Suresh Moolgavkar

Summary

Affiliation: Fred Hutchinson Cancer Research Center
Country: USA

Publications

  1. pmc Impact of reduced tobacco smoking on lung cancer mortality in the United States during 1975-2000
    Suresh H Moolgavkar
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109, USA
    J Natl Cancer Inst 104:541-8. 2012
  2. pmc On the number of founding germ cells in humans
    Chang Jiang Zheng
    Department of Occupational and Environmental Medicine, Regions Hospital, University of Minnesota, Saint Paul, MN 55101, USA
    Theor Biol Med Model 2:32. 2005
  3. ncbi request reprint Air pollution and daily mortality in two U.S. counties: season-specific analyses and exposure-response relationships
    Suresh H Moolgavkar
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N MP 665, Seattle, WA 98109, USA
    Inhal Toxicol 15:877-907. 2003
  4. ncbi request reprint Multistage carcinogenesis and the incidence of human cancer
    Suresh H Moolgavkar
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Chromosomes Cancer 38:302-6. 2003
  5. pmc Air pollution and daily mortality in three U.S. counties
    S H Moolgavkar
    Fred Hutchinson Cancer Research Center and Sciences International, Inc, Seattle, Washington, USA
    Environ Health Perspect 108:777-84. 2000
  6. ncbi request reprint Biopersistence, fiber length, and cancer risk assessment for inhaled fibers
    S H Moolgavkar
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Inhal Toxicol 13:755-72. 2001
  7. ncbi request reprint Fine particles and mortality
    Suresh H Moolgavkar
    Fred Hutchinson Cancer Research Center Seattle, Washington 98109, USA
    Inhal Toxicol 18:93-4. 2006
  8. doi request reprint Pleural and peritoneal mesotheliomas in SEER: age effects and temporal trends, 1973-2005
    Suresh H Moolgavkar
    Exponent Inc, Bellevue, WA, USA
    Cancer Causes Control 20:935-44. 2009
  9. ncbi request reprint Air pollution and hospital admissions for chronic obstructive pulmonary disease in three metropolitan areas in the United States
    S H Moolgavkar
    Division of Public Health Sciences MP 665, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Inhal Toxicol 12:75-90. 2000
  10. ncbi request reprint The role of promotion in carcinogenesis from protracted high-LET exposure
    S B Curtis
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Phys Med 17:157-60. 2001

Research Grants

  1. Stochastic models for radiation carcinogenesis: tempora*
    Suresh Moolgavkar; Fiscal Year: 2004
  2. BIOMATHEMATICAL APPROACHES TO CANCER
    Suresh Moolgavkar; Fiscal Year: 2005
  3. Lung Cancer in the U.S.: Trends and Prevention
    Suresh Moolgavkar; Fiscal Year: 2007
  4. Lung Cancer in the U.S.: Trends and Prevention
    Suresh Moolgavkar; Fiscal Year: 2006
  5. BIOMATHEMATICAL APPROACHES TO CANCER
    Suresh Moolgavkar; Fiscal Year: 2000
  6. BIOMATHEMATICAL APPROACHES TO CANCER
    Suresh Moolgavkar; Fiscal Year: 1993

