked whether presence of FMc, routinely acquired during pregnancy, is a protective factor for breast cancer...
  16. ncbi request reprint Male DNA in female donor apheresis and CD34-enriched products
    Kristina M Adams
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 102:3845-7. 2003
    ..In summary, male DNA was frequently detected in G-PBMC and CD34-enriched products from female donors. Whether fetal microchimerism contributes to GVHD merits further investigation...
  17. ncbi request reprint Myocardial-tissue-specific phenotype of maternal microchimerism in neonatal lupus congenital heart block
    Anne M Stevens
    Fred Hutchinson Cancer Research Center, Immunogenetics, Seattle, WA 98109, USA
    Lancet 362:1617-23. 2003
    ..The most serious complication of NLS is inflammation of the atrioventricular node leading to congenital heart block (CHB)...
  18. pmc Acquisition of the rheumatoid arthritis HLA shared epitope through microchimerism
    Zhen Yan
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Arthritis Rheum 63:640-4. 2011
    ..This study was undertaken to discover whether RA patients who lack the SE can acquire it through microchimerism...
  19. ncbi request reprint Your cells are my cells
    J Lee Nelson
    University of Washington, Seattle, USA
    Sci Am 298:64-71. 2008
  20. ncbi request reprint Soluble donor DNA concentrations in recipient serum correlate with pancreas-kidney rejection
    Vijayakrishna K Gadi
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Chem 52:379-82. 2006
    ..There is no reliable serum marker available to monitor incipient pancreas or islet-cell rejection. We tested the hypothesis that quantification of donor-specific genomic DNA in serum (from tissue damage) can serve as a marker of rejection...
  21. ncbi request reprint Microchimerism in autoimmune disease: more questions than answers?
    Nathalie Lambert
    Program in Human Immunogenetics, Immunogenetics D2 100, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109 1024, USA
    Autoimmun Rev 2:133-9. 2003
    ....
  22. ncbi request reprint Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation
    Kristina M Adams
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Human Immunogenetics Program, 1100 Fairview Ave N, D2 100, PO Box 19024, Seattle, WA 98109 19024, USA
    Blood 104:1894-7. 2004
    ..01). Overall, risk factors were similar to those described in GVHD. Although an independent effect of parity could not be completely separated from other factors, donor and recipient pregnancy history merits further investigation...
  23. ncbi request reprint Liver biopsies from human females contain male hepatocytes in the absence of transplantation
    Anne M Stevens
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Lab Invest 84:1603-9. 2004
    ..Whether fetal cells play a role in autoimmune diseases like PBC merits further investigation...
  24. pmc Incidence, risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease
    Yoshihiro Inamoto
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA and
    Blood 121:5098-103. 2013
    ..We found a substantial incidence of sclerosis in patients with chronic GVHD. Development of sclerosis can cause disability but does not affect mortality or recurrent malignancy in patients with chronic GVHD. ..
  25. pmc Male microchimerism in the human female brain
    William F N Chan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS ONE 7:e45592. 2012
    ..06) of male microchimerism in the brains of women with Alzheimer's disease than the brains of women without neurologic disease. In conclusion, male microchimerism is frequent and widely distributed in the human female brain...
  26. pmc Microchimerism in the rheumatoid nodules of patients with rheumatoid arthritis
    William F N Chan
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Arthritis Rheum 64:380-8. 2012
    ..This study was undertaken to investigate rheumatoid nodules for microchimerism...
  27. pmc Allogeneic marrow transplantation in patients with severe systemic sclerosis: resolution of dermal fibrosis
    Richard A Nash
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Arthritis Rheum 54:1982-6. 2006
    ..To evaluate the safety and efficacy of allogeneic hematopoietic cell transplantation (HCT) after myeloablative conditioning in patients with severe systemic sclerosis (SSc)...
  28. pmc Naturally acquired microchimerism
    Hilary S Gammill
    Department of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Int J Dev Biol 54:531-43. 2010
    ..This review will provide an overview of microchimerism during pregnancy and of current knowledge regarding long-term effects of naturally acquired fetal and maternal microchimerism...