Detail Information

Publications35

  1. pmc Impact of reduced tobacco smoking on lung cancer mortality in the United States during 1975-2000
    Suresh H Moolgavkar
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109, USA
    J Natl Cancer Inst 104:541-8. 2012
    ..We quantified the cumulative impact of changes in smoking behaviors that started in the mid-1950s on lung cancer mortality in the United States over the period 1975-2000...
  2. pmc On the number of founding germ cells in humans
    Chang Jiang Zheng
    Department of Occupational and Environmental Medicine, Regions Hospital, University of Minnesota, Saint Paul, MN 55101, USA
    Theor Biol Med Model 2:32. 2005
    ..In this paper we obtain a new estimate for the value in humans by using a mathematical model of germ cell development that depends on available oocyte counts for adult women...
  3. ncbi request reprint Air pollution and daily mortality in two U.S. counties: season-specific analyses and exposure-response relationships
    Suresh H Moolgavkar
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N MP 665, Seattle, WA 98109, USA
    Inhal Toxicol 15:877-907. 2003
    ..Exposure-response analyses using flexible smoothers showed significant departures from linearity, particularly for PM effects...
  4. ncbi request reprint Multistage carcinogenesis and the incidence of human cancer
    Suresh H Moolgavkar
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Chromosomes Cancer 38:302-6. 2003
    ..As a corollary, intervention strategies that decrease this rate are to be preferred to strategies that decrease the rate of early mutational events in carcinogenesis...
  5. pmc Air pollution and daily mortality in three U.S. counties
    S H Moolgavkar
    Fred Hutchinson Cancer Research Center and Sciences International, Inc, Seattle, Washington, USA
    Environ Health Perspect 108:777-84. 2000
    ..In general, the gases, particularly CO, but not ozone, were much more strongly associated with mortality than was particulate matter. This association was particularly striking in Los Angeles County...
  6. ncbi request reprint Biopersistence, fiber length, and cancer risk assessment for inhaled fibers
    S H Moolgavkar
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Inhal Toxicol 13:755-72. 2001
    ..We propose an approach to estimating human lung cancer risk associated with inhaled fibers from animal studies...
  7. ncbi request reprint Fine particles and mortality
    Suresh H Moolgavkar
    Fred Hutchinson Cancer Research Center Seattle, Washington 98109, USA
    Inhal Toxicol 18:93-4. 2006
  8. doi request reprint Pleural and peritoneal mesotheliomas in SEER: age effects and temporal trends, 1973-2005
    Suresh H Moolgavkar
    Exponent Inc, Bellevue, WA, USA
    Cancer Causes Control 20:935-44. 2009
    ..8 per million person-years) exhibit no temporal trends over the period of the study. We estimate that approximately 94,000 cases of pleural and 15,000 cases of peritoneal mesothelioma will occur in the US over the period 2005-2050...
  9. ncbi request reprint Air pollution and hospital admissions for chronic obstructive pulmonary disease in three metropolitan areas in the United States
    S H Moolgavkar
    Division of Public Health Sciences MP 665, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Inhal Toxicol 12:75-90. 2000
    ....
  10. ncbi request reprint The role of promotion in carcinogenesis from protracted high-LET exposure
    S B Curtis
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Phys Med 17:157-60. 2001
    ....
  11. ncbi request reprint A new perspective of carcinogenesis from protracted high-LET radiation arises from the two-stage clonal expansion model
    S B Curtis
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Adv Space Res 30:937-44. 2002
    ..e., the traversal of normal cells by alpha particles, followed by the signaling of these cells to nearby initiated cells which then modify their proliferation kinetics...
  12. pmc Longitudinal multistage model for lung cancer incidence, mortality, and CT detected indolent and aggressive cancers
    William D Hazelton
    Fred Hutchinson Cancer Research Center, Public Health Sciences Division, 1100 Fairview Avenue North, Box 19024, Seattle, WA 98109, USA
    Math Biosci 240:20-34. 2012
    ..Females may have an inherently higher proportion of indolent lung cancers than males, or aggressive lung cancers may be brought into check by the immune system more frequently among females than males...
  13. ncbi request reprint Evidence of health impacts of sulfate-and nitrate-containing particles in ambient air
    Richard Reiss
    Exponent, Inc, Alexandria, Virginia 22314, USA
    Inhal Toxicol 19:419-49. 2007
    ..There is insufficient evidence to include or exclude these processes as being potentially important to PM-associated health risk...
  14. ncbi request reprint Analysis of a historical cohort of Chinese tin miners with arsenic, radon, cigarette smoke, and pipe smoke exposures using the biologically based two-stage clonal expansion model
    W D Hazelton
    Fred Hutchinson Cancer Research Center, Public Health Sciences Division, MP 665, 1100 Fairview Avenue North, Box 19024, Seattle, WA 98109 1024, USA
    Radiat Res 156:78-94. 2001
    ..Smoking a bamboo water pipe or a Chinese long-stem pipe appears to confer less risk than cigarette use, given equivalent tobacco consumption...
  15. ncbi request reprint Long man-made fibers and lung cancer risk
    S H Moolgavkar
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, MP 665, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Regul Toxicol Pharmacol 33:138-46. 2001
    ..The data are consistent with the hypothesis that fibers act as initiators in the rat lung. We present an estimate of the dose-dependent initiation parameter that is based on all the available data...
  16. ncbi request reprint From mechanisms to risk estimation--bridging the chasm
    S B Curtis
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Adv Space Res 34:1404-9. 2004
    ..Important directions in critical experiment definition are suggested, including a renewed emphasis on well-designed animal experiments over extended periods of time...
  17. ncbi request reprint The power of the European Union protocol to test for carcinogenicity of inhaled fibers
    S H Moolgavkar
    Division of Public Health Sciences-MP665, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington, 98109, USA
    Regul Toxicol Pharmacol 33:350-5. 2001
    ..However, the EU protocol has very low power to detect effects of short-lived fibers, such as X607, with WHL of about 10 days...
  18. ncbi request reprint Re: "Bayesian projections: what are the effects of excluding data from younger age groups?"
    Mark S Clements
    Am J Epidemiol 164:292-3; author reply 293-4. 2006
  19. ncbi request reprint Biologically based analysis of lung cancer incidence in a large Canadian occupational cohort with low-dose ionizing radiation exposure, and comparison with Japanese atomic bomb survivors
    William D Hazelton
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Toxicol Environ Health A 69:1013-38. 2006
    ....
  20. ncbi request reprint Analysis of lung cancer incidence in the Nurses' Health and the Health Professionals' Follow-Up Studies using a multistage carcinogenesis model
    Rafael Meza
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Causes Control 19:317-28. 2008
    ..The age-adjusted risk among ex-smokers is somewhat higher in NHS, possibly due to differences in the age-distribution between the two cohorts...
  21. pmc Does folic acid supplementation prevent or promote colorectal cancer? Results from model-based predictions
    E Georg Luebeck
    Fred Hutchinson Cancer Research Center, Biostatistics and Biomathematics, 1100 Fairview Avenue North, M2 B500, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1360-7. 2008
    ..Experimental studies are needed to provide direct evidence for this dual role of folate in colorectal cancer and to validate and improve the model predictions...
  22. pmc Age-specific incidence of cancer: Phases, transitions, and biological implications
    Rafael Meza
    Program in Biostatistics and Biomathematics and Program in Computational Biology, Fred Hutchinson Cancer Research Center 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 105:16284-9. 2008
    ..The linear phase of the age-specific incidence curve represents this conversion, which is the result of recessive inactivation of a gatekeeper gene, such as the APC gene in the colon and the CDKN2A gene in the pancreas...
  23. pmc Multistage carcinogenesis and the incidence of colorectal cancer
    E Georg Luebeck
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P O Box 19024, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 99:15095-100. 2002
    ..By contrast, interventions that decrease the rate of mutations at the adenomatous polyposis coli locus are much less effective in reducing the risk of colon cancer...
  24. ncbi request reprint Multistage models and the incidence of cancer in the cohort of atomic bomb survivors
    Wolfgang F Heidenreich
    GSF National Research Center for Environment and Health, Institute for Radiation Protection, 85764 Neuherberg, Germany
    Radiat Res 158:607-14. 2002
    ..Unfortunately for hypothesis generation, the data appear to be consistent with a number of different mechanistic interpretations of the role of radiation in carcinogenesis...
  25. ncbi request reprint Effects of exposure uncertainties in the TSCE model and application to the Colorado miners data
    Wolfgang F Heidenreich
    GSF National Research Center for Environment and Health Institute for Radiation Protection, 85764 Neuherberg, Germany
    Radiat Res 161:72-81. 2004
    ..The estimated promoting action of radon increases by a factor of up to 1.2 for the largest assumed exposure uncertainties...
  26. ncbi request reprint Modulation of liver tumorigenesis in Connexin32-deficient mouse
    E Georg Luebeck
    Fred Hutchinson Cancer Research Center, Public Health Sciences Division, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Mutat Res 570:33-47. 2005
    ..Our findings also underscore the importance of the timing (6 weeks versus 2 weeks) of the genotoxic insult in relation to the developmental stage of the liver and the importance of clonal selection during tumor promotion...
  27. ncbi request reprint Lung cancer rate predictions using generalized additive models
    Mark S Clements
    National Centre for Epidemiology and Population Health, The Australian National University, Canberra, ACT 0200, Australia
    Biostatistics 6:576-89. 2005
    ..In summary, the two-dimensional GAM performed well. The GAMs make the important prediction that female lung cancer rates in these countries will be stable or begin to decline in the future...
  28. ncbi request reprint Choice of stratification in Poisson process analysis of recurrent event data with environmental covariates
    Anup Dewanji
    Applied Statistics Unit, Indian Statistical Institute, 203 B T Road, Calcutta, India
    Stat Med 21:3383-93. 2002
    ..We suggest a cross-validation approach to choosing a stratification model to balance the trade-off between bias and variance. We also establish a connection between the Poisson process approach and case cross-over studies...
  29. ncbi request reprint Multistage carcinogenesis and lung cancer mortality in three cohorts
    William D Hazelton
    Fred Hutchinson Cancer Research Center, Public Health Sciences Division, M2 B500, 1100 Fairview Avenue North, Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1171-81. 2005
    ..The importance of smoking duration on lung cancer risk in these cohorts is a direct consequence of promotion. Intervention and treatment strategies should focus on promotion as the primary etiologic mechanism in lung carcinogenesis...
  30. ncbi request reprint Age effects and temporal trends in adenocarcinoma of the esophagus and gastric cardia (United States)
    Jihyoun Jeon
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Cancer Causes Control 17:971-81. 2006
    ..Temporal trends in the incidence of both cancers are dominated by dramatically increasing period effects...
  31. ncbi request reprint A review and critique of the EPA's rationale for a fine particle standard
    Suresh H Moolgavkar
    Sciences International, Inc, King Street Station, 1800 Diagonal Road, Suite 500, Alexandria, VA 22314, USA
    Regul Toxicol Pharmacol 42:123-44. 2005
    ..If the Agency justifies a particulate matter mass standard on these grounds then the debate over the form and level of the standard will, for all practical purposes, belong strictly in the Policy arena...
  32. ncbi request reprint Commentary: Fifty years of the multistage model: remarks on a landmark paper
    Suresh H Moolgavkar
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Int J Epidemiol 33:1182-3. 2004
  33. ncbi request reprint Response to the commentary of Donald A. Pierce (Radiat. Res. 160, 718-723, 2003)
    Wolfgang F Heidenreich
    Radiat Res 161:369-70; author reply 370-1. 2004
  34. ncbi request reprint Gestational mutations and carcinogenesis
    Rafael Meza
    Department of Applied Mathematics, University of Washington, and Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P O Box 19024, Seattle, WA 98109 1024, USA
    Math Biosci 197:188-210. 2005
    ..The analysis of the SEER data also shows that gestational mutations could contribute to inter-individual variations in colorectal cancer risk...
  35. pmc Evaluation of screening strategies for pre-malignant lesions using a biomathematical approach
    Jihyoun Jeon
    Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA
    Math Biosci 213:56-70. 2008
    ..We further demonstrate the utility of our approach by computing the benefits of up to two colonoscopies on the lifetime risk of colorectal cancer...