  29. pmc Autoimmune disease during pregnancy and the microchimerism legacy of pregnancy
    Kristina M Adams Waldorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Immunol Invest 37:631-44. 2008
    ..Fetal and maternal microchimerism will be reviewed with a focus on systemic sclerosis (scleroderma), autoimmune thyroid disease, neonatal lupus and type I diabetes mellitus...
  30. ncbi request reprint Microchimerism: incidental byproduct of pregnancy or active participant in human health?
    J Lee Nelson
    Program in Human Immunogenetics, Immunogenetics D2 100, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Trends Mol Med 8:109-13. 2002
    ....
  31. pmc The otherness of self: microchimerism in health and disease
    J Lee Nelson
    Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Trends Immunol 33:421-7. 2012
    ....
  32. ncbi request reprint Fetal microchimerism in women with breast cancer
    Vijayakrishna K Gadi
    Clinical Research Division, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Cancer Res 67:9035-8. 2007
    ..Further studies are indicated and, if confirmed, extended studies to examine whether allogeneic immune surveillance from FMc is deficient in women with breast cancer...
  33. pmc Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis
    Veronika Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 100:9452-7. 2003
    ..These results suggest that a profound dysregulation of NKG2D and its MIC ligands may cause autoreactive T cell stimulation, thus promoting the self-perpetuating pathology in RA and possibly other autoimmune diseases...
  34. ncbi request reprint Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer
    Nathalie C Lambert
    Fred Hutchinson Cancer Research Center the University of Washington Medical Center and the Virginia Mason Medical Center, Seattle, WA 98109 1024, USA
    Blood 100:2845-51. 2002
    ....
  35. ncbi request reprint Human leukocyte antigen class II and cervical cancer risk: a population-based study
    Margaret M Madeleine
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle 98109 1024, USA
    J Infect Dis 186:1565-74. 2002
    ..7; 95% CI, 0.5-1.0) and DRB1*13-DQB1*06 (OR, 0.6; 95% CI, 0.4-0.9) haplotypes. These results add to the evidence that certain HLA class II alleles or allele combinations, or genes linked to them, make some women more susceptible to SCC...
  36. ncbi request reprint Microchimerism in human health and disease
    J Lee Nelson
    Program in Human Immunogenetics, Fred Hutchinson Cancer Research Center, and Rheumatology, University of Washington, Seattle, WA 98109 1024, USA
    Autoimmunity 36:5-9. 2003
    ....
  37. doi request reprint Intrauterine environment and multiple sclerosis: a population- based case-control study
    Beth A Mueller
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, USA
    Mult Scler 19:106-11. 2013
    ..Associations of several autoimmune disorders with intrauterine and early life exposures have been reported...
  38. ncbi request reprint Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families
    Damini Jawaheer
    Center for Genomics and Human Genetics, Manhasset, New York 11030, USA
    Arthritis Rheum 48:906-16. 2003
    ..A number of non-HLA loci that have shown evidence (P < 0.05) for linkage with rheumatoid arthritis (RA) have been previously identified. The present study attempts to confirm these findings...
  39. ncbi request reprint Pregnancy and microchimerism in autoimmune disease: protector or insurgent?
    J Lee Nelson
    Arthritis Rheum 46:291-7. 2002
  40. ncbi request reprint Significant fetal cell microchimerism in a nontransfused woman with hepatitis C: Evidence of long-term survival and expansion
    Kirby L Johnson
    Hepatology 36:1295-7. 2002
  41. pmc High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomes
    Peter A McSweeney
    University of Colorado Health Sciences Center, Denver 80262, USA
    Blood 100:1602-10. 2002
    ..Responses in skin and mHAQ-DI scores exceed those reported with other therapies, suggesting that HDIT is a promising new therapy for SSc that should be evaluated in prospective randomized studies...
  42. ncbi request reprint Microchimerism detection by human leucocyte antigen-specific quantitative-polymerase chain reaction analysis in recipients of allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes
    Kenneth G Lucas
    Br J Haematol 129:443-4. 2005
  43. pmc Skewed X-chromosome inactivation in scleroderma
    Elif Uz
    Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Bilkent, Ankara, 06800, Turkey
    Clin Rev Allergy Immunol 34:352-5. 2008
    ..Skewed XCI mosaicism could be considered as an important risk factor in scleroderma...