Research Grants22

  1. Stochastic models for radiation carcinogenesis: tempora*
    Suresh Moolgavkar; Fiscal Year: 2004
    ..The main goals of these analyses are to explore the effects of various age- and time-related factors and of protraction of exposure on the risk of radiation carcinogenesis. ..
  2. BIOMATHEMATICAL APPROACHES TO CANCER
    Suresh Moolgavkar; Fiscal Year: 2005
    ..The results of analyses will be used to help generate biologically relevant questions and hypotheses and to plan further experiments and studies, which, in turn, will lead to more refined models. ..
  3. Lung Cancer in the U.S.: Trends and Prevention
    Suresh Moolgavkar; Fiscal Year: 2007
    ..We propose to explore collaboration with other investigators supported by CISNET, particularly those interested in using our model as the 'natural history' component of screening models. ..
  4. Lung Cancer in the U.S.: Trends and Prevention
    Suresh Moolgavkar; Fiscal Year: 2006
    ..We propose to explore collaboration with other investigators supported by CISNET, particularly those interested in using our model as the 'natural history' component of screening models. ..
  5. BIOMATHEMATICAL APPROACHES TO CANCER
    Suresh Moolgavkar; Fiscal Year: 2000
    ....
  6. BIOMATHEMATICAL APPROACHES TO CANCER
    Suresh Moolgavkar; Fiscal Year: 1993
    ..A previously developed stochastic two-stage model for carcinogenesis will be extended to allow the incorporation of time- dependent covariates. The properties of this model will be investigated within the context of risk assessment